viernes, 29 de junio de 2018

Building the green

MIT has a long connection with the sport of golf, on and off the course. The Institute’s varsity golf program existed from 1902 to 2009 and won at least eight recorded team or tournament championships and included at least 13 individual champions and medalists. And today MIT’s Club Golf Team is a competitive group that is part of the National Collegiate Club Golf Association.

Off the course, MIT Technology Review has attempted to characterize the perfect golf swing; Professor Anette “Peko” Hosoi has chronicled the impact of follow-through; and Professor Pedro Reis has studied how golf ball dimples might improve vehicle efficiency.

One alumnus, however, has truly gotten his hands onto the putting green. Ken Wang ’71, former MIT Alumni Association president who graduated with a degree from MIT's Department of Economics and currently serves on the MIT Corporation, developed one of the most highly regarded public golf courses in the country: the 170-acre Pound Ridge Golf Course, located less than an hour outside New York City.

Wang purchased the Pound Ridge course with his father as a lightly played nine-hole course in 1980, and completely rebuilt it as an 18-hole course in 2008. It’s known today as one of America’s premier public golf courses.

“We bought the course with no grander strategy than to have a place to golf near our family country home,” he says. “But today it’s very rare to find modern courses built near urban cities.”

The 18-hole transformation was the work legendary course architect Pete Dye, who is known for course designs that blend traditional golfing features with unique, thought-provoking twists.

“Pete thinks like a mathematician or engineer,” Wang says. “And he is a kindred spirit to the MIT community. His aw-shucks image notwithstanding, every angle has been figured out — to the nearest decimal. That precision has always appealed to the MIT side of me.”

As in previous years, Wang's course will be the site of this year's annual MIT Alumni Golf Classic.

“Being an MIT alum means more than just being a scientist or engineer,” Wang says. “It’s about connecting with the MIT community and having fun.”

The 2018 MIT Alumni Golf Classic will take place Tuesday, Sept. 25, at Pound Ridge Golf Club in Pound Ridge, New York. A discounted early bird price for individuals and foursomes is available until July 1. Free coach bus transportation from MIT campus will be available for Boston-area golfers.

A version of this article first appeared on the Slice of MIT blog.



de MIT News https://ift.tt/2lLwKhQ

MindHandHeart announces 12 new Innovation Fund winners

From a garden wall to a sleep challenge to a storytelling showcase, the newest MindHandHeart Innovation Fund winners aim to make MIT a more welcoming and healthy place. Sponsored by the Office of the Chancellor and MIT Medical, the fund offers grants of up to $10,000 to students, faculty, and staff with ideas to promote mental health and well-being.

MindHandHeart (MHH) awarded $42,138 to 12 projects, half of which are student-driven. Each proposal was reviewed by a committee comprised of members of the Undergraduate Association (UA) and Graduate Student Council (GSC); past Innovation Fund winners; and the MindHandHeart’s leadership team, including Chancellor Cynthia Barnhart, Medical Director Cecilia Stuopis, and Media Lab Professor and MHH Faculty Chair Rosalind Picard.

Several projects aim to promote mental health and well-being on campus. “MIT Prevention 2.0 Advanced Training for Gatekeepers” consists of a series of trainings for MIT gatekeepers to better support students. Gatekeepers include those who work directly with students and are in a position to respond to crisis situations, such as graduate resident advisors and tutors (GRA/GRTs), iREFs (Institute-wide Resources for Easing Friction and Stress) peer mentors, and Medlinks, liaisons between undergraduate students and MIT Medical.

Zan Barry, senior program manager in Community Wellness at MIT Medical, is spearheading this project and reflects on its potential, saying: “This joint effort will combine the expertise of students, mental health clinicians, student life professionals, and others. MIT is such a caring community, and Prevention 2.0 is another expression of that care.”

“Sleep Well” is a student-led challenge where members of the MIT community are encouraged to prioritize sleep and develop effective bedtime routines. Sponsored by the Teaching and Learning Lab, “Growth Mindset Video Resources for University Teaching Staff” are videos and supplemental resources to promote growth mindset, which has been associated with resiliency in times of academic stress.

Several projects are altering MIT’s physical landscape to build community and foster a sense of calm. Sponsored by LGBTQ@MIT, “Healing Gardens” is establishing indoor greenery in student spaces, encouraging socialization through cultivating gardens that signify growth, healing, and resilience. “MIT Medical Restorative Garden Wall” will create a garden wall and seating where MIT Medical patients can relax while waiting for their appointments. And, “Cozy Eddies- Lovely and Comforting Spaces that Remind Us to Pause” will build a playful, relaxing space inside of Building 9 to bring joy to passersby.

Additionally, a painting of doves in flight is coming to Building W11, courtesy of an undergraduate-led project entitled “Peaceful Painting.”

Five projects are working to build community at MIT in innovative ways. The “DUSP Healthy Masculinities Discussion Group Retreat” will offer a weekend retreat to members of the Department of Urban Studies and Planning (DUSP) Healthy Masculinities Discussion Group, where students will discuss topics of masculinity and vulnerability. The “Modern Family Mindfulness Program” will provide classes encouraging healthy relationships for adults living in MIT’s family housing communities as well as fun exercises for their children.

“OneWeek” is a student-driven series of events celebrating the many cultures represented in the MIT community as well as a venue to discuss global issues. “MITell Storytelling Showcase” will showcase personal stories told by members of the MIT community. Organized by the Social Justice Programming and Cross Cultural Engagement Intercultural (SPXCE) Center, “The SPXCE Race” consists of events and activities bringing students together in the style of the TV show “The Amazing Race.”

MindHandHeart is accepting applications for the next funding cycle from Oct. 1 to 30. To learn more about how MIT faculty, students, and staff can apply for grants of up to $10,000, visit the MindHandHeart Innovation Fund page.



de MIT News https://ift.tt/2KzQBv4

Let it rain! New coatings make natural fabrics waterproof

Fabrics that resist water are essential for everything from rainwear to military tents, but conventional water-repellent coatings have been shown to persist in the environment and accumulate in our bodies, and so are likely to be phased out for safety reasons. That leaves a big gap to be filled if researchers can find safe substitutes.

Now, a team at MIT has come up with a promising solution: a coating that not only adds water-repellency to natural fabrics such as cotton and silk, but is also more effective than the existing coatings. The new findings are described in the journal Advanced Functional Materials, in a paper by MIT professors Kripa Varanasi and Karen Gleason, former MIT postdoc Dan Soto, and two others.

“The challenge has been driven by the environmental regulators” because of the phaseout of the existing waterproofing chemicals, Varanasi explains. But it turns out his team’s alternative actually outperforms the conventional materials.

“Most fabrics that say ‘water-repellent’ are actually water-resistant,” says Varanasi, who is an associate professor of mechanical engineering. “If you’re standing out in the rain, eventually water will get through.” Ultimately, “the goal is to be repellent — to have the drops just bounce back.” The new coating comes closer to that goal, he says.

Comparison of droplets on a coated surface (left) and an untreated one (right). (Varanasi and Gleason research groups)

Because of the way they accumulate in the environment and in body tissue, the EPA is in the process of revising regulations on the long-chain polymers that have been the industry standard for decades. “They’re everywhere, and they don’t degrade easily,” Varanasi says.

The coatings currently used to make fabrics water repellent generally consist of long polymers with perfluorinated side-chains. The trouble is, shorter-chain polymers that have been studied do not have as much of a water-repelling (or hydrophobic) effect as the longer-chain versions. Another problem with existing coatings is that they are liquid-based, so the fabric has to be immersed in the liquid and then dried out. This tends to clog all the pores in the fabric, Varanasi says, so the fabrics no longer can breathe as they otherwise would. That requires a second manufacturing step in which air is blown through the fabric to reopen those pores, adding to the manufacturing cost and undoing some of the water protection.

Research has shown that polymers with fewer than eight perfluorinated carbon groups do not persist and bioaccumulate nearly as much as those with eight or more — the ones most in use. What this MIT team did, Varanasi explains, is to combine two things: a shorter-chain polymer that, by itself, confers some hydrophobic properties and has been enhanced with some extra chemical processing; and a different coating process, called initiated chemical vapor deposition (iCVD), which was developed in recent years by co-author Karen Gleason and her co-workers. Gleason is the Alexander and I. Michael Kasser Professor of Chemical Engineering and associate provost at MIT. Credit for coming up with the best short-chain polymer and making it possible to deposit the polymer with iCVD, Varanasi says, goes primarily to Soto, who is the paper’s lead author.

Using the iCVD coating process, which does not involve any liquids and can be done at low temperature, produces a very thin, uniform coating that follows the contours of the fibers and does not lead to any clogging of the pores, thus eliminating the need for the second processing stage to reopen the pores. Then, an additional step, a kind of sandblasting of the surface, can be added as an optional process to increase the water repellency even more. “The biggest challenge was finding the sweet spot where performance, durability, and iCVD compatibility could work together and deliver the best performance,” says Soto.

Testing of the coated surfaces shows that it gets a perfect score on a standard rain-repellancy test. The coatings are suited for substrates as diverse as fabrics, paper, and nanotextured silicon. (Varanasi and Gleason research groups)

The process works on many different kinds of fabrics, Varanasi says, including cotton, nylon, and linen, and even on nonfabric materials such as paper, opening up a variety of potential applications. The system has been tested on different types of fabric, as well as on different weave patterns of those fabrics. “Many fabrics can benefit from this technology,” he says. “There’s a lot of potential here.”

The coated fabrics have been subjected to a barrage of tests in the lab, including a standard rain test used by industry. The materials have been bombarded not only with water but with various other liquids including coffee, ketchup, sodium hydroxide, and various acids and bases — and have repelled all of them well.

The coated materials have been subjected to repeated washings with no degradation of the coatings, and also have passed severe abrasion tests, with no damage to the coatings after 10,000 repetitions. Eventually, under severe abrasion, “the fiber will be damaged, but the coating won’t,” he says.

The team, which also includes former postdoc Asli Ugur and Taylor Farnham ’14, SM ’16, plans to continue working on optimizing the chemical formula for the best possible water-repellency, and hopes to license the patent-pending technology to existing fabric and clothing companies. The work was supported by MIT's Deshpande Center for Technological Innovation.



de MIT News https://ift.tt/2tGRNq9

jueves, 28 de junio de 2018

The value of late-in-life health care spending

Around 25 percent of Medicare spending in the U.S. occurs in the last year of people’s lives. This is sometimes discussed as a questionable use of resources: Is society throwing large amounts of medical treatment at some patients in a futile, if noble, effort to extend lives that are bound to end soon?

A new study co-authored by an MIT health care economist offers a resounding answer: No.

After examining millions of medical records, the study found that although Medicare spending is concentrated among people who die, there is very little Medicare spending on patients whose death within the year is highly likely. For example, the researchers discovered, less than 5 percent of Medicare spending is applied to the single highest-risk percentile of all individuals — and their predicted one-year mortality rate is still just 46 percent.

“What we discovered is, very little money is spent on people who we know with high probability are going to die in a short amount of time,” says Amy Finkelstein, a professor in MIT’s Department of Economics and co-author of a paper in the journal Science that details the study’s findings. To the extent that such cases exist, she adds, “they’re just not the drivers of spending” in bulk.

The study also illuminates the general circumstances of late-in-life mortality. Fewer than 10 percent of people who die in a given year have a predicted one-year mortality rate over 50 percent. As the researchers found, even when people are admitted to a hospital in what turns out to be their last year of life, fewer than 4 percent of those patients have a predicted one-year mortality rate of 80 percent or higher at the time of admission.

In a sense, the study shows, the apparent concentration of spending on last-year-in-life patients is a byproduct of the fact that even relatively low-mortality health scenarios for the elderly will include a certain number of deaths — not that the individual treatment decisions represent longshot cases.

“I do hope we stop pointing to end-of-life spending as an obvious problem,” Finkelstein says. “That’s not to say there aren’t problems in the U.S. health care system, but this is not a symptom of them.”

The paper, “Predictive modeling of U.S. healthcare spending in late life,” is published today in Science. The authors are Liran Einav, a professor of economics at Stanford University; Finkelstein, the John and Jennie S. MacDonald Professor at MIT; Sendhil Mullainathan, a professor in the economics department at Harvard University; and Ziad Obermeyer, an assistant professor at Harvard Medical School.

Highly unpredictable

To conduct the study, the research team examined a random sample of almost 6 million Medicare enrollees who were in the program as of Jan. 1, 2008. For survivors, the study examines health care spending for all of 2008; for people who died in 2008, it examines spending over the year prior to death. The analysis produces mortality predictions as of Jan. 1, 2008, using data on demographics, health care use, and more.

The analysis also deployed a standard form of machine learning to evaluate the impact of a wide range of variables on health care trajectories, and to produce a probability of death within one year for every enrollee in the study.

The overarching result, as the authors write in the paper, is simple: “Death is highly unpredictable.”

Take, for instance, that top percentile of high-risk Medicare enrollees, those whose one-year predicted mortality rate is 46 percent: Of those patients, 44 percent survived for at least one year after the start of the study. Similarly, the predicted one-year mortality rate at the 95th percentile of people in the study is just 25 percent.

Moreover, the study finds, the basic fact that we spend more money on people who are sick — in the study, both those who recovered and those who died — accounts for 30 to 50 percent of the concentration of spending on people in their last 12 months of life.

“I think the typical narrative is: ‘Wow, the U.S. spends so much on health care and a quarter of that is in the last 12 months of life. That money is obviously a waste; we spent all this money and they died,’” says Finkelstein. “But that’s not the right way to look at it. We don’t know in advance who’s going to die this year, and some of the people we spend money on survive.”

“Let’s not get distracted by misleading statistics”

The paper’s authors suggest that productive new avenues for research on efficiency and medical spending will look concretely at more specific parts of the picture. Or, as they write in the paper, “a focus on end-of-life spending is not, by itself, a useful way to identify wasteful spending.”

Instead, Finkelstein contends, it would be more productive to zoom in on particular kinds of treatments and procedures, among other things, to assess their effectiveness, rather than generalizing about efficiency based on massive aggregate numbers such as the last-year-of-life Medicare figure.

“What we need to do is engage in the challenging task of figuring out which kinds of spending are yielding health benefits, and what types aren’t,” Finkelstein says. “Let’s focus on the real problem and not get distracted by misleading statistics. There’s a lot of hard work ahead of us, not easy answers.”

Finkelstein adds: “The policy upshot is: It’s important we understand the things we’re talking about.”

The study was supported, in part, by the National Institute on Aging, the National Institutes of Health, and the National Instiutute for Health Care Management.



de MIT News https://ift.tt/2yNROha

viernes, 22 de junio de 2018

Evelyn Wang named head of Department of Mechanical Engineering

Evelyn Wang, the Gail E. Kendall (1978) Professor and director of MIT’s Device Research Laboratory, has been named head of the MIT Department of Mechanical Engineering, effective July 1.

“Professor Wang’s accomplishments as a researcher and as an educator have been remarkable,” says Anantha Chandrakasan, dean of the School of Engineering. “I am very pleased she has agreed to take on this role for Course 2. She is a true community builder and will do great things for the department. I look forward to her leadership and her input on the School of Engineering’s future.”

An internationally recognized leader in phase change heat transfer on nanostructure surfaces, Wang’s research focuses on high-efficiency energy and water systems. Her work on solar cells that convert heat into focused beams of light was named as one of MIT Technology Review’s 10 breakthrough technologies of 2017. Her work on the development of a device that can extract fresh water from the air in arid environments was selected by Scientific American and the World Economic Forum as one of 2017’s 10 promising emerging technologies. 

Currently the associate department head for operations in MechE, Wang has served as co-chair of the department’s strategic planning committee and the MechE-Lincoln Laboratory Task Force. She has taught and mentored hundreds of Course 2 students; more than 10 of her former graduate students and postdocs currently serve as faculty members at various institutions.

Wang received a DARPA Young Faculty Award in 2008, an Air Force Office of Scientific Research Young Investigator Award in 2011, the American Society of Mechanical Engineers Bergles-Rohsenow Young Investigator Award in Heat Transfer in 2012, and she was honored by the Office of Naval Research Young Investigator Program Award in 2012. Wang is also a 2016 recipient of the ASME Electronic and Photonic Packaging Division Women Engineer Award; in 2017 she won the ASME Gustus Larson Memorial Award and the MIT Bose Award, and was named one of Foreign Policy’s “Global ReThinkers.” Wang is also an ASME Fellow and has 20 filed or pending patents.

Wang received her bachelor’s degree in mechnical engineering from MIT in 2000, and MS and PhD degrees from Stanford University in 2001 and 2006, respectively. 

She will replace Gang Chen, the Carl Richard Soderberg Professor in Power Engineering, who has been department head since July 1, 2013. “I am thankful for Gang’s tremendous leadership in MechE,” Chandrakasan noted. “He has hired amazing new faculty members, deftly managed the challenges of huge growth in Course 2 enrollments, and been a key leader in securing support for students and faculty, as well as for spaces that will allow for continued cutting-edge research and other activities that make MechE such a distinctive community.”



de MIT News https://ift.tt/2tl2Sx5

miércoles, 20 de junio de 2018

Biologists discover how pancreatic tumors lead to weight loss

Patients with pancreatic cancer usually experience significant weight loss, which can begin very early in the disease. A new study from MIT and Dana-Farber Cancer Institute offers insight into how this happens, and suggests that the weight loss may not necessarily affect patients’ survival.

In a study of mice, the researchers found that weight loss occurs due to a reduction in key pancreatic enzymes that normally help digest food. When the researchers treated these mice with replacement enzymes, they were surprised to find that while the mice did regain weight, they did not survive any longer than untreated mice.

Pancreatic cancer patients are sometimes given replacement enzymes to help them gain weight, but the new findings suggest that more study is needed to determine whether that actually benefits patients, says Matt Vander Heiden, an associate professor of biology at MIT and a member of the Koch Institute for Integrative Cancer Research.

“We have to be very careful not to draw medical advice from a mouse study and apply it to humans,” Vander Heiden says. “The study does raise the question of whether enzyme replacement is good or bad for patients, which needs to be studied in a clinical trial.”

Vander Heiden and Brian Wolpin, an associate professor of medicine at Harvard Medical School and Dana-Farber Cancer Institute, are the senior authors of the study, which appears in the June 20 issue of Nature. The paper’s lead authors are Laura Danai, a former MIT postdoc, and Ana Babic, an instructor in medicine at Dana-Farber.

Starvation mode

In a 2014 study, Vander Heiden and his colleagues found that muscle starts breaking down very early in pancreatic cancer patients, usually long before any other signs of the disease appear.

Still unknown was how this tissue wasting process occurs. One hypothesis was that pancreatic tumors overproduce some kind of signaling factor, such as a hormone, that circulates in the bloodstream and promotes breakdown of muscle and fat.

However, in their new study, the MIT and Dana-Farber researchers found that this was not the case. Instead, they discovered that even very tiny, early-stage pancreatic tumors can impair the production of key digestive enzymes. Mice with these early-stage tumors lost weight even though they ate the same amount of food as normal mice. These mice were unable to digest all of their food, so they went into a starvation mode where the body begins to break down other tissues, especially fat. 

The researchers found that when they implanted pancreatic tumor cells elsewhere in the body, this weight loss did not occur. That suggests the tumor cells are not secreting a weight-loss factor that circulates in the bloodstream; instead, they only stimulate tissue wasting when they are in the pancreas.

The researchers then explored whether reversing this weight loss would improve survival. Treating the mice with pancreatic enzymes did reverse the weight loss. However, these mice actually survived for a shorter period of time than mice that had pancreatic tumors but did not receive the enzymes. That finding, while surprising, is consistent with studies in mice that have shown that calorie restriction can have a protective effect against cancer and other diseases.

“It turns out that this mechanism of tissue wasting is actually protective, at least for the mice, in the same way that limiting calories can be protective for mice,” Vander Heiden says.

Human connection

The intriguing findings from the mouse study prompted the research team to see if they could find any connection between weight loss and survival in human patients. In an analysis of medical records and blood samples from 782 patients, they found no link between degree of tissue wasting at the time of diagnosis and length of survival. That finding is important because it could reassure patients that weight loss does not necessarily mean that the patient will do worse, Vander Heiden says.

“Sometimes you can’t do anything about this weight loss, and this finding may mean that just because the patient is eating less and is losing weight, that doesn’t necessarily mean that they’re shortening their life,” he says.

The researchers say that more study is needed to determine if the same mechanism they discovered in mice is also occurring in human cancer patients. Because the mechanism they found is very specific to pancreatic tumors, it may differ from the underlying causes behind tissue wasting seen in other types of cancer and diseases such as HIV.

“From a mechanistic standpoint, this study reveals a very different way to think about what could be causing at least some weight loss in pancreatic cancer, suggesting that not all weight loss is the same across different cancers,” Vander Heiden says. “And it raises questions that we really need to study more, because some mechanisms may be protective and some mechanisms may be bad for you.”

Clary Clish, director of the Metabolomics Platform at the Broad Institute, and members of his research group also contributed to this work. The research was funded, in part, by the Lustgarten Foundation, a National Institutes of Health Ruth Kirschstein Fellowship, Stand Up 2 Cancer, the Ludwig Center for Molecular Oncology at MIT, the Koch Institute Frontier Research Program through the Kathy and Curt Marble Cancer Research Fund, the MIT Center for Precision Cancer Medicine, and the National Institutes of Health.



de MIT News https://ift.tt/2MIk8EC

MIT researchers release evaluation of low-cost cooling devices in Mali

Across the Sahel, a semiarid region of western and north-central Africa extending from Senegal to Sudan, many small-scale farmers, market vendors, and families lack an affordable and effective solution for storing and preserving vegetables. As a result, harvested vegetables are at risk of spoiling before they can be sold or eaten.

That means loss of income for farmers and vendors, reduced availability of nutritious foods for local communities, and an increase in the time spent traveling to purchase fresh produce. The problem is particularly acute in off-grid areas, and for anyone facing financial or technical barriers to refrigeration.

Yet, as described in a recently released report “Evaporative Cooling Technologies for Improved Vegetable Storage in Mali” from MIT’s Comprehensive Initiative on Technology Evaluation (CITE) and the MIT D-Lab, there are low-cost, low-tech solutions for communities in need of produce refrigeration that rely on an age-old method exploiting the air-cooling properties of water evaporation. Made from simple materials such as bricks or clay pots, burlap sack or straw, these devices have the potential to address many of the challenges that face rural households and farmers in need of improved post-harvest vegetable storage.

The study was undertaken by a team of researchers led by Eric Verploegen of the D-Lab and Ousmane Sanogo and Takemore Chagomoka from the World Vegetable Center, which is engaged in ongoing work with horticulture cooperatives and farmers in Mali. To gain insight into evaporative cooling device use and preferences, the team conducted interviews in Mali with users of the cooling and storage systems and with stakeholders along the vegetable supply chain. They also deployed sensors to monitor product performance parameters. 

A great idea in need of a spotlight

Despite the potential for evaporative cooling technologies to fill a critical technological need, scant consumer information is available about the range of solutions available.

“Evaporative cooling devices for improved vegetable storage have been around for centuries, and we want to provide the kind of information about these technologies that will help consumers decide which products are right for them given their local climate and specific needs,” says Verploegen, the evaluation lead. 

The simple chambers cool vegetables through the evaporation of water, in the same way that the evaporation of perspiration cools the human body. When water (or perspiration) evaporates, it takes the heat with it. And in less humid climates like Mali, where it is hot and dry, technologies that take advantage of this cooling process show promise for effectively preserving vegetables.

The team studied two different categories of vegetable cooling technologies: large-scale vegetable cooling chambers constructed from brick, straw, and sack suitable for farming cooperatives, and devices made from clay pots for individuals and small-scale farmers. Over time, they monitored changes in temperature and humidity inside the devices to understand when they were most effective.

“As predicted,” says Verploegen, “the real-world performance of these technologies was stronger in the dry season. We knew this was true in a lab-testing environment, but we now have data that documents that a drop in temperature of greater than 8 degrees Celsius can be achieved in a real-world usage scenario.”

The decrease of temperature, along with the increased humidity and protection from pests provided by the devices, resulted in significant increases in shelf life for commonly stored vegetables including tomatoes, cucumbers, eggplant, cabbage, and hot peppers.

“The large-scale vegetable cooling devices made of brick performed significantly better than those made out of straw or sacks, both from a technical performance perspective and also from an ease-of-use perspective,” notes Verploegen. “For the small-scale devices, we found fairly similar performance across differing designs, indicating that the design constraints are not very rigid; if the basic principles of evaporative cooling are applied, a reasonably effective device can be made using locally available materials. This is an exciting result. It means that to scale use of this process for keeping vegetables fresh, we are looking at ways to disseminate information and designs rather than developing and distributing physical products.” 

The research results indicate that evaporative cooling devices would provide great benefit to small-scale farmers, vendors selling vegetables in a market, and individual consumers, who due to financial or energy constraints, don’t have other options. However, evaporative cooling devices are not appropriate for all settings: they are best suited to communities where there is access to water and vegetable storage is needed during hot and dry weather. And, users must be committed to tending the devices. Sensor data used in the study revealed that users were more inclined to water the cooling devices in the dry season and reduce their usage of the devices as the rainy season started.

Resources for development researchers and practitioners

In addition to the evaluation report, Verploegen has developed two practitioner resources, the “Evaporative Cooling Decision Making Tool” (which is interactive) and the “Evaporative Cooling Best Practices Guide,” to support the determination of evaporative cooler suitability and facilitate the devices’ proper construction and use. The intended audience for these resources includes government agencies, nongovernmental organizations, civil society organizations, and businesses that could produce, distribute, and/or promote these technologies.

Both resources are available online.

As part of an ongoing project, the MIT D-Lab and the World Vegetable Center are using the results of this research to test various approaches to increase dissemination of these technologies in the communities that can most benefit from them.

“This study provided us with the evidence that convinced us to use only the efficient types of vegetable cooling technologies — the larger brick chambers,” says World Vegetable Center plant health scientist Wubetu Bihon Legesse. “And, the decision support tool helped us evaluate the suitability of evaporative cooling systems before installing them.”

Launched at MIT in 2012, CITE is a pioneering program dedicated to developing methods for product evaluation in global development. Currently based at MIT D-Lab, CITE’s research is funded by the USAID U.S. Global Development Lab. CITE is led by Professor Dan Frey of the Department of Mechanical Engineering and MIT D-Lab, and additionally supported by MIT faculty and staff from the Priscilla King Gray Public Service Center, the Sociotechnical Systems Research Center, the Center for Transportation and Logistics, the School of Engineering, and the Sloan School of Management.



de MIT News https://ift.tt/2M4ARAH

Daniel Hastings named head of Department of Aeronautics and Astronautics

Daniel E. Hastings, the Cecil and Ida Green Education Professor at MIT, has been named head of the Department of Aeronautics and Astronautics, effective Jan. 1, 2019.

“Dan has a remarkable depth of knowledge about MIT, and has served the Institute in a wide range of capacities,” says Anantha Chandrakasan, dean of the School of Engineering. “He has been a staunch advocate for students, for research, and for MIT’s international activities. We are fortunate to have him join the School of Engineering’s leadership team, and I look forward to working with him.”

Hastings, whose contributions to spacecraft and space system-environment interactions, space system architecture, and leadership in aerospace research and education earned him election to the National Academy of Engineering in 2017, has held a range of roles involving research, education, and administration at MIT.

Hastings has taught courses in space environment interactions, rocket propulsion, advanced space power and propulsion systems, space policy and space systems engineering since he first joined the faculty in 1985. He became director of the MIT Technology and Policy Program in 2000 and was named director of the Engineering Systems Division in 2004. He served as dean for undergraduate education from 2006 to 2013, and from 2014 to 2018 he has been director of the Singapore-MIT Alliance for Research and Technology (SMART).

Hastings has also had an active career of service outside MIT. His many external appointments include serving as chief scientist from 1997 to 1999 for the U.S. Air Force, where he led influential studies of Air Force investments in space and of preparations for a 21st-century science and technology workforce. He was also the chair of the Air Force Scientific Advisory Board from 2002 to 2005; from 2002 to 2008, he was a member of the National Science Board.

A fellow of the American Institute of Aeronautics and Astronautics (AIAA), Hastings was also awarded the Losey Atmospheric Sciences Award from the AIAA in 2002. He is a fellow (academician) of the International Astronautical Federation and the International Council in System Engineering. The U.S Air Force granted him its Exceptional Service Award in 2008, and in both 1997 and 1999 gave him the Air Force Distinguished Civilian Award. He received the National Reconnaissance Office Distinguished Civilian Award in 2003. He was also the recipient of MIT’s Gordon Billard Award for “special service of outstanding merit performed for the Institute” in 2013.

Hastings received his bachelor’s degree from Oxford University in 1976, and MS and PhD degrees in aeronautics and astronautics from MIT in 1978 and 1980, respectively. 

Edward M. Greitzer, the H.N. Slater Professor of Aeronautics and Astronautics, will serve as interim department head from July 1 to Dec. 31, 2018.  

Hastings will replace Jaime Peraire, the H. N. Slater Professor in Aeronautics and Astronautics, who has been department head since July 1, 2011. “I am grateful to Jaime for his excellent work over the last seven years,” Chandrakasan noted. “During his tenure as department head, he led the creation of a new strategic plan and made significant steps in its implementation. He addressed the department's facilities challenges, strengthened student capstone- and research-project experience, and led the 2014 AeroAstro centennial celebrations, which highlighted the tremendous contributions MIT has made to aerospace and national service.”



de MIT News https://ift.tt/2tbe4MI

martes, 19 de junio de 2018

Audit Division announces Infinite Mile Awards

On June 13, the MIT Audit Division announced its 18th annual Infinite Mile Award recipients. The awards were presented at a luncheon celebrating and honoring the two individuals, Suwen Duan and Erin Coates, who received the awards for their 2018 contributions.

Suwen Duan, senior data analyst, was honored in the category of Collaboration and Community Building. Duan has an excellent capacity to initiate discussions with anyone who may have valuable input — all with the goal of ensuring the best information is available for any data analytics request. Her role is such that she works with everyone, from the senior auditors within various teams to the Institute auditor. Whether it is an ad-hoc request, often under tight deadline, or a long-term project, Duan has worked successfully with her colleagues in the Audit Division to design successful final products. She has also reached out to her colleagues around the Institute in order to engage them, learn, and assist if and when needed. A highlight of her hard work took place on May 21, when she hosted the first MIT Data Analyst Meeting with the goal of promoting and establishing an Institute group that can continue to collaborate in the quest for innovative ways to explore the vast amount and variety of data at MIT.

Erin Coates, senior internal auditor, was recognized in the category of Communication, Collaboration and Community Building and Excellence and Accountability. Coates excels on many levels in regard to her communication skills. She is always courteous when discussing topics with the auditees, well prepared and to the point, with a goal to take minimal necessary valuable clients’ time but also obtain the information needed. Coates is first to suggest ideas to recognize and celebrate a colleague’s milestone, thus promoting an inclusive and mutually respective community. Individuals outside the Audit Division appreciate Coates’ demeanor and her quality of work. All work product and tasks are executed to the best of her ability and in a timely manner. She understands the concept of accountability and in doing so thoroughly ensures audit methodology is followed during audits. Coates has exhibited the desire to learn as much about the Institute as possible through participating in and volunteering in events outside the division.

The Infinite Mile Awards have been a longstanding tradition within MIT. The Infinite Mile Award is intended to recognize individuals or teams from within the Audit Division or other collaborators who have made extraordinary contributions to help the division carry out its mission of being an independent, objective, innovative, and flexible business partner that adds value to the Institute. Nominations are submitted by colleagues who have recognized an individual that they feel has made a significant impact to the division's work and/or been a strong support or inspiration to them.



de MIT News https://ift.tt/2yrtvVY

Charting a path to better cell models of the intestine

For many years, drug development has relied on simplified and scalable cell culture models to find and test new drugs for a wide variety of diseases. However, cells grown in a dish are often a feint representation of healthy and diseased cell types in vivo. This limitation has serious consequences: Many potential medicines that originally appear promising in cell cultures often fail to work when tested in patients, and targets may be completely missed if they do not appear in a dish.

A highly collaborative team of researchers from the Harvard-MIT Program in Health Sciences and Technology (HST) and Institute for Medical Engineering and Science (IMES) at MIT recently set out to tackle this issue as it relates to a type of cell found in the intestine that is implicated in inflammatory bowel disease (IBD). In new work, the team was able to generate an intestinal cell that is a substantially better mimic of the real cell and can therefore be used in studies of diseases such as IBD. They reported their findings in a recent issue of BMC Biology.

The team was led by Ben Mead, a doctoral student in the HST Medical Engineering and Medical Physics Program; Jeffrey Karp, a professor at Brigham and Women’s Hospital, working closely with Jose Ordovas-Montanes, a postdoc in the lab of Pfizer-Laubach Career Development Assistant Professor Alex K. Shalek in the MIT Department of Chemistry; and the labs of MIT professor of biological engineering Jim Collins, Institute Professor Robert Langer, and scientists from the Broad Institute of Harvard and MIT and Koch Institute for Integrative Cancer Research.

Understanding genetic risk at the level of single cells

This study was catalyzed by the new technology of high-throughput single-cell RNA-sequencing, which enables transcriptome-wide profiling of tissues at the level of individual cells. Through the lens of single-cell RNA-sequencing, scientists are now able to ‘map’ our single cells and potentially the changes which give rise to disease. The team of researchers turned this method towards determining how well an existing cell culture model mimics a particular type of cell within the body, comparing two single cell ‘maps’: one of a mouse’s small intestine, and another of an adult stem cell-derived model of the small intestine, known as an organoid.

They used these maps to isolate a single cell type and ask how well the organoid-derived cell matched its natural counterpart. “Based on the differences between model and actual cell, we utilized a computationally driven bioengineering approach to improve the fidelity of the model.” said Karp. “We believe this approach may be key to unlocking the next generation of therapeutic development from cellular models, including those made from patient-derived stem cells.”

Individual genes can alter one’s risk of developing diseases such as Crohn’s disease, a type of IBD. One active area of research is understanding where these genes act in a tissue in order to further our understanding of disease mechanisms and propose novel therapeutic interventions. To address this, techniques are needed to reliably map “risk” genes not only within an affected tissue, but to individual cells, to properly surmise if a drug screen can correct a faulty gene or potentially improve a patient’s condition.

Single-cell RNA-sequencing at scale, a revolutionary technique pioneered for low-input clinical biopsies at MIT between Alex K. Shalek’s and Chris Love’s group, now allows researchers to deconstruct a tissue into its elemental components — cells — and identify the key patterns of gene expression which specify each cell type. The ability to efficiently profile tens of thousands of cells economically has unlocked the possibility to identify critical cell types in tissues whose genetic makeup had previously been difficult to discern.

Using single-cell “maps” to re-orient the development of a key cell type

Mapping tissues, such as the small intestine, is highly important in understanding where specific “risk” genes are acting. However, the key advances required to translate findings to the clinic will inevitably be through representative models for the cell types identified as interpreting genes and displaying a disease phenotype. One key IBD-relevant cell type already implicated through genetic studies is known as the Paneth cell, responsible for a key anti-microbial role in the small intestine and defending the stem cell niche.

When adult intestinal stem cells are grown in a dish, they self-organize into remarkable structures known as intestinal organoids: 3-D cellular structures that contain many of the cell types found in a real intestine. Nevertheless, how these intestinal organoids correspond to the bona fide cell types found in the intestine has proven challenging for researchers to tackle. To directly address this question, Shalek suggested a “quick” experiment to Mead, which then gave rise to the fruitful collaboration between the labs. 

Mead and Ordovas-Montanes developed a single-cell map of the true characteristics of small intestinal cell types as found within the mouse and, when comparing them to what a map of the intestinal-derived organoid looks like, identified several differences, particularly within the key IBD-relevant cell type known as the Paneth cell. Since the field’s map of an organoid didn’t quite correspond to the real tissue, it may have led them astray in the hunt for drug targets.

Fortunately, through their single-cell data, the team was able to learn how the maps were mis-aligned, and correct” the developmental pathways which were missing in the dish. As a result, they were able to generate a Paneth cell that is a substantially better mimic of the real cell and can now function to kill bacteria and support the neighboring stem cells which give rise to them.

Translational opportunities afforded by improved representations of tissues

With this improved cell in-hand, we are now developing a screening platform that will allow us to target relevant Paneth cell biology,” says Mead, who plans to continue the work he started as a postdoc in Shalek’s group.

Their approach for generating physiologically faithful intestinal cell types is a major technological advance that will provide other researchers a powerful tool to further their understanding of the specialized cell states of the epithelial barrier. “As we begin to understand which cell types specifically express genes that alter risk for IBD, it will be critical to ensure the disease models provide an accurate representation of that cell type,” says Ordovas-Montanes.

“We want to make better cell models to not only understand basic disease biology, but also to fast-track development of therapeutics” says Mead. “This research will have impact beyond the intestinal organoid community as organoids are increasingly employed for liver, kidney, lung, and even brain research, and our approach can be generalized for relating and aligning the cell types found in vivo with the models generated from these tissues.”



de MIT News https://ift.tt/2K3fUFS

Study: Climate action can limit Asia’s growing water shortages

Even “modest” action to limit climate change could help prevent the most extreme water-shortage scenarios facing Asia by the year 2050, according to a new study led by MIT researchers.

The study takes an inventive approach to modeling the effects of both climate change and economic growth on the world’s most heavily populated continent. Roughly 60 percent of the global population lives in Asia, often with limited access to water: There is less than half the amount of freshwater available per inhabitant in Asia, compared to the global average.

To examine the risk of water shortages on the continent, the researchers conducted detailed simulations of many plausible economic and climate pathways for Asia in the future, evaluating the relative effects of both pathways on water supply and demand. By studying cases in which economic change (or growth) continues but the climate remains unchanged — and vice versa — the scholars could better identify the extent to which these factors generate water shortages.

The MIT-based team found that with no constraints on economic growth and climate change, an additional 200 million people across Asia would be vulnerable to severe water shortages by 2050. However, fighting climate change along the lines of the 2015 Paris Agreement would reduce by around 60 million the number of people facing severe water problems.

But even with worldwide efforts to limit climate change, there is a 50 percent chance that around 100 million people in southern and eastern Asia will experience a 50 percent increase in “water stress” — their inability to access safe water — and a 10 percent chance that water shortages will double for those people.

“We do find that a mitigation strategy can reduce the heightened risk of water stress in Asia,” says Adam Schlosser, deputy director for science research at MIT’s Joint Program on the Science and Policy of Global Change, and co-author of a newly published paper detailing the findings. “But it doesn’t solve it all.”

The paper, “The Impact of Climate Change Policy on the Risk of Water Stress in Southern and Eastern Asia,” is being published today in the journal Environmental Research Letters. The authors are Xiang Gao, a Joint Program research scientist; Schlosser; Charles Fant, a former Joint Program postdoc and a researcher at Industrial Economics, Inc; and Kenneth Strzepek, a Joint Program research scientist and a professor emeritus at the University of Colorado.

The research team also uses models that track municipal and industrial activities and their specific water-demand consequences across many smaller subregions in Asia. Irrigation tends to be a major driver of water consumption, leading to diminished access to water for other uses.

Overall, the researchers conclude, through the mid-21st century, “socioeconomic growth contributes to an increase in water stress” across the whole region, but climate change can have “both positive and negative effects on water stress.” The study turns up a notable amount of regional variation in the effects of climate change within Asia. Climate change by itself is likely to have a more adverse impact on water access in China than in India, for instance, where a warming climate could produce more rain.

Apart from the most likely scenarios, another significant finding is that the potential for extreme water stress is associated with unabated climate change. As the authors state in the paper, “A modest greenhouse gas mitigation pathway eliminates the likelihood of … extreme outcomes” in water access. But without any such climate measures, “both countries have a chance of experiencing extreme water shortages by midcentury,” Gao says.

The study is part of a series of papers the research team is producing to assess water risks across southern and eastern Asia, based on modeling that captures the natural and managed aspects of the water systems across the region. A 2016 paper by the group established that there was a significant risk of water shortages for about 1 billion people in Asia by 2050. The current paper focuses on the impact of climate change policy, and a future paper will analyze the implications of adaptation strategies.

‘There are no easy options,” Schlosser says, of the various ways of limiting climate change. “All of them carry associated costs, and our continued research is looking at the extent to which widespread adaptive and water-efficient measures can reduce risks and perhaps be cost-effective and more resilient.”

The study was supported, in part, by the U.S. Department of Energy, as well as the government, industry and foundation sponsors of the MIT Joint Program on the Science and Policy of Global Change.



de MIT News https://ift.tt/2lhs8zH

lunes, 18 de junio de 2018

Robert Langer named 2018 US Science Envoy

Robert S. Langer, the David H. Koch (1962) Institute Professor at MIT, has been named one of five U.S. Science Envoys for 2018. As a Science Envoy for Innovation, Langer will focus on novel approaches in biomaterials, drug delivery systems, nanotechnology, tissue engineering, and the U.S. approach to research commercialization.

One of 13 Institute Professors at MIT, Langer has written more than 1,400 articles. He also has over 1,300 issued and pending patents worldwide. Langer's patents have been licensed or sublicensed to over 350 pharmaceutical, chemical, biotechnology and medical device companies. He is the most cited engineer in history (h-index 253 with over 254,000 citations, according to Google Scholar).

Langer is one of four living individuals to have received both the United States National Medal of Science (2006) and the United States National Medal of Technology and Innovation (2011). He has received over 220 major awards, including the 1998 Lemelson-MIT Prize, the world's largest prize for invention, for being "one of history's most prolific inventors in medicine."

Created in 2010, the Science Envoy Program engages eminent U.S. scientists and engineers to help forge connections and identify opportunities for sustained international cooperation. Science Envoys engage internationally at the citizen and government levels to enhance relationships between other nations and the United States, develop partnerships, and improve collaboration. These scientists leverage their international leadership, influence, and expertise in priority countries to advance solutions to shared science and technology challenges. Science Envoys travel as private citizens and usually serve for one year.

Previous Science Envoys with connections to MIT include Susan Hockfield, president emerita of MIT, and Alice P. Gast, president of Lehigh University and former chemical engineering professor at MIT.



de MIT News https://ift.tt/2lklatQ

Letter regarding the retirement of John Charles, vice president for information systems and technology

The following email was sent today to the MIT community by Executive Vice President and Treasurer Israel Ruiz.

Dear MIT faculty and staff,

I write to share the news that John Charles has let us know of his decision to retire as MIT's Vice President (VP) for Information Systems and Technology (IS&T) at the end of this calendar year, following five years of dedicated service to the Institute.

John came to MIT with extensive experience serving in both public and private research and education institutions. He has had a distinguished 25-year career as an IT leader, and has been a key member of our senior management team. As VP, John set a vision for the transformation of “IT@MIT”. Under his leadership, IS&T migrated 17 years of legacy SAP data to the SAP HANA cloud platform, and moved the majority of IS&T’s managed servers to the cloud, laying the groundwork for a new operating model for enterprise resource planning and data centers. With John’s guidance, the IS&T team implemented a number of cybersecurity enhancements designed to strengthen protections for the Institute’s core administrative systems, demonstrated the benefits of platform-based API-centric architecture, and modernized several key administrative and student systems. Working with the Information Technology Governance Committee, he has been a key contributor to the development of information technology policy at MIT.

I am grateful that John will continue in his current role through the upcoming fall semester. I also appreciate that Deputy Executive Vice President Tony Sharon will work with him and the IS&T team during this transition. As we begin the search for the right individual to build on what John has accomplished and fill the important role of leading IS&T, I welcome your input regarding potential candidates, as well as thoughts about the role. Please send comments or suggestions via email to me at evpt-hiring@mit.edu, or to Room 4-204. All correspondence received will be treated as confidential.

There will be an occasion to celebrate John and his contributions, but for now, I hope you will join me in expressing our gratitude for his tremendous service to the MIT community.
 

Sincerely,

Israel Ruiz
Executive Vice President and Treasurer



de MIT News https://ift.tt/2t7jzfn

Broadening the range of material rewards

Inside a high-performance integrated circuit, the copper wiring is tens of nanometers in diameter, with a coating that is a few nanometers thick. “If you took all this wiring and connected it and stretched it out, it would be about 20 kilometers long,” says Carl Thompson, MIT professor of materials science and engineering. “And it all has to work, and it has to work for years.”

That’s just one sample, from his own work, of the challenges MIT’s enormous spectrum of materials research — ranging from quantum devices all the way to buildings and roads. “There’s one researcher in metallurgy who makes objects that weigh a ton, in the same laboratory where people make objects that weigh nanograms,” Thompson notes.

Formed in 2017 by combining two longstanding MIT centers, the Materials Research Laboratory (MRL) acts as an umbrella for this work. About 70 faculty members are directly involved in the MRL. The total materials research community at MIT includes about 150 faculty, from all departments in the School of Engineering and many in the School of Science.

Materials research spans many disciplines, and projects often bring together researchers with very different sets of expertise, Thompson says. He emphasizes that the MRL’s strengthened ability to foster and accelerate such interdisciplinary work will boost partnerships with industry, where interdisciplinary collaborations are a norm.

Incentives for collaborations

Corporate connections have been central to Thompson’s own research, which focuses primarily on making thin films, micromaterials, and nanomaterials and integrating them into microelectronic and microelectromechanical devices.

“I’ve found that I can have impact on real systems that people can buy only by being deeply involved with industry,” Thompson says. “Industry partnerships have informed not only my research but my teaching, because I can talk about why some of the more fundamental problems in materials science and engineering are very important in applications that we all depend on.”

“It’s incredibly important for students and postdocs to interact with industry, and to understand the real problems and the real constraints,” he adds. “Many things sound great in the laboratory, and many of them are great, and eventually will become part of devices and systems. But there are many steps in between, and it’s very important for everybody in an academic community to understand that.”

Thompson’s research also underlines the necessity for cross-discipline collaborations — for instance, in his current research on thin-film batteries.

“There are projections that by 2025 there will be hundreds of billions of sensors out there in the internet of things, and we can't do that if we have to change the batteries on all of those all the time,” he remarks. “If you can make them with batteries and an energy source, then they can be autonomous, so you don't need to ever change the battery.”

His group seeks not only to develop thin-film battery materials but to integrate these materials with other components such as circuits, sensors and microelectromechanical devices.

“There’s a relationship between how you make the materials, what their structure is, and the performance of not only the material in the device but also the device itself,” Thompson says. “That work is very highly collaborative with people in other disciplines, such as electrical engineering and mechanical engineering. Materials research is critical; chemistry and physics are critical. So is understanding the factors that lead to the failure of batteries, and a mathematician here at MIT in collaboration with engineers and physical scientists has made a very important contribution to that topic.”

“In batteries, a small interdisciplinary working group has blossomed into an area of great expertise that is very highly interactive with industry,” he says. “Now the MRL is ideally positioned to help make collaborations like this happen.”

Merging into the MRL

The MRL combines MIT’s long-established Materials Processing Center (which was funded by industry, government agencies, and foundations) with the Center for Materials Science and Engineering (which performed basic science with experimental facilities supported by the National Science Foundation). Geoffrey Beach, associate professor of materials science and engineering, is MRL co-director.

“One of the main reasons we did the merger was so that we could do all these complementary activities together,” Thompson says. “Academics tend to work in silos, and you want to take people out of them to see how what they do is relevant to applications that other people do. MIT is very good about that. But the MRL, which takes the two communities together, will be an even better place to make those matches.”

Importantly, the MRL is also tightly joined to the new MIT.nano facility, a 200,000-square-foot center for nanoscience and nanotechnology, scheduled to open this summer, that was designed as a global powerhouse for research expertise and equipment. MRL researchers will be able to leverage the newly assembled MIT.nano resources that are unique within academia, Thompson says.

Even more broadly, Thompson and his colleagues are using MIT’s convening power to provide leadership outside the Institute as well. One set of efforts will be workshops in industrial sectors such as aerospace and microelectronics, which will bring companies, academics, and often government agencies to discuss research opportunities and current development challenges.

Other projects will build consortia designed to create a sustained mechanism for companies to collaborate to support pre-competitive research that benefits them all. For example, one existing consortium studies the use of carbon nanotubes to create stronger and lighter aircraft fuselage materials.

On a larger scale, MRL can sponsor meetings with industry, academia, and government to address global challenges, such as sustainable materials processing and supply of critical materials. “For instance, cobalt is mined primarily in the Congo, which is not a good situation on many levels, but are there alternatives?” Thompson says. “And how can you make material with lower energy costs, not only in making the material but over the period of its use? How do you make it in a way that doesn't affect the environment? And how do you recycle the materials?”

“There's been a real renaissance in looking at these questions, at the same times in the same laboratories where people are doing fundamental innovations at the atomic scale,” Thompson adds. “That's one of the exciting aspects of materials research.”



de MIT News https://ift.tt/2tgkB83

Chris Caplice honored for creating first MicroMasters recognized by MIT

Chris Caplice, director of the MITx MicroMasters Program in Supply Chain Management and executive director of the MIT Center for Transportation and Logistics, has been recognized with several key awards for spearheading the first-ever MicroMasters online credential program.

Caplice and his team were honored with the Irwin Sizer Award for the Most Significant Improvement to MIT Education at the 2018 MIT Awards Convocation on May 10. The Sizer award is presented to any member or group in the MIT community to honor significant innovations and improvements to education across the institute. The award memorializes Irwin Whiting Sizer, a champion of the recruitment of women and minority students, who taught at MIT for over 60 years. 

Caplice accepted the award with Eva Ponce, the executive director of the MITx MicroMasters Program in Supply Chain Management and a research scientist at the MIT Center for Transportation and Logistics.

“The team has truly succeeded in transforming Supply Chain education and set a standard for the other EdX MicroMasters programs,” said Krishna Rajagopal, a professor of physics and Dean for Digital Learning at MIT who presented the award. “Dr. Caplice, Dr. Ponce, and the entire SCM MicroMasters/Blended Master's Program are reinventing how MIT educates leaders of tomorrow around the world.”

In accepting, Caplice remarked that it “truly takes a large team to make this happen.”

“Creating the MOOC is one thing, but running the MOOC, especially a series of MOOCs with 20,000 to 30,000 students per course, takes significant effort and work. It couldn’t be done without the course leaders who create these courses and bring their experience and the energy to them,” he said. “Learners may recognize me from the course videos, but the entire team has invested in running these courses and keeping them alive — the real work is being done by them.”

Ponce said that the team “is dedicating a tremendous effort to provide a high-touch experience to our learners across the world.”

“This has only been possible because every member of the team has a passion to educate the world in supply chain management,” she said. “They also share the curiosity to learn every single day from our community of online learners.”

In addition to the Sizer Award, Caplice has also been the recipient of two other recent honors. At the quarterly Significant Interest Event on May 11, he received the MITx Prize for Teaching and Learning in MOOCs (massive open online courses), whice recognizes educators who have devoted themselves to better engaging learners around the world through digital classrooms.

He has also been honored with the MIT Teaching with Digital Technology Award. This accolade is a student-nominated award to recognize instructors who effectively use digital technology to improve teaching and learning at MIT. Announced on June 5, the Teaching with Technology award is co-sponsored by the Office of Open Learning and the Office of the Vice Chancellor, with the intent to recognize instructors for their innovations and give the MIT community the opportunity to learn from their practices.

The MITx MicroMasters credential is a stand-alone credential in supply chain management that is also recognized by MIT as carrying the equivalent of one semester’s worth of credit that can be applied toward a master’s degree in supply chain management on campus for a credential holder that applies to and is accepted into the program.

Since 2014 when the program was launched, 245,524 learners have enrolled in at least one of the five MicroMasters in supply chain management courses. More than 10,000 learners have earned over 20,000 individual course certificates, and 1,062 learners have completed the MicroMasters credential. Forty of these learners were students at MIT this spring as part of the Blended Master’s Program and received master’s degrees in supply chain management upon completion of the program.



de MIT News https://ift.tt/2Myio0m

Setting The Standard for excellence

“As a member of The Standard,

I pledge to grow in character with the men around me;

I pledge to exemplify excellence both in and outside of the classroom;

I pledge to respect all people and the diversity of the world…”

Twenty-two first-year undergraduate students, all men of color, recited these words as part of an oath inducting them into the inaugural cohort of The Standard. Sponsored by the Office of Minority Education (OME), The Standard is a program designed to holistically support the academic, personal, and professional achievements of MIT’s undergraduate men of color.

Students admitted to The Standard accept a number of responsibilities, including working to foster a diverse community at MIT based on respect and openness, maintaining a competitive GPA, attending workshops and lectures when their schedules permit, and remaining in contact with program staff. 

Mentorship is an essential part of the program. Students join in their first year and are paired with upperclassmen, who serve as peer mentors and help them to navigate the MIT community. They are also matched with alumni mentors, men of color who support their professional development. Faculty liaisons help to guide the program and serve as an additional resource for students.

Lawrence Sass, associate professor in the Department of Architecture at MIT, joined The Standard as a faculty liaison this winter. An MIT alumnus, Sass recognized the need for this program.

“I had my own struggles earning my PhD as a student of color at MIT,” he says. “So my motivation is to help men of color with their issues. I know that their specific challenges will be different, but we have a lot of common concerns.”

“Statistically, men of color struggle in university settings,” he continues. “And the struggle is not because of academic performance, it’s a social issue. It can be very difficult to navigate the interpersonal nuances associated with success at a place like MIT, Harvard, or Yale. It can be challenging to find a trusted group of peers and mentors to relate to. It’s very few people who have an understanding of the social complexity behind academic success for African American men.”

Though the program has only been running for one semester, students have already gained a sense of community through participating in it.

“It’s a very strong, encouraging environment,” says rising sophomore Braden Cook, a member of the cohort. “It’s good to be surrounded by people who look like you and want to be academically and personally excellent — just like you do.”

In addition to mentorship opportunities, members of The Standard attend fun outings, guest lectures, and workshops on a variety of topics, including professional development, life skills, self-care, and financial literacy. Select workshops are not only open to members of The Standard, but to all undergraduate men of color. The Standard also offers financial subsidies to members to cover the cost of graduate school preparation and professional development activities, such as conference fees.

This year, The Standard organized a retreat at Endicott House, where members participated in a series of team-building activities.

“It was really fun,” says rising sophomore Francisco Zepeda. “We all felt really comfortable with each other. It was a safe space to talk about what The Standard means for us, what’s going on in our minds, and national events. I felt like I got a lot closer to the cohort there.”

In order to offer an array of programming for members and men of color at MIT, The Standard is partnering with several campus offices, including the Global Education and Career Development office, the Army ROTC, the MIT Alumni Association, Student Mental Health and Counseling at MIT Medical, Student Support Services, Student Financial Services, the Division of Student Life, and the Office of Graduate Education. In December 2017, The Standard was awarded a grant to pilot its first cohort through the MindHandHeart Innovation Fund.

The program is part of a larger, campus-wide effort to support diversity and inclusion at MIT. Other MindHandHeart Innovation Fund projects, sponsored by the Office of the Chancellor and MIT Medical, include My Sister’s Keeper, a program fostering community among black women at MIT; Hermanas Unidas, which brings together Latinas from across campus; and WiSTEM Week, a week of events celebrating women in STEM at MIT.

DiOnetta Jones Crayton, associate dean in the Office of the Vice Chancellor and director of the OME, envisioned The Standard and reflects on its progress.

“We are extremely excited about The Standard because it is something that young men at MIT have been asking us to create for years,” she says. “We believe that we have developed a program that not only utilizes high impact practices set by similar initiatives across the nation, but that directly meets the needs of MIT men of color.”

Cook says members of The Standard are also shaping the direction of the group. “If we’re called ‘The Standard,’ then I think we need to have an impact outside of ourselves and become a force for good on campus. Because we’re brand new, we’re still figuring out where we want the program to go and what projects we take on.”

Zepeda is also inspired by his participation in group and looks forward to welcoming the next cohort. “I would encourage any student who feels like they want to make an impact for MIT’s men of color to join The Standard,” he says.

The Standard is now accepting applications for the next cohort. For more information on the program, please contact Devan Monroe, program coordinator for The Standard.



de MIT News https://ift.tt/2I089P0

viernes, 15 de junio de 2018

CSAIL launches new five-year collaboration with iFlyTek

The MIT Computer Science and Artificial Intelligence Laboratory (CSAIL) has announced a new five-year collaboration with iFlyTek, a leading Chinese company in the field of artificial intelligence (AI) and natural language processing.

iFlyTek’s speech-recognition technology is often described as “China’s Siri” and is used extensively across multiple industries to translate languages, give directions, and even transcribe court testimony. Alongside Baidu, Alibaba, and Tencent, they are one of four companies designated by the Chinese Ministry of Science and Technology to develop open platforms for AI technologies. Their researchers will collaborate with CSAIL on several projects in fundamental AI and related areas, including computer vision, speech-to-text systems, and human-computer interaction.

“We are very excited to embark on this scientific journey with the innovative minds at iFlyTek,” says CSAIL Director Daniela Rus, the Andrew (1956) and Erna Viterbi Professor of Electrical Engineering and Computer Science at MIT. “Some of the biggest challenges of the 21st century concern developing the science and engineering of intelligence and finding ways to better harness the strengths of both human and artificial intelligence. I am looking forward to the advances that will come from the collaboration between MIT CSAIL and iFlyTek.”

This week CSAIL hosted Qingfeng Liu, chairman and CEO of iFlyTek, as well as Shipeng Li, corporate vice president of iFlyTek and co-president of iFlyTek Research. Representatives from the two organizations talked about the collaboration in more detail and formally signed the research agreement on Thursday.

“We look forward to this exciting collaboration with MIT CSAIL, home of many of the greatest innovations and the world’s brightest talents,” says Liu. “This also shows iFlyTek’s commitment to fundamental research. iFlyTek is applying AI technologies to improve some very important functions of our society, including education, health care, judicature, et cetera. There are no doubt many challenging issues in AI today. We are thrilled to have this opportunity to join hands with MIT CSAIL to push the boundary of AI technology further and to build a better world together.”

Participating researchers from CSAIL include professors Randall Davis, Jim Glass, and Joshua Tenenbaum. Davis will collaborate with iFlyTek on human-computer interaction and creating interfaces to be used in health care applications. Glass’s research will focus on unsupervised speech processing. Tenenbaum’s work will center around trying to build more human-like AI by integrating insights from cognitive development, cognitive neuroscience, and probabilistic programming.



de MIT News https://ift.tt/2JSVbrn

MIT engineers build smart power outlet

Have you ever plugged in a vacuum cleaner, only to have it turn off without warning before the job is done? Or perhaps your desk lamp works fine, until you turn on the air conditioner that’s plugged into the same power strip.

These interruptions are likely “nuisance trips,” in which a detector installed behind the wall trips an outlet’s electrical circuit when it senses something that could be an arc-fault — a potentially dangerous spark in the electric line.

The problem with today’s arc-fault detectors, according to a team of MIT engineers, is that they often err on the side of being overly sensitive, shutting off an outlet’s power in response to electrical signals that are actually harmless.

Now the team has developed a solution that they are calling a “smart power outlet,” in the form of a device that can analyze electrical current usage from a single or multiple outlets, and can distinguish between benign arcs — harmless electrical spikes such as those caused by common household appliances — and dangerous arcs, such as sparking that results from faulty wiring and could lead to a fire. The device can also be trained to identify what might be plugged into a particular outlet, such as a fan versus a desktop computer.

The team’s design comprises custom hardware that processes electrical current data in real-time, and software that analyzes the data via a neural network — a set of machine learning algorithms that are inspired by the workings of the human brain.

In this case, the team’s machine-learning algorithm is programmed to determine whether a signal is harmful or not by comparing a captured signal to others that the researchers previously used to train the system. The more data the network is exposed to, the more accurately it can learn characteristic “fingerprints” used to differentiate good from bad, or even to distinguish one appliance from another.

Joshua Siegel, a research scientist in MIT’s Department of Mechanical Engineering, says the smart power outlet is able to connect to other devices wirelessly, as part of the “internet of things” (IoT). He ultimately envisions a pervasive network in which customers can install not only a smart power outlet in their homes, but also an app on their phone, through which they can analyze and share data on their electrical usage. These data, such as what appliances are plugged in where, and when an outlet has actually tripped and why, would be securely and anonymously shared with the team to further refine their machine-learning algorithm, making it easier to identify a machine and to distinguish a dangerous event from a benign one.

“By making IoT capable of learning, you’re able to constantly update the system, so that your vacuum cleaner may trigger the circuit breaker once or twice the first week, but it’ll get smarter over time,” Siegel says. “By the time that you have 1,000 or 10,000 users contributing to the model, very few people will experience these nuisance trips because there’s so much data aggregated from so many different houses.”

Siegel and his colleagues have published their results in the journal Engineering Applications of Artificial Intelligence. His co-authors are Shane Pratt, Yongbin Sun, and Sanjay Sarma, the Fred Fort Flowers and Daniel Fort Flowers Professor of Mechanical Engineering and vice president of open learning at MIT.

Electrical fingerprints

To reduce the risk of fire, modern homes may make use of an arc fault circuit interrupter (AFCI), a device that interrupts faulty circuits when it senses certain potentially dangerous electrical patterns.

“All the AFCI models we took apart had little microprocessors in them, and they were running a regular algorithm that looked for fairly primitive, simple signatures of an arc,” Pratt says. 

Pratt and Siegel set out to design a more discerning detector that can discriminate between a multitude of signals to tell a benign electrical pattern from a potentially harmful one.

Their hardware setup consists of a Raspberry Pi Model 3 microcomputer, a low-cost, power-efficient processor which records incoming electrical current data; and an inductive current clamp that fixes around an outlet’s wire without actually touching it, which senses the passing current as a changing magnetic field.

Between the current clamp and the microcomputer, the team connected a USB sound card, commodity hardware similar to what is found in conventional computers, which they used to read the incoming current data. The team found such sound cards are ideally suited to capturing the type of data that is produced by electronic circuits, as they are designed to pick up very small signals at high data rates, similar to what would be given off by an electrical wire.

The sound card also came with other advantages, including a built-in analog-to-digital converter which samples signals at 48 kiloherz, meaning that it takes measurements 48,000 times a second, and an integrated memory buffer, enabling the team’s device to monitor electrical activity continuously, in real-time.

In addition to recording incoming data, much of the microcomputer’s processing power is devoted to running a neural network. For their study, they trained the network to establish “definitions,” or recognize associated electrical patterns, produced by four device configurations: a fan, an iMac computer, a stovetop burner, and an ozone generator — a type of air purifier that produces ozone by electrically charging oxygen in the air, which can produce a reaction similar to a dangerous arc-fault.

The team ran each device numerous times over a range of conditions, gathering data which they fed into the neural network.

“We create fingerprints of current data, and we’re labeling them as good or bad, or what individual device they are,” Siegel says. “There are the good fingerprints, and then the fingerprints of the things that burn your house down. Our job in the near-term is to figure out what’s going to burn down your house and what won’t, and in the long-term, figure out exactly what’s plugged in where.”

“Shifting intelligence”

After training the network, they ran their whole setup — hardware and software — on new data from the same four devices, and found it was able to discern between the four types of devices (for example, a fan versus a computer) with 95.61 percent accuracy. In identifying good from bad signals, the system achieved 99.95 percent accuracy — slightly higher than existing AFCIs. The system was also able to react quickly and trip a circuit in under 250 milliseconds, matching the performance of contemporary, certified arc detectors.

Siegel says their smart power outlet design will only get more intelligent with increasing data. He envisions running a neural network over the internet, where other users can connect to it and report on their electrical usage, providing additional data to the network that helps it to learn new definitions and associate new electrical patterns with new appliances and devices. These new definitions would then get shared wirelessly to users’ outlets, improving their performance,and reducing the risk of nuisance trips without compromising safety.

“The challenge is, if we’re trying to detect a million different devices that get plugged in, you have to incentivize people to share that information with you,” Siegel says. “But there are enough people like us who will see this device and install it in their house and will want to train it.”

Beyond electrical outlets, Siegel sees the team’s results as a proof of concept for “pervasive intelligence,” and a world made up of everyday devices and appliances that are intelligent, self-diagnostic, and responsive to people’s needs.

“This is all shifting intelligence to the edge, as opposed to on a server or a data center or a desktop computer,” Siegel says. “I think the larger goal is to have everything connected, all of the time, for a smarter, more interconnected world. That’s the vision I want to see.”



de MIT News https://ift.tt/2t0rHOq

MIT Professor Emerita Joan Jonas receives the 2018 Kyoto Prize

Joan Jonas, professor emerita in the MIT Program in Art, Culture and Technology, is one of three individuals honored with the 2018 Kyoto Prize.  

The Kyoto Prize is Japan’s highest private award for global achievement, created by Japanese philanthropist Kazuo Inamori and awarded by the Inamori Foundation. As part of the prize, Jonas will receive a diploma, a gold Kyoto Prize medal, and 100 million yen (approximately $915,000) at a ceremony in Kyoto, Japan, on Nov. 10. 

“Joan is a giant and she deserves all recognition for a lifetime of superlative achievements,” says Hashim Sarkis, dean of the MIT School of Architecture and Planning. “Yet the Kyoto Prize cannot overshadow the work that is to come — the continuously bold, experimental work, the eternally youthful outlook, and her perpetually poetic insights into our world’s problems. Her best work will always be her next work.”

Awarded annually in three categories — Advanced Technology, Basic Sciences, and Arts and Philosophy — the prize honors individuals who have contributed significantly to the scientific, cultural, and spiritual betterment of humankind. Jonas is this year’s recipient in the Arts and Philosophy category for her lifetime of accomplishment and global influence as an artist.

“Jonas created a new artistic form by integrating performance art and video art, and has evolved her original medium at the forefront of contemporary art continuously,” the prize announcement states. “Creating labyrinth-like works that lead audiences to diverse interpretations, she hands down the legacy of 1960s avant-garde art by developing it into a postmodern framework, profoundly impacting artists of later generations.”

More than 50 years of influence in the arts

Trained in art history and sculpture, Jonas was a central figure in the performance art movement of the late 1960s, and her experiments and productions in the late 1960s and early 1970s continue to be crucial to the development of many contemporary art genres, from performance and video to conceptual art and theater. Since 1968, her practice has explored ways of seeing, the rhythms of ritual, and the authority of objects and gestures.

The Inamori Foundation cited “Vertical Roll,” a Jonas piece from 1972 that integrated a performance with its real-time video screened on a TV monitor, as an archetype of the genre and her practice. “This work featured a revolutionary structure of coexistence of a live performance and its represented image,” the foundation stated, “with a discrepancy in time and space between the audience’s viewpoints and camera angles, as well as the effect of electrical delay within the system.”

Jonas received a BA in art history from Mount Holyoke College in 1958, studied sculpture at the School of the Museum of Fine Arts in Boston, and received an MFA in sculpture from Columbia University in 1965. Jonas taught at MIT from 1998 to 2014, and is currently professor emerita in ACT within the School of Architecture and Planning.

The recipient of numerous honors and awards, Jonas represented the United States in the U.S. Pavilion at the 56th Venice Biennale in 2015 with an installation organized by the MIT List Visual Arts Center and commissioned by its director, Paul Ha.

“Contemporary art would not be where it is today without Joan Jonas’s trailblazing work in performance and video art,” says Ha. “The Biennale exhibition demonstrates that her extraordinary contribution to the field and her experimental approach to art making continues. We are thrilled to see Joan receive this singular recognition from the Kyoto Prize committee.”

The Biennale installation, entitled “They Come to Us Without a Word,” was praised as “a triumph” by Roberta Smith, art critic and writer for The New York Times.

“Performance art is a young person’s sport, most often pursued in heat, often accompanied by sensationalism and abandoned as stamina fades,” Smith wrote in 2015. “But, at 78, Joan Jonas has avoided all of the above, quietly but determinedly elaborating performance into an immersive multimedia art form that has sustained her for more than five decades.”

Jonas has had numerous significant solo exhibitions around the world, including a career retrospective currently on view in London at the Tate Modern through August 5. Other recent examples include the NTU Centre for Contemporary Art Singapore (CCA) (2016); Centre for Contemporary Art, Kitakyushu Project Gallery in Japan (2014); Kulturhuset Stadsteatern Stockholm (2013); Proyecto Paralelo in Mexico (2013); Contemporary Arts Museum in Houston (2013); Bergen Kunsthall in Norway (2011); and Museum of Modern Art in New York (2010). Jonas has been represented in dOCUMENTA in Kassel, Germany, six times since 1972, and has had major retrospectives at the Stedelijk Museum in Amsterdam, Galerie der Stadt Stuttgart in Germany, and the Queens Museum of Art in New York.

2018 Kyoto laureates

Jonas is one of three Kyoto laureates for 2018 in the fields at Arts and Philosophy, Advanced Technology, and Basic Sciences. The honoree for Advanced Technology is Karl Deisseroth, a professor at Stanford University, for his research in optogenetics and the development of causal systems neuroscience. In Basic Sciences, the foundation selected Masaki Kashiwara, a professor at Kyoto University, for his outstanding contributions to a broad spectrum of modern mathematics.

Jonas is the 13th individual from the MIT community, including alumni, to receive the Kyoto Prize. Including this year’s laureates, 108 individuals and one organization have received the honor.



de MIT News https://ift.tt/2t0dJMs

miércoles, 13 de junio de 2018

MIT engineers recruit microbes to help fight cholera

MIT engineers have developed a probiotic mix of natural and engineered bacteria to diagnose and treat cholera, an intestinal infection that causes severe dehydration.

Cholera outbreaks are usually caused by contaminated drinking water, and infections can turn fatal if not treated. The most common treatment is rehydration, which must be done intravenously if the patient is extremely dehydrated. However, intravenous treatment is not always available to patients who need it, and the disease kills an estimated 95,000 people per year.

The MIT team’s new probiotic mix could be consumed regularly as a preventative measure in regions where cholera is common, or used to treat people soon after infection occurs, says James Collins, the Termeer Professor of Medical Engineering and Science in MIT’s Institute for Medical Engineering and Science (IMES) and Department of Biological Engineering.

“Our goal was to use synthetic biology to develop an inexpensive means to detect and diagnose as well as suppress or treat cholera infections,” says Collins, who is the senior author of the study. “If one could inexpensively and quickly track the disease and treat it with natural or engineered probiotics, it could be a game-changer in many parts of the world.”

The lead authors of the paper, which appears in the June 13 issue of Science Translational Medicine, are former Boston University graduate student Ning Mao, MIT postdoc Andres Cubillos-Ruiz, and former MIT postdoc D. Ewen Cameron.

Detection and treatment

To create their “living diagnostic” for cholera, the researchers chose a strain of bacteria called Lactococcus lactis, which is safe for human consumption and is used in the production of cheese and buttermilk.

They engineered into this bacterium a genetic circuit that detects a molecule produced by Vibrio cholerae, the microbe that causes cholera. When engineered L. lactis encounters this molecule, known as CAI-1, it sets off a signaling cascade that turns on an enzyme called beta-lactamase. This enzyme produces a red color that can be detected by analyzing stool samples. This process now takes several hours, but the researchers hope to shorten that time.

The researchers had hoped to further engineer L. lactis so that it could treat or prevent cholera infections. They began by engineering the microbes to produce antimicrobial peptides that could kill V. cholerae, but they eventually found that the peptides were being rendered harmless after being secreted by the cells.

Serendipitously, however, the team discovered that unmodified L. lactis can actually kill cholera microbes by producing lactic acid, a natural byproduct of their metabolism. Lactic acid makes the gastrointestinal environment more acidic, inhibiting the growth of V. cholerae.

The engineered version of L. lactis does not produce enough lactic acid to kill cholera microbes, so the researchers combined the engineered bacteria with the unmodified version to create a probiotic mixture that can both detect and treat cholera. In tests in mice, the researchers found that this probiotic mixture could successfully prevent cholera infections from developing and could also treat existing infections.

Alternatives to antibiotics

Collins says he anticipates that the probiotic, which could be incorporated into a pill or a yogurt-like drink, could be used either as a preventative measure or for treating infections once they begin. Having the ability to diagnose cholera easily could also help public health officials detect outbreaks earlier and monitor the spread of the disease.

“I am particularly excited about this study because it presents a series of far-reaching, practical possibilities as well as scientific advances,” says Matthew Chang, an associate professor of biochemistry at the National University of Singapore, who was not involved in the research.

“For instance, this work certainly enables us to envision the direct use of probiotics in combination with their modified forms for the surveillance and prevention of cholera,” Chang says. “Even further, many can leverage this study, in particular its generalizable ‘sense-and-respond’ approach, to devise various diet-based prophylactic strategies against other communicable infectious diseases.”

The MIT team is now exploring the possibility of using this approach to combat other microbes, such as Clostridium difficile, which causes gastrointestinal infections, and bacteria known as enterococci, which can cause many types of infections.

“There is emerging interest in using probiotics to treat disease, largely from the growing recognition of the microbiome and the role it plays in health and disease, and the pressing need to find alternatives to antibiotics,” Collins says.

The research was funded by the Defense Threat Reduction Agency, the Gates Foundation, and the Paul G. Allen Frontiers Group.



de MIT News https://ift.tt/2JHNhh2