Using reason, again and again

You probably think you are rational. Day to day, you try to “make the best possible use of the information available to you,” as MIT philosopher Brian Hedden PhD ’12 writes in his 2015 book, “Reasons without Persons.” 

If you think you are rational because of how you plan for the future, and change your beliefs over time, however, Hedden will be skeptical. Circumstances change, and when using reason, he thinks, all that matters is the present. Thus, he also writes: “The requirements of rationality should be impersonal, avoiding reference to the relation of personal identity over time.”

This is what Hedden calls “time-slice rationality,” the idea that in applying reason, we exist in little slivers of time and knowledge. There are not permanently reasonable people, just reasonable decisions. 

“We are temporally extended people with hopefully long lifespans, but we’re made up of lots of different time slices,” Hedden says. “So there’s me now, me yesterday, me next year. We should think of the locus of rationality as the time slice, not the temporally extended person.” 

Those past versions of you, Hedden thinks, are like teammates in sports: You are connected to them, but not quite the same person. The payoff from viewing things this way, he contends, is a more streamlined and realistic picture of our thinking. 

“Time-slice rationality” helped launch Hedden’s career. Today he is a professor in MIT’s Department of Linguistics and Philosophy and associate dean for MIT’s Social and Ethical Responsibilities of Computing (SERC) initiative. In a nod to his work, let’s examine some time slices from Hedden’s career.

Falling for philosophy

Hedden grew up in Virginia and attended Princeton University as an undergraduate, where he expected to study electrical engineering. But early on in college, he took some philosophy classes — an introductory course in logic, a history of early modern philosophy — and liked them. A lot. 

“Engineering is still near and dear to my heart, but I really got into philosophy,” Hedden says. 

Almost before he knew it, Hedden had found his primary intellectual interest. Upon graduating from Princeton, Hedden spent a year working for an education nonprofit in Nicaragua, but he had already decided on his next stop: graduate school in philosophy.

That led Hedden to MIT. He wanted to study the philosophy of language, and at MIT, the famous linguistics program is part of the same department as philosophy. Hedden applied to the Institute, was accepted, and arrived on campus eager to pursue his chosen field. 

Lounge life

A funny thing happened to Hedden after he arrived at MIT, however: He stopped studying the philosophy of language. Blame Frank Gehry, the architect. 

MIT’s Department of Linguistics and Philosophy is in the Stata Center, which opened in 2004 and was designed by Gehry to have all kinds of common spaces, including double-height lounges. After Hedden started graduate school at MIT, he got drawn into the philosophical discussions happening in these common areas. Before long, he had changed his intellectual focus. 

“This was largely due to conversations that were happening in the lounge,” Hedden recalls. “The Stata Center has spaces that really encourage collaboration. A lot of people there were talking about puzzles involving probability, epistemology, and decision theory, and I found those things really stimulating, and wound up specializing in those areas. Things wouldn’t be the same if the building were differently arranged.”

Advised by MIT professors Caspar Hare, Robert Stalnaker, and Roger White, Hedden wound up writing his doctoral thesis — three papers — on rationality and decision-making. That formed the basis of “Reasons without Persons,” whose title alludes to a famous work by philosopher Derek Parfit.

While it might seem unusual to draw to draw a distinction between our past, present, and future selves, Hedden thinks we actually do that frequently, in everyday life and cultural work. In Greek mythology, Odysseus rationally chains himself to the mast of his ship, anticipating that his future self will be irrationally unable to resist the call of the sirens.

“That’s a dramatic example, but we do this all the time, like when we buy a gym membership and hope that our future selves will irrationally care about sunk costs and go to the gym to avoid having wasted the money,” Hedden says. 

Heading down under

After earning his MIT PhD, Hedden spent two years as a junior research fellow at Oxford University, then landed his first faculty job in academia — at the University of Sydney, in Australia, in 2015. Five years later, he moved to Australian National University, in Canberra, leaving when he returned to MIT in 2025. 

“I love Australia; I think the quality of life is amazing, the culture is great, the natural world is unbelievable,” Hedden says. The country also has, he observes, “a great philosophy scene,” fed in part by decades of interaction with American scholars. 

Hedden’s work kept evolving during his decade in Australia. He started examining specific, applied topics more often, including many questions about legal processes and evidence. For instance: Should juries even deliberate? In one 2017 paper, Hedden suggested they should not, because, among other things, “deliberation destroys the independence of jurors’ judgments” in ways that can be counterproductive. 

Or: Is there such a thing as “higher-order” evidence, which is evidence about what conclusions your evidence supports? In a 2021 paper, Hedden and now-MIT colleague Kevin Dorst concluded that virtually all evidence fits this billing. 

Hindsight bias: Not bias

Or take another Hedden paper in this vein, from 2019, casting new light on the familiar topic of “hindsight bias.” We often alter our views about things after they happen, which can seem like gratuitous second-guessing. 

Is it, though? Suppose you are investigating a railroad crash and find evidence that a crash was more likely than people imagined. That might simply be useful new knowledge. Suppose your favorite basketball team loses a game, and you reexamine why you thought they would win; perhaps a star player’s injury was more serious than you imagined. Are you changing your basic views, or just conducting a realistic reassessment?

“This is perfectly rational and what we should expect,” Hedden says. “Some people say, ‘Oh, that’s hindsight bias.’ I think it’s just a reasonable conclusion to draw.”

To be sure, in the paper itself, Hedden engages with theoretical philosophical work about evidence and view formation; much of his work bridges academic theory and practical everyday applications. Like many of his papers, this one also evinces the fun of reworking conventional wisdom. 

“I do think that these contrarian views are right,” Hedden says. “But I also find a certain joy in going my own way, or having a skeptical take to get people to rethink views they’re falling into without fully realizing it.” 

After an odyssey, back at MIT

After nearly a decade in Australia, Hedden received an offer to return to one of his intellectual homes: MIT offered him a place on the faculty. Arriving back at the Institute in 2025, Hedden found many things had changed — new buildings on campus, new programs — while some were recognizably the same. 

“The philosophy department looks very similar in terms of the healthy culture,” Hedden says. “It’s always been known as a collaborative, high-energy place with a fantastic graduate program. And it’s really welcoming. That lounge discussion culture is still there. Sometimes cultures can be fragile. There could have been people who let it lapse. But it’s still there, and that’s great.”

Meanwhile, Hedden has added to his intellectual portfolio by becoming associate dean at SERC, a burgeoning initiative at MIT examining a wide range of civic issues around computing. SERC has supported 40 postdocs around MIT since 2022, in all five MIT schools plus the MIT Schwarzman College of Computing. It has also awarded 30 seed grants for faculty research in the last three years.

“There’s been really broad interest from faculty and students,” Hedden says. “I’m interacting a lot with computer scientists especially, but people across the Institute everywhere. The College of Computing is a unifying force.” 

For that matter, the SERC Scholars program had 75 students accepted last fall, from first-year undergraduates to doctoral candidates, working on projects including surveillance, artificial intelligence, the energy impact of the sector, and more. Hedden is also making a point to develop more courses across SERC topics.

“It’s often the younger people, undergraduates and graduate students, the postdocs, the junior faculty, that gives us a constant infusion of new ideas and energy,” Hedden says. “We’re hoping to keep the momentum going.”

In this slice of time, that sounds pretty reasonable. 

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Building energy security through more sustainable batteries

For Hugh Smith, the challenge of building an energy-secure future isn’t about creating the world’s “best” battery. It’s about designing the right battery for the right job.

As a fifth-year PhD candidate in MIT’s Department of Materials Science and Engineering, Smith studies sodium-ion batteries, an emerging alternative to the lithium-ion batteries that power everything from smartphones to electric vehicles. By replacing expensive critical minerals like lithium, nickel, and cobalt with more readily available elements like sodium, iron, and manganese, his research aims to make energy storage both more affordable and more sustainable.

“I’ve believed for a very long time that the biggest engineering problem humanity faces is the transition to clean energy,” Smith says. “Batteries are a critical bottleneck in that transition.”

Growing up in Albany, New York, Smith was drawn to materials science because it combined two of his favorite subjects: chemistry and math. What kept him interested, however, was the field’s ability to touch nearly every aspect of everyday life.

“Anytime you interact with a solid material, there are people who intentionally designed that material for a specific purpose,” he says.

That idea of designing materials with a real-world purpose eventually led him to batteries. After earning his undergraduate degree in materials science from Case Western Reserve University, Smith came to MIT to explore how new battery chemistries could reduce costs without sacrificing performance.

Consumers often want batteries that charge quickly, last for years, store large amounts of energy, and remain inexpensive. But in reality, improving one characteristic of this technology usually means compromising another. A smartphone battery, for example, prioritizes energy density and long lifespan, while a battery storing electricity for the power grid doesn’t need to be lightweight or compact. Instead, cost and reliability become the most important considerations.

Rather than chasing an all-encompassing solution, Smith focuses on finding the right balance for specific applications, often juggling competing priorities. Instead of strengthening a singular characteristic, Smith works to maximize as many components of the battery as possible, including cost, performance, sustainability, and reliability, depending on how it will be used.

“It’s trying to balance everything,” he says. “It’s not catering extremely to some properties and then abandoning others.” 

The sodium-ion batteries Smith studies could eventually provide lower-cost options for electrical grids or more affordable electric vehicles. Because sodium-ion batteries can largely be manufactured using the same infrastructure already developed for lithium-ion batteries, they also offer a potentially smoother path toward commercialization than many emerging battery technologies.

Smith’s graduate school journey has been defined as much by the process of learning how to do research as by the science itself. He joined a brand-new research group at MIT as its first graduate student, and helped establish the lab run by Professor Iwnetim Abate. Without senior graduate students or postdocs to turn to for day-to-day guidance, he often had to teach himself new techniques and how to troubleshoot when things went wrong.

“I learned not to be fearful of new things,” Smith says. “Just because I didn’t know how to do something didn’t mean I couldn’t figure it out.”

He says the experience transformed him into a more independent researcher and someone who is willing to dive headfirst into unfamiliar problems.

Before beginning graduate school, Smith spent seven months at the Battery Innovation Center in Newberry, Indiana, an experience that broadened his understanding of how scientific discoveries become real technologies. Working alongside materials scientists, chemists, mechanical engineers, and chemical engineers showed him that no single discipline can solve the challenges of battery development alone.

“It requires a huge team effort,” Smith says. “It requires a lot of different types of knowledge.”

He says the experience also helped him better understand where his own expertise could make the greatest impact and when collaboration across disciplines is essential.

Outside the lab, Smith makes time to stay active through MIT’s intramural sports program, where he plays soccer, ultimate frisbee, football, and volleyball on teams with fellow graduate students. The games offer a chance to unwind after long days of research while strengthening the friendships he’s built throughout graduate school. He also enjoys fishing around the Boston area with friends and exploring New England’s coastal towns, museums, and historic sites.

As he prepares to graduate in the winter and pursue a career in battery research and development, Smith hopes to continue designing technologies that support the transition to clean energy. 

“Lots of smart people have already made wind and solar very cheap,” Smith says. “The issue is reliability, and batteries can help solve that problem. I hope the work I’m doing helps to affordably unlock the transition to an electric grid powered by reliable clean energy, and an electrified transportation network.”

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Connecting research to policy on Capitol Hill

This spring, 25 MIT students and postdocs traveled to Washington to meet with congressional staffers and advocate for sustained federal investment in scientific research. 

With recent cuts to National Science Foundation programs and continued uncertainty surrounding the federal research budget, these conversations were especially timely. Over the course of just two days, participants met with 62 congressional offices representing 32 states to discuss the importance of federal support for scientific research, higher education, and other policy concerns related to their individual research areas.

Each spring, the MIT Science Policy Initiative (SPI) organizes Congressional Visit Days (CVD), a program that introduces graduate students and postdocs to the federal policymaking process while demonstrating the many ways scientists can engage in policy advocacy. In addition to meeting with congressional offices, participants connect with Washington-based MIT alumni and members of the MIT Washington Office to learn about careers at the intersection of science and public policy.

This year's CVD was co-organized by Audrey Parker, a PhD student in civil and environmental engineering at MIT, and Ian Robertson, a PhD student in physical oceanography at MIT and the Woods Hole Oceanographic Institution (WHOI). Robertson reflects on the experience:

"Having attended the trip as a participant last year, stepping into the role of a co-leader this year was a big commitment that was well worth the payoff. It was rewarding to build on the work of past leaders, strengthening the CVD experience for participants by training and encouraging them to discuss not just general science funding advocacy in their meetings, but also specific policies tied to their research. I look forward to the future success of the CVD program in continuing to provide students and postdocs a template for science policy conversations with Congress and helping them realize the various avenues in which they can connect research to policy throughout their careers."

To prepare for the trip, participants attended three training sessions led by SPI in collaboration with the MIT Washington Office and the MIT Policy Lab. These sessions provided background on the federal appropriations process, the role of congressional staff in shaping legislation, and practical strategies for communicating scientific expertise to policymakers. The training sessions also gave participants a chance to practice sharing their research and policy pitches with each other in mock "Hill meetings."

While on the Hill, students advocated for both general science funding for the upcoming fiscal year as well as specific policies tied to their research in artificial intelligence, environmental science and engineering, energy, space, and health. They encouraged offices to edit language in bills, support bills already on the floor, or sponsor new bills. Staffers on both sides of the aisle were particularly interested in discussing AI privacy and security across disciplines. They also expressed strong interest in hot environmental topics, such as deep-sea mining, and were eager to learn more about its associated environmental consequences. In many cases, conversations about participants' research and science-based policy priorities reinforced the need for continued federal funding of science, enabling staffers to connect abstract funding decisions with the researchers and projects they support.

The experience proved valuable for both the MIT delegation and the congressional offices they visited. Rodrigo Zuniga, a first-year PhD student participant, highlights:

"Going to Washington, D.C., offered a whole new perspective of the role of science in politics for me. In today's news and social media landscape, it's really easy to see Washington as irreversibly polarized, but in talking to staffers from both the majority and minority parties, I saw a general desire for bipartisanship and widespread support for science. What's most clear to me after this experience with CVD is that there is a lot of room and pressing need for humans with scientific training and expertise to participate proactively in local, state, and federal government."

As scientific and technological issues continue to shape public policy, opportunities for researchers to engage with policymakers have never been more important. Programs like Congressional Visit Days help equip the next generation of scientists with the knowledge and confidence to communicate the value of research beyond the laboratory, strengthening connections between the scientific community and the policymakers whose decisions shape its future.

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Why some nitrogen-processing enzymes are more efficient than others

Nitrogen gas is abundant in Earth’s atmosphere, but most living organisms can’t readily use this nitrogen. Only a subset of microbes that have enzymes known as nitrogenases can break nitrogen gas apart and convert it into ammonia.

There are three different classes of nitrogenases found in nitrogen-fixing microbes, which vary based on the types of metal that they contain. Nitrogenases that contain the metal molybdenum are the most efficient, and two new studies from MIT offer an explanation for why that is.

The findings could help guide the design of engineered enzymes or synthetic catalysts that can convert nitrogen gas to ammonia, the researchers say.

The team found that while molybdenum doesn’t directly bind to nitrogen, it helps nearby iron atoms bind to nitrogen more strongly. This is a critical first step in breaking the bond between the two nitrogen atoms that form nitrogen gas.

“It’s that initial binding step that’s really the hard part. Once you’ve started to break the nitrogen-nitrogen triple bond and make some new nitrogen-hydrogen bonds, it’s pretty easy to get the rest of the way,” says Daniel Suess, the Arthur Amos Noyes Associate Professor of Chemistry at MIT and a senior author of both papers.

MIT postdoc Tong Wu and former postdoc Madeleine Ehweiner are the lead authors of one of the papers, and Alexandra Brown PhD ’23 is the lead author of the other. Kyle Lancaster, a professor of chemistry at Cornell University, is a senior author of the latter paper, along with Suess. Both papers appear today in the journal Chem.

Efficient enzymes

Before microbes evolved the ability to fix nitrogen around 3 billion years ago, the strong triple bond between atoms of N₂ could only be split with high-energy events such as a lightning strike.

“Once an enzyme came along that could convert dinitrogen to ammonia, that changed the game because now cells could harvest nitrogen from the air for biomass,” Suess says.

Within the active site of nitrogenase is a catalytic cofactor that typically consists of a cluster of iron, sulfur, carbon, and in some cases another metal. Nitrogenases whose cofactors contain molybdenum are the most efficient, followed by those containing the metal vanadium. Nitrogenases that don’t have any metal other than iron are the least efficient.

Why the molybdenum-containing enzyme is more efficient has been a puzzle, especially because it’s thought that molybdenum itself doesn’t bind directly to nitrogen gas.

“In all cases, iron is thought to interact with N₂, so it’s a bit of a mystery,” Suess says. “If all the chemistry is happening at iron, why is it that this molybdenum is affecting catalysis?”

To answer that question, Suess’s lab has developed simpler versions of iron-sulfur clusters that they can use to model the naturally occurring cofactors. These can be modified by adding different metal atoms, allowing the researchers to study how those metals change the cofactors’ properties. 

In the first paper, led by Wu and Ehweiner, the researchers swapped in different metal atoms and then measured the ability of the iron in the cofactor to bind to nitrogen. They found that only cofactors with a large metal atom, such as molybdenum or tungsten, were able to strongly bind N₂. With vanadium,  chromium, or iron, which are smaller, the cofactors did not bind N₂ and performed other reactions instead.

“That paper essentially recapitulates what you see in biology, which is that the iron-sulfur clusters that have molybdenum in them seem to be better at binding dinitrogen than those with lighter metals,” Suess says.

Sharing electrons

In the second paper, led by Brown, the researchers uncovered a possible mechanism that explains that phenomenon. 

In that paper, the researchers studied how cofactors containing different metals interact with compounds called N-heterocyclic carbenes. These molecules behave similarly to N₂ in some ways, making them a good model for this type of study. Like N₂, they are resistant to accepting any electrons from another molecule, which is an essential step to breaking chemical bonds. 

The researchers found that when molybdenum was included in the cluster, it became easier for iron to donate some of its electrons to the N-heterocyclic carbenes, in a process known as back-bonding. This occurs because molybdenum, a large atom, has large orbitals that can overlap with the orbitals of the nearby iron atom. That alters iron’s electron density in ways that make it easier for iron to pass electrons to N₂.

“Without these direct metal-metal interactions, the iron has to do all the work, but adding the molybdenum allows for this electronic cooperativity,” Suess says.

Once N₂ is bound to an iron atom, the rest of the reaction can proceed. A proton can come in from water or another source to create an N-H bond, which then makes it much easier for the remaining N-N bonds to be broken and bind to protons, forming NH₃. 

The findings could help guide scientists who are working on designing enzymes that could be engineered into organisms that help them generate their own NH₃, eliminating or reducing the need for fertilizer. The results could also help chemists to design synthetic catalysts that could produce ammonia industrially, using less energy than the Haber-Bosch process. 

“The general principle is that you can make an iron site in any context behave differently when you have these metal-metal interactions than when you don’t have these interactions,” Suess says. “The primary result of these findings is to teach us about the natural world and how nature accomplishes this really important and miraculous reaction. And, maybe that can be translated into new processes.”

The research was funded primarily by the U.S. Department of Energy, the National Science Foundation, and the National Institute of General Medical Sciences.

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MIT and Broad Institute researchers break diffraction barrier in super-resolution microscopy

Researchers in the lab of Sam Peng, the Pfizer Inc. - Gerald Laubach Career Development Assistant Professor of Chemistry at MIT and a core institute member of the Broad Institute of MIT and Harvard, have developed a groundbreaking super-resolution imaging technology that allows scientists to visualize molecular structures with sub-angstrom-level localization precision — three orders of magnitude beyond the nanometer limits of standard fluorescent dyes — while drastically simplifying the imaging process. 

Unlike traditional dyes that fade rapidly under illumination and limit data collection, the platform, called U-STORM (Upconversion enabled Stochastic Optical Reconstruction Microscopy) utilizes a new class of compositionally engineered upconverting nanoparticles (UCNPs) that blink spontaneously and indefinitely. 

This work represents a fundamental shift in both optical materials and biological imaging. An open-access description of the study was published July 27 in Nature Nanotechnology.

Overturning a decades-old paradigm

For decades, the scientific community widely considered upconverting nanoparticles to be completely photostable and non-blinking. Because localization-based super-resolution microscopy techniques like STORM rely entirely on the stochastic “blinking” (switching between “on” and “off” states) of light emitters to distinguish closely packed molecules, UCNPs were historically deemed unsuitable for this type of imaging.

“Our laboratory has long been interested in overcoming these limitations,” says Peng. “Our work began with a question: Can we develop a super-resolution imaging platform that is simultaneously long-term, multicolor, simple to operate, and capable of achieving extremely high localization precision without using imaging buffers or additional optical control?”

By meticulously controlling nanoparticle composition, the MIT and Broad Institute team discovered that these small (~10nm) core-shell particles could actually be coaxed into spontaneous blinking under continuous near-infrared excitation. Remarkably, this blinking behavior continues indefinitely without the need for complex imaging buffers, oxygen scavengers, or external optical modulation.

U-STORM’s key breakthroughs

An angstrom is a tiny unit of measurement used by chemists to measure size and distances at the atomic level. U-STORM’s ability to blink indefinitely has afforded researchers the opportunity to collect over 88,000 localization events from the same particle, sharpening the localization precision down to an unprecedented 0.6 Å.

Unlike conventional multicolor super-resolution imaging, which requires multiple expensive lasers and meticulous optical alignment, U-STORM can operate with just one near-infared laser, which works to simultaneously excite nanoparticles emitting different colors. This results in a drastic reduction of an experiment’s complexity.

To obtain images with multiple colors, rather than capturing images sequentially over multiple rounds, U-STORM captures multiple colors simultaneously. Researchers have successfully demonstrated this by mapping epidermal growth factor receptor dimers and multimers in biological samples under physiological conditions without any specialized imaging buffers.

Broader impact

Beyond expanding the boundaries of microscopy, this research establishes an entirely new design principle for lanthanide nanomaterials. The team is already working to expand the color palette, make the particles even smaller and brighter, and deploy U-STORM to investigate complex nanoscale protein organizations and cellular signaling pathways.

Ultimately, U-STORM promises to provide laboratories worldwide with an accessible, easy-to-implement, yet incredibly powerful route toward high-precision molecular imaging.

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How a medical database developed at MIT evolved into a global standard of data-sharing

Before the advancement of scientific data storage and collaboration via the cloud, medical investigators seeking health research breakthroughs had to overcome significant obstacles to collaboration and key clinical data gathering. 

Data were siloed and difficult to distribute, so those looking to undertake research had no option but to gather them themselves. This not only made research more expensive, but it was challenging to compare findings across datasets. 

In 1975, researchers studying arrhythmias at MIT and Boston’s Beth Israel Hospital envisioned another way: the team began collecting and digitizing electrocardiogram recordings with the intention of not only studying them, but of also making them available to the wider research community.

The team built their own computers for the process, painstakingly duplicated tapes one by one, and created more than 100,000 annotations for the recordings. The process took years, but by summer 1980, the tapes were finally ready. The team initially thought their tool would reach fewer than a dozen academic and industry groups. But interest kept pouring in. Over the next decade, they went on to mail about 100 copies. 

The data eventually became the first database of the global platform PhysioNet — founded in 1999 at the Harvard-MIT program in Health Sciences and Technology — as a clinical data repository for complex physiological signals. 

At the time, that type of data-sharing, which may seem like the default today, was a near-revolutionary idea. PhysioNet’s “founding was incredibly visionary,” says Thomas Heldt, Richard J. Cohen (1976) Professor in Medicine and Biomedical Physics, associate director of MIT’s Institute for Medical Engineering and Science, and the senior author of a recent paper in Nature Health examining the platform’s impact. 

Eventually, those magnetic tapes sent through the mail became burned CD-ROMs, which then evolved into FTP servers hosted on the newly minted internet. Today, as PhysioNet looks back at over 25 years of operation, the platform hosts hundreds of databases, and has become one of the most comprehensive biomedical and clinical data repositories in existence. Last year, more than 15,000 scientific publications cited PhysioNet, and users from more than 180 countries have registered on the platform. It is widely used by researchers, manufacturers, and clinical decision-makers.

“The research impact is truly significant,” says Heldt, who is also a professor in the MIT Department of Electrical Engineering and Computer Science and a principal investigator at the Research Laboratory of Electronics, “and quite humbling.” 

“It is really beautiful to see that such a vision has proven right and so enabling for so many people.”

Setting a standard 

Around 2009, a PhD student named Tom Pollard was conducting research on critically ill patients at one of London’s leading hospital systems. Although the hospital generated large volumes of valuable clinical data, the infrastructure and processes needed to curate and support their wider research use were still developing. 

“Hospital data were collected primarily to support immediate patient care, with less attention given to how they might be curated and reused for research,” says Pollard, now a research scientist at MIT’s Laboratory for Computational Physiology (LCP), technical director of PhysioNet, and the lead author on the Nature Health paper. 

The problem was not simply privacy. Hospital information systems were built primarily to support patient care and administration, not research. Data were fragmented across systems and rarely curated with future reuse in mind, making it difficult and expensive to turn them into coherent research resources.

But Pollard needed data to complete his dissertation. After poking around on the internet, he eventually discovered the Medical Information Mart for Intensive Care (MIMIC), a database of de-identified electronic health records hosted by PhysioNet. Recognizing its potential, his clinical supervisor, Kevin Fong, organized a visit to Boston. Soon afterward, Fong and Pollard were sitting across the table from Roger Mark, discussing how their teams might collaborate.

Academic incentives have long favored publications and exclusive analyses over the less-visible work involved in preparing data for others to use. That tension persists today. PhysioNet’s founders embraced a different model, believing that sharing research resources could accelerate discovery and ultimately improve human health, he says. MIMIC became central to Pollard’s dissertation, and after completing his PhD, he came to MIT to help build the next generation of the database. 

In the years since PhysioNet was established, the value of sharing research data has gained much wider recognition. The late Roger Mark, MIT’s distinguished professor of health sciences and technology emeritus and one of PhysioNet’s founders, described its purpose as building an “accessible multinational community around data” to “positively impact global health.”

Earlier this year, Mark and the late George Moody, PhysioNet’s co-founder, jointly received the prestigious IEEE Biomedical Engineering Award for their contributions to PhysioNet and biomedical signal processing. IEEE cited their “leadership in ECG signal processing and global dissemination of curated biomedical and clinical databases, thereby accelerating biomedical research worldwide.”

The source code for the platform, like much of its data, is public. According to the Nature piece: “As the platform evolved, PhysioNet’s community broadened substantially beyond its origins in signal processing and cardiovascular health to encompass clinical informatics, critical care and machine learning for health.” People have used that to build their own PhysioNet-esque infrastructure, says Heldt. Pollard points to similar platforms like Health Data Nexus as examples of PhysioNet’s legacy. 

Although there are now more resources out there hosting similar electronic health data, according to Google DeepMind researcher Vivek Natarajan, both PhysioNet and MIMIC “set the standard,” he says, “and it’s still the standard right now.”

That standard, according to those who use the platform, changed how research is conducted. Access to data should not be the determinant for which ideas are possible, according to Ziad Obermeyer, an associate professor at the University of California at Berkeley School of Public Health and the College of Computing, Data Science, and Society. 

“PhysioNet changed how I think about the bottleneck in research. It is often not ideas or talent. It is friction. When access to data is slow, expensive, and hard, the ideas that die first are the high-risk ones, the things that probably will not work, but would be transformative if they did. That is exactly the wrong model if you want real progress,” he says. “PhysioNet lowers the fixed cost of trying ambitious ideas, and that changes what science becomes possible.”

The AI boom

PhysioNet, once a repository mainly for those working in biomedical signal processing and the health-care fields, has evolved in its 25 years. Originally, the holdings consisted solely of cardiovascular ECG data. Now PhysioNet is a largely a source for electronic health records, imaging data, and software and AI models.  

Particularly as artificial intelligence approaches took off, “the community shifted,” Heldt explains. Those in need of signal processing data still use PhysioNet databases, but the pool of users has expanded to encompass staff at large tech companies, teachers, and practitioners in all areas of medicine, as well as researchers in health-related machine learning and AI. Today, that latter group “dominates the user community,” says Heldt. 

The platform hosts the highest-quality datasets available for health-care AI research, according to Natarajan, whose research involves AI, science, and medicine and who has published several papers that used its datasets. 

“It has been an important cornerstone that has catalyzed all the progress in health-care AI over the last decade,” says Natarajan. In addition to using PhysioNet data, he and his colleagues have contributed data to the platform, helping create the self-sustaining ecosystem that typifies PhysioNet. 

Looking toward the coming decades, stewards of the platform like Heldt and Pollard envision continuing to expand its reach with an annual conference. The team is also preparing to pilot a new system that will allow users to annotate data and contribute their own expertise, enriching PhysioNet’s resources for the next phase of the platform.

“The kind of research that people want to do now needs to be interdisciplinary. Statisticians, computer scientists, clinicians, pharmacists, and nurses must all come together and contribute their knowledge to develop algorithms that are useful for people” says Pollard. “The community has broadened, and advances in AI have expanded both the questions researchers can address and what they believe is possible.” 

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Professor Emeritus Robert Cohen, pioneering polymers researcher and devoted mentor, dies at 79

Robert E. Cohen, the Raymond A. (1921) and Helen E. St. Laurent Professor of Chemical Engineering, Emeritus, whose pioneering research helped shape the fields of polymers and soft matter while inspiring generations of students, passed away peacefully on July 9 following a long battle with Parkinson's disease. He was 79.

"Bob Cohen was an innovator in every sense of the word: in his research, his approach to mentorship, and in every aspect of our community at MIT," says Kristala Prather '94, the Arthur D. Little Professor and head of the Department of Chemical Engineering (ChemE). "Bob combined extraordinary intellect with remarkable humility. As a teacher, colleague, advisor, and friend, he had a gift for making people feel respected, valued, and heard. That generosity shaped every part of his work and inspired everyone fortunate enough to know him."

During more than four decades at MIT, Cohen continually reimagined how chemical engineering students should be educated. Recruited for his expertise in polymer science, he brought to MIT the polymer laboratory course he had developed during his postdoctoral work at the University of Oxford, establishing class 10.467 (Polymer Science Laboratory). The rigorous undergraduate course introduced generations of students to polymer synthesis, physical chemistry, and the evaluation of mechanical properties through hands-on experimentation.

In 1986, Cohen founded the Program in Polymer Science and Technology, now known as the Program in Polymers and Soft Matter (PPSM). Recognizing that advances in polymer science require expertise spanning chemistry, physics, engineering, and materials science, he created one of MIT's first truly interdisciplinary graduate programs. PPSM continues to prepare doctoral students to tackle complex challenges across the broad field of polymers and soft materials.

"Bob Cohen is the reason I returned to MIT as a graduate student," says Paula Hammond '84, PhD '93, Institute professor, dean of the School of Engineering, and a PPSM alumna. "His vision for multidisciplinary polymer education was unlike anything I had experienced. I benefited from him as a teacher in the classroom, as a member of my thesis committee, and a life-long mentor. As a department head, I saw firsthand the extraordinary impact he had on generations of students and on the field itself."

Cohen also conceived the unique PhD in chemical engineering practice (PhDCEP) degree, recognizing that future leaders in chemical engineering would benefit from combining advanced research with industrial experience and business education. The first and only program if its kind, the PhDCEP program integrates coursework, MIT's renowned David H. Koch School of Chemical Engineering Practice, doctoral research, and study at the MIT Sloan School of Management. 

Cohen also founded and directed the DuPont/MIT Alliance from 2000 to 2012, creating a highly successful partnership that brought together researchers from MIT and DuPont to develop innovative materials and manufacturing technologies. The collaboration advanced research in bioelectronics, biomimetic materials, alternative energy, and metabolic engineering, while fostering lasting collaborations across disciplines.

Cohen was a prolific collaborator whose pioneering research established him as one of the world's leading chemical engineers. His contributions include omniphobic surfaces, block copolymer nanoreactors for inorganic cluster synthesis, tough-stiff nanocomposites, chain folding in confined geometries, and layer-by-layer assemblies at the biotic-abiotic interface. Yet when asked about his proudest accomplishments, he rarely pointed to his scientific discoveries. Instead, he spoke about his students, and took immense pride in watching many former PhD students go on to become faculty members and leaders at top institutions around the world.

Raised in Oil City, Pennsylvania, Cohen developed an early appreciation for chemical engineering. After earning his master's and doctoral degrees from Caltech and completing a postdoctoral fellowship at the University of Oxford, he joined the MIT faculty in 1973. Over the next four decades, he became internationally recognized as a groundbreaking researcher, educator, entrepreneur, and mentor. 

Cohen was a member of the National Academy of Engineering and the American Academy of Arts and Sciences, as well as a fellow of the American Institute of Chemical Engineers, the Polymer Division of the American Chemical Society, the American Physical Society and the Materials Research Society. Cohen co-founded MatTek Corp., helping translate advances in biomaterials into practical applications.

Although Cohen received many prestigious honors throughout his career, he often said the award that meant the most to him was the inaugural Paul J. Flory Polymer Education Award, presented by the American Chemical Society in 2012. The honor recognized his leadership in building the interdisciplinary PPSM program and transforming undergraduate polymer education. Fittingly, it celebrated what he valued most: helping students discover their potential.

Cohen is survived by his beloved wife, Jane; his son, Eliot Cohen, his wife Jacqueline Aldred Cohen, and their children Ada, Brennan, and Callan; his daughter, Genevieve Cohen, and her daughter Emma; his sister, Nancy Stein, and her husband Herb; sisters-in-law Lee Woodman and Betsy Woodman; brother-in-law Wally Coleman; and many beloved nieces and nephews.

A memorial service is scheduled for Oct. 17 at the MIT Chapel. In lieu of flowers, donations may be made in Cohen’s memory to the Michael J. Fox Foundation.

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