Big strides in cancer detection and treatment from the tiniest technologies

That there is tremendous potential for nanotechnology to transform cancer detection and treatment is a vision that has guided faculty at the Marble Center for Cancer Nanomedicine through its first 10 years. 

On April 9, the center gathered researchers, entrepreneurs, clinicians, industry collaborators, and members of the public at the Broad Institute of MIT and Harvard and the Koch Institute for Integrative Cancer Research galleries to celebrate a milestone anniversary and reflect on its journey.

“Our purpose has always been clear: to empower discovery and community in nanomedicine at MIT,” said Sangeeta Bhatia, faculty director at the Marble Center for Cancer Nanomedicine and the John J. and Dorothy Wilson Professor of Health Sciences and Technology and Electrical Engineering and Computer Science at MIT.

“A decade in, we are seeing that vision materialize not just in publications, but in our community, our startups, and ultimately, in patients whose lives are being changed,” Bhatia told an audience of about 150 gathered in person for the celebration.

The event featured an overview of the Marble Center by Bhatia and a perspective on nanomedicine by Robert S. Langer, the David H. Koch (1962) Institute Professor and faculty member at the Marble Center. 

A panel on translational nanomedicine followed the talks. It was moderated by Susan Hockfield, president emerita and professor of neuroscience at MIT, and included Noor Jailkhani, former MIT postdoc in the laboratory of the late MIT professor of biology Richard Hynes and CEO, co-founder and president of Matrisome Bio; Peter DeMuth ’13, chief scientific officer at Elicio Therapeutics; Vadim Dudkin, founding chief technology officer at Soufflé Therapeutics; and Viktor Adalsteinsson ’15, co-founder of Amplifyer Bio and director of the Gerstner Center for Cancer Diagnostics at the Broad Institute.

A decade of impact in nanomedicine

Established in 2016 through a generous gift from Kathy and Curt Marble ’63, the Marble Center brings together leading Koch Institute faculty members and their teams to focus on grand challenges in cancer detection, treatment, and monitoring through miniaturization and convergence — the blending of the life and physical sciences with engineering, a core concept fueling multidisciplinary research at the Koch Institute. 

At the center’s founding, Bhatia and Langer were joined by five additional faculty members: Daniel G. Anderson, professor of chemical engineering and member of the Institute for Medical Engineering and Science; Angela M. Belcher, the James Mason Crafts Professor in the departments of Biological Engineering and Materials Science and Engineering; Michael Birnbaum, professor of biological engineering; Paula T. Hammond, Institute professor and dean of the School of Engineering; and Darrell J. Irvine, who is now professor and vice-chair at the Department of Immunology and Microbiology at the Scripps Research Institute in La Jolla, California.

“Over the past decade, the center and its member laboratories have trained close to 500 researchers. Among them, 109 have become faculty in 79 clinical and research universities. We also have worked in close collaboration with clinical and industry partners to produce the results you are seeing today,” said Tarek Fadel, associate director of the Marble Center and director of strategic alliance at the Koch Institute. 

“Twenty-three startup companies have emerged from Marble Center laboratories during that time with companies such as Cision Vision, Soufflé Therapeutics, Orna Therapeutics, Matrisome Bio, Amplifyer Bio, Gensaic, among several others that hold so much promise for the early detection of disease and drug delivery,” Fadel added.

The Marble Center has launched several topical programs aimed at trainee development and industry engagement. At monthly seminars, trainees at the Marble Center lead an open forum on emerging issues in their fields. The Convergence Scholars Program, which was originally launched in 2017 to further the development of postdocs beyond the laboratory bench, is now a competitive award program offered to postdocs at the Koch Institute. Through an industry affiliate program, the center worked closely with several key players in the field of nanoscience. Industry collaborators mentor trainees and participate as judges in an annual poster symposium. 

More recently, MIT-wide grants have catalyzed new collaborations: In 2023, the Global Oncology in Nanomedicine grant supported a project on leveraging AI-based approaches to speed the development of RNA vaccines and other RNA therapies. The project was led by Giovanni Traverso, the Karl Van Tassel (1925) Career Development Professor and a professor of mechanical engineering.

From lab to clinic: Lessons in nanomedicine translation

Panelists at the anniversary event shared candid reflections on the often messy, but exhilarating process of turning their ideas into commercial technologies. 

DeMuth described how Elicio Therapeutics, whose core technologies originated from his graduate research in Irvine’s group, harnesses the natural power of the lymph nodes to generate enhanced immune responses against tumors. The amphiphile platform uses the body’s natural albumin transport system to “shuttle” medicines into the lymph nodes, boosting immune cell activation. Elicio is now advancing their platform through a Phase 2 trial in pancreatic ductal adenocarcinoma and colorectal cancer.  

Jailkhani co-founded Matrisome Bio with Bhatia and Hynes. Matrisome Bio is pioneering a new class of therapies, small protein binders called nanobodies that deliver potent payloads directly to the extracellular matrix of tumors and metastases while sparing normal tissues. Matrisome Bio is currently testing radioligand modalities with their targeting platform for the treatment of cancer. 

Adalsteinsson co-founded Amplifyer Bio with Bhatia and J. Christopher Love, the Raymond A. (1921) and Helen E. St. Laurent Professor of Chemical Engineering and associate director of the Koch Institute, with the goal of developing priming agents for liquid biopsy. Priming agents injected before a blood draw transiently slow the clearance of cell-free DNA from the bloodstream, thus allowing up to 100-fold more tumor DNA to be recovered for liquid biopsy applications. While injection for medical diagnostics has been done for decades in the context of imaging scans, Amplifyer Bio’s approach would be the first of its kind in the field of liquid biopsy.

Dudkin described Soufflé Therapeutics’ vision to enable targeted delivery with receptor-mediated uptake to any type of cell in the human body. Soufflé Therapeutics is working to engineer cell-specific ligands to deliver siRNA-based medicines that are precise and transferred across the cell membrane to their target, by combining proprietary technologies for identification of cell-specific receptors, ligand optimization, and potent siRNA engineering. 

Panelists stressed that successful translation requires complex choices. While platform technologies can theoretically address many cancer problems, startups must focus on specific indications and clinical modalities to succeed in resource-limited, commercial settings. While the academic lab offers freedom to explore multiple applications, commercialization demands strategic narrowing of scope. 

Reproducibility during scale-up emerged as another critical consideration: Founders building platform companies must demonstrate not only that their technology works, but that their underlying discovery is reproducible and robust enough to support a business. All panelists agreed that thinking about manufacturability early in research, rather than as an afterthought, significantly improves a startup’s path to the clinic. Highlighting tension between selecting cutting-edge approaches and managing their inherent regulatory risks, they recommended minimizing risk by leveraging established processes and chemistries that have already been validated in approved drugs.

Finally, panelists highlighted the importance of institutional collaborations, particularly with centers like the Marble Center for Cancer Nanomedicine. These partnerships offer access to collaborative, mission-driven researchers who can push technological boundaries, while startups maintain focus on narrow clinical applications. Panelists emphasized that faculty collaborators, such as at the Marble Center, often provide “big sky thinking” that explores new directions and applications that complement the company’s core mission.

The next chapter in nanomedicine at MIT

As the Marble Center enters its second decade, the community is focused on expanding collaborations, leveraging advances in computation and other intersecting disciplines, and exploring new disease indications. 

“The next 10 years will be defined by our ability to leverage insights gained at the nanoscale to push the boundaries of precision medicine. The Marble Center is in a unique position to do just that, as we evolve this incredible community at MIT to be a global hub for nanomedicine research,” said Bhatia. 

Bhatia also announced that in June, the Marble Center will launch a new grant, Integrated Nanoscale Sensing, Imaging, and Health Technologies (INSIHT), aimed at advancing new imaging and sensing technologies for precision medicine. 

Similarly, panelists expressed optimism about nanomedicine’s transformative potential, centered on precision medicine. The field, they argued, will focus on minimizing side effects while opening previously unavailable therapeutic windows — enabling treatments that are fundamentally more targeted and effective. This precision could render many currently untreatable diseases manageable, or even curable, while also enabling in some cases the repurposing of drugs that failed in earlier clinical contexts. 

“Ten years ago, Sangeeta, Tyler Jacks, and the Marble Center community had a vision” said Matthew Vander Heiden, director of the Koch Institute and Lester Wolfe (1919) Professor of Molecular Biology. 

“Today, that vision is creating a place where bold ideas turn into transformative advances that can help cancer patients and non-cancer patients as well. It is exciting to see this momentum in nanomedicine at MIT and what will happen in the coming decade.” 

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How the war in the Middle East is impacting global energy systems

One day after the announcement of a ceasefire between the United States and Iran, the head of the International Energy Agency (IEA) outlined the implications of the war in the Middle East on the global energy system and the world’s economy, offering his expertise to an MIT audience.

“This is the largest energy crisis we’ve ever had in the world,” Fatih Birol, the executive director of the IEA, said at the MIT Energy Initiative’s (MITEI) Earth Day Colloquium on April 8. Birol put the current disruption of the world’s energy markets into historical perspective, shared what he believes will be the long-term impacts of this war — even in the best-case scenario where the ceasefire paves a path toward peace — and emphasized the need to create a more sustainable, resilient system moving forward.

In 1973, and again in 1979, there were oil crises that led the world economy into recession, with many countries — especially those with developing economies — spiraling into debt. More recently, Russia’s invasion of Ukraine led to a natural gas crisis. “The current crisis, the amounts of oil and gas we’ve lost, is bigger than all those three put together,” Birol stated. According to data received two hours before the seminar, Birol confirmed that 80 energy facilities in the Middle East had been damaged, with over one-third of those having been severely damaged.

The IEA has played a significant role in the global response to the war. “Our job is to have a real-world impact,” said Birol. Earlier in the conflict, after making clear to policymakers and members of the press the scale of the problem at hand, the IEA turned to its member countries — which are required to have significant oil stock reserves — to bring their reserves to the market. “Since the disruption was so big, we brought all the countries together, which is not easy,” Birol said. “We released 400 million barrels of oil, which is the highest we have ever done. This calmed markets and put downward pressure on prices.” The IEA also released a suite of recommendations for conserving oil quickly, many of which countries around the world are already implementing, said Birol.

The implications of this crisis are far-reaching, and will vary in severity depending on how long the war lasts and how quickly normal operations resume afterwards — which could take some time, considering the extent of the damage to the Middle East’s energy infrastructure, Birol said.

Birol explained the more immediate impacts of the war on the gas industry. Although the natural gas industry has presented itself as a reliable, affordable, and flexible energy source, Birol highlighted that the two major gas crises in the last four years have brought that assertion into question.

“Is [natural gas] still reliable? Is it still flexible? Is it still affordable? After these two big crises, the natural gas industry needs to work hard to regain its brand,” he said.

Birol also outlined three potential outcomes that this shift may bring to the renewable energy sector. First, there is historical precedent for building up nuclear power plants in response to the oil crises of the 1970s. “Around 45 percent of nuclear power plants operating today were built as a response to those crises,” said Birol. He believes there will be another large push for nuclear power, including small nuclear reactors.

Second, renewables may be the biggest beneficiaries of this situation, he said. “In Europe, after Russia’s invasion of Ukraine, the renewable annual installations increased by a factor of three,” he said.

Third, especially in Asia, we will likely see an increase in the market penetration of electric vehicles, Birol said. This is especially important to note because Asia is the center of current oil demand growth, but the adoption of more electric vehicles could have an impact on that, he suggested. Previous crises have also led to car manufacturers improving the fuel efficiency of their cars.

“The energy security premium will be a factor of the energy trade in the future, in addition to the cost of energy,” said Birol, speaking to the longer-term effects on the global energy market. “Countries will be more careful now with whom they are trading.”

Addressing the current crisis also necessitates changes to our energy system going forward, according to Birol. He explained that the entire global economy is being held hostage by the 50 kilometers of the Strait of Hormuz, which is a critical path not only for oil and gas shipments, but for materials used to make fertilizer, which are needed to feed the world’s population, and materials such as helium, which are needed to manufacture products like cell phones.

“I'm afraid that after this is finished, some of the countries will come back faster because they have stronger financial muscles, better engineering capabilities, and better technologies, whereas other countries will suffer,” he said. “It will be, in my view, not easy for the global economy. I believe who will be suffering under this economic damage will be mainly developing countries.”

The burden on developing countries will not only come in the form of energy prices, but also lasting impacts on fertilizer consumption, food security, and food prices, which Birol emphasized is a global problem. “What should be the response to have a more secure, but also more sustainable, future for everybody?” he asked.

Birol suggested the best possible outcome to the current global energy and economic disruption would be if the ceasefire leads to a peaceful settlement of the war. Still, this “best possible outcome” includes significant risk for much of the world.

If there is a settlement of peace, Birol said he expects oil and the gas production in the region to restart. He noted that there are about 200 fully laden oil tankers and 15 loaded liquid natural gas ships that could leave the Gulf fairly quickly if the Strait of Hormuz fully reopens.

“But I don’t think that in a very short period of time we will go back where we were before the war,” Birol said. “And this may keep the prices at elevated levels. This is surely not good news, especially in the emerging world. I would be surprised if we don’t see significant inflationary pressures in Asian developing countries, in Africa, and in Latin America,” Birol said. “In addition to that, the petrochemical industry, fertilizers, we will discover how important those commodities are for the supply chains we have … I expect a bit of volatility in the markets.”

This speaker series highlights energy experts and leaders at the forefront of the scientific, technological, and policy solutions needed to transform our energy systems. Visit the MIT Energy Initiative’s events page for more information on this and additional events. The series will return this fall.

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Building “hardcore” advanced machines

MIT class 2.72/2.270 (Elements of Mechanical Design) offers undergraduate and graduate students advanced study of modeling, design, and integration, along with best practices for use of machine elements like bearings, bolts, belts, flexures, and gears.

“[Students] learn how to use basically everything from the MechE undergraduate curriculum to build hardcore advanced machines,” says Martin Culpepper, the Ralph E. and Eloise F. Cross Professor in Manufacturing and professor of mechanical engineering (MechE) at MIT.

The course employs modeling and analysis exercises based on rigorous application of physics, mathematics, and core mechanical engineering principles, which are then reinforced through lab experiences and a mechanical system design project.

Culpepper, known to students and colleagues as Marty, says one of his main goals in the course is to “make students into stronger engineers.” His methods involve a mix of teaching and coaching techniques that push students to explore the bounds of what’s possible. 

“Marty likes to say that ‘as long as something doesn't break the laws of physics, it’s possible. You just have to figure out how to engineer it,’” says Yasin Hamed, a teaching assistant for the course.

For the system design projects, students build a lathe that can meet repeatability, accuracy, and functional requirements, and that can also “pass ‘Marty’s death test,’” says MechE graduate student Sarah Stoops. “What that means practically,” explains fellow graduate student Amber Velez, “is, at the end of class, Marty takes all our lathes and drops them and hits them with a hammer, and if they explode, you don’t pass the class.”

This final test may seem harsh, but it is an important part of the process and helps build to additional, critical skills: resilience and perseverance.

“The students are very resilient. They learn to persevere and take some time to try and figure things out, and through that process … you learn so much,” says Hannah Gazdus, a teaching assistant for the course.

Before the so-called “death test,” students tackle two other challenges: precision and material removal. “All of our lathes are required to cut to within 50 microns of precision,” explains Velez. In the material removal rate competition, teams compete to see who can turn down a piece of stock by one inch the fastest. Velez’s team completed the later task in approximately 27 seconds.

“The core classes are important — things like mechanics, materials, dynamics, controls — but many of them have a degree of abstraction that separates the content within those courses from the mechanical elements that you use in designing an actual machine,” says Hamed. “I feel like this class serves very well to bridge that [and] inspire that confidence as working engineers.”

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From technical solution to systems change: Tackling the problem of plastic waste

When Akorfa Dagadu arrived at MIT, she had a solution in mind: a mobile app to improve recycling and environmental engagement in her home country of Ghana. The project, called Ishara, aimed to make it easier for people to participate in local recycling systems while creating economic opportunities.

“I grew up in what people often call the trash capital of Accra,” she recalls. “I thought I knew what would fix it. So [my Ishara co-founders and I] built a solution — an app — behind some desk in a library … We did what I thought was market research, but looking back, we were basically asking people what they thought about our idea instead of asking how things actually worked … Implementation humbled us very quickly.”

On the ground, Dagadu encountered a reality very different than she anticipated.

“Informal networks of waste pickers and aggregators were already doing the work,” she explains. They’d developed a system that was already working, but it was “invisible, undervalued, and excluded from larger recycling conversations.” 

From technical solutions to systems change 

Soon after arriving at MIT, Dagadu discovered the PKG Center for Social Impact as a place that could help her pivot, taking a step back from her technical solution to understand the systemic context of the problem she was trying to solve.

As a first-year student, Dagadu received a PKG Fellowship, which provides funding and mentorship for students to pursue community-engaged research and development. This early support positioned Dagadu to apply to PKG’s IDEAS Social Innovation Incubator to further refine her social enterprise, Ishara. Dagadu was one of few first-year students selected for IDEAS among an applicant pool dominated by MBA and other graduate students. 

“At MIT, there are a lot of opportunities focused on entrepreneurship. But not as many that emphasize how you can do something for the environment or your community,” says Dagadu. IDEAS trains technical founders in systems change for social impact and community-engaged innovation.

Dagadu obtained another PKG Fellowship to iterate on Ishara the following summer, and was accepted to the IDEAS incubator a second time. Eventually, she refined her app from a technical solution the community didn’t need to one that connects existing recycling networks to the broader value chain, in ways that are transparent and fair, using a blockchain-enabled buyback center. 

“The biggest thing PKG has given me is a way of thinking,” Dagadu explains. “The systems thinking mindset really stays with you. You start to see everything as connected. Technical solutions are not just technical; they have social and economic implications. I find myself applying that in all my classes. Whether I am designing a reactor system or working through a materials problem, I am always asking how this fits into the larger system and who it affects.” 

Community-engaged chemical engineering

Dagadu says that “PKG has shaped both how I do research and how I think about it.” She grew to understand the importance of research grounded in local partnerships, and points to her collaboration with Chanja Datti, a recycling company in Nigeria, as a prime example. 

“That collaboration has directly informed my research,” says Dagadu. “What started as a PKG-supported exploration has now grown into a full undergraduate-led research project at MIT, supported by D-Lab, focused on one of the hardest questions in recycling: what to do with multilayer plastic waste.”

“This is where my chemical engineering and materials background comes in,” explains Dagadu, who studies how random heteropolymers can stabilize enzymes for plastic degradation through the Alexander-Katz Lab. “Thinking about polymer structure, processing, and what is actually feasible,” is critical to her work on the ground. “But it is also shaped by everything PKG emphasizes. You cannot separate the material from the system it lives in.”

Dagadu also appreciates the personal community she’s developed through her journey at MIT, especially as her venture evolved and her co-founders stepped away. “I went from being part of a strong team of three to building Ishara largely on my own,” she recalls. “That’s when I understood what people mean by entrepreneurship being lonely. The doubt, the weight of decisions — it became very real, very quickly.”

She drew on relationships developed through PKG and the Kuo Sharper Center for Prosperity and Entrepreneurship, where Dagadu is a student fellow, to ground her and remind her of her personal mission. “It’s not just about having a team,” she realized. “It’s about having a community that can hold you through the moments when things fall apart.” 

The PKG Center’s assistant dean, Alison Hynd, who supported Dagadu through multiple PKG Fellowships, sees Dagadu’s ability to create community as a tremendous asset: “As a first-year student, she came through the door with an intellectual vision and drive to do this work, but at MIT, she’s found her voice to pull other people into it.”

Same question, different scale

Next year, Dagadu will broaden her community still more, as a Schwarzman Scholar at Tsinghua University in Beijing. While the context of her studies will change, her motivation remains the same as when she entered MIT.

“I want to keep asking the same question that’s shaped so much of my work so far,” she says, “not just how we design better materials, but how we design systems where those materials can actually work. That means zooming out and exploring the policy and economics of material flow.” 

Through Ishara, Dagadu’s social enterprise, she’s seen how systems intersect and function on the ground in the case of recycling in Ghana. “Now, I want to understand forces at a much larger scale,” she says, “and I can’t think of a better place to explore this question than in China, the manufacturing hub of the world.”

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3Q: Why science is curiosity on a mission

This week, MIT launches a new initiative — titled Science Is Curiosity on a Mission — to make the case for the long-horizon, curiosity-driven science that has powered generations of American innovation. Through stories of scientists pursuing open-ended questions, the project highlights how fundamental discovery research sparks advances in medicine, technology, national security, and economic growth.

MIT News spoke with Alfred Ironside, the Institute’s vice president for communications, about what inspired the effort, what’s at stake for the U.S. research enterprise, and why curiosity remains one of America’s greatest strengths.

Q: What is “Science Is Curiosity on a Mission,” and why launch it now?

A: Science has been under threat for some time now, and public investment in discovery science has been flagging. We want to remind people in Washington and across the country what curiosity-driven science is all about, and why it matters so much in our individual lives and in the life of the country. 

Science begins with curiosity — someone asking a question and refusing to let it go. History’s most important discoveries did not begin with a commercial objective or a guaranteed outcome. They began because someone wanted to understand how the world works. Think Ben Franklin and his kite: This drive to discover goes back to the beginnings of the United States. 

That’s the story we want to tell, but in today’s terms. We’re spotlighting researchers whose years-long pursuit of core questions has seeded breakthroughs that have changed lives for the better.

We’re launching this storytelling initiative now because public investment is declining, and in all the debates about funding what’s gotten lost is an appreciation for the incredible gifts of curiosity-driven discovery science. 

Over generations, the United States became the world’s scientific leader by investing in research of this kind, especially at universities, where long-term scientific undertakings have time and space to thrive. In turn, those investments have created an extraordinary pipeline of innovation, the envy of the world.

When public investment in basic science falters, the long-term losses start right away — and cascade. Labs close. Young scientists leave the field. Entire avenues of discovery go unexplored. Those losses are not always immediately visible, but eventually we feel them through what’s missing: treatments that never arrive, industries that never emerge, talent that migrates elsewhere.

Other countries understand this. They’re watching us stumble — and they’re growing their research investments aggressively. America’s scientific leadership has been built over decades — and maintaining it requires similar commitment.

It’s important to note that while this initiative to tell the story of discovery science was sparked at MIT, it is not about MIT. We want to spotlight university-based scientists across the country whose work is critical in advancing discovery, educating talent, and fueling innovation that benefits all of us.

Q: Why emphasize the idea of “curiosity”?

A: We start with curiosity for two reasons. First, it’s a human experience we’ve all had, so everyone can relate to it. Everyone knows the feeling of just wanting to know why something happens or how something works. Second, it’s the essential fuel that drives discovery science. 

There’s sometimes a tendency to talk about science in terms of outputs: breakthroughs, startups, commercial applications. Those things matter enormously, but they usually come much later. The beginning is more human. It’s someone wondering why something behaves the way it does, or whether a seemingly impossible problem might have an answer.

Some of the most transformative breakthroughs arose from questions that once appeared disconnected from practical use. MRI technology grew from research on atomic nuclei. The foundations of immunotherapy came from scientists trying to understand how the immune system works. GPS depends on what was once viewed as purely theoretical physics.

Curiosity fuels scientific discovery by pushing people to keep pursuing deep questions because they simply need to know: How does the brain work? How does cancer start? What is the universe made of?

That’s why the second half of the phrase matters: “on a mission.” University researchers are not indulging in idle speculation. They are pursuing knowledge to expand our understanding — and that new knowledge can be the key to startling new solutions.

Universities are uniquely important environments for this work. They bring together people from different disciplines and backgrounds who challenge assumptions and generate new questions. That concentration of talent and openness is extraordinarily productive.

After World War II, the American research university system became one of the most successful engines of discovery in human history. Public investment in university research has helped produce new medicines, computing technologies, communications networks, energy systems, and entire industries that shape modern life.

This effort aims to reconnect all of us with that story.

Q: What’s at stake if the U.S. fails to sustain support for basic research?

A: What’s at stake is not just scientific leadership, but the future pace of American innovation and opportunity.

The innovation pipeline operates across long time horizons. The discoveries powering today’s companies and medical treatments often crystallized 10, 20, or 30 years ago. The breakthroughs that will define the 2040s and 2050s are being explored in laboratories right now.

Basic research is the foundation of that pipeline, and private-sector innovation depends on it. Private investment plays a critical role, but it naturally gravitates toward projects with clearer commercial returns. Public funding supports the earliest, highest-risk stages of inquiry, where outcomes are uncertain but the potential benefit to society is enormous.

If that pipeline dries up, the consequences are stark. Fewer discoveries lead to fewer technologies, startups, and industries. We also risk losing scientific talent to countries that are watching our shifting national priorities — and making larger and more sustained investments in advancing science.

At the same time, there is enormous reason for optimism. The American scientific enterprise remains one of the great achievements of the modern era. It has delivered extraordinary gains in health, prosperity, and quality of life. Millions of people are alive today because of advances rooted in publicly supported research.

This system was built through sustained national commitment across generations. The question now is whether the country will continue investing in curiosity, discovery, and the people pursuing the new knowledge that will allow us to solve the intractable problems of tomorrow.

When curiosity is given room to run, the results can be life-changing for us all.

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Elazer Edelman receives the 2026-2027 Killian Award

Elazer R. Edelman ’78, SM ’79, PhD ’84, an engineer and cardiologist who helped develop cardiovascular stents that have been used by more than 100 million people, has been named the recipient of the 2026-2027 James R. Killian Jr. Faculty Achievement Award.

The award committee recognized Edelman, the Edward J. Poitras Professor in Medical Engineering at MIT’s Institute for Medical Engineering and Science, for his work at the interface of engineering, science, and medicine. In addition to his work on stents, he has made significant contributions to tissue engineering and to deciphering the fundamental biological processes underling cardiovascular disease.

A member of the MIT faculty for more than 30 years, Edelman is renowned as a teacher and mentor. He is also a professor of medicine at Harvard Medical School and a critical care cardiologist at Brigham and Women’s Hospital, and he served as director of MIT’s Institute for Medical Engineering and Science from 2018 to 2024.

“He is a clinician of the highest order who has touched the lives of many, a teacher of greatest passion who has mentored hundreds and taught thousands, and an engineer whose work has reached around the globe,” states the award citation, which was presented at today’s faculty meeting by Xuanhe Zhao, chair of the Killian Award Selection Committee and a professor of mechanical engineering at MIT.

The Killian Award was established in 1971 to recognize outstanding professional contributions by MIT faculty members. It is the highest honor that the faculty can give to one of its members.

“It’s deeply meaningful that your colleagues think enough of you to want to recognize your life’s work. This is an incredibly awe-inspiring group, and for them to feel that way is a truly special honor,” Edelman told MIT News after learning that he had been selected for the award.

Edelman, who grew up in Brookline, Massachusetts, got his first MIT experience as a high school student, taking classes as part of the Institute’s High School Studies Program. That experience led him to apply to MIT, where he earned two bachelor’s degrees, in applied biology and electrical engineering and computer science, followed by a master’s in bioelectrical engineering and a PhD in medical engineering and medical physics. He also earned an MD from Harvard Medical School through the Harvard-MIT Program in Health Sciences and Technology.

As a graduate student, Edelman was one of the first students to join the lab of Robert Langer, the David H. Koch Institute Professor at MIT. Working with Langer, he developed mathematical approaches to guide the design of controlled drug-delivery systems.

“Bob opened my eyes to what it really means to use MIT science to make the world a better place,” Edelman says.

Early in his career, Edelman brought a scientist’s eye to one of medicine’s most urgent clinical challenges: how to address diseased blood vessels without provoking further injury. His studies of the cellular and molecular mechanisms of atherosclerosis and vascular healing — work that continues to this day — coupled with fundamental insights from engineering and physics, helped enable the optimization of bare-metal stents and the development of drug-eluting stents. 

Roughly 90 percent of the more than 100 million stents implanted worldwide now release drugs through principles his work helped define and advance, saving countless lives and improving quality of life for patients around the globe.

Edelman’s work reflects a continuing cycle of discovery: Basic insights in biology shaped transformative medical technologies, and the challenges posed by those technologies, in turn, continue to push biology, science, technology, and engineering together toward new discoveries and clinical advances.

“His landmark work on the cellular mechanisms underlying atherosclerosis and on the biology of cell-material interfaces established the scientific foundations that transformed bare-metal cardiovascular stents from a promising mechanical concept into a biologically informed and clinically transformative therapy with enduring legacy — paving the way for a cascade of innovations that changed the landscape of medicine,” the award committee wrote.

More recently, Edelman’s lab has designed novel heart valves and other innovative approaches to mechanical organ support.

During his tenure as the director of IMES, he led an MIT-wide effort to provide personal protective equipment to health care workers and emergency responders in the early stages of the Covid-19 pandemic. 

“One of the things I’m most proud of is working with many people at MIT in the Covid response. At the height of Covid, we were supplying 23 percent of all PPE throughout New England,” he says. “Every single person who could possibly contribute contributed.”

As director of MIT’s Center for Clinical Translational Research and faculty lead for the Hood Pediatric Innovation Hub, he is now working to help clinical research thrive at MIT and to address the inequities in technology access for society’s most vulnerable population — children.

Throughout his career, Edelman has devoted himself to mentoring students and trainees.

“I’m really proud of what our students have accomplished, not only scientifically, but on a personal level, and not only with me, but everything they’ve done afterwards. The greatness of a place like MIT is that you enable people to grow beyond their potential. That’s really the extraordinary thing about our community,” he says.

In recognition of his scientific achievements, Edelman has been elected a fellow of the American College of Cardiology, the American Heart Association, the Association of University Cardiologists, the American Society of Clinical Investigation, American Institute of Medical and Biological Engineering, the American Academy of Arts and Sciences, National Academy of Inventors, the Institute of Medicine/National Academy of Medicine, and the National Academy of Engineering.

“The Selection Committee is delighted to have this opportunity to honor Professor Elazer Edelman for his exceptional contributions to medical engineering and science, to MIT, and to the world,” the award citation concludes.

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MIT chemists discover and isolate a new boron-oxygen molecule

Oxygen is a cornerstone of chemistry, largely because it is so good at building the organic molecules that make up our world. Some oxygen-based compounds, called peroxides, are famous for being highly reactive — they act like oxygen delivery trucks, transferring atoms to other molecules. This process is essential for everything from creating new medicines to industrial manufacturing.

In an open-access study published April 24 in Nature Chemistry, researchers from the labs of MIT professors Christopher C. Cummins and Robert J. Gilliard, Jr. have revealed a brand-new type of peroxide containing boron. This molecule, called a dioxaborirane, represents a major advance in a field where such structures were long-proposed, but considered too unstable to actually isolate.

Room-temperature breakthrough

Dioxaborirane forms when a specially engineered boron molecule reacts with oxygen gas. What makes this discovery remarkable is that the reaction happens almost instantly at room temperature. Usually, creating strained oxygen-containing rings like this requires extreme, “punishing” conditions — like freezing temperatures or high pressure — to keep the molecule from falling apart.

Using advanced tools such as crystallography and computational modeling, the team proved the existence of a highly strained, three-member ring made of one boron and two oxygen atoms.

A molecule with two personalities

The most exciting part of the discovery is how the molecule behaves. Depending on its electrical charge, it acts in two very different ways:

• The builder: It can donate oxygen atoms to help construct new chemical compounds.
• The trapper: It can react with carbon dioxide, potentially offering a new way to capture and transform greenhouse gases.

“By showing that these compounds can be generated under mild conditions, our work opens the door to entirely new types of chemistry,” says Chonghe Zhang, the first author of the paper and an MIT chemistry graduate student co-advised by Cummins and Gilliard. “In the long term, these findings could provide us with powerful new tools for oxidation reactions in synthesis and materials science.”

Additional co-authors on the paper are Noah D. McMillion and Chun-Lin Deng of MIT and Junyi Wang of Baylor University. The work was funded, in part, by the U.S. National Science Foundation.

de MIT News https://ift.tt/o1UdINr