Research from the ground up

When Sonya Atalay conducted her doctoral research, she studied pottery in Çatalhöyük, a remarkable ancient site in Turkey. It’s one of the world’s earliest known urban settlements, flourishing by at least 7000 B.C.E.

Yet even as Atalay was conducting field research and writing her doctoral thesis, she was scrutinizing standard archaeological practices, believing the discipline to be in need of an update. Indeed, it’s an issue she had been grappling with going back to her undergraduate days, when she first went to a dig site near Rome.

“When I started doing archaeological work, the local people were labor,” says Atalay, now a professor at MIT. “They came, they cleaned your clothes, they cleaned the dig house, they weren’t thought of as having important connections with the archaeology, and that really bothered me.” 

Surely, she believed, a culture producing the remarkable things worth studying is worth including in that research process, too. As she says, given “their place-based knowledge, it seemed like we should be talking to people about their heritage. They’re the ones who live on or near sites. I started thinking about what archaeology could look like if it included local communities in a meaningful way.” 

Atalay completed her dissertation while continuing to examine how researchers could alter their approach. She has since published articles and books about the subject, worked to introduce new research practices, and today, as an MIT professor, is a leader in the growing field of community-based archaeology, building partnerships between researchers and local residents.

Among other things, Atalay is the director and principal investigator of the Center for Braiding Indigenous Knowledges and Science (CBIKS), a National Science Foundation-backed project that helps train scholars and implement community-oriented work. She is convinced that community-oriented work creates better outcomes in many fields. 

“A community-based approach is highly applicable beyond archaeology and anthropology, outside of the social sciences,” Atalay says. “I think there’s a lot for engineers or designers or folks in a lot of different fields to learn by involving community members in the research process.”

Atalay joined MIT with tenure in 2024, where she is a professor in MIT’s Anthropology Section.

Roll me away

Atalay grew up in Michigan, not far from Detroit, where she was the first person from her family to go to college. Growing up, she hoped to be a physician. 

“I wanted to be a doctor. That’s what I thought I was going to do,” Atalay says. “I wanted to be a pediatrician.” 

But she also developed an interest in ancient history, something she can date to a precise moment. A 4th grade teacher named Barbara Eisman would give Atalay extra reading when Atalay would finish homework early. One day, Eisman produced a book about ancient Greece and Rome. 

“I remember thinking, this is amazing, discovering things I never knew existed,” Atalay says. “And that stuck with me.”

By the time Atalay enrolled at the University of Michigan, she was still planning to become a doctor. But as an undergraduate, she enjoyed taking archaeology electives to such an extent that she simply changed career paths. 

“I loved it and just got so into it,” Atalay says. And Michigan even provided opportunities for undergraduate fieldwork near Rome, although that meant Atalay had to dig deep to finance her first trip to an archaeological site. 

“I worked at a nightclub and put myself through college by bartending,” Atalay says. “I had a motorcycle, so I was tooling around Ann Arbor. Then I sold my motorcycle to buy the plane ticket to go to Rome so I could take part in the archaeological fieldwork.”

“Relationships are the task”

After graduating, Atalay was accepted into the graduate program for anthropology at the University of California at Berkeley, where she earned an MA and then, in 2003, her PhD. While Atalay’s doctoral research focused on the ancient pottery at Çatalhöyük, she maintained a steady interest in helping archaeology evolve. 

And increasingly, she started drawing on her own observations about fieldwork in the U.S., too. Atalay is Native American, and she recognized the same patterns of exclusion and archaeological extraction being applied to the historical study of Native American societies. 

One additional influence in shaping Atalay’s thinking was the North American Graves Protection and Repatriation Act (NAGPRA), passed by the U.S. federal government in 1990. It requires federal institutions to return human remains, sacred objects, and other cultural materials to Native Americans. Seeing the law enacted reinforced to Atalay that progress in this domain is possible. 

“The push for that act was really about Indigenous people standing up for sovereignty. To return what was wrongfully taken and to carry out research in an ethical way moving forward, there has to be trust and partnerships built,” Atalay says. While observing advocates trying to get NAGPRA passed, she adds, “I learned a lot from them.”

Over time, Atalay went on to serve multiple terms on the commission overseeing NAGPRA, first appointed by President George W. Bush and then President Barack Obama. Ultimately, her perspective has been fed by many sources, converging on similar themes.   

“I was really uncomfortable with how local people weren’t involved with studies of their own heritage,” Atalay says. “So I started thinking about what would it look like to truly partner with communities to plan and carry out research. And that’s how I started my first book, trying to set up a model for how to do ethical work in partnership with communities.”

That book, “Community-Based Archaeology: Research with, by, and for Indigenous and Local Communities” was published by the University of California Press in 2012. In her work, Atalay has focused on a range of specific practices, from research development to fieldwork methods and protecting intellectual property rights for Indigenous people. But the starting point for any work, she emphasizes, is relationship-building and the creation of mutual trust. 

“I tell students, ‘Relationships are the task,’” Atalay says. “I know you want to get in there and carry out fieldwork, but the relationships are everything. Sitting down and talking and sharing life stories and developing trust. Those relationships move at the speed of trust. And that takes time to develop. That’s the key piece. And that’s going to lead to good research outcomes.”

Stronger together

After receiving her PhD, Atalay had postdocs at UC Berkeley as well as Stanford University, then joined the faculty at Indiana University. In 2012, Atalay moved to the University of Massachusetts at Amherst, before joining MIT two years ago.

Currently Atalay is working on multiple projects. As director of CBIKS, she is running an organization with eight research “hubs,” where nearly 100 affiliated scholars are working with over 50 Indigenous communities to establish partnerships that advance environmental, and scientific research projects. 

In some cases, the scholars are involved in familiar-seeming archaeological work, while other center projects involve topics such as enhancing salmon farming, clam cultivation, or returning native seeds from museums to tribes in the Southwest, where elders still retain knowledge for their appropriate use and care.

“Our team members across multiple disciplines are learning from each other,” Atalay says. “So archaeologists and heritage management scholars are talking to environmental scientists and team members who study seeds and agriculture.” The NSF sometimes refers to this as ”convergence science.” The center’s name uses the metaphor of braiding, to represent the ways different strands of knowledge can be woven together to form a sturdy whole.

“With braiding, each of the strands retains its integrity, and they’re stronger when they’re brought together,” says Atalay. She is also currently working on another book project, “Braiding Knowledges,” about how the community-based approach can enhance and strengthen research within universities; it is under contract with the University of Arizona Press. 

At MIT, Atalay adds, she is delighted by the range of students who have started taking her classes, begun thinking about applications to all kinds of projects, and who in turn may end up leading innovative, community-oriented projects of their own.

“I would encourage anyone, no matter what field they’re in, to think about working with a community,” Atalay says. “What we’re learning isn’t just about working with Indigenous communities. It’s applicable outside of anthropology, outside of the social sciences. There is a lot you can learn and contribute to society by carrying out research this way, in any number of fields.”

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Tod Machover receives George Peabody Medal for contributions to music and technology

Tod Machover, the Muriel R. Cooper Professor of Music and Media, faculty director of the MIT Media Lab, and director of the Opera of the Future research group, will receive the George Peabody Medal for Outstanding Contributions to Music and Dance in America — the highest honor bestowed by the Peabody Institute of the Johns Hopkins University. 

As a composer and music tech pioneer, Machover has helped expand music’s possibilities for artists and audiences alike through his work in participatory opera, artificial intelligence, and creative technologies. He joins a roster of previous George Peabody Medal recipients that includes Stevie Wonder, Misty Copeland, Herbie Hancock, Renée Fleming, Yo-Yo Ma, Wynton Marsalis, Ella Fitzgerald, and Leonard Bernstein.

In the citation for the Peabody Medal, Peabody Institute Dean Fred Bronstein writes: “The breadth and depth of Tod Machover’s career — his work in participatory opera, as an educator and faculty director of the MIT Media Lab, his genuinely groundbreaking and prescient work at the intersection of music and technology, along with an overall and broad impact on the American music scene — make him an ideal recipient for the Peabody Medal … Machover continues to provide inspiration especially in the fast-evolving relationship between AI and the creative process. We are honored to welcome to campus a true pioneer and thought leader.”

Hailed as a “musical visionary” and “America’s most wired composer,” Machover is recognized as one of the most innovative composers active today. He is praised for creating music that breaks traditional artistic and cultural boundaries and for developing technologies that expand music’s potential for everyone. 

Machover was the first director of musical research at Pierre Boulez's IRCAM in Paris and was inducted as a fellow of the American Academy of Arts and Sciences in 2024. His work has been recognized by organizations including the American Academy of Arts and Letters, the National Endowment for the Arts, and the French Culture Ministry.

The Peabody Institute, the first music conservatory in the United States, advances a dynamic model of the performing arts, empowering musicians and dancers from diverse backgrounds to create and perform at the highest level. As division of Johns Hopkins University, Peabody provides opportunities for interdisciplinary studies and is a leading voice at the intersection of art and education.

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A new vaccine adjuvant could make it easier to eradicate polio

In the United States, children routinely receive an injectable form of the polio vaccine. This vaccine is very effective at preventing illness, but it doesn’t block transmission of the polio virus as well as the oral polio vaccine does.

Poliovirus is usually transmitted through contaminated food or water, so the GI tract is where the body is first exposed. Because the oral vaccine induces a mucosal immune response within the GI tract, it is much more effective at preventing infection and spread of the virus. However, there is a small chance that the oral vaccine can become infectious, so many countries have stopped using it.

Researchers at MIT have now come up with a way to modify the injectable vaccine so that it can also promote a mucosal immune response. This vaccine could help to achieve polio eradication while avoiding the risks of the oral polio vaccine.

“People who are vaccinated with the injectable vaccine are not getting sick, but they may be helping the virus circulate. Mucosal immunity could help lower that shedding and ideally eliminate it,” says Ana Jaklenec, a principal investigator in MIT’s Koch Institute for Integrative Cancer Research.

The researchers’ new vaccine consists of the current injectable, inactivated polio vaccine (IPV), delivered with a nanoparticle-based adjuvant that helps steer immune cells to the mucosal lining of the intestine. In a study of rats, the researchers found that this vaccine produced a 20-fold increase in the type of antibodies needed for mucosal immunity, compared to IPV alone.

Jaklenec and Robert Langer, the David H. Koch Institute Professor at MIT, are the senior authors of the study, which appears today in Science Advances. MIT postdoc Behnaz Eshaghi is the lead author of the paper. 

Targeting polio

Polio, which can cause paralysis in severe cases, is now rare in most of the world due to extensive vaccination campaigns. The virus is highly contagious and is most commonly spread through consumption of food or water contaminated with the stool of an infected person.

Cases are occasionally seen in the United States and other countries, and the virus is endemic in Pakistan and Afghanistan. While most of these cases are caused by the virus spreading among unvaccinated individuals, some cases may be due to the evolution of the live viruses used in the oral polio vaccine (OPV). These viruses are attenuated, meaning they are alive but weakened. In rare cases, they can mutate and evolve to become infectious again.

It’s also possible that wild poliovirus can be spread by people who have received the injected polio vaccine. These people would likely not experience any symptoms, but they could still shed the virus in their stool. Eventually, this could expose someone who isn’t vaccinated. Studies have shown that even in countries that with very high polio vaccination rates, the virus can be detected in wastewater.

To boost the chances of completely eradicating polio, it would be ideal to use a vaccine that cannot evolve to cause infection, like the current injectable IPV, and would also induce mucosal immunity, like the OPV. 

In hopes of achieving that, the MIT researchers teamed up with researchers at Harvard Medical School who have shown that using a derivative of vitamin A as a vaccine adjuvant can help stimulate immune cells to go to the GI tract.

That adjuvant, known as Am80, works well, but to generate a strong response, it needs to be injected for several days in a row, which is not feasible for most vaccine campaigns. 

To eliminate the need for repeated daily injections, the researchers set out to develop a nanoparticle formulation that would enable the adjuvant to be released slowly over several days. They tested several different types of nanoparticles and found that the one that worked best was a lipid nanoparticle (LNP).

“The purpose of the nanoparticle is making sure that we can engineer a platform with a sustained release of the cargo for a few days,” Eshaghi says. “That way we can overcome the bottleneck that for free administration of Am80 you need multiple daily injections.” 

Mucosal immunity

In tests in rats, the researchers delivered an injection of an inactivated polio vaccine, similar to the one that is now used in the United States, along with a separate injection of Am80 encapsulated in LNPs. After the first dose, boosters were given at four weeks and eight weeks.

After injection, the nanoparticles accumulate in the lymph nodes, where they interact with B and T cells that are also exposed to the polio vaccine. This interaction stimulates the B and T cells to produce two surface proteins that act as homing signals directing them to the GI tract.

The B cells also begin producing a type of antibodies called IgA, which protect body surfaces from infection by coating the mucosal membranes. In addition, the rats also produce IgG antibodies that circulate in the bloodstream, similar to the antibodies that are normally produced in response to the injected polio vaccine.

“IPV is a safe vaccine, but it cannot create mucosal immunity. OPV can create that mucosal response, but it is not as safe,” Eshaghi says. “By adding Am80 to lipid nanoparticle as an adjuvant, we are combining the safety of IPV with an adjuvant that can produce the mucosal immunity that normally you can only get with OPV.” 

The researchers now plan to test the vaccine in additional larger animal models, where they will inject the vaccine and adjuvant mixed together.

Using Am80 or other adjuvants to induce a mucosal response could also help researchers design improved vaccines for other pathogens that infect the GI tract, or for diseases that infect the lungs or reproductive tract. 

“You could potentially add it to any vaccine that’s injected,” Jaklenec says. “This particular work shows that cells can be directed to the gut and increase enteric mucosal immunity. Whether it works for the respiratory or vaginal mucosa is not yet clear.”

The research was funded by the Gates Foundation.

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MIT chemists design impact-resistant plastics

With help from a novel cross-linking molecule, MIT chemists have shown they can substantially improve the ballistic impact resistance of common polymers, including polystyrene and a type of rubber used to make shoe soles.

Polystyrene is a hard, glassy polymer that is used to make many types of plastic containers, such as bottles and mugs, as well as disposable cutlery. It is also found in coatings for electronic devices, and its foam form is the basis for Styrofoam and other lightweight packaging. (While sometimes labeled with recycling code No. 6, polystyrene is difficult to recycle and rarely collected for reuse in the U.S.)

To make the polymer more resistant to sudden impact, the MIT team added weak bonds scattered throughout the material as cross-links, which allows the material to dissipate energy much more effectively under deformations. When struck by a projectile, these weak bonds selectively break at the site of impact to open up pathways for enhanced energy absorption.

The researchers found that this approach can also fortify styrene-butadiene-styrene rubber, and they are now investigating whether it will also work for other types of polymers such as latex or the rubber that is used to make tires. 

“These cross-linkers can substantially increase the amount of energy that the material absorbs under ballistic impact. You can imagine many applications of that, especially if this could be generalized to other polymers,”says Jeremiah Johnson, the A. Thomas Geurtin Professor of Chemistry at MIT and a member of the Koch Institute for Integrative Cancer Research.

Johnson and Keith Nelson, the Haslam and Dewey Professor of Chemistry, are the senior authors of the study, which appears today in Nature. Former MIT postdocs Zhen Sang and Suong T. Nguyen and MIT graduate student Kwangwook Ko are the paper’s lead authors.

Tougher plastics

In a study published in 2023, Johnson and colleagues at MIT and Duke University showed that they could make polymers tougher using a counterintuitive strategy: adding weak cross-linkers that are distributed throughout a polymer network. These weak linkages, also called mechanophores, break under tearing conditions in a way that helps preserve the stronger bonds that bear the load, allowing the material to dissipate more energy.

“As a crack starts to propagate through the material, these mechanophores split in two, which helps to dissipate energy and redirect where the crack goes. That means you have to put in more energy to tear the material,” Johnson says. 

Unlike their previous study, which examined toughening under slow tearing conditions, the new Nature study aimed to develop mechanophore-enabled strategies for resisting rapid deformation, such as that caused by sudden impact. The researchers were especially interested in applying the strategy to some of the most widely used polymers, such as polystyrene.

To do that, they developed a way to directly incorporate mechanophores as cross-links into common polymers. Then, they used a system invented by Nelson — laser-induced microprojectile impact testing (LIPIT) — to study how the resulting polymers respond to projectile impacts. With this system, tiny projectiles — silica beads about 10 microns in diameter — are fired at the film at about 750 meters per second (more than 1,600 miles per hour). The amount of energy absorbed by the material can be calculated by measuring the change in the particle’s velocity before and after it passes through the film. 

“We first developed this method to study microparticle impact and penetration into bulk polymer samples, where we would monitor particle propagation through about 100 microns of material and analyze after impact how polymer morphology had changed,” Nelson says. “Our new measurements show how much additional information can be extracted from particle velocities before and after penetration through a thin layer. They also show deeply informative deformation patterns both during particle impact and afterward.”

This technique allowed the researchers to mimic the type of forces that might be seen in the real world when a plastic object is hit with another object, or when you drop your phone on the ground. In their experiments, the researchers showed that mechanophore cross-linked polystyrene was able to absorb substantially more energy from an impact than regular polystyrene.

“It turned out that the mechanophore leads to substantial increases in energy dissipation compared to both uncross-linked and conventionally cross-linked polystyrene, a behavior that had not been observed in related previous work,” Johnson says.

Absorbing impact

To figure out how the mechanophores help make polystyrene more impact resistant, the MIT team enlisted help from collaborators at MIT, Purdue University, Northwestern University, and Duke University. 

Through experiments and simulations, they found that when a high-speed particle strikes the material, it raises the temperature at the impact site high enough to form a mobile zone. In this zone, the mechanophore bonds are selectively broken under force, opening controlled pathways that better absorb the energy of impact while leaving the area beyond the impact site relatively unaffected and stable.

“What is particularly attractive about this approach is the ability to bestow these properties upon ‘off-the-shelf’ commodity plastics, both glassy and elastomeric, with minimal chemistry which makes it in principle quite scalable and relevant. This study combines an elegant approach while providing an in-depth mechanical analysis of the failure mechanism,” says Yoan Simon, an associate professor in the School of Molecular Sciences at Arizona State University, who was not involved in the research.

The researchers also found that they could insert these mechanophores into styrene-butadiene-styrene (SBS) rubber — which is used in shoe soles as well as asphalt and roofing materials — and observe a similar effect. They are now exploring whether this approach could also work with a related material, styrene-butadiene rubber, which is one of the major components of tires. 

If successful, this technology could yield longer-lasting tires and also cut down on the amount of microplastics generated when tires contact the road, which is estimated to account for at least 10 percent of the microplastics in the environment. 

“Materials with energy-absorbing mechanophores could one day help keep your vehicle's tires from blowing out on the highway or provide more protective cases for personal electronics,” says Katharine Covert, program director of the U.S. National Science Foundation Centers for Chemical Innovation, which invested in the team’s research. “This work really demonstrates how valuable new insights can be rapidly generated by bringing together researchers with different areas of expertise.”

The research was funded by the National Science Foundation Center for the Chemistry of Molecularly Optimized Networks, the U.S. Army Research Office through MIT’s Institute for Soldier Nanotechnologies, a Schmidt Science Postdoctoral Fellowship, and the U.S. Air Force Office of Scientific Research.

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MIT researchers teach AI models to interpret charts

To accelerate and refine decision-making in a fast-paced, global marketplace, enterprises may deploy generative artificial intelligence models to help summarize and interpret the charts that often fill market summaries and financial reports.

But even the latest vision-language models sometimes struggle with this task, since it requires a model to integrate visual, numerical, and linguistic understanding. A company that invests in a state-of-the-art model might still receive inaccurate or incomplete information.

To fill this performance gap, researchers from MIT and the MIT-IBM Computing Research Lab developed a multifaceted resource for AI users that is specifically designed to teach vision-language models (VLMs) how to effectively interpret charts. 

They used a novel data generation method to build a state-of-the-art dataset that includes more than a million varied charts. The dataset also encodes many visual, linguistic, and numerical components of each chart image, which enable models to robustly reason about the information in a chart.

The researchers used this dataset, called ChartNet, to train a series of open-source VLMs.  Many of these smaller models significantly outperformed orders of magnitude larger, commercial models on tasks like data extraction and chart summarization.

By enabling open-source models to outperform their commercial counterparts, ChartNet could allow small firms with limited budgets to more readily utilize AI. The open-source dataset can be used to improve the capabilities of AI models for tasks like business trend analysis and scientific figure interpretation.

“We developed ChartNet to be a one-stop shop for chart understanding, covering basically anything that an AI model and a practitioner who is training that model might need. We hope our work motivates researchers to achieve state-of-the-art performance with smaller models that don’t require infinite amounts of computation,” says Jovana Kondic, an MIT electrical engineering and computer science (EECS) graduate student and lead author of a paper on ChartNet.

She is joined on the paper by many co-authors from MIT, the MIT-IBM Computing Research Lab, and IBM Research, including Pengyuan Li, a research staff member at IBM Research; Dhiraj Joshi, a senior scientist at IBM Research; Isaac Sanchez, a software engineer at IBM Research; Aude Oliva, director of strategic industry engagement at the MIT Schwarzman College of Computing, MIT director of the MIT-IBM Computing Research Lab, and a senior research scientist in the Computer Science and Artificial Intelligence Laboratory (CSAIL); and Rogerio Feris, a principal scientist and manager at the MIT-IBM Computing Research Lab. The research will be presented at IEEE Computer Vision and Pattern Recognition Conference.

A dataset bottleneck

Researchers have made great strides developing generative AI models that excel at natural language processing and reasoning about natural images. But less work has focused on interpreting complex multimodal data contained within charts, Kondic says.

Yet for large and small businesses in nearly every industry, chart understanding is a critical task.

“The finance industry thrives on charts. If vision-language models can extract information out of charts, like descriptions of trends, that facilitates a lot of workflows that happen downstream,” Joshi says.

The lack of high-quality training data is a major bottleneck holding back the development of VLMs that can accurately interpret charts. Many datasets contain limited chart images pulled from the internet and often lack the necessary scale and additional information to help a model interpret the underlying data.

“A vision-language model, unlike our brains, may need to see thousands of examples during training to reliably recognize something as a line chart,” Kondic says.

The researchers sought to overcome those shortcomings by generating synthetic data. Synthetic data are artificially generated by algorithms to mimic the statistical properties of actual data. 

The ChartNet dataset holds more a million high-quality chart images, along with the corresponding code used to generate each chart, a textual description, and a table that contains its numerical information. In addition, each datapoint includes question-and-answer pairs to teach the model how to correctly answer questions about the chart image.

“These additional modes of data guide the model to connect and align the different pieces of information that the chart image encodes,” Kondic says.

Data generation

To build ChartNet, the researchers created a two-step, synthetic data generation pipeline.

First, their automated system translates any pre-existing set of chart images into code. Then the system iteratively augments that code to change different aspects of each chart, such as chart type, data values, topic, colors, etc.

“We can start from a single chart that we use as a seed and come up with hundreds of augmentations of it. This is how we were able to build a dataset with more than a million diverse images,” Kondic explains.

They also incorporated an automated quality check process to ensure the synthetic data are high quality. This process verifies that the code is executable and rendered chart images are accurate and clean.

“We don’t want to just be generating diverse samples. We also want the information to be presented in a meaningful way,” she says.

ChartNet also includes a selection of chart datapoints annotated by human experts. This provides access to additional types of charts and supporting data that carry validity guarantees.

A practitioner could use the annotated data to fine-tune an existing VLM, further boosting performance for a specific application, Joshi adds.

The researchers tested ChartNet by training IBM’s Granite Vision series of models as well as several other open-source models of various sizes and evaluating them on various chart interpretation tasks. The dataset improved the accuracy of all models in chart reconstruction, chart data extraction, chart summarization, and chart question answering. 

With ChartNet, small open-source models consistently outperformed much larger  commercial models. 

“A lot of prior training datasets only focused on answering simple questions about a chart. We tried to go beyond that with ChartNet by generating data that support all aspects of robust chart understanding,” Kondic says.

In the future, the researchers plan to continue expanding ChartNet by incorporating data with added levels of complexity. They also want to draw on feedback from the research community. 

This research was funded, in part, by the MIT-IBM Computing Research Lab.

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Ambassadors of STEM

When a team of MIT students turned up at a national robotics tournament, their robot — aptly named Timbot — wouldn’t work. They’d been invited to demonstrate Timbot at the inaugural United States Governors Cup in Washington, D.C., a March Madness-like competition for high school robotics teams from all 50 states.

Troubleshooting on the fly is par for the course at robotics tournaments. Timbot had a few technical issues, mostly with Wi-Fi, so the team sat cross-legged on the floor and set to work. Meanwhile, high school students started gathering around and asking questions about wiring and subsystems. After about an hour, Timbot was up and running again, scooping up and throwing foam balls as it was designed to do.

“It actually turned into a great moment,” says first-year student Lily Sand. “We ended up tethering the robot with a long Ethernet cable, instead of using wireless, and a lot of students were like, ‘whoa, we do that too!’ It was a nice connection point.”

Leveraging a cultural touchstone for good

Connecting younger students to robotics is one of the MIT students’ goals as members of a new club, FIRSTxMIT, which launched at the beginning of the academic year. Members are all alumni of programs offered by FIRST Robotics (FIRST), a nonprofit that aims to inspire interest in STEM for K-12 students worldwide through team-based robotics programs and competitions.

FIRST has deep roots at MIT. Inventor Dean Kamen collaborated with the late MIT Professor Woodie Flowers, a pioneer in hands-on engineering design education, to establish the FIRST Robotics Competition in 1992. The competition was modeled after the novel robotics competition Flowers had developed for his iconic mechanical engineering class 2.70 (Introduction to Design), which is now 2.007 (Design and Manufacturing I).

Through FIRST, students learn about more than designing, building, and programming robots. The program emphasizes the ethos of “gracious professionalism,” a term coined by Flowers for high-quality work, respect, and cooperation, even in the context of competition. Students also build self-confidence, gain leadership experience, and hone communication skills, as well as technical expertise. 

Many FIRST alumni feel deep gratitude for the program and a strong desire to stay involved. Debbie Ang, co-founder of FIRSTxMIT, still mentors her high school’s team in New Hampshire. Yet, there are few FIRST alumni clubs at universities. Ang and co-founder Perry Han, also a sophomore, met in high school through FIRST and reconnected at MIT. “We noticed that FIRST was founded here, and yet there wasn’t anything organized on campus, even though we kept running into people who had done FIRST and still cared about the community,” she explains.

In fact, participation in FIRST is somewhat of a cultural touchstone among MIT students. MIT associate director of admissions Trinidad Carney, a liaison to FIRST Robotics, estimates that 15-20 percent of undergraduates have participated in the program.

Han and Ang collaborated with Carney to launch FIRSTxMIT, under the auspices of the Edgerton Center, to foster connections among the MIT FIRST community and provide a way for members to channel their passion for FIRST into outreach and public service. Their hunch about the untapped potential an alumni club was spot-on: the kickoff event drew 185 students, and there are about 200 on their Discord channel.

Sharing the “power of FIRST”

Now the club is off and running. They have hosted a gathering for New England FIRST alumni; collaborated with the Josiah Quincy Elementary School in Boston to launch a LEGO Robotics league; volunteered as judges at local competitions; and helped the MIT Admissions Office with outreach. Carney, who advises the club, says, “We’ve actually had other universities reach out to us to say, ‘How did MIT manage to launch a club that’s so successful and compelling?’”

One of the club’s most ambitious undertakings to date was building Timbot, in three days, during Independent Activities Period in January. Robot in 3 Days (Ri3D) is a collegiate challenge in which students build a FIRST Robotics Competition-level robot in 72 hours, a feat that would take about six weeks for a high school team. Experiential Robotics, a consortium that leverages an experiential robotics platform to promote engineering and public service, provided support for MIT’s Ri3D challenge and invited the team to act as STEM ambassadors at the Governors Cup.

In addition to the robotics competition, the two-day event brought together governors and leaders from government, education, industry, and others to underscore the crucial role that states play in supporting STEM education.

To that end, the FIRSTxMIT team demonstrated Timbot, chatted with high schoolers, staffed the MIT Admissions booth, and mingled with VIPs, sharing the value of project-based STEM enrichment opportunities like FIRST. “Having MIT students tell the story of the power of FIRST is incredibly compelling,” says Carney. “They can say: I did this in high school, it shaped who I am, and now I’m at MIT continuing to build and give back.”

A number of governors stopped by the MIT Admissions booth to chat with the students, including Massachusetts Governor Maura Healey. “She talked about the importance of K-12 STEM education and was very supportive,” says Sand, FIRSTxMIT’s logistics coordinator. 

In addition to inspiring others, the MIT students drew inspiration themselves at the Governors Cup. Han recalls speaking to a state senator from Ohio, a former teacher and strong advocate for programs like FIRST. “It really showed me that, when you have people in government that are excited about STEM education, it can really go places.”

Building a better future

Looking forward, Han and Ang plan to take some time to further refine the club’s organization and future goals. Hands-on outreach figures prominently in their plans. “FIRST places a big focus on starting new teams, supporting underserved communities, and spreading awareness,” says Ang. “A lot of us feel that FIRST played a major role in shaping our academic and career paths, so we want to give that opportunity to others.”

“Part of our goal is, we want to put a robot in as many students’ hands as possible to kind of give them a sense that, STEM isn’t just reading the AP Physics C-Mechanics textbook,” Han adds. “It’s actually putting these ideas into practice and building something useful.”

They have no shortage of new ideas they are kicking around, as well. Han is particularly interested in advocating for students to earn Undergraduate Research Opportunities Program or class credit for projects like Ri3D, or for those in the Gordon Engineering Leadership Program to get leadership credit by mentoring a robotics team. He also wants to explore how to leverage FIRST alumni networks to help students with professional development.

Whatever path they take, Carney has no doubt they make an impact. She saw their potential on full display when they built Timbot.

“These students, many of whom hadn’t met before, came from all kinds of backgrounds: different schools, different regions, different life experiences,” she says. “But they worked together with respect, curiosity, and generosity. They’re collaborative, mission-driven, and passionate about making opportunities for others. They make MIT better, and they will make the future better.”

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Ultrasound-based pacemaker noninvasively steadies the heart

MIT engineers have developed a noninvasive pacemaker that stimulates the heart using ultrasound. The design could one day provide a surgery-free alternative to traditional cardiac implants.

The new device is designed as a small sticker that can be worn on the chest. Tiny transducers on the sticker send ultrasound pulses through the chest to stimulate the heart. The ultrasound waves trigger the opening of certain ion channels in heart cells, an effect the researchers amplified through genetic engineering. When the channels open, they let in calcium, which signals a heart cell to squeeze and beat. 

In experiments in the lab, the researchers applied ultrasound waves to engineered human cardiac cells and found that the pulses effectively maintained the cells’ healthy contractions. They also tested the ultrasound sticker on rats and found the device quickly, safely, and noninvasively corrected arrhythmias and restored normal, regular heart contractions. 

The team has fabricated a prototype that includes the ultrasound sticker (about the size of a postage stamp) and a small, pocket-sized device containing associated batteries and electronics. The same group previously demonstrated a sticker design that uses ultrasound to image deep organs and tissues. They now plan to combine the two approaches into one ultrasound sticker to simultaneously monitor and regulate the heart’s activity. 

“We believe you could one day have stickers on the body that could do long-term imaging deep in the body and also do stimulation for therapeutic effects, in a noninvasive closed-loop way,” says Xuanhe Zhao, professor of mechanical engineering and of civil and environmental engineering at MIT.

Zhao and his colleagues, together with collaborators from Professor Qifa Zhou’s group at the University of Southern California (USC), have published their results in a study appearing today in the journal Nature Biomedical Engineering. The study’s MIT co-authors include first author Chen Gong, together with Runze Li, Won Jun Song, and former postdocs Gengxi Lu, Shucong Li, and Hsiao-Chuan Liu. Other collaborators include researchers from Harvard University, the University of California at Los Angeles, and other groups at USC.

Sound genes

Today, around 3 million adults in the United States live with pacemakers. The small battery-powered devices are surgically implanted in a person’s chest, and act to deliver electrical impulses to regulate heart rate. Implantable pacemakers are a well-established and generally safe medical treatment that nonetheless comes with risks.

“Pacemakers are one of the most important and widely used human implants, and they have saved millions of lives,” the paper’s co-corresponding author, Gengxi Lu, says. “But they are invasive, and they make direct contact with the beating heart. The dream for many years has been noninvasive heart stimulation with ultrasound.” 

Ultrasound encompasses a range of acoustic waves that safely penetrates the body. Ultrasound waves reflect and resonate off structures in characteristic ways that allow technicians to resolve and image organs and tissues inside the body. Ultrasound can also be directed and focused to stimulate certain therapeutic effects, for instance in the brain, where scientists are exploring the use of ultrasound to treat Parkinson’s disease, Alzheimer’s, and other brain disorders. 

Scientists have also found that ultrasound can benefit the heart. Previous studies in animals have shown that focused ultrasound can safely activate heart cells, though the effect has been inconsistent and weak. 

Zhao and his colleagues looked to amplify ultrasound’s effects on the heart. In their new study, they applied sonogenetics, which is a relatively new approach that takes after optogenetics — a technique that involves genetically manipulating specific parts of a cell to respond to light. Similarly, sonogenetics aims to genetically engineer cells to respond to sound, including ultrasound. 

In their work to develop an ultrasound pacemaker, the team first looked to increase heart cells’ sensitivity to ultrasound, through sonogenetics. In the lab, they used standard practices to derive heart cells from embryonic stem cells, and then delivered a genetic alteration to the cells that increased their sensitivity to ultrasound. Specifically, the manipulation produced ion channels that opened more readily in response to ultrasound. 

“These channels can now ‘hear’ ultrasound better, and can open to let calcium in, which is what directly activates the cell and causes it to beat,” explains by the paper’s first author, Chen Gong. 

Sticker health

In experiments with sonogenetically engineered heart cells, the researchers found that when they exposed the cells to ultrasound, the cells beat in sync with the waves, unlike cells that were not genetically manipulated. 

In any clinical application of an ultrasound pacemaker, the team envisions that a patient could first receive a one-time injection, similar to a vaccine, that would act to genetically boost the sensitivity of cardiac cells to the pacemaker’s ultrasound waves. The injection would be a form of gene therapy — a treatment that is currently approved by the FDA to treat certain inherited conditions such as sickle cell disease and spinal muscular dystrophy.

“We think this step would be clinically translatable as a form of gene therapy that could enable noninvasive pacemakers,” Gong says.

The team then designed the core of the ultrasound pacemaker, in the form of a postage-stamp-sized sticker embedded with tiny ultrasound transducers. The sticky part of the device is made from a hydrogel material that Zhao’s group has refined over the years to adhere strongly to skin and many types of materials, while also allowing ultrasound waves to pass through without weakening. The transducers within the sticker can be tuned to generate ultrasound waves at specific frequencies. 

In experiments with rats, the researchers first administered a sonogenetic, ultrasound-boosting solution through their tails. They then adhered a miniature version of the pacemaker to the rats’ chests. When they turned the stickers on, they observed that the ultrasound quickly regulated the animals’ hearts. Some individuals with slow heart rates were brought up to a normal rate, while others with irregular heartbeats were steadied, keeping in sync with ultrasound’s “ticks.”

“We can now use low-intensity ultrasound to open ion channels in cells to have very effective heart pacing,” Gong says. “We are now making these stickers into smaller form factors, and more integrated, so they are easier to wear, more stable, and more accurate over a longer term.”

“In this paper, we demonstrated noninvasive pacemaking. However, we think this concept could be useful beyond just the heart,” Zhao says. “We believe you could one day have stickers over different parts of the body that could do long-term imaging, monitoring, and closed-loop therapeutic stimulation.”

This work was supported, in part, by the National Institutes of Health, the National Science Foundation, the Department of Opthamology from Research to Prevent Blindness, and the U.S. Department of War.

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