Startup helps retailers track their products in real-time

When you picture a worker at a retail store, you probably think of someone at a cash register or helping a customer. But employees also spend a lot of their time combing through stockrooms and shop floors, fulfilling requests or online orders and generally trying to keep track of all their inventory.

Keeping track of inventory takes so much time, in part, because retailers don’t always know where everything is located. That’s why when you ask a store associate to check if they have a shirt in your size, it may take them 20 minutes to get back to you.

Cartesian is helping retailers keep track of inventory with a technology invented at MIT. The system uses wireless signals from radio frequency identification (RFID) tags attached to items to find their precise location in a store, from the stockroom to the shop floor.

Last year, Cartesian did a study with a retailer and found its platform delivered meaningful annual savings at the store level by streamlining inventory tracking, optimizing workflows, and improving customer experiences.

“The big problem we’re solving is that about 50 percent of working hours in retail stores go to managing inventory,” says co-founder Fadel Adib SM ’13, PhD ’17, an associate professor at MIT. “That is roughly a $15 billion problem in the U.S. alone. We use algorithms to decipher indoor locations using wireless signals. The core technology enables a new level of indoor localization.”

Cartesian is already deployed in more than 700 stores across 15 countries and is working with one of the world’s largest fashion groups, Inditex, which is the parent company to brands like ZARA, Pull&Bear, and Oysho.

Beyond retailers and warehouses, Cartesian’s platform could also improve indoor location tracking for manufacturers, logistics operators, and robotics companies.

“The broad vision for what we are doing is spatial AI,” says Adib. “Today, AI does extremely well in the digital world. Now it has to move into the physical world. That means allowing machines to perceive their environment in such a way that they can interact with it. That’s where spatial AI comes in and where Cartesian sits.”

From technology to product

Adib, who holds a joint appointment in MIT’s Media Lab and Department of Electrical Engineering and Computer Science, has been studying wireless signals at the Institute for more than 15 years, dating back to research during his master’s degree.

“My group today researches how to use wireless signals to sense the world in ways that were not possible before,” Adib says. “We develop the fundamental technology and then we build systems around them. Our goal is to see these systems deployed in the real world for impact.”

When Adib joined MIT’s faculty, the first project he worked on was indoor localization using RFID tags. Isaac Perper ’20, MEnG ’21 later joined his lab as a student, and together they developed machine-learning algorithms to process RFID data to translate them into location patterns, with an initial focus on helping robots locate RFIDs indoors.

In 2021, Adib went through the National Science Foundation’s I-Corps program, which challenges researchers to interview potential customers to find the right problems to solve with their technologies. That’s when he realized how big of a problem inventory management is for retailers.

Cartesian was officially founded by Adib and Perper in the beginning of 2023, after they received a small business award from the National Science Foundation. The pair worked with MIT’s Technology Licensing Office to license patents from Adib’s lab. They also received support from MIT’s Venture Mentoring Service.

“Our goal was to reduce the cost of the technology to make it scalable,” Adib recalls. “Isaac focused on simplifying the product, leveraging progress in machine learning, and making it fast. It was a lot of iterating and testing early on.”

Retail workers spend much of their time locating items for a number of reasons. They might get an online order to fulfill, need to restock store shelves, or get a customer inquiry about items in the back.

Stores differ in how they organize their inventory. Most separate items by categories in specific shelves and bins then use barcodes or inventory systems that tend to get outdated fast.

“It’s a big problem for stores because customers may just leave before asking an employee to look for their size, or customers may get frustrated and leave if it takes too long,” Adib says. “The associate also wastes time looking for items they could spend doing higher-value work.”

Cartesian’s platform works with retailers’ existing handheld RFID readers, which store associates already use to manage inventory. Each store installs Cartesian’s software into their existing inventory apps or uses a custom app for employees to access directly.

“The RFID readers are how stores tell what’s in stock and what’s out of stock,” Perper says. “We figured out a way to leverage the same scans they’re already using with the reader, put the data they generate into our machine-learning algorithms, and generate maps of where all the items are.”

Customers can build analytics on top of Cartesian’s technology to keep track of inventory levels, show customers maps of where each item is located, and create other services.

“They use our location intelligence platform and build different products on top,” Adib says. “We can work with any device, any store, any type of RFID. It’s a simple interface. All the sophisticated location algorithms sit in the cloud.”

Beyond retail

Cartesian signed its first big contract in 2025 and soon expanded to several hundred stores. One of Cartesian’s advantages is its ability to quickly scale. Perper says they can add a store in about one minute. Cartesian’s team doesn’t even have to travel to a new store to turn on its system if it’s already working with the company.

“It’s as simple as flipping a switch, preparing the data, and sending it to our customers,” Perper says. “One of our first big bets was, ‘Can we build this entirely on existing hardware?’ That bet is starting to pay off.”

Cartesian’s models can also work with Wi-Fi and Bluetooth signals, which the company plans to use with customers in other verticals.

“Right now, we’re focused on applications in retail, but this technology has a lot of value in manufacturing, warehouses, and other locations,” Adib says.

Cartesian’s team aims to be deployed in tens of thousands of stores over the next year and then begin expanding beyond retail into industries like manufacturing and robotics.

“What’s most exciting about Cartesian to me is we’ve built a lot of the technology foundation, and now that we have the fundamentals in place, we hope to build specific application layers,” Perper says. “Then we can ask customers in different verticals about their problems and apply our technology in different ways to solve it.”

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Developing innovative alternatives to conventional carbon capture methods

Carbon capture is an important climate change mitigation strategy, but it faces technological barriers and can be energy-intensive and expensive. To help make necessary advances in this area, a team of MIT researchers, with support from the MIT Climate and Sustainability Consortium (MCSC), are exploring energy-efficient and scalable alternatives to conventional carbon dioxide (CO₂) capture methods. 

Conventional amine scrubbing, which is the current standard for CO₂ capture, is energy-intensive and difficult to scale, limiting its impact despite the urgent need to reduce carbon emissions and upgrade CO₂ into valuable products. In a new article published in Nature Energy, MIT researchers — graduate students Fang-Yu Kuo of the Department of Chemical Engineering, and Gi Hyun Byun of the Department of Mechanical Engineering (MechE); Professor Betar Gallant of MechE; and former MCSC postdoctoral Impact Fellows Glen Junor and Akachukwu Obi — investigate a promising alternative to these conventional CO₂ capture methods. Their findings could move the needle on achieving efficient and flexible carbon capture and removal.

In their paper, the team explores an alternative, electrochemically mediated CO₂ capture (EMCC). This approach enables electrification of CO₂ separation — driven ideally by renewables — but currently faces challenges, such as relying on sorbents that require highly reducing potentials, where oxygen reduction side reactions become significant. This can compromise both efficiency and long-term performance. To tackle this shortcoming of EMCC, the MIT team researched whether N-heterocyclic imines (NHIs) is a useful new class of EMCC sorbent.

“NHIs have shown promise in recent years as CO₂ sorbents because of the ease of NHI molecular modifications for tuning basicity,” says Fang-Yu Kuo. “Our work translates these NHIs for the first time into the EMCC application space, and demonstrates that NHI-based sorbents can be modulated electrochemically for CO₂ separation by a unique separation mechanism that avoids the need of applying highly reducing potentials.”

The team’s initial research establishes a novel bis(NHI) structure that can enable a theoretical CO₂ modulation of two molecules per electron during cell operation. The initial published result also indicates that with further molecular engineering of bis(NHI) structures to strengthen CO₂ binding affinity, the bis(NHI) could operate in more diverse electrolyte environments, opening new possibilities to optimize system performance in terms of electron efficiency, energy efficiency, and operational flexibility.

“A critical future direction of our work involves gaining deeper mechanistic insight into the stability and degradation pathways of the bis(NHI) radical cation,” says Kuo. “Understanding these pathways will inform the rational design of next-generation bis(NHI) molecules, enabling longer operational lifetimes and enhanced cycling durability for practical deployment.”

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PATH to boost AI training and career opportunities for industry-aligned jobs

MIT, in collaboration with Georgia State University and a growing network of educational institutions, has announced expanded work under PATH (Pathways for AI Training and Hiring) — a multiyear initiative designed to scale effective, affordable, industry-aligned AI training for entry-level and current workers, with a particular focus on transforming community colleges into engines powering an AI-enabled workforce for the nation. 

“In the era of AI, economic opportunity and mobility will increasingly depend on whether people can develop practical, industry-relevant AI skill sets and mindsets, not just familiarity with tools,” says Cynthia Breazeal, principal investigator (PI) of PATH and professor of media arts and sciences at MIT. “That means combining hands-on, work-learn experiences with strong technical foundations and the responsible design, professional, and human skills that employers are looking for.”

To make that possible, the initiative is building state-based hubs anchored by research universities and community colleges. Each hub works with regional employers to design curricula that reflect local industry needs. The program also provides professional development for instructors and develops modular, open educational materials that institutions can adapt and share.

“Artificial intelligence is shaping every sector of the economy, and the United States will need far more people who understand how to build with these technologies and apply them responsibly,” says MIT President Sally Kornbluth. “Through PATH, MIT RAISE is using our convening power to bring community colleges, industry, research universities, and government together to build human-centered AI pathways that lead to shared prosperity. When research universities contribute their expertise to expand access and economic mobility, we strengthen both the nation’s workforce and our collective capacity for innovation.”

Unlike many large-scale online training efforts, PATH emphasizes in-person, collaborative learning. Students work in teams to address real problems brought by industry collaborators. These projects mirror the kinds of challenges graduates will face in the workplace, helping them build technical skills alongside the judgment, communication, collaboration, and ethical awareness that employers increasingly value.

The initiative’s first two hubs launched earlier this year in Massachusetts and Georgia.

“As PIs for the Georgia PATH hub, we are very excited with the significant early momentum, with over 1,000 GSU students enrolled in PATH courses,” says Arun Rai, regents’ professor, Howard S. Starks Distinguished Chair, and director of the Center for Digital Innovation at Georgia State University (GSU), with Balasubramaniam Ramesh, regents’ professor and the George E. Smith Eminent Scholar’s Chair at GSU. “Our curriculum, co-designed with MIT RAISE and spanning AI foundations, data science, deep learning, and agentic AI systems, is now being shared with partner institutions including Georgia Gwinnett College, GSU Perimeter College, and Clark Atlanta University. By leveraging the University System of Georgia’s FinTech Academy to expand work-based learning opportunities, we are building a collaborative ecosystem that rapidly advances the state’s AI workforce capabilities and creates tangible, job-ready skills for our diverse student population.” 

GSU President Brian Blake says, “Our collaboration with MIT reflects a shared commitment to strengthening the nation’s AI talent pipeline. Georgia State University brings a distinctive strength to this effort — the ability to prepare students from all backgrounds for AI-enabled careers at scale. By combining academic rigor with strong industry partnerships and work-based learning, we are translating advances in AI into practical skills and expanding access to opportunities in this transformative era.”

In Massachusetts, students at Quinsigamond Community College are participating in Data Science in Action, a course that introduces AI-enabled data analysis and engineering. The class includes a hands-on Action Lab, modeled after experiential learning programs at the MIT Sloan School of Management. David Birnbach, lecturer at MIT Sloan, leads the design framework for the PATH Action Labs. Working with industry partners, students tackle real data challenges while building portfolio projects and professional connections. 

Beyond individual courses, PATH is building clearer pathways for students to turn AI learning into real job opportunities. Through industry-informed micro-credentials and a shared set of workforce skills, students will gain practical abilities that employers are actually looking for, along with the human skills needed to succeed at work, like communication, problem-solving, and collaboration. 

The MIT skills taxonomy team, led by Katerina Bagiati in collaboration with Professor Tom Malone from the MIT Sloan Center for Collective Intelligence, is mapping the skills and roles emerging in AI across fields such as financial technology (fintech), information technology, and business operations, with plans to expand into areas such as health care, manufacturing, and creative media. The goal is to help students build skills that are relevant, recognized, and directly connected to growing career paths.

The initiative is supported by a grant to MIT from Google.org, which is helping MIT and its collaborators build a multi-state network for AI workforce development.

“MIT’s PATH initiative offers a blueprint for expanding opportunity in the age of AI,” says Shanika Hope, director of Google.org. “By connecting research universities, community colleges, and industry partners, it helps translate innovation into real jobs and sustainable career pathways.”

PATH is led by Breazeal, who has brought together a cross-MIT team with expertise in AI literacy, workforce pedagogy, educator professional development, open education, research, and the future of work. Breazeal is a professor and director of the MIT RAISE Initiative. Eric Klopfer, director of the STEP Lab and co-director of the MIT RAISE Initiative, serves as a co-PI on this award. The GSU leadership team includes PIs Arun Rai and Balasubramaniam Ramesh.

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Research from the ground up

When Sonya Atalay conducted her doctoral research, she studied pottery in Çatalhöyük, a remarkable ancient site in Turkey. It’s one of the world’s earliest known urban settlements, flourishing by at least 7000 B.C.E.

Yet even as Atalay was conducting field research and writing her doctoral thesis, she was scrutinizing standard archaeological practices, believing the discipline to be in need of an update. Indeed, it’s an issue she had been grappling with going back to her undergraduate days, when she first went to a dig site near Rome.

“When I started doing archaeological work, the local people were labor,” says Atalay, now a professor at MIT. “They came, they cleaned your clothes, they cleaned the dig house, they weren’t thought of as having important connections with the archaeology, and that really bothered me.” 

Surely, she believed, a culture producing the remarkable things worth studying is worth including in that research process, too. As she says, given “their place-based knowledge, it seemed like we should be talking to people about their heritage. They’re the ones who live on or near sites. I started thinking about what archaeology could look like if it included local communities in a meaningful way.” 

Atalay completed her dissertation while continuing to examine how researchers could alter their approach. She has since published articles and books about the subject, worked to introduce new research practices, and today, as an MIT professor, is a leader in the growing field of community-based archaeology, building partnerships between researchers and local residents.

Among other things, Atalay is the director and principal investigator of the Center for Braiding Indigenous Knowledges and Science (CBIKS), a National Science Foundation-backed project that helps train scholars and implement community-oriented work. She is convinced that community-oriented work creates better outcomes in many fields. 

“A community-based approach is highly applicable beyond archaeology and anthropology, outside of the social sciences,” Atalay says. “I think there’s a lot for engineers or designers or folks in a lot of different fields to learn by involving community members in the research process.”

Atalay joined MIT with tenure in 2024, where she is a professor in MIT’s Anthropology Section.

Roll me away

Atalay grew up in Michigan, not far from Detroit, where she was the first person from her family to go to college. Growing up, she hoped to be a physician. 

“I wanted to be a doctor. That’s what I thought I was going to do,” Atalay says. “I wanted to be a pediatrician.” 

But she also developed an interest in ancient history, something she can date to a precise moment. A 4th grade teacher named Barbara Eisman would give Atalay extra reading when Atalay would finish homework early. One day, Eisman produced a book about ancient Greece and Rome. 

“I remember thinking, this is amazing, discovering things I never knew existed,” Atalay says. “And that stuck with me.”

By the time Atalay enrolled at the University of Michigan, she was still planning to become a doctor. But as an undergraduate, she enjoyed taking archaeology electives to such an extent that she simply changed career paths. 

“I loved it and just got so into it,” Atalay says. And Michigan even provided opportunities for undergraduate fieldwork near Rome, although that meant Atalay had to dig deep to finance her first trip to an archaeological site. 

“I worked at a nightclub and put myself through college by bartending,” Atalay says. “I had a motorcycle, so I was tooling around Ann Arbor. Then I sold my motorcycle to buy the plane ticket to go to Rome so I could take part in the archaeological fieldwork.”

“Relationships are the task”

After graduating, Atalay was accepted into the graduate program for anthropology at the University of California at Berkeley, where she earned an MA and then, in 2003, her PhD. While Atalay’s doctoral research focused on the ancient pottery at Çatalhöyük, she maintained a steady interest in helping archaeology evolve. 

And increasingly, she started drawing on her own observations about fieldwork in the U.S., too. Atalay is Native American, and she recognized the same patterns of exclusion and archaeological extraction being applied to the historical study of Native American societies. 

One additional influence in shaping Atalay’s thinking was the North American Graves Protection and Repatriation Act (NAGPRA), passed by the U.S. federal government in 1990. It requires federal institutions to return human remains, sacred objects, and other cultural materials to Native Americans. Seeing the law enacted reinforced to Atalay that progress in this domain is possible. 

“The push for that act was really about Indigenous people standing up for sovereignty. To return what was wrongfully taken and to carry out research in an ethical way moving forward, there has to be trust and partnerships built,” Atalay says. While observing advocates trying to get NAGPRA passed, she adds, “I learned a lot from them.”

Over time, Atalay went on to serve multiple terms on the commission overseeing NAGPRA, first appointed by President George W. Bush and then President Barack Obama. Ultimately, her perspective has been fed by many sources, converging on similar themes.   

“I was really uncomfortable with how local people weren’t involved with studies of their own heritage,” Atalay says. “So I started thinking about what would it look like to truly partner with communities to plan and carry out research. And that’s how I started my first book, trying to set up a model for how to do ethical work in partnership with communities.”

That book, “Community-Based Archaeology: Research with, by, and for Indigenous and Local Communities” was published by the University of California Press in 2012. In her work, Atalay has focused on a range of specific practices, from research development to fieldwork methods and protecting intellectual property rights for Indigenous people. But the starting point for any work, she emphasizes, is relationship-building and the creation of mutual trust. 

“I tell students, ‘Relationships are the task,’” Atalay says. “I know you want to get in there and carry out fieldwork, but the relationships are everything. Sitting down and talking and sharing life stories and developing trust. Those relationships move at the speed of trust. And that takes time to develop. That’s the key piece. And that’s going to lead to good research outcomes.”

Stronger together

After receiving her PhD, Atalay had postdocs at UC Berkeley as well as Stanford University, then joined the faculty at Indiana University. In 2012, Atalay moved to the University of Massachusetts at Amherst, before joining MIT two years ago.

Currently Atalay is working on multiple projects. As director of CBIKS, she is running an organization with eight research “hubs,” where nearly 100 affiliated scholars are working with over 50 Indigenous communities to establish partnerships that advance environmental, and scientific research projects. 

In some cases, the scholars are involved in familiar-seeming archaeological work, while other center projects involve topics such as enhancing salmon farming, clam cultivation, or returning native seeds from museums to tribes in the Southwest, where elders still retain knowledge for their appropriate use and care.

“Our team members across multiple disciplines are learning from each other,” Atalay says. “So archaeologists and heritage management scholars are talking to environmental scientists and team members who study seeds and agriculture.” The NSF sometimes refers to this as ”convergence science.” The center’s name uses the metaphor of braiding, to represent the ways different strands of knowledge can be woven together to form a sturdy whole.

“With braiding, each of the strands retains its integrity, and they’re stronger when they’re brought together,” says Atalay. She is also currently working on another book project, “Braiding Knowledges,” about how the community-based approach can enhance and strengthen research within universities; it is under contract with the University of Arizona Press. 

At MIT, Atalay adds, she is delighted by the range of students who have started taking her classes, begun thinking about applications to all kinds of projects, and who in turn may end up leading innovative, community-oriented projects of their own.

“I would encourage anyone, no matter what field they’re in, to think about working with a community,” Atalay says. “What we’re learning isn’t just about working with Indigenous communities. It’s applicable outside of anthropology, outside of the social sciences. There is a lot you can learn and contribute to society by carrying out research this way, in any number of fields.”

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Tod Machover receives George Peabody Medal for contributions to music and technology

Tod Machover, the Muriel R. Cooper Professor of Music and Media, faculty director of the MIT Media Lab, and director of the Opera of the Future research group, will receive the George Peabody Medal for Outstanding Contributions to Music and Dance in America — the highest honor bestowed by the Peabody Institute of the Johns Hopkins University. 

As a composer and music tech pioneer, Machover has helped expand music’s possibilities for artists and audiences alike through his work in participatory opera, artificial intelligence, and creative technologies. He joins a roster of previous George Peabody Medal recipients that includes Stevie Wonder, Misty Copeland, Herbie Hancock, Renée Fleming, Yo-Yo Ma, Wynton Marsalis, Ella Fitzgerald, and Leonard Bernstein.

In the citation for the Peabody Medal, Peabody Institute Dean Fred Bronstein writes: “The breadth and depth of Tod Machover’s career — his work in participatory opera, as an educator and faculty director of the MIT Media Lab, his genuinely groundbreaking and prescient work at the intersection of music and technology, along with an overall and broad impact on the American music scene — make him an ideal recipient for the Peabody Medal … Machover continues to provide inspiration especially in the fast-evolving relationship between AI and the creative process. We are honored to welcome to campus a true pioneer and thought leader.”

Hailed as a “musical visionary” and “America’s most wired composer,” Machover is recognized as one of the most innovative composers active today. He is praised for creating music that breaks traditional artistic and cultural boundaries and for developing technologies that expand music’s potential for everyone. 

Machover was the first director of musical research at Pierre Boulez's IRCAM in Paris and was inducted as a fellow of the American Academy of Arts and Sciences in 2024. His work has been recognized by organizations including the American Academy of Arts and Letters, the National Endowment for the Arts, and the French Culture Ministry.

The Peabody Institute, the first music conservatory in the United States, advances a dynamic model of the performing arts, empowering musicians and dancers from diverse backgrounds to create and perform at the highest level. As division of Johns Hopkins University, Peabody provides opportunities for interdisciplinary studies and is a leading voice at the intersection of art and education.

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A new vaccine adjuvant could make it easier to eradicate polio

In the United States, children routinely receive an injectable form of the polio vaccine. This vaccine is very effective at preventing illness, but it doesn’t block transmission of the polio virus as well as the oral polio vaccine does.

Poliovirus is usually transmitted through contaminated food or water, so the GI tract is where the body is first exposed. Because the oral vaccine induces a mucosal immune response within the GI tract, it is much more effective at preventing infection and spread of the virus. However, there is a small chance that the oral vaccine can become infectious, so many countries have stopped using it.

Researchers at MIT have now come up with a way to modify the injectable vaccine so that it can also promote a mucosal immune response. This vaccine could help to achieve polio eradication while avoiding the risks of the oral polio vaccine.

“People who are vaccinated with the injectable vaccine are not getting sick, but they may be helping the virus circulate. Mucosal immunity could help lower that shedding and ideally eliminate it,” says Ana Jaklenec, a principal investigator in MIT’s Koch Institute for Integrative Cancer Research.

The researchers’ new vaccine consists of the current injectable, inactivated polio vaccine (IPV), delivered with a nanoparticle-based adjuvant that helps steer immune cells to the mucosal lining of the intestine. In a study of rats, the researchers found that this vaccine produced a 20-fold increase in the type of antibodies needed for mucosal immunity, compared to IPV alone.

Jaklenec and Robert Langer, the David H. Koch Institute Professor at MIT, are the senior authors of the study, which appears today in Science Advances. MIT postdoc Behnaz Eshaghi is the lead author of the paper. 

Targeting polio

Polio, which can cause paralysis in severe cases, is now rare in most of the world due to extensive vaccination campaigns. The virus is highly contagious and is most commonly spread through consumption of food or water contaminated with the stool of an infected person.

Cases are occasionally seen in the United States and other countries, and the virus is endemic in Pakistan and Afghanistan. While most of these cases are caused by the virus spreading among unvaccinated individuals, some cases may be due to the evolution of the live viruses used in the oral polio vaccine (OPV). These viruses are attenuated, meaning they are alive but weakened. In rare cases, they can mutate and evolve to become infectious again.

It’s also possible that wild poliovirus can be spread by people who have received the injected polio vaccine. These people would likely not experience any symptoms, but they could still shed the virus in their stool. Eventually, this could expose someone who isn’t vaccinated. Studies have shown that even in countries that with very high polio vaccination rates, the virus can be detected in wastewater.

To boost the chances of completely eradicating polio, it would be ideal to use a vaccine that cannot evolve to cause infection, like the current injectable IPV, and would also induce mucosal immunity, like the OPV. 

In hopes of achieving that, the MIT researchers teamed up with researchers at Harvard Medical School who have shown that using a derivative of vitamin A as a vaccine adjuvant can help stimulate immune cells to go to the GI tract.

That adjuvant, known as Am80, works well, but to generate a strong response, it needs to be injected for several days in a row, which is not feasible for most vaccine campaigns. 

To eliminate the need for repeated daily injections, the researchers set out to develop a nanoparticle formulation that would enable the adjuvant to be released slowly over several days. They tested several different types of nanoparticles and found that the one that worked best was a lipid nanoparticle (LNP).

“The purpose of the nanoparticle is making sure that we can engineer a platform with a sustained release of the cargo for a few days,” Eshaghi says. “That way we can overcome the bottleneck that for free administration of Am80 you need multiple daily injections.” 

Mucosal immunity

In tests in rats, the researchers delivered an injection of an inactivated polio vaccine, similar to the one that is now used in the United States, along with a separate injection of Am80 encapsulated in LNPs. After the first dose, boosters were given at four weeks and eight weeks.

After injection, the nanoparticles accumulate in the lymph nodes, where they interact with B and T cells that are also exposed to the polio vaccine. This interaction stimulates the B and T cells to produce two surface proteins that act as homing signals directing them to the GI tract.

The B cells also begin producing a type of antibodies called IgA, which protect body surfaces from infection by coating the mucosal membranes. In addition, the rats also produce IgG antibodies that circulate in the bloodstream, similar to the antibodies that are normally produced in response to the injected polio vaccine.

“IPV is a safe vaccine, but it cannot create mucosal immunity. OPV can create that mucosal response, but it is not as safe,” Eshaghi says. “By adding Am80 to lipid nanoparticle as an adjuvant, we are combining the safety of IPV with an adjuvant that can produce the mucosal immunity that normally you can only get with OPV.” 

The researchers now plan to test the vaccine in additional larger animal models, where they will inject the vaccine and adjuvant mixed together.

Using Am80 or other adjuvants to induce a mucosal response could also help researchers design improved vaccines for other pathogens that infect the GI tract, or for diseases that infect the lungs or reproductive tract. 

“You could potentially add it to any vaccine that’s injected,” Jaklenec says. “This particular work shows that cells can be directed to the gut and increase enteric mucosal immunity. Whether it works for the respiratory or vaginal mucosa is not yet clear.”

The research was funded by the Gates Foundation.

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MIT chemists design impact-resistant plastics

With help from a novel cross-linking molecule, MIT chemists have shown they can substantially improve the ballistic impact resistance of common polymers, including polystyrene and a type of rubber used to make shoe soles.

Polystyrene is a hard, glassy polymer that is used to make many types of plastic containers, such as bottles and mugs, as well as disposable cutlery. It is also found in coatings for electronic devices, and its foam form is the basis for Styrofoam and other lightweight packaging. (While sometimes labeled with recycling code No. 6, polystyrene is difficult to recycle and rarely collected for reuse in the U.S.)

To make the polymer more resistant to sudden impact, the MIT team added weak bonds scattered throughout the material as cross-links, which allows the material to dissipate energy much more effectively under deformations. When struck by a projectile, these weak bonds selectively break at the site of impact to open up pathways for enhanced energy absorption.

The researchers found that this approach can also fortify styrene-butadiene-styrene rubber, and they are now investigating whether it will also work for other types of polymers such as latex or the rubber that is used to make tires. 

“These cross-linkers can substantially increase the amount of energy that the material absorbs under ballistic impact. You can imagine many applications of that, especially if this could be generalized to other polymers,”says Jeremiah Johnson, the A. Thomas Geurtin Professor of Chemistry at MIT and a member of the Koch Institute for Integrative Cancer Research.

Johnson and Keith Nelson, the Haslam and Dewey Professor of Chemistry, are the senior authors of the study, which appears today in Nature. Former MIT postdocs Zhen Sang and Suong T. Nguyen and MIT graduate student Kwangwook Ko are the paper’s lead authors.

Tougher plastics

In a study published in 2023, Johnson and colleagues at MIT and Duke University showed that they could make polymers tougher using a counterintuitive strategy: adding weak cross-linkers that are distributed throughout a polymer network. These weak linkages, also called mechanophores, break under tearing conditions in a way that helps preserve the stronger bonds that bear the load, allowing the material to dissipate more energy.

“As a crack starts to propagate through the material, these mechanophores split in two, which helps to dissipate energy and redirect where the crack goes. That means you have to put in more energy to tear the material,” Johnson says. 

Unlike their previous study, which examined toughening under slow tearing conditions, the new Nature study aimed to develop mechanophore-enabled strategies for resisting rapid deformation, such as that caused by sudden impact. The researchers were especially interested in applying the strategy to some of the most widely used polymers, such as polystyrene.

To do that, they developed a way to directly incorporate mechanophores as cross-links into common polymers. Then, they used a system invented by Nelson — laser-induced microprojectile impact testing (LIPIT) — to study how the resulting polymers respond to projectile impacts. With this system, tiny projectiles — silica beads about 10 microns in diameter — are fired at the film at about 750 meters per second (more than 1,600 miles per hour). The amount of energy absorbed by the material can be calculated by measuring the change in the particle’s velocity before and after it passes through the film. 

“We first developed this method to study microparticle impact and penetration into bulk polymer samples, where we would monitor particle propagation through about 100 microns of material and analyze after impact how polymer morphology had changed,” Nelson says. “Our new measurements show how much additional information can be extracted from particle velocities before and after penetration through a thin layer. They also show deeply informative deformation patterns both during particle impact and afterward.”

This technique allowed the researchers to mimic the type of forces that might be seen in the real world when a plastic object is hit with another object, or when you drop your phone on the ground. In their experiments, the researchers showed that mechanophore cross-linked polystyrene was able to absorb substantially more energy from an impact than regular polystyrene.

“It turned out that the mechanophore leads to substantial increases in energy dissipation compared to both uncross-linked and conventionally cross-linked polystyrene, a behavior that had not been observed in related previous work,” Johnson says.

Absorbing impact

To figure out how the mechanophores help make polystyrene more impact resistant, the MIT team enlisted help from collaborators at MIT, Purdue University, Northwestern University, and Duke University. 

Through experiments and simulations, they found that when a high-speed particle strikes the material, it raises the temperature at the impact site high enough to form a mobile zone. In this zone, the mechanophore bonds are selectively broken under force, opening controlled pathways that better absorb the energy of impact while leaving the area beyond the impact site relatively unaffected and stable.

“What is particularly attractive about this approach is the ability to bestow these properties upon ‘off-the-shelf’ commodity plastics, both glassy and elastomeric, with minimal chemistry which makes it in principle quite scalable and relevant. This study combines an elegant approach while providing an in-depth mechanical analysis of the failure mechanism,” says Yoan Simon, an associate professor in the School of Molecular Sciences at Arizona State University, who was not involved in the research.

The researchers also found that they could insert these mechanophores into styrene-butadiene-styrene (SBS) rubber — which is used in shoe soles as well as asphalt and roofing materials — and observe a similar effect. They are now exploring whether this approach could also work with a related material, styrene-butadiene rubber, which is one of the major components of tires. 

If successful, this technology could yield longer-lasting tires and also cut down on the amount of microplastics generated when tires contact the road, which is estimated to account for at least 10 percent of the microplastics in the environment. 

“Materials with energy-absorbing mechanophores could one day help keep your vehicle's tires from blowing out on the highway or provide more protective cases for personal electronics,” says Katharine Covert, program director of the U.S. National Science Foundation Centers for Chemical Innovation, which invested in the team’s research. “This work really demonstrates how valuable new insights can be rapidly generated by bringing together researchers with different areas of expertise.”

The research was funded by the National Science Foundation Center for the Chemistry of Molecularly Optimized Networks, the U.S. Army Research Office through MIT’s Institute for Soldier Nanotechnologies, a Schmidt Science Postdoctoral Fellowship, and the U.S. Air Force Office of Scientific Research.

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