Unmasking “zombie cells” in aging tissue with an AI-powered barcode

As we age, some of the cells in our body enter a state of senescence, in which they stop dividing but do not die. Those senescent cells can contribute to age-related disorders such as cancer, tissue degeneration, and inflammatory diseases.

In an advance that could lead to better ways to diagnose and treat those diseases, MIT researchers have developed a noninvasive way to detect biomarkers of senescence. Their method is based on Raman microscopy, which can reveal the biochemical composition of cells without harming them.

By combining Raman microscopy with gene expression data at single-cell resolution from the same cells, the researchers were able to identify unique “barcodes” that can be used to quickly identify senescent cells. This study was done in mouse cells, but the researchers are now working on adapting it for use with human tissue.

“You can imagine that one day we may develop an endoscope that can look inside your body and identify cellular senescence,” says Jeon Woong Kang, an MIT research scientist and one of the senior authors of the study.

The research is part of a National Institutes of Health initiative called the Cellular Senescence Network, which is pursuing a deeper understanding of senescence in hopes of developing therapies that could combat some of the tissue-damaging effects of senescent cells.

Peter So, director of the MIT Laser Biomedical Research Center (LBCR) and an MIT professor of biological engineering and mechanical engineering, and Jian Shu, an assistant professor at Massachusetts General Hospital (MGH) and Harvard Medical School, and an associate member of the Broad Institute and Ragon Institute, are also senior authors of the paper, which appears today in Nature Aging. Lead authors of the paper are Ke Zhang, an instructor at MGH and Harvard Medical School; Xingjian Chen, a postdoc at MGH and Harvard Medical School; Francesco Monticolo, a postdoc at MGH and Harvard Medical School; and Salvatore Sorrentino, a postdoc at MIT. 

Characterizing senescence

Cell senescence is often triggered by DNA damage, which leads to an irreversible arrest of the cell cycle. These cells don’t die, but they undergo significant changes to their shape, metabolic processes, and gene expression profiles. 

The immune system is responsible for clearing out these “zombie cells,” but as people age, this process becomes less efficient. When senescent cells accumulate, they may contribute to sagging skin, muscle weakness, and chronic conditions such as osteoarthritis and type 2 diabetes.

Cellular senescence also has beneficial effects, playing critical roles in embryonic development and tissue regeneration.

“Senescence is not just a pathological condition,” So says. “The idea behind the NIH Cellular Senescence Network is to take a very comprehensive approach to understand senescence and identify senescent cells, because it plays a role in so many normal physiological conditions and many pathological conditions.”

Scientists have already identified a few biomarkers for senescence, including two proteins called p16 and p21, which are involved in halting the cell cycle. However, those proteins can only be identified using a process that ends up destroying the cells.

The MIT team wanted to find a way to noninvasively identify senescent cells using Raman microscopy. Unlike RNA-sequencing, which consumes the cells as it analyzes them, Raman microscopy is a nondestructive technique that reveals the chemical composition of tissues or cells by shining near-infrared or visible light on them.

In the new study, the researchers used Raman microscopy in conjunction with spatial RNA sequencing — a technique that reveals where genes are active within a tissue — to identify new markers of senescence. By combining these two techniques, they were able to generate a much broader picture of the distinctive features of senescent cells, including gene expression levels, spatial location, and other biochemical information.

“Our idea was to look at many different features to characterize senescence. That’s why we wanted to combine both single-cell gene expression and Raman microscopy, so that we can characterize the senescence from two complementary views,” Shu says.

Using both methods of analysis, the researchers examined skin and lung tissue from 2-month-old mice and 26-month-old mice.

One of the most dramatic changes seen in both lung and skin cells was an increase in lipid synthesis in older cells, along with accumulation of lipids. How this affects the physiology of the cells is not yet known, the researchers say.

The researchers also found some effects that were specific to each tissue. In senescent skin cells, they discovered that cellular pathways associated with muscle contraction and with remodeling of collagen and the extracellular matrix were significantly affected. And in aged lung tissue, they found increased activity of genes involved in immune activation and inflammation.

In future work, the researchers hope to study further what role these changes play in senescent cells. 

Identifying senescent cells

Using these data, the researchers were able to identify combinations of Raman peaks that correlate with senescence. These peaks, which represent specific chemical bonds, are linked to the presence of certain lipids, proteins, or other molecules.

“Combining the most important Raman features with the most important gene signatures, we were able to create a barcode that can help us to identify senescent cells in a more unbiased way,” Sorrentino says. “Using this barcode, we can focus on a few Raman bands that emerged as the most informative in this work.” Using these bands, it could be possible to identify senescent cells by looking for just those bands of the Raman spectrum. This could help to enable diagnostics that would detect cells that have become senescent. 

To help make that possible, the researchers are now working on a higher-speed version of their Raman imaging system. Currently, it takes about 30 hours to analyze a tissue sample about one square millimeter in size, but they hope to develop a system that can quickly pick out the Raman barcodes they identified from larger samples.

The research was funded by the National Institutes of Health and Massachusetts General Hospital. 

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A new understanding of how enzymes influence bacterial protein production

Antimicrobial resistance is one of the most pressing global health and development challenges of our time. Bacteria and other pathogens are rapidly developing resistance to existing treatments, making infections harder to treat. Without new approaches, minor inconveniences today, such as routine surgeries or even a paper cut, could become life-threatening tomorrow. 

Now, an international group of scientists reports the discovery of aminovaleramididine synthetase (AvaS), the first identified pyridoxal phosphate (PLP)-dependent enzyme responsible for producing a chemical modification linked to how bacteria respond to metabolic stress. This discovery sheds new light on how bacteria use RNA modification to control protein production, opening new avenues to study bacterial adaptation and identify future targets and better strategies for developing antimicrobial therapeutics. 

The work was led by researchers from the Singapore-MIT Alliance for Research and Technology’s Antimicrobial Resistance interdisciplinary research group (SMART AMR), alongside collaborators from MIT, Nanyang Technological University in Singapore, and institutions in the United States, Poland, and France.

“While many RNA modifications have been known for decades, researchers are still uncovering the full extent of their roles. The discovery of AvaS opens a previously unknown chapter in RNA biology and is an important step forward in our understanding of processes relevant to antimicrobial resistance,” says Professor Peter Dedon, co-lead principal investigator at SMART AMR, professor of biological engineering at MIT, and co-corresponding author of a new paper on the work. “As we continue to map the RNA modification landscape, we expect many more discoveries with meaningful implications for infectious disease, antimicrobial resistance, and fundamental biology.”

Bacteria can develop resistance to antibiotics using various strategies, many of which depend on the bacteria’s ability to regulate which proteins are made, when they are made, and how accurately they are produced — whether by pumping drugs out of their cell, creating enzymes that break down drugs, or developing new cell processes to avoid the antibiotics’ target.

To build these proteins, bacteria rely on RNA molecules to read genetic instructions and direct protein production. Among these RNA molecules are transfer ribonucleic acid (tRNAs), a specialized class of RNA that acts as molecular delivery vehicles bringing chemical “stickers” to help bacteria control how proteins are made in response to stress and changing conditions such as exposure to antibiotics.

In the open-access paper, “Pyridoxal phosphate-dependent biosynthesis of aminovaleramide by AvaS in tRNA,” published Sept. 9 in Nature Chemical Biology, the researchers described their discovery of the new enzyme and identified it as being responsible for creating a tRNA chemical modification known as aminovaleramide cytidine (ava²C) in Pseudomonas aeruginosa, a harmful bacterium responsible for a range of serious human infections such as pneumonia and sepsis. While ava²C had previously been detected in several bacteria and plants, the enzyme responsible for producing this modification was previously unknown.

Using SMART AMR’s high-throughput liquid chromatography-tandem mass spectrometry (LC-MS/MS)-based RNA modification profiling platform, the team systematically screened thousands of P. aeruginosa mutants and discovered AvaS. The researchers also confirmed the presence of ava²C in other organisms, including the bacteria Acinetobacter baumannii and Vibrio cholerae, as well as the plant Arabidopsis thaliana.

The research revealed that AvaS uses PLP, a vitamin B6 derivative, to convert a known modification, lysidine (k²C), into ava²C; marking the first time that a PLP-dependent enzyme has been linked to tRNA modification. Traditionally, PLP-dependent enzymes have only been associated with amino acid metabolism and related biochemical pathways. 

The research findings revealed a few important insights about PLP-dependent enzymes. First, the discovery establishes PLP-dependent enzymes as a previously unrecognized class of tRNA-modifying enzymes, expanding the known chemical mechanisms, such as methylation, thiolation, and isomerisation, that bacteria use to regulate protein production. Second, it reveals an entirely new biological function of PLP-dependent enzymes, demonstrating that they can directly modify tRNA in addition to their well-established roles in metabolic processes.

The research also found that ava²C changes how bacteria read genetic codes, enabling the bacteria to produce protein faster and more efficiently while helping them adapt to metabolic and oxidative stress.

“Our discovery has revealed, for the first time, that PLP-dependent enzymes can directly modify tRNA, expanding our knowledge and understanding of RNA-modifying chemistry,” says Jingjing Sun, research scientist at SMART AMR, first author, and co-corresponding author of the paper. “This opens up new avenues for studying bacterial adaptation and developing new and more effective strategies to overcome drug-resistant bacteria.”

Building on this discovery, the SMART AMR team plans to investigate how ava²C affects bacterial stress responses and metabolism and explore how the modification can be disrupted or prevented. Understanding this process could uncover new ways to fight harmful bacteria and develop future antimicrobial therapeutics. With ava²C also being observed in plants, future studies could explore whether other living organisms use similar biological tools to produce certain chemical modifications and how ava²C influences the way proteins are built beyond bacteria.

More broadly, this work highlights the strength of SMART AMR’s first-of-its-kind epitranscriptomics platform as a powerful engine in discovering more unknown RNA-modifying enzymes at scale. This capability could also support biotechnology and pharmaceutical researchers in finding new drug targets and developing better treatments, particularly as bacteria continue to develop resistance against existing drug treatments.

The research conducted at SMART is supported by the National Research Foundation Singapore under its Campus for Research Excellence and Technological Enterprise program.

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A new understanding of how enzymes influence bacterial protein production

Antimicrobial resistance is one of the most pressing global health and development challenges of our time. Bacteria and other pathogens are rapidly developing resistance to existing treatments, making infections harder to treat. Without new approaches, minor inconveniences today, such as routine surgeries or even a paper cut, could become life-threatening tomorrow. 

Now, an international group of scientists reports the discovery of aminovaleramididine synthetase (AvaS), the first identified pyridoxal phosphate (PLP)-dependent enzyme responsible for producing a chemical modification linked to how bacteria respond to metabolic stress. This discovery sheds new light on how bacteria use RNA modification to control protein production, opening new avenues to study bacterial adaptation and identify future targets and better strategies for developing antimicrobial therapeutics. 

The work was led by researchers from the Singapore-MIT Alliance for Research and Technology’s Antimicrobial Resistance interdisciplinary research group (SMART AMR), alongside collaborators from MIT, Nanyang Technological University in Singapore, and institutions in the United States, Poland, and France.

“While many RNA modifications have been known for decades, researchers are still uncovering the full extent of their roles. The discovery of AvaS opens a previously unknown chapter in RNA biology and is an important step forward in our understanding of processes relevant to antimicrobial resistance,” says Professor Peter Dedon, co-lead principal investigator at SMART AMR, professor of biological engineering at MIT, and co-corresponding author of a new paper on the work. “As we continue to map the RNA modification landscape, we expect many more discoveries with meaningful implications for infectious disease, antimicrobial resistance, and fundamental biology.”

Bacteria can develop resistance to antibiotics using various strategies, many of which depend on the bacteria’s ability to regulate which proteins are made, when they are made, and how accurately they are produced — whether by pumping drugs out of their cell, creating enzymes that break down drugs, or developing new cell processes to avoid the antibiotics’ target.

To build these proteins, bacteria rely on RNA molecules to read genetic instructions and direct protein production. Among these RNA molecules are transfer ribonucleic acid (tRNAs), a specialized class of RNA that acts as molecular delivery vehicles bringing chemical “stickers” to help bacteria control how proteins are made in response to stress and changing conditions such as exposure to antibiotics.

In the open-access paper, “Pyridoxal phosphate-dependent biosynthesis of aminovaleramide by AvaS in tRNA,” published Sept. 9 in Nature Chemical Biology, the researchers described their discovery of the new enzyme and identified it as being responsible for creating a tRNA chemical modification known as aminovaleramide cytidine (ava²C) in Pseudomonas aeruginosa, a harmful bacterium responsible for a range of serious human infections such as pneumonia and sepsis. While ava²C had previously been detected in several bacteria and plants, the enzyme responsible for producing this modification was previously unknown.

Using SMART AMR’s high-throughput liquid chromatography-tandem mass spectrometry (LC-MS/MS)-based RNA modification profiling platform, the team systematically screened thousands of P. aeruginosa mutants and discovered AvaS. The researchers also confirmed the presence of ava²C in other organisms, including the bacteria Acinetobacter baumannii and Vibrio cholerae, as well as the plant Arabidopsis thaliana.

The research revealed that AvaS uses PLP, a vitamin B6 derivative, to convert a known modification, lysidine (k²C), into ava²C; marking the first time that a PLP-dependent enzyme has been linked to tRNA modification. Traditionally, PLP-dependent enzymes have only been associated with amino acid metabolism and related biochemical pathways. 

The research findings revealed a few important insights about PLP-dependent enzymes. First, the discovery establishes PLP-dependent enzymes as a previously unrecognized class of tRNA-modifying enzymes, expanding the known chemical mechanisms, such as methylation, thiolation, and isomerisation, that bacteria use to regulate protein production. Second, it reveals an entirely new biological function of PLP-dependent enzymes, demonstrating that they can directly modify tRNA in addition to their well-established roles in metabolic processes.

The research also found that ava²C changes how bacteria read genetic codes, enabling the bacteria to produce protein faster and more efficiently while helping them adapt to metabolic and oxidative stress.

“Our discovery has revealed, for the first time, that PLP-dependent enzymes can directly modify tRNA, expanding our knowledge and understanding of RNA-modifying chemistry,” says Jingjing Sun, research scientist at SMART AMR, first author, and co-corresponding author of the paper. “This opens up new avenues for studying bacterial adaptation and developing new and more effective strategies to overcome drug-resistant bacteria.”

Building on this discovery, the SMART AMR team plans to investigate how ava²C affects bacterial stress responses and metabolism and explore how the modification can be disrupted or prevented. Understanding this process could uncover new ways to fight harmful bacteria and develop future antimicrobial therapeutics. With ava²C also being observed in plants, future studies could explore whether other living organisms use similar biological tools to produce certain chemical modifications and how ava²C influences the way proteins are built beyond bacteria.

More broadly, this work highlights the strength of SMART AMR’s first-of-its-kind epitranscriptomics platform as a powerful engine in discovering more unknown RNA-modifying enzymes at scale. This capability could also support biotechnology and pharmaceutical researchers in finding new drug targets and developing better treatments, particularly as bacteria continue to develop resistance against existing drug treatments.

The research conducted at SMART is supported by the National Research Foundation Singapore under its Campus for Research Excellence and Technological Enterprise program.

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Fueling a return journey from Mars

When Lanie McKinney was 3 years old, her parents stopped at a massive meteor crater during a road trip through the U.S. Southwest. As they prepared to leave, McKinney began to protest.

“I want to wait here for the next one,” she told them.

She didn’t yet understand that another meteor wasn’t likely to land in exactly the same spot. But the story, which her parents still tell, captures a fascination that has remained with McKinney throughout her life.

“I just always remember being captivated by space and what is out there,” she says.

Today, McKinney is entering her fifth year as a PhD candidate at MIT, where she works in the Aerospace Plasma Group with Esther and Harold E. Edgerton Associate Professor Carmen Guerra-Garcia. McKinney’s research focuses on developing technologies that could help humans explore Mars.

One of the challenges of sending humans to the Red Planet is figuring out how to supply them once they arrive — including how to enable their journey back home. Rather than transporting everything from Earth, McKinney is interested in using the resources already available on the planet, a concept known as in-situ resource utilization, or ISRU.

“If we don’t build gas stations on Mars, it will be very difficult to get humans back to Earth,” she says. “We’re going to need some way to produce the propellant on site.”

McKinney’s research uses cold plasma to convert carbon dioxide, which is abundant in the martian atmosphere, into oxygen and carbon monoxide, a technology that could eventually be used to produce life support and propellant on Mars. 

An Oklahoma native, McKinney earned her bachelor’s at the University of Tulsa, where she studied physics and applied mathematics. She had initially expected to pursue astrophysics, but a summer research internship at the University of Colorado at Boulder introduced her to plasma physics through a project involving dusty plasmas in the lunar environment. 

“I thought it was an incredibly interesting problem,” she says. 

At MIT, McKinney has developed a small reactor that can convert carbon dioxide into oxygen and other products. The challenge now is separating out the oxygen before it recombines.

“We can actually perform the conversion step really well,” she says. “But what happens in a plasma is we convert it, and then we get a mixture that needs to be separated.”

Her current work pairs the plasma reactor with an oxygen-selective membrane designed to extract oxygen rapidly. The integration process isn’t well-understood, leaving McKinney and her colleagues with questions about how the reactive plasma environment will affect the membrane.

“We are not entirely sure what we will see,” she says.

For McKinney, the possibility of connecting laboratory experiments to future human missions is what makes the work particularly rewarding.

“I get to work in a really cool lab and develop exciting experiments,” she says. “I get ownership over an entire experimental system, and then I get to connect that to performance requirements for a future Mars system. That’s just the dream.” 

That same philosophy has shaped McKinney’s work beyond her thesis. Through MIT’s Space Resources Workshop, she has participated in NASA competitions focused on sustaining humans in space. Her first competition involved designing a self-sustaining Mars mission for 10 years.

“I had no clue what was going on,” she says. “I  didn’t know anything about space systems. So, my mentality was, let me jump in and learn.”

She later co-led MIT’s CERBERUZ team for NASA’s LunaRecycle Challenge, which asked teams to develop ways to recycle waste on missions to the moon and deep space. The MIT team recently won first prize in Phase 2, receiving $775,000 in awards for a system that grinds mixed trash into powder that can be reused via injection molding to make spare parts and 3D-printing filament. 

Another project McKinney enjoyed brought together engineers and architects through MAS.S66/4.154/16.89 (Space Architecture) to tackle a different problem: how to protect lunar habitats from radiation using only resources available on the moon. The students’ solution was to produce cast bricks from lunar regolith that could be stacked without mortar or another binder. For McKinney, the project demonstrated the value of bringing together people with different expertise.

“The kinds of innovative solutions that can be discovered when you work on a team that brings together different expertise and experiences was one of the project’s major takeaways,” she says.

The experience reflects a broader lesson McKinney has taken from MIT: Research may involve focused individual work, but solving the problems of human space exploration will require collaborations across disciplines.

“I feel like I have learned so much from being a part of these different teams,” she says. 

McKinney sees that collaboration as essential to the future she hopes to help build. Reaching the Moon and Mars is only the first step: “What comes next is building up a permanent presence so that we can do amazing science and be really effective at exploration,” she says.

McKinney’s fascination with exploration extends beyond her research. She is an avid hiker and mountaineer, having grown up hiking with her family in the Rockies. She recently completed a mountaineering course in Alaska and summited Mount Baker in the Cascade Range. She sees a connection between those adventures and the curiosity that first drew her to space.

“I love to explore and go on adventures,” she says. “And space is the ultimate thing you could explore.”

That curiosity has also shaped how McKinney approaches her work. When she arrived at MIT from the University of Tulsa, she initially felt intimidated.

“I thought that it was a fluke that I’d gotten in,” she says. “I was very nervous that I was not going to measure up to the environment.”

Over time, she learned to approach unfamiliar problems by asking questions and committing fully to whatever interested her.

“If something interests you, try it and go all in,” she says.

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Understanding the world, from the Cold War to the age of AI

At a moment when global alliances are shifting, technological change is accelerating, and the boundaries between science and geopolitics are dissolving, understanding the world demands new ways of thinking. 

For 75 years, the MIT Center for International Studies (CIS) has helped meet that challenge — bringing together engineers, social scientists, and policy practitioners to confront the most pressing global challenges of their time. From developing the foundations of modern international security to redefining how the United States engages with the world, CIS has not only studied global affairs, it has helped shape them. 

What distinguishes CIS is not just the scope of its work, but the way it approaches it. 

At MIT, international studies does not sit apart from science and technology, it is embedded within it. This proximity has enabled generations of scholars to tackle geopolitical problems with tools and perspectives rarely found in traditional academic and policy environments. 

“Being situated within the world’s leading technical institution enables a lot of exciting possibilities,” says Evan Lieberman, the director of CIS and the Total Professor of Political Science and Contemporary Africa. “We focus on critical problems in international development and security — always with an eye towards the challenges and opportunities presented by technological change. Beyond that, a big part of our mission is to provide global perspectives and engagement avenues relevant to scientists and engineers.” 

Established during the dawn of the Cold War, CIS pioneered a new understanding of global power: that science, technology, and geopolitics were becoming deeply intertwined. From the beginning, it convened faculty across disciplines — economics, political science, engineering, and beyond — setting a template that has since become a model for institutions around the world. Over the decades, this approach has produced an outsized impact. 

In 1961, a memorandum to President John F. Kennedy from MIT economist Max Millikan — the inaugural director of CIS — helped inspire the creation of the Peace Corps, fundamentally reshaping how the United States engages in global development. 

CIS scholars such as Lincoln Bloomfield and William “Bill” Kaufman played a central role in establishing security studies as a rigorous academic field in the late 1950s. Less than two decades later, Jack Ruina and George Rathjens founded the center’s Arms Control and Defense Policy Program (now known as the MIT Security Studies Program), which has influenced generations of policymakers and trained generations of scholars.

The study of modernization and political development has also long been central to the work of the center, with notable luminaries such as Lucian Pye and Myron Weiner helping to lead the way. 

A legacy of global exchange 

At the same time, CIS has reshaped how knowledge flows across borders. The MIT International Science and Technology Initiatives (MISTI), launched in 1983 by Institute Professor Suzanne Berger, has sent thousands of MIT students abroad to work, study, and conduct research alongside international partners — experiences that extend far beyond traditional study abroad. In doing so, it helped change longstanding assumptions about the United States’ role in the world, demonstrating that learning is most powerful when it is reciprocal. 

That ethos of mutual exchange continues to define CIS today. Through initiatives such as the Global Seed Funds, MIT faculty, researchers, and their students collaborate with academic partners around the world to advance shared research agendas. 

The connection between these initiatives can be traced to Richard Samuels, Ford International Professor of Political Science and director of CIS from 2000 until 2023. His creation of the MIT-Japan Program in 1981 served as the model for MISTI. He was also the visionary behind the launch of the Global Seed Funds in 2008. 

Together, these programs reflect a consistent vision: that the strongest ideas emerge through sustained engagement with partners around the world. 

Expertise in action 

Drawing on deep regional expertise, CIS also serves as a platform for global engagement across MIT, mobilizing cross-disciplinary knowledge to respond to unfolding international crises and inform both scholarly and policy debates. 

Its MIT-MENA Program, led by Richard Nielsen, associate professor of political science, recently convened experts to assess the energy and security implications of disruptions in the Strait of Hormuz; the MIT-Ukraine Program, under the direction of Elizabeth Wood, Ford International Professor of History, brings together scientific, technical, and academic expertise to design sustainable solutions for a nation at war; and the MIT-China Program, directed by Yasheng Huang, professor of global economics and management at the MIT Sloan School of Management, is creating a hub for scholars and policy experts focused on balancing the Institute’s engagement with China. 

Scholarship that shapes security 

For decades, the MIT Security Studies Program, directed since 2019 by Taylor Fravel, the Arthur and Ruth Sloan Professor of Political Science, has been a leading incubator of ideas that have shaped debates on grand strategy, nuclear policy, civil conflict and Asian security. Its affiliated scholars, fellows, and graduate students have produced policy relevant research that continues to inform policymakers grappling with an increasingly complex international security challenges. 

Building on that legacy, SSP recently established the Center for Nuclear Security Policy (CNSP) — made possible by a $45 million gift from the Stanton Foundation. Directed by Vipin Narang, the Frank Stanton Professor of Nuclear Security and Political Science, the CNSP aims to expand MIT’s leadership in addressing one of the most urgent challenges of our time: managing the risks posed by nuclear weapons in a rapidly evolving and uncertain geopolitical environment. 

Another cornerstone of CIS’s security work is Seminar XXI, currently led by Kelly Greenhill, who holds faculty appointments at MIT and Tufts University. The annual, nine-month program brings together rising leaders from across the U.S. government, military, and national security community. In three decades, more than 2,500 participants have engaged deeply with issues such as nationalism, technological disruption, and global conflict — developing new frameworks for decision-making in high-stakes environments. 

Advancing research, expanding dialogue beyond its anchor programs, CIS continues to invest in the next generation of scholars and practitioners. Undergraduate research initiatives, postdoctoral fellowships, and visiting scholar programs — including the Robert E Wilhelm Fellowship — create space for emerging and established leaders to explore critical questions, from governance and corruption to political reform and social change. 

It also prioritizes policy-relevant research by supporting conferences, workshops, labs, and research initiatives on key problems in international affairs. 

Finally, CIS plays a vital role in connecting MIT to the broader world. Through public events like the Starr Forum, the center brings leading global voices to campus, fostering dialogue on issues that shape international politics and policy. 

The next 75 years 

As CIS looks to the future, its mission is evolving to meet a dramatically changing global landscape. 

“The moment we’re in now is so different from the Cold War era,” says Lieberman. “We’re seeing a much more complex global system, with new actors and new kinds of challenges.” 

In what Lieberman describes as CIS 2.0, the center is sharpening its focus on the forces that will define the coming decades. This includes the geopolitical implications of artificial intelligence, the future of global cooperation in an era of climate crisis, and the evolving role of the United States within an increasingly contested international order. 

Addressing these challenges will require exactly the kind of interdisciplinary, globally engaged approach that has defined CIS for the past 75 years. It will also require a renewed commitment to collaboration — across fields, across institutions, and across countries. 

“A key source of our value added is to convene complementary sources of expertise,” Lieberman says. “It’s about bringing people together who might not otherwise be in the same room, and asking how we can have the greatest possible impact.” 

Seventy-five years after its founding, CIS remains guided by a simple but powerful idea: that understanding the world — and improving it — demands more than any single discipline, perspective, or nation can offer alone.

The CIS’s 75th anniversary symposium, taking place Oct. 15-16, will explore the defining challenges of today with leading thinkers.

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Lincoln Laboratory summer research interns take on national security challenges

Nearly 170 interns recently dispersed from MIT Lincoln Laboratory to return to their undergraduate or advanced degree programs. For Anna Raymaker and Vivek Jagadeesh, however, the work is just getting started. They are among more than two dozen interns staying on as student technical assistants, continuing to support the laboratory's national security research during the 2026-27 academic year.

"Our summer research program is a key pathway for developing talent to support defense-critical programs," says Robert Loynd, executive officer in the Director's Office. "Interns are embedded in R&D teams across nearly all mission areas, from missile defense and cyber operations to advanced communications and quantum technologies."

In 2026, the laboratory's intern program was named to Yello and WayUp's Top 100 Internship Program list and received the organizations' Public Service Award. This award recognizes programs that demonstrate exceptional commitment to meaningful intern engagement that benefits the public good. 

Anna Raymaker: Securing maritime infrastructure

Anna Raymaker found her bearings when she began researching maritime security. Four years ago, the PhD student at Georgia Tech had just started her cybersecurity studies, but hadn't yet settled on a focus area. When her advisor offered a project building a boat test bed, the Florida native was hooked.

As she began presenting her test bed research at academic cybersecurity conferences, she noticed a gap: "No one was really looking at shipping security," she says. That realization led her to speak directly with mariners to learn about the cybersecurity issues they faced.

One issue mariners repeatedly raised was the security of the Automatic Identification System (AIS), a device that helps ships avoid collisions by broadcasting their location, speed, and course. International regulations require all ships over 300 gross tons — such as cargo, tanker, and cruise ships — to transmit their identity via AIS at all times. 

"Mariners told me that AIS is their source of truth, so it was very scary when they experienced it being manipulated in the wild," Raymaker says. For example, so-called "ghost fleets" could use AIS to disguise themselves as other vessel types to evade sanctions. Such deception is possible because AIS does not require identity verification.

This summer, Raymaker examined AIS security firsthand at Lincoln Laboratory. Her goal was to analyze the trust assumptions built into the system and identify where those assumptions could be exploited. Her research revealed several methods of interfering with AIS, including radio-based "spoofing," in which false messages can appear to come from a legitimate device. Spoofed messages could, for instance, instruct ships to switch transmission channels or report a fake vessel position, potentially causing ships to change course. Working with her Lincoln Laboratory advisor, Hamed Okhravi, she then explored defenses against these false signals.

"Recent events have demonstrated that AIS security is not merely a theoretical concern, as manipulation or spoofing of maritime positioning data can directly affect navigation, safety, and global shipping. Anna's work directly contributes to understanding and mitigating these emerging risks," Okhravi says. "She built a new experimental test bed from scratch, conducted detailed experiments, analyzed the results, and helped turn the work into a publication, demonstrating excellent hands-on technical and research skills."

Raymaker says she has been both surprised and encouraged by the laboratory's collaborative culture. Mentioning her AIS project in a hallway conversation would prompt staff to offer help or connect her with relevant experts. "The opportunity to network with all these experts and see what other groups do is extremely unique. Any student would benefit from that kind of exposure," she says. 

As a student technical assistant, Raymaker will research other dimensions of maritime security. She's particularly interested in preventing the malicious cutting of undersea cables, which has become a major geopolitical security concern. "Ships are big and slow. If we have data on where they're moving, maybe we could use it to predict when a ship is going to do something bad," she says.

After graduation in the spring, she hopes to keep working through the problems she heard from mariners: "I want to go one by one down that list to create solutions that might help. Their job at sea is hard, and they deserve to be protected."

Vivek Jagadeesh: Readying cyber technology for industry adoption

Vivek Jagadeesh is a master's student at Worcester Polytechnic Institute. His path to Lincoln Laboratory came together naturally. After interviewing for a summer position, he learned that his advisor had a connection with staff in the Secure Resilient Systems and Technology Group. That connection gave him the confidence that the laboratory was the right fit for his interests. As it turned out, the group's work aligned closely with the problems Jagadeesh was tackling in his research: securing operating systems.

Specifically, Lincoln Laboratory researchers have been developing Hardware-Assisted Kernel Compartmentalization (HAKC). The core software of an operating system, a kernel typically has the highest level of access to a computer's hardware. Because of that access, a single bug in kernel code can lead to catastrophic security failures. HAKC mitigates this risk by dividing kernel code into smaller components, each separated by access-control checks. The team anticipates that the technology can resolve vulnerabilities in Linux kernels, which power most of the world's devices.

Jagadeesh's focus has been on supporting HAKC's transition to industry. "The idea is to make the technology less proprietary, so that any of the big distributors of Linux, like Red Hat, or Canonical, can use it," he says. Those distributors, however, need clear insight into how HAKC modifies the kernel code. To enable this insight, Jagadeesh developed a tool called a source-to-source compiler, or transpiler. 

A compiler converts C source code into binary for machines to execute. Different compilers process code differently, and the compiler HAKC uses differs from the compiler used frequently by the greater Linux community. Modifications to code are usually done at an intermediate stage — a translated version of the code that compilers use before generating binary — but interfacing with the code at this stage varies by compiler, making modifications hard to transfer between systems. To avoid this problem, Jagadeesh's transpiler inserts HAKC code directly into the original C source file, while preserving the source file's original information and making additions easily identifiable. As a result, any developer can audit the changes HAKC implements, and HAKC can cleanly integrate into the complicated build systems used by kernel developers and distributors.  

"Creating a transpiler is a non-trivial task, but that is nevertheless what Vivek achieved. His transpiler is capable of transforming the entire Linux kernel, a key milestone we need to bring HAKC to industry," says his Lincoln Laboratory advisor, Derrick McKee, who began developing HAKC as a student researcher himself five years ago.

According to McKee, the transpiler will serve as the foundation for the next iteration of HAKC. That new version is planned for release under the Open Resilient Compartmentalization Alliance, a Linux Foundation initiative dedicated to bringing compartmentalization technology to Linux systems.

Jagadeesh says he felt strongly supported throughout the internship, meeting with the project's two principal investigators at least twice a week. "It felt like we were working on this together in a big way — and I got a lot of support from everyone responsible for it," he says. He looks forward to working on other aspects of system security in the group this fall. 

For students considering a laboratory internship, Jagadeesh offers this perspective: "You get to work on real things that have an actual impact. It's work that, after you go back to school, you'll apply to more research going forward."

More information on Lincoln Laboratory's summer research program and other student opportunities can be found here. 

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Robotic lab sets up and runs optics experiments on demand

Every new generation of phone display, television screen, and solar panel is a result of precision optics experiments, which use lasers and other light sources to measure the optical properties of candidate materials. These experiments can take months to run, requiring scientists to meticulously angle and adjust delicate light sources, mirrors, cameras, and other components, in a careful and constant tuning that can be physically tedious and time-consuming. 

But MIT scientists say the whole process of building and running an optics experiment could one day be fully automated. Taking a step toward such a future, they have developed a reconfigurable, robotic optics laboratory. 

The new robotic lab autonomously assembles standard optical components into desired configurations. It can then tune the angle and position of mirrors and lenses with micron-scale precision to produce beams of light with specific properties. The system can also safely dismantle an experiment and reassemble the parts into an entirely new setup. 

The team showed that the robotic system could autonomously build and fine-tune a tabletop laser cavity — a key element of most optics experiments. The system could also precisely manipulate components to perform several optical tasks, such as centering a laser beam, aligning multiple beams, and automatically stabilizing the beams in response to physical disturbances.

“We start with randomly placed components,” says Sachin Vaidya, a postdoc in MIT’s Research Laboratory of Electronics. “At the end, we have a fully functioning laser that the robot has built.”

The researchers are expanding the robotic lab, in a physical and virtual sense. In addition to improving the system’s physical sensing, maneuvering, and overall space, they are developing a cloud-based application that gives users virtual access to the physical robot. They envision that one day, scientists from anywhere will be able to remotely access robotic optics labs and virtually submit experimental protocols or queries that the labs would then set up and run autonomously. 

“There are many things this could enable,” says Marin Soljacic, the Cecil and Ida Green Professor of Physics at MIT. “A robot isn’t going to get bored. It can work 365 days, 24 hours a day, on very boring things. That will free up so much creativity and time for scientists to then push theories and see what we can do. Science could progress much faster.”

The MIT team will present the details of the new system at the Intelligent Robots and Systems (IROS) conference later this month. Along with Soljacic and Vaidya, project team members include co-lead Seou Choi, Caio Silva, and Shrish Choudhury from MIT, Shiekh Uddin of Nokia Bell Labs, and Sajib Shuvo of Arizona State University.

A city of light

A tabletop optics experiment can resemble a miniature city of densely packed mirrors, lenses, and light sources. Scientists manually arrange and align the various components in precise configurations, then shine light into the experiment. The lenses and mirrors bounce and focus the beam into a desired wavelength, frequency, or intensity that can then be used to probe or manipulate a given material. 

“Sometimes this manual setup takes days or months depending on the complexity of the experiment,” Soljacic says. “It’s meticulous work that has to be done again and again for each experiment.”

Most labs do incorporate some level of automation in an optics setup, such as motorized tuners that mechanically turn knobs to precisely angle a mirror. 

“These components can automate the most tedious parts of an experiment,” Vaidya notes. “But no one has built a full system that goes from no setup to a completely aligned setup in one tool. That was our goal, to show complete automation through all the steps that go into an optics experiment.”

Auto-tuned optics

The team’s robotic lab centers around a robotic arm with seven moveable joints that is attached to a metallic tabletop. The robot picks and places lenses, mirrors, and other optical components, each of which the researchers installed in its own 3D-printed plastic housing. 

The housings are designed such that the robot can easily and safely grip and move each component. The researchers etched the top of each housing with a QR code containing information about the component within the housing (such as whether it is a lens versus a mirror, and its exact dimensions and capabilities). Each housing has a magnetic base that helps stabilize a component once the arm places it down on the metallic tabletop. 

The researchers designed a Wi-Fi-enabled “fine-adjustment tool” that clips onto the mount of standard optical components. The motorized tool can be wirelessly controlled to turn a component’s knobs, for instance to angle a mirror. 

“The way humans do this tuning is by feel, and based on a lot of intuition,” Vaidya says. “This tool is at least as precise as a human, but in reality it is much more precise.”

The team also installed a pair of cameras over the entire setup that provides a birds-eye view of the tabletop experiment. Finally, they developed a “software stack,” or a set of programs that enables the robot to navigate through every step of setting up and continuously tuning an experiment. These steps include recognizing a specific component, knowing how to safely approach and pick it up, where to move it, and how to avoid collisions with other parts of the experiment along the way. 

Finally, they designed a simple virtual user interface to allow an experimenter to remotely direct the robot. For instance, when a user drags the icon for a mirror from one spot to another, and clicks a button to confirm, the robot responds by picking up the actual mirror and placing it down at the corresponding location on the table. 

As a demonstration, they directed the robot to assemble various components into a laser cavity. A laser cavity consists of two mirrors arranged on either side of a crystal. When a beam of light is shone into the setup, it pings back and forth between the two mirrors. With each pass, the light also passes through the crystal, which amplifies the light’s intensity, to a point that whatever light escapes, is intense enough to form a laser. 

“We wanted to pick a demonstration in optics that’s reasonably challenging,” says co-lead author Seou Choi, a graduate student in electrical engineering and computer science. “This is not something a new trainee could do in an afternoon. It requires a lot of alignment and component experience.”

In the end, the robot successfully built a functional laser cavity by autonomously carrying out 50 maneuvers, all within 30 minutes. When the researchers introduced physical disturbances to the setup, such as randomly moving a component on the table, the system automatically readjusted components to maintain the laser’s intensity. 

“Even tiny vibrations or temperature changes can degrade an optics experiment,” Vaidya says. “An autonomous lab could continuously monitor its own performance and repair the alignment before valuable data is lost.”

The researchers envision that robotic labs like theirs could be paired with a nearby library of physical components that another robot could fetch and deliver to a tabletop robot to arrange into an experiment. Such a system could work to build and run experiments, then break them down and set up new ones on demand, or continuously run an experiment that requires active 24/7 monitoring.

“A system like this could help industry test prototypes faster, for everything from cameras and displays to solar cells and AR/VR goggles,” Vaidya says. 

For their part, the researchers are applying the new robot lab to test promising carbon-capture materials. By shining light with specific properties at these materials, they can get information about how a material absorbs carbon dioxide. 

“Experimental optics is the backbone of many important fields,” Vaidya says. “Our work takes the first step toward optical labs that can operate faster, more reliably, and without manual intervention in a domain that demands extreme precision and diversity of experimental setups.”

This research was supported, in part, by the Korea Foundation for Advanced Studies Overseas PhD Scholarship, the U.S. National Science Foundation, the U.S. Army DEVCOM ARL Army Research Office, Parviz Tayebati, the MIT Undergraduate Research Opportunities Program (UROP), the MIT Generative AI Impact Consortium (MGAIC), and Shell International Exploration and Production Inc.

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