viernes, 30 de noviembre de 2018

MIT Lincoln Laboratory wins 10 R&D 100 Awards

Ten technologies developed at MIT Lincoln Laboratory have been honored with 2018 R&D 100 Awards. The awards have been presented by R&D Magazine annually since 1963 and recognize the 100 most significant inventions of the year.

“The R&D 100 Award is one of the top awards for recognizing new technology,” says Eric Evans, the director of Lincoln Laboratory. “Receiving 10 awards in one year is a great recognition of the quality and scale of Lincoln Laboratory work and all of the excellent technical and support staff involved.”

A panel of independent experts selected the winning technologies from hundreds of nominations submitted from industry, government laboratories, and research institutions worldwide. The awards were presented during a banquet on Nov. 16 in Orlando, Florida.

Including this year's honors, Lincoln Laboratory has received 48 R&D 100 Awards since 2010.

Algorithms and software for decision making

Three of the R&D 100 Award winners are new algorithms or software platforms that help experts make decisions and gain insight from data quickly.

Lincoln Laboratory worked with the Department of Homeland Security Science and Technology Directorate to develop a modernized hurricane decision support platform. The resulting web-based HURREVAC-Extended (HVX) platform is helping emergency managers to make timely and accurate hurricane evacuation decisions. The platform integrates advanced analytics, such as a storm surge explorer tool and evacuation zone–based impact assessments, simulations, and timelines and reports onto a single user-interface. Used experimentally during last year's Harvey, Irma, and Maria crises, it became fully operational this 2018 hurricane season.

In collaboration with the Office of Naval Research, Lincoln Laboratory developed the Collaborative Optimization via Apprenticeship Scheduling (COVAS) algorithm to perform real-time ship defense for the U.S. Navy. It uses artificial intelligence techniques to first learn from Naval officers as they demonstrate ship-defense tactics. From these demonstrations, COVAS reasons how to best allocate defenses and then provides real-time solutions for problems too large for a single human expert to manage. COVAS’s architecture has been applied to other challenging resource-management problems such as hospital logistics, triaging, and more.

The laboratory's FastID and TachysSTR algorithms are the fastest known methods in the world for comparing DNA samples against large datasets of reference profiles. The algorithms encode single nucleotide polymorphisms (SNPs) and short tandem repeats (STRs) in a DNA sample to bits (for example, by assigning each major SNP allele a 0 value and a minor SNP allele a 1 value) and then use computer hardware instructions to compare the sample to reference profiles. While current techniques require large computing systems and can take hours, the FastID and TachysSTR algorithms can compare a sample profile against 20 million reference profiles in just over five seconds on a laptop.

Innovative processes and techniques

Three new processes or techniques to advance technology or to protect it were awarded R&D 100 Awards.

Lincoln Laboratory developed a breakthrough process for fabricating superconducting electronics. Superconducting electronics rely on precisely engineered microscopic switches called Josephson junctions (JJs). The process sets the world record for both the number and density of JJs in superconducting digital circuits. The circuits produced through this process are faster and more energy efficient than semiconductor-based technologies.

The multi-rate differential phase shift keying (DPSK) technique developed at Lincoln Laboratory enables efficient free-space laser communications over a wide range of data rates by using a single easy-to-implement transmitter and receiver design. The multi-rate DPSK will be the optical communications technology base for NASA’s Laser Communications Relay Demonstration scheduled for launch in 2019.

The laboratory invented a new technique called Dynamic Flow Isolation (DFI) to improve network security. The technique uses software-defined networking to minimize unnecessary connectivity between assets on enterprise networks. This connectivity is what cyber attackers often rely on to expand a small foothold to a full-scale attack. DFI enables and enforces policies that allow only minimal network-level connectivity for operations, thwarting an attacker’s attempts to move laterally.

New devices and systems

The R&D 100 Awards recognized four devices or systems that are providing new or improved capabilities.

The laboratory invented an optical fiber device, called a photonic lantern, that provides the ability to scale the power in, shape, and steer a laser beam in the presence of optical turbulence and disturbances. These abilities can benefit a wide range of laser applications. For example, scaling a beam's power improves the productivity of laser manufacturing processes by delivering energy to its target with higher efficiency. Beam shaping improves the laser's transmission through scattering media, like biological tissue, for applications in endoscopes and medical imaging.

With funding from the Department of Homeland Security Science and Technology Directorate, Lincoln Laboratory developed a wide-area video surveillance system called the Immersive Imaging System. It provides very high-resolution images and 360-degree coverage from a single vantage point, monitoring an area equivalent to that of seven football fields. Unlike other surveillance cameras that reduce their field of view when zooming in on a target, this imaging systems provides operators a high-resolution zoomed image while maintaining a big-picture view.

In collaboration with the U.S. Army Communications-Electronics Research, Development, and Engineering Center and Wyle Labs, Lincoln Laboratory built the Intelligent Power Distribution (IPD) device. The IPD forms the power distribution backbone of tactical microgrids. The device allows soldiers to interactively monitor power systems and coordinate energy resources and loads so that mission-critical systems are maintained.

Lincoln Laboratory and the MIT Laboratory for Information and Decisions Systems teamed up to create Peregrine: Network Navigation. The novel system enables navigation in places where GPS is unavailable, particularly indoors. The system is powered by cooperative algorithms and for the first time demonstrates scalable, highly accurate, and efficient localization networks that are based on small, low-cost, and easily deployable devices.



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The long and short of CDK12

Mutations in the BRCA1 and BRCA2 genes pose a serious risk for breast and ovarian cancer because they endanger the genomic stability of a cell by interfering with homologous recombination repair (HR), a key mechanism for accurately repairing harmful double-stranded breaks in DNA. Without the ability to use HR to fix double-stranded breaks, the cell is forced to resort to more error-prone — and thus more cancer-prone — forms of DNA repair.

The BRCA1 and BRCA2 genes are not the only genes whose mutations foster tumorigenesis by causing an inability to repair DNA double strand breaks by HR. Mutations in twenty-two genes are known to disrupt HR, giving rise to tumors with what researchers call “BRCAness” characteristics. All but one of these BRCAness genes are known to be directly involved in the HR pathway.

The one exception, CDK12, is thought to facilitate a set of different processes altogether, involving how RNA transcripts are elongated, spliced and cleaved into their mature forms. While the connection between this RNA-modulating gene to DNA repair remained poorly understood, the identification of CDK12 as a BRCAness gene piqued significant clinical interest.

The researchers who pinpointed this connection, Sara Dubbury and Paul Boutz, both work in the laboratory of Phillip Sharp, Institute Professor, professor of biology, and member of the Koch Institute for Integrative Cancer Research. In a study appearing online in Nature on Nov. 28, they describe how they discovered a previously unknown mechanism by which CDK12 enables the production of full-length RNA transcripts and that this mechanism was especially critical to maintain functional expression of the other BRCAness genes.

When the researchers knocked out expression of CDK12, mouse stem cells showed many signs of accumulating DNA damage that prevented DNA replication from going forward, classic indications of a BRCAness phenotype. To identify what roles CDK12 may play in regulating gene expression, the researchers turned to RNA sequencing to determine which genes had increased or decreased their overall expression.

To their surprise, only genes activated by p53 and early differentiation (side effects of accumulating unrepaired DNA damage and BRCAness in mouse stem cells) accounted for the lion’s share of changes to RNA transcription. However, when the researchers instead focused on the types of RNAs transcribed, they found that many genes produced unusually short transcripts when CDK12 was absent.

Not every stretch of DNA in a gene makes it into the final RNA transcript. The initial RNA from a gene often includes sections, which researchers call “introns,” that are cut out of transcript, the discovery that earned Sharp the 1993 Nobel Prize in Physiology or Medicine and the remaining sections. “Exons,” are spliced together to form a mature transcript (mRNA). Alternately, an intronic polyadenylation (IPA) site may be activated to cleave away the RNA sequence that follows it preventing intron removal and generating a prematurely shortened transcript. These processes allow the same gene to produce alternate forms of messenger RNA (mRNA), and thus be translated into different protein sequences.

Surprisingly CDK12 knockout cells produced significantly more IPA-truncated transcripts genome-wide, while full-length transcripts for the same genes were reduced. These shortened mRNAs can vary greatly in their stability, their ability to be translated into protein, and their protein function. Thus, even while a gene may be actively transcribed, its translation into functional proteins can be radically altered or depleted by IPA activation.

While this observation began to illuminate CDK12’s role in regulating mRNA processing, what remained puzzling was why CDK12 loss affected the HR pathway so disproportionately. In investigating this question, Dubbury and Boutz found that BRCAness genes were overrepresented as a group among those genes that have increased IPA activity upon CDK12 loss.

Additionally, while CDK12 suppresses IPA activity genome-wide, 13 of the other 21 BRCAness genes were found to be particularly vulnerable to CDK12 loss, in part, because they possess multiple high-sensitivity IPA sites, which have a compound effect in decreasing the total amount of full-length transcripts. Moreover, because multiple CDK12-senstive BRCAness genes operate in the same HR pathway, the researchers believe that the disruption to HR repair of double-stranded DNA breaks is amplified.

CDK12 mutations are found recurrently in prostate and ovarian cancer patients, making them an attractive diagnostic and therapeutic target for cancer. However, not enough is known about CDK12 to distinguish between true loss-of-function mutations and so-called “passenger mutations” with no functional consequence.

“The ability to identify patients with true loss-of-function mutations in CDK12 would enable clinicians to label a new cohort of patients with bona fide BRCAness tumors that could benefit from certain highly effective and targeted chemotherapeutics against BRCAness, such as PARP1 inhibitors,” says Dubbury, a former David H. Koch Fellow.

Dubbury and Boutz were able to confirm that IPA sites in key BRCAness genes were also used more frequently upon CDK12 loss in human tumor cells using RNA sequencing data from prostate and ovarian tumor patients with CDK12 mutations and by treating human prostate adenocarcinoma and ovarian carcinoma cells with a CDK12 inhibitor. This result suggests that the CDK12 mechanism observed in mouse cell lines is conserved in humans and that CDK12 mutations in human ovarian and prostate tumors may promote tumorigenesis by increasing IPA activity and thus functionally attenuating HR repair.

“These results not only give us a better understanding how CDK12 contributes to BRCAness, they also may have exciting potential impact in the clinic,” Dubbury says. “Currently available diagnostic techniques could be used to probe the usage of IPA sites found in this study to rapidly screen for patients with true loss-of-function CDK12 mutations, who would respond to BRCAness-targeted treatments.”

Paul Boutz, a research scientist in the Sharp Lab, is co-first author of the study, and has plans to follow-up many of these implications for ovarian and prostate cancer his lab at the University of Rochester School of Medicine and Dentistry.

“CDK12 provides a remarkable example of how factors that control the processing of RNA molecules can function as master regulators of gene networks, and thereby profoundly affect the physiology of both normal and cancerous cells,” he says.

Phil Sharp, the senior author on the work, says “Sara’s and Paul’s surprising discovery that CDK12 suppresses intronic polyadenylation has implications for fundamental new insights into gene structure as well as for control of cancer.”



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jueves, 29 de noviembre de 2018

Startup founded by MIT alumnus unveils electric vehicles for the future

Electric vehicle startup Rivian Automotive has spent the first nine years of its existence in stealth mode working to design vehicles around what it believes are future trends in mobility, such as electrification, subscription-based ownership, and autonomy. This week the company is finally revealing what it’s been up to, dropping the curtains on its first two products, an all-electric pickup truck and SUV, at the Los Angeles Auto Show.

Rivian has garnered interest over the years for quietly securing some of the building blocks of mass production, including raising nearly $500 million in capital and purchasing a 2.6-million-square-foot manufacturing facility in Illinois that once produced 200,000 cars a year for Mitsubishi. Now Rivian says it will begin shipping its vehicles to customers in 2020.

The abrupt transition from stealth mode to large vehicle supplier is all part of the plan for Rivian founder and CEO R.J. Scaringe SM ’07 PhD ’09. Scaringe didn’t want to hype up the company until he could show something off that customers could actually drive in a reasonable amount of time.

“It would’ve been easy to make statements early on and show sketches,” Scaringe says. “But we wanted to get all the pieces aligned: To build out a robust team with robust processes, get capital in place, line up key suppliers, acquire a large-scale production facility, and align it with our products. All that is done now. It’s been blood, sweat, and tears for a period of years to get in a position where we’re very comfortable showing our products.”

Designing a vehicle from the ground up has taken time, but the process has allowed Rivian to create some novel vehicles with intriguing performance specifications. The company describes its first two products, named the R1T and R1S, as high-end adventure vehicles that can be driven on- or off-road.

“They’re designed to be comfortable to use and invite you to get dirty,” Scaringe says. “When I say truck or SUV, you’re thinking inefficient and not particularly sophisticated. But we’ve used technology to make the traditional weaknesses of these vehicles strengths.”

Users purchasing trucks or SUVs have traditionally had to make compromises in areas like acceleration, control, and gas mileage in return for more space and towing capacity. Rivian uses an innovative design and powertrain to change that.

A high-tech transportation solution

Both the R1T and R1S will come with a hardware suite including cameras and sensors, which gives them self-driving capabilities on highways. The vehicles have a unique quad-motor setup that allows the electronic control unit to send 147 kilowatts of power to each wheel.

The fastest versions of the vehicles go from 0 to 60 miles per hour in three seconds and 0 to 100 miles per hour in less than seven seconds. Scaringe says the products’ ride and handling feel more like a sports sedan than a truck or SUV. He also says the vehicles can “go off-road better than any vehicle on the planet today” thanks to high ground clearance and wheel articulation that’s helped by a suspension system that adjusts to the environment, stiffening on the road and immediately loosening off the road.

Rivian’s battery configuration has been referred to as “skateboard architecture” because the battery pack stretches across the floor of the vehicle. The packs come in different sizes, the largest of which gives the vehicles over 400 miles in range. Rivian assembles its own battery packs, using proprietary cooling systems to achieve energy efficiency that Scaringe claims is better than anything on the EV market today.

“We’re doing all of the electronics, control systems, and battery packaging in-house,” Scaringe says. “And the digital architecture of the vehicle is a complete clean-sheet approach. So we’ve done the hardware design, the software design, the full stack development. It gives us complete control over how we move data around the vehicle and synchronize it with our cloud platform. We have a real-time sense of the health of all of our assets in the field.”

The high-tech platform comes inside two spacious vehicles that are designed to be stylish and functional. Both models include a 330-liter front trunk and a long compartment under the rear seats that Scaringe says is perfect for objects like surfboards, skis, and golf bags.

Rivian is listing the R1S at $65,000 and the R1T at $61,500 after federal tax rebates. The company is planning to release lower-priced cars in the future.

MIT past helps change the future

Scaringe studied mechanical engineering  for his master’s and PhD in the Sloan Automotive Laboratory, where he was a member of the automotive research team. He worked with some of the biggest car companies in the world in that role, and realized how difficult it would be for them to reorient around the big changes in transportation that he believed were coming.

Immediately after earning his PhD in 2009, in a year when General Motors and Chrysler would declare for bankruptcy, Scaringe founded Rivian. At a time when many people were wondering if America’s biggest car companies would make it another day, Scaringe set out to start a company that would lead the market decades into the future.

“In 2020, we’d love to have you use one of our vehicles. But in 2035, when you’re thinking about those trips to the beach or hiking, we want you to immediately think about using a Rivian,” Scaringe says. “The brand position we set up in 2020 lays the foundation for us.”

Scaringe knew fulfilling his vision would be difficult, but he believes his time at MIT helped him persevere in the face of the major challenges that come with starting something as complex and capital-intensive as a automotive company.

“MIT draws together some of the smartest minds in the world to study and work on deeply challenging problems,” Scaringe says. “That environment helps demonstrate that even the most challenging problems can be solved through the application of time and effort. … The foundation around solving complex and difficult problems is precisely what has enabled Rivian to this point.”

Now that Rivian’s first vehicles have been revealed, Scaringe hopes the company can move beyond thinking about these trends and start accelerating their arrival.

“It comes back to these big fundamental shifts in how we think of mobility,” Scaringe says. “The change in how we power our vehicles; how the vehicles are controlled and operated, going from human operation to machine operation; and because of those changes, the significant changes to how we think about the business model. Like how consumers purchase vehicles and how manufacturers make money, shifting away from the traditional asset sale model. We think it’s really important to line up the megatrends with our business strategy, and now it’s about making sure the strategy helps drive those megatrends.”



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Gift from Carmen ’78 and John ’77 Thain supports Met Warehouse renovation project

The proposed renovation of the Metropolitan Storage Warehouse as a new location for the MIT School of Architecture and Planning (SA+P) is one step closer to becoming a reality thanks to a significant gift from Carmen ’78 and John ’77 Thain, both members of the MIT Corporation. 

The project, announced by the Institute in June, would create a new hub for interdisciplinary education and research in art, design, and urbanism at MIT with ties to dozens of other departments and centers across the Institute. Relocating SA+P to the Metropolitan Storage Warehouse, centrally located on campus, could expand MIT’s classroom and design studio space, increase exhibition capacity, create a new center for the arts, incorporate areas for collaboration-based work, and open new spaces for public use. The possible move would also bring SA+P into closer proximity with the residential population of MIT’s campus. A new makerspace in the renovated building, with expanded design and fabrication facilities, would be available to the entire MIT community. 

“We are happy to support the effort to reimagine the historic Metropolitan Storage Warehouse for SA+P,” says Carmen, who earned a bachelor’s degree in architecture at the Institute. “This is an exciting opportunity for MIT to create new spaces that serve the needs of today’s students and educators while preserving a historic building of distinctive character at the heart of campus.” Adds John: “This renovation has the potential to benefit SA+P — and indeed the whole of MIT — in many ways, from adding modernized facilities to consolidating MIT’s strengths in cross-disciplinary design research and education to connecting communities across the Institute. Carmen and I are proud to be a part of this important project.”

The Thains have a long history of support for the Institute. Carmen is a term member of the MIT Corporation and serves on the Corporation Visiting Committee for Architecture. She is a co-chair of the MIT Campaign for a Better World and a member of the MIT Campaign Leadership Council. John, a former chairman and CEO of the CIT Group, is a life member of the MIT Corporation and serves on the Corporation Executive Committee. He is chair of the Corporation Visiting Committee for the MIT Sloan School of Management and is on the MIT Sloan Americas Executive Board. He is also on the Corporation Visiting Committee for the Department of Electrical Engineering and Computer Science. The couple have also hosted events during the MIT Campaign for a Better World. They are long-term supporters of the MIT Sloan Annual Fund and various core needs across campus.

“For many years, John and Carmen's foresight, wisdom, and generosity have contributed greatly to the life of the Institute,” says MIT President L. Rafael Reif. “Their support for the proposed conversion of the Metropolitan Storage Warehouse into a new design hub will help to transform a building whose purpose was to shield its contents from the outside into a vibrant, open community brimming with new ideas and inspirations and eager to share them with the world. We are deeply grateful to the Thains for their commitment to advancing MIT's mission.”

SA+P is consistently ranked as one of the world’s top schools of architecture, planning, and design. It is a place of many “firsts”: the first department of architecture in the United States — which this year is celebrating the 150th anniversary of its first graduating class — and the oldest continuously running department of urban studies and planning. SA+P was also the first academic center for real estate to offer a professional degree and the first school to graduate an African-American architect (Robert Robinson Taylor in 1892). 

“For more than a century, SA+P has been turning out some of the most influential figures in architecture and design. Today, our students, faculty, and alumni are the leading voices in their fields, offering inspiring new visions for the built environment, a livable planet, and the innovation economy,” says Hashim Sarkis, dean of SA+P. “With the extraordinary support of the Thains, the Metropolitan Warehouse renovation project is poised to add fresh energy to this impactful work, generating opportunities for design research and education and creating a new gateway for MIT.” 



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3 Questions: Catherine Nikiel on tackling global climate change at the regional scale

Global climate change is a serious concern for the future of our entire planet. However, the regional impacts of climate change are often overlooked. Catherine Nikiel, a PhD student in the Department of Civil and Environmental Engineering, is studying the impact of climate change on different aspects of the hydrological cycle as part of her research in the lab of Breene M. Kerr Professor Elfatih Eltahir. Nikiel studies the impact of land-use change on regional climate in the midwestern United States. In particular, Nikiel examines agricultural changes over the past century, contributing to climate change, such as the expansion of agriculture, increases in productivity, and the expansion of irrigation. 

Q: What are the real-world implications of your research?

A: My PhD work focuses on what climate change will do to humid heat waves and droughts, looking specifically at the Great Plains and the Midwest region. It is important to understand what the impacts are going to be at smaller scales, because that is where the adaptation is going to take place.

Understanding how climate change will affect various areas at a regional scale makes it easier to communicate what the effects are going to be for communities. These areas are going to experience more heat waves, the potential of drought is going to increase, and we have to ask what the lasting impact is going to be for a community or even a group of multiple states; or what that means for an economic sector. 

Droughts and heat waves are extremely damaging for crops; and the Midwest is the corn belt of the United States, which is important because a great deal of corn and soybean is exported both nationally and internationally. It is important to make climate change tangible, and link the potential damages to those impacts. 

Q: What opportunities have you had to delve deeper into your research?

A: Since being at MIT, I have had the chance to explore ways that climate, water, and agriculture all come together in very specific ways. For example, this past spring, Professor Eltahir put together a workshop called “The Future of the Nile Water.” There’s conflict about the Nile River because it is the only water resource in a dry area, and it is shared between many different countries. There is a lot of interest in how factors such as water, population growth, climate change, and agricultural expansion will influence these countries.

The workshop invited journalists, academics, and industry professionals from Egypt, India, and Sudan to talk about the issues that could arise in the future, and some of the factors that are important to bring into the discussion now such as climate change, population growth, and agricultural productivity. The forum discussed these considerations and how to identify how they’re interconnected. 

The goal is to take climate change impacts and make them tangible for a specific issue and region. Prior to the forum, we were each assigned a topic and researched that area for six-weeks, familiarizing ourselves with the region, the history, and the science. The workshop lasted two days, and it was our chance to bring together the knowledge we had collected, and also learn from the attendees of the workshop who are from those regions; who are dealing with those issues, and are the ones who are really familiar with the situation. We learned that it is not just a resource issue — it is a social, political, and economical issue. The forum showed us the importance of having the voices that truly experience these issues first-hand present. 

I have also had the opportunity to work with climate models, which I have had never used prior to MIT. We hear about the impacts of what climate change is going to do, and it’s interesting to see what comes before the IPCC (Intergovernmental panel on climate change) reports, and understand how the models are made, and how to apply them appropriately.

Q: What’s the next step for you?

A: What I ultimately want to do, and what I studied as an undergraduate, is focusing on the impacts of hurricanes. Since moving to MIT, I have been interested in how communities can be more resilient towards natural disasters. Understanding how climate change is going to impact virtually every system is so important in helping communities build resilience. We can’t only plan for what is happening now, we need to plan for what might happen in the future. When planning for the future, it is crucial to consider how communities and climate might evolve. 

When I leave MIT, I want to continue to do something that helps cities, states and countries become more resilient. I am really interested in coastal communities, which I think stems from my initial interest in hurricanes. I spent a lot of time in Houston, a city that deals with water in all of its forms, and I have seen firsthand how natural disasters can affect a city. It is something that’s going to have to be dealt with, and something of interest to me. As a response to climate change, mitigation is important, but adaptation is even more important and not something that can be avoided. I see myself doing something more policy focused. I am unsure if that will be in the public sector or industry, I am not tied down to the exact sector, but whatever is going to be most impactful interests me the most. 



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Accelerating 3-D printing

Recent work from an MIT lab may help 3-D printing fulfill its long-standing promise to transform manufacturing by enabling the rapid design and production of customized and complex objects.

The key to 3-D printing is the printhead, which deposits successive layers of material onto a surface until the final three-dimensional object is complete. The researchers have designed a novel printhead that can melt and extrude material with unprecedented speed, creating a complex handheld object in a few minutes rather than the hour required by a typical desktop 3-D printer. The researchers have also demonstrated a room-temperature process for 3-D printing with cellulose — a renewable, biodegradable alternative to the plastics that are now generally used. To show the chemical flexibility of cellulose, they’ve mixed in an antimicrobial dye and printed a pair of bacteria-resistant surgical tweezers.

Imagine a world in which objects could be fabricated in minutes and customized to the task at hand. An inventor with an idea for a new product could develop a prototype for testing while on a coffee break. A company could mass-produce parts and products, even complex ones, without being tied down to part-specific tooling and machines that can’t be moved. A surgeon could get a bespoke replacement knee for a patient without leaving the operating theater. And a repair person could identify a faulty part and fabricate a new one on site — no need to go to a warehouse to get something out of inventory.

Such a future could be made possible by 3-D printing, says A. John Hart, an associate professor of mechanical engineering and director of the Laboratory for Manufacturing and Productivity and the Mechanosynthesis Group at MIT.

“3-D printing compels us to rethink how we develop, produce, and service products,” he says.

A common method of 3-D printing, extrusion, starts with a polymer rod, or filament. The filament is heated, melted, and forced through a nozzle in a printhead. The printhead moves across a horizontal surface (the print bed) in a prescribed pattern, depositing one layer of polymer at a time. On each pass over the print bed, instructions tell the printhead exactly where material should and shouldn’t be extruded so that, in the end, the layers stack up to form the desired, freestanding 3-D object.

“So rather than starting with a solid block and grinding material away, in 3-D printing — also called additive manufacturing — you start with nothing and build up your object one layer at a time,” Hart explains.

Engineers have used 3-D printing as a tool for rapid prototyping since its invention some three decades ago, but in recent years its use has expanded. Hart credits that expansion to better 3-D printers, but also to the widespread adoption of computer-aided design, or CAD, and emerging software tools for 3-D shape optimization. Today’s designers can use CAD software to create a virtual 3-D model of their targeted product, and in the process they generate a digitized description of it.

That description can feed into software that develops the instructions for controlling the path of the 3-D printer. As a result, designers no longer have to confine themselves to structures that can be made by machining or molding. “For instance, you can make an airplane seat with a complex internal structure that makes it light and saves fuel in flight,” notes Hart.

Even though it has made great strides, 3-D printing is still a long way from what Hart envisions it can be. Two recent advances out of his lab may help accelerate the adoption of 3-D printing: A machine that can print hand-held objects far faster than today’s desktop 3-D printers can, and a process for using cellulose as an inexpensive, biorenewable replacement for the usual plastics.

Sources of the slowdown

To find out what slows down current 3-D printers, Hart teamed up with Jamison Go SM ’15, who now a mechanical engineer at Desktop Metal, and Adam Stevens SM ’15, a doctoral student in Hart’s lab, to examine several commercial, extrusion-based desktop models. They concluded that their so-called volumetric building rates were limited by three factors: how much force the printhead could apply as it pushed the material through the nozzle; how quickly it could transfer heat to the material to get it to melt and flow; and how fast the printer could move the printhead.

Based on those findings, they designed a machine with special features that address all three limitations. In their novel design, a filament with a threaded surface goes into the top of the printhead between two rollers that keep it from twisting. It then enters the center of a rotating nut, which is turned by a motor-run belt and has internal threads that mesh with the external threads on the filament. As the nut turns, it pushes the filament down into a quartz chamber surrounded by gold foil (see Figure 1 in the slideshow above). There, a laser enters from the side and is reflected by the gold foil several times, each time passing through the center of the filament to preheat it. The softened filament then enters a hot metal block, which heats it further (by conduction) to a temperature above its melting point. As it descends, the molten material is further heated and narrowed and finally extruded through a nozzle onto the print bed.

That design overcomes the limits on force and heating that slow current 3-D printers. In a standard printer, the filament is pushed by two small, rotating wheels. Add more force to speed things up, and the wheels lose traction and the filament stops moving. That’s not a problem with the new design. Matching the threads on the filament and the nut ensures maximum contact between the two. As a result, the system can transfer a high force to the filament without losing its grip.

The standard printer also relies on thermal conduction between the moving filament and a heated block, and that process takes time. At a higher feed rate, the core may not completely melt, with two impacts: Pushing the material through the nozzle will be harder, and the extruded material may not adhere well to the previously deposited layer. Preheating the filament with a laser ensures that the filament is thoroughly melted by the time it reaches the nozzle.

Tests showed that their novel printhead can deliver at least two and a half times more force to the filament than standard desktop models can, and it can achieve an extrusion rate that’s 14 times greater.

Given such a high extrusion rate, the researchers needed to find a way to move the printhead fast enough to keep up. They designed a mechanism with a metal overhead suspension gantry that’s shaped like an “H” and has a continuous belt that travels around pulleys powered by two motors mounted on the stationary frame. The printhead sits atop a stage that’s connected to the belt and is carried quickly and smoothly through the prescribed positions within each plane.

To test the new gantry, the researchers subjected it to a battery of tests. In one, they commanded it to execute a continuous back-and-forth motion between two positions at various speeds and checked the consistency of where it ended up. Based on those challenges, the researchers concluded that the gantry was sufficiently fast and accurate to do the job.

Fabricating test objects

To demonstrate their system, the team printed a series of test objects, including those shown in Figure 2 in the slideshow above. Printing a pair of eyeglass frames took 3.6 minutes, a small spiral cup just over 6 minutes, and a helical bevel gear (a circular gear with angled teeth) about 10 minutes. Microscopic examination of the objects confirmed that the individual deposited layers were highly uniform at 0.2 mm thick, and tests of their mechanical properties confirmed that they were strong and robust.

The complex shape of the bevel gear made it a particularly good test subject. The interior surface is tapered such that the open space is wider at the bottom than the top. The researchers have produced even more complex shapes with greater interior openings, and the machine successfully created the thin, solid legs that are initially needed to provide support and are removed after the piece solidifies.

To better evaluate their printer, the researchers used it and several commercial desktop models to print the same object — a triangular prism 20 millimeters tall. For a comparable resolution (based on nozzle diameter and layer height), their printer achieved an average volumetric build rate up to 10 times higher than the desktop models. It even did three times better than an industrial-scale system that has a significantly larger printhead and motion system, and costs over $100,000.

The researchers have been identifying and tackling issues introduced by the high-speed deposition conditions. For example, at high build rates, they found that their layers didn’t adhere well and the shapes sometimes became distorted. Directing a controlled flow of cooling air onto newly deposited material solved those problems. They also determined that they should be able to improve the coupling between the laser and the filament, getting even more efficient heating. The team is also improving the system’s accuracy by coordinating the extrusion rate and printhead speed, and implementing new control algorithms for the printer.

The researchers aren’t ready to estimate the potential cost of their printer. Their prototype system costs about $15,000, two-thirds of which comes from the laser and motors. Thus, it’s unlikely to replace today’s personal desktop systems. But it should be cost-competitive with state-of-the-art professional systems while offering decreased operating costs from faster output.

Cellulosic feedstocks

Another critical component of Hart’s vision for 3-D printing is the ability to process materials that are abundant and environmentally friendly. Hart and Sebastian Pattinson, a former postdoc in mechanical engineering who is now a lecturer at the University of Cambridge in the U.K. demonstrated a technique using the world’s most abundant natural polymer: cellulose.

Cellulose offers many advantages over current plastics-based feedstocks: It’s inexpensive, biorenewable, biodegradable, mechanically robust, and chemically versatile. In addition, it’s widely used in pharmaceuticals, packaging, clothing, and a variety of other products, many of which could be customized using 3-D printing.

The problem is that past efforts to 3-D print cellulose have largely been unsuccessful. The abundant hydrogen bonding between the cellulose molecules — the thing that makes it strong in plants — makes it not conducive to 3-D printing. Heat up cellulose, and it decomposes before it becomes sufficiently flowable to extrude from the nozzle of a printhead.

To solve that problem, Hart and Pattinson worked with cellulose acetate, a chemically treated form of cellulose that has fewer hydrogen bonds. They first dissolve the cellulose acetate in an acetone solvent to form a viscous feedstock, which flows easily through the printer nozzle at room temperature. As the mixture spreads across the print bed, the acetone solvent rapidly evaporates, leaving behind the cellulose acetate. Immersing the finished cellulose acetate object in sodium hydroxide removes the acetate and restores the cellulose with its full network of hydrogen bonds.

Using that procedure, the researchers printed complex objects out of their cellulosic materials, and the mechanical properties of the parts were good. Indeed, after the sodium hydroxide treatment, their strength and stiffness — measured in any direction — were superior to those of parts made out of commonly used 3-D printing materials.

Hart also notes that cellulose provides chemical versatility. “You can modify cellulose in different ways, for example, to increase its mechanical properties or to add color,” he says.

One option the researchers explored was adding antimicrobial properties. They printed a series of disks, some from plain cellulose acetate and some with an antimicrobial dye added, and deposited a solution containing E. coli bacteria on each one. They then left some of the disks in the dark and exposed others to light from a fluorescent bulb like those used in laboratories and hospitals. Analysis of the bacteria surviving after 20 hours showed that the disks made with dye and exposed to the light had 95 percent fewer bacteria than the others. As a sample product, they printed surgical tweezers — an instrument that could be highly valuable in any surgical setting where ensuring sterility might be an issue.

Hart thinks that the opportunities offered by their cellulose printing process could be of commercial interest. It uses a commodity product that’s widely available and less expensive than the typical extrusion filament material. It takes place at room temperature, so there’s no need for a costly heat source such as the laser used in the novel printhead described earlier. And as long as the acetone is captured and recycled, the process is environmentally friendly.

One more ingredient

Hart hopes that these and other developments coming out of his lab will help advance 3-D printing. But there’s another critical element that’s needed: a workforce knowledgeable in both the technical and business aspects of additive manufacturing.

To that end, he teaches a graduate-level MIT class in additive manufacturing, which is proving highly popular; and in 2018, he launched an online professional course via MIT xPRO that enrolled nearly 1,200 people during its first run. He also offers a five-day, on-campus MIT Short Program that has attracted worldwide participants who want to learn about using additive manufacturing in their design and manufacturing operations.

He is now leading MIT’s new Center for Additive and Digital Advanced Production Technologies, and plans are in the works for symposia at which its members will share their knowledge, ideas, and experiences. The enthusiastic response to these offerings suggests that Hart’s vision of 3-D printing and digitized design and production may at last be on its way to becoming a reality.

The research was supported, in part, by Lockheed Martin Corporation. Sebastian Pattinson was supported by a National Science Foundation Science, Engineering, and Education for Sustainability postdoctoral fellowship. 

This article originally appeared in the Autumn 2018 issue of Energy Futures, the magazine of the MIT Energy Initiative.



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Populism: a case-by-case study

Discussions about populism have been front and center in recent societal debates — online, in the news, and in social settings. The subject has also drawn intense interest from academics and brought attention to those who have studied the phenomenon over the years.

While many people associate the populist wave with current political leaders, such as Donald Trump in the United States, Nigel Farage in the U.K., and Marine Le Pen in France, its current manifestation has roots in movements, beliefs, and deficiencies in the liberal democratic order that predate these leaders' rise to power.

For many countries experiencing an increase in support for populist ideas — or in the more extreme cases, whose current leader or leading party is of the populist mold — it represents a very acute risk, one that has endangered basic civil liberties and societal harmony, and has seen hateful and intolerant rhetoric permeate the public sphere.

At its latest Starr Forum, MIT’s Center for International Studies brought together a panel of academics whose work has focused on some of the most extreme forms of populism seen in the past years, and whose leaders have become synonymous on a global level with the state capture that is part and parcel of governments led by populists.

The three countries — Brazil, India, and Turkey — share certain characteristics. All of them are very influential in their part of the world, both in size and political clout. They are all emerging economic powerhouses, and they all boast ethnically diverse populations. In their presentations in front of the MIT public, the speakers, all academics who are either from these countries or have studied them over a long period of time, highlighted the way in which the current populist governments slowly accumulated power and made use of the deficiencies in their societies to amass wide voter support.

General overview

Pippa Norris, the Paul F. McGuire Lecturer in Comparative Politics at the Harvard Kennedy School, explained the rise in support for populist parties as a result of what she called a “cultural backlash” leveled at the mainstreaming of progressive and liberal values. According to Norris’ research with Ronald Inglehart, to be published soon in a book titled “Cultural Backlash: Trump, Brexit, and Authoritarian Populism,” this wave of populist support is buttressed by social conservatives who are uncomfortable with cosmopolitan lifestyles that encourage diverse sexual and gender identities, as well as other markers of progressive thinking.

This group supports authoritarian populists and strongmen, she said, because they offer forms of “tribal protection” against “perceived risks of instability and disorder,” and feed into their insecurities by promoting a hostile approach towards “outsiders” such as immigrants, people of religious or ethnic backgrounds different from their own. These parties and leaders react to perceptions of cultural threat, and they in turn offer the leaders their loyalty in the voting booths.

Norris explained that this is the main reason for an increase in populist support for leaders like Trump, Farage, and Le Pen.

Brazil: a sharp turn to the far right

“Brazil’s perfect storm of negative trends began in the late 2000s, which led to the ascension of the radical right,” explained Elizabeth Leeds, a research affiliate of the Center for International Studies, is a leading expert on police reform and issues of citizen security in Brazil. Leeds has conducted research on these topics over the last four decades. “The economic downturn and the subsequent recession starting around 2013 due in part to the worldwide drop in petroleum prices — petroleum is one of the engines of the Brazilian economy — and China’s economic retrenchment which caused drops in Brazilian exports to China, led to a sense of hopelessness and unemployment, especially amongst the Brazilian youth that had recently graduated from college.”

In the mid-20th century, Brazil emerged from a military coup and subsequent military dictatorship as a country that largely voted for left-wing or left-leaning parties. The progressive spirit of these parties embraced its rich cultural composition and included many welfare programs to pull its most disenfranchised segments of society out of poverty. The deficiencies of these policies — lack of equal distribution of resources — proved to be its undoing.

“The Workers Party, what it had become famous for and praised in its first eight years, its redistributor policies, its poverty alleviation programs, the Bolsa Familia, racial justice, gender equality, LGBT rights, gay marriage — all of these policies became fodder for those who were not benefitting from economic redistribution and were resentful at the attempt for racial justice,” Leeds said.

The founder of Brazil’s previous ruling party, Luiz Inacio Lula da Silva or “Lula”, and the creator of its landmark social welfare programs, was found to have been part of a massive corruption scandal and initially wanted to run his campaign from prison, where he is currently serving a sentence.

“The massive corruption scandal that occurred on the Worker Party’s watch and involved all parties [severely damaged their electoral success],” Leeds explained. “This provided further pretext for attacking the Worker’s Party and its redistributor policies.”

“The increase in violent crime, prison rebellions and the spread of organized criminal activity in the country, led people to search for a savior,” she said.

In this chaos, Jair Bolsonaro, the head of the Social Liberal party and a former military officer, provided an appealing contrast to everything the Worker’s Party represented. Fernando Haddad was put forward as the candidate of the Worker’s Party. While having a clean slate, he did not offer the appeal of “Lulism” and did not offer strong opposition to Bolsonaro.

The news that Bolsonaro won the October presidential elections with 55 percent of the vote was met with shock in intellectual and political circles around the world and led to headlines claiming that Brazil had “elected a fascist” to office. Bolsonaro has openly praised Donald Trump’s foreign policies, has said that women and men should not be paid the same salaries, and is thought to be against progressive policies towards the LGBT community in the country.

Of the things he is expected to reverse during his policy, Leeds explains that his lack of commitment to the Amazon and wildlife reserves in the country is causing the most outrage.

“The most acute issues that people are aware of and afraid of are reversal in economic regulations especially in the Amazon. He is planning to reverse may of the indigenous reserves to expand agricultural development and mining,” Leeds said.

He also wants to quash dissent, by “criminalizing social movements,” she said.

“The well-known MST or Landless Workers Movement may be prosecuted under the anti-terrorism laws,” said Leeds, who believes Bolsonaro also wants to quash the liberal ideas that seem as if they support his predecessor’s beliefs. “He has attempted to constrain academic expression or ideological expression labelled communist, he has asked students to report professors for spreading objectionable or ideological speech. The protection of minority rights, gender rights, is in jeopardy.”

India: a reversal of diversity

Sana Aiyar, an associate professor of history at MIT, explored the ways in which populist nationalism has reversed the progressive and inclusive policies of post-independence India, and the way it clashes with the beliefs of the post-colonial secular and supra-ethnic state.

India’s current Prime Minister, Narendra Modi, of the Bharatiya Janata Party or BJP, is a proponent of the belief that India should be ruled by its Hindu-centered party and that ethnic and religious minorities, such as the Muslim population, should not have a central role in the government.

“Modi turned his back on India’s spirit of tolerance, its inclusive pluralism,” said Aiyar of Modi’s beliefs. “When India declared independence in 1947 ... the nationhood of India was defined by its equality and diversity.”

India’s first post-independence Prime Minister, Jawaharlal Nehru of the Indian National Congress, insisted on an Indian identity that was secular — thus eradicating, at least in the political sphere, the ethnic differences between the various religious groups in the country. However, in a large country with many states composed of different groups, this status quo was difficult to maintain. 

“The Indian National Congress (INC), the party that ruled India in its post-independence period began to decline in the 1960s and 1970s as regional populist parties began to form,” explained Aiyar. “Through the 1990s and 2000s two major changes took place. First the Congress itself began to decline, primarily in the states where regional parties began emerging at the state level, and eventually at the national level.” 

From the late 1990s onwards, there was a change and a shift towards coalition governments. The INC and the BJP would form alliances with these regional parties that had been emerging over the years. In 1991, India shifted from a socialist to a neoliberal country through economic reforms, and the Indian middle class began expanding.

One of the promises of these reforms, Aiyar said, is “that the economy will be depoliticized. That the institutions will be the mediators between the public and the state.”

“As this unravels in the 2000s, growth falls from around 7 percent at the turn of the century, there is rising inequality, and there is a sense that aspirations were not fulfilled,” sais Aiyar, explaining the spread of disenchantment across the country. “The institutions begin being seen, at best, as ineffective and at worst as incredibly corrupt, the INC blames this on coalition politics and regional parties.”

“The one state that began defying this all-India trend of inefficiency, corruption and lack of development is Gujarat, where Narendra Modi had been the Chief Minister since 2001. He builds up a reputation as being pro-business, as being an extremely effective leader, attracting huge foreign investments,” Aiyar continued.

“Modi, with his strong record, transforms his anti-corruption movement into an anti-Congress one. He cast the Congress leaders as being very out of touch with the nation,” he said. “The Congress was cast as corrupt, out of touch with the pulse of the nation, its leaders as elites. Congress beliefs, such as socialism, secularism, and the focus on diversity were depicted as being Western or English notions of the nation.”

Modi was part of a group of politicians in India at the time who were offering various definitions of populism. The approaches attempted to define Indian nationhood, and his belief centred around the fact that India should be dominated by its majority ethnic and religious group.

Modi supported “the idea that a nation’s political destiny is [should] be determined by its religious and ethnic majority,” Aiyar said.

“Majoritarianism has two components that one should keep in mind. It differentiates between citizens – those who are seen as having the majority faith are seen as being true citizens, the sons of the soil. The rest are minorities or courtesy citizens,” he said. “For the first years after independence, by defining India as secular rather than Hindu, Nehru manages not to commit India to the decolonization’s original sin. India defines herself not as majoritarian — not because these tendencies didn’t exist but precisely because there were these notions that had existed from the 1920s onwards.”

In many countries around the world, populist politicians attempt to instill the fear amongst the majority populations or ethnic groups — those they rely on for electoral victories — that they are being threatened by a minority or that they have to “appease” to them rather than assert their dominance, Aiyar said. In many of these countries, the minority populations can be first-generation immigrants; religious, ethnic or linguistic minorities that have always been present in the country or those who plan to move there in larger numbers for academic or work opportunities.

For Modi, promoting the idea that only Hindus were truly autochthonous in India since it was the birthplace of Hinduism helped him secure a win in 2014 and continues to be a hallmark of his mandate as prime minister. Aiyar described the ideology as emphasizing “a common fatherland, and a common holy land. This meant that all Hindus are Indians and that minorities, for whom the holy land lays in the west, are seen as somewhat suspect.”

Turkey: a blueprint for populism

Turkey’s president Recep Tayyip Erdogan has been making headlines in the past couple of years as his authoritarian grasp on the country grows stronger. His Justice and Development Party, or AKP in Turkish, has become the largest party in the country and promotes a conservative platform that insists on an Islamic identity for Turkey and fondly looks back at the Ottoman Empire, the predecessor of modern Turkey that controlled vast territories in the Balkans and the Middle East.

Intially seen as a reformer when he started making gains on the political scene in the early 2000s, Erdogan has asserted his dominance by weakening Turkey’s strong military, which promoted the country’s secularism in the 20th century, and by expanding the powers and mandate of the president in a referendum held last year.

His mandate has seen a crackdown on critical journalists, NGOs, and academics, and he has persecuted opponents both within the country and abroad. Aysen Candas, an associate professor at Bogazici University and a visiting associate professor at Yale University, explained what she called the core components of “a successful populist takeover.”

According to Candas, the populist checklist includes certain key components. “Secularization, no matter what religion the country is based on, is detrimental for the constitutional order of the country,” she said. For populists, constitutions are not binding. “When movements that rely on a majority’s identitarian claims monopolize power, they acquire the ability to reverse the accomplishments of constitutional democracies, no matter how weak or strong these accomplishments may be.”

Another component is that populism is only a transitional phase. “Turkey’s experience with unhinged advanced populism proves that populism is a temporary phase, a snapshot, within the [counter]revolutionary transformation process of constitutional states, into right-leaning totalitarianisms,” she said. “The only remedy against it is forging a common front.”

Candas explains that populism comes from a feeling of insecurity, where people feel that opportunities they are given in life are becoming constrained.

“They respond to the shrinking or uncertainty of the economic pie, and the associated crisis of solidarity in the most regressive manner,” she said. “Populism's political proposal consists of a counterrevolution, against egalitarian, liberal democratic sources of political legitimacy to reinstall status hierarchies.”

Candas said populist ideologies and influences should not be taken lightly. “The ideology of populists must be taken very seriously, as they do fulfil their campaign promises and they are not short-termers but marathon runners.”

The Turkey of the 20th century was a modern, secular country that consciously split from its Islamic identity following the fall of the Ottoman Empire. “A Pew Research study, repeated every year, shows that only 12 percent of the people in Turkey want to live under Islamic rule. The rest, the majority, want to live in a secular society. How could it then be that political Islamists monopolized power in Turkey? The short answer to that question is that the majority failed to forge a common front.”

The two main fault lines along which the country is divided include the religion issue, but also the question of the large Kurdish minority, consisting of 20 percent of the population. “Since the 1980s there is an ongoing kulturkampf on two major fault lines in Turkey. The first one is on the Kurdish issue,” she said. "Recognition of Kurdish identity, some form of regional autonomy, equal representation, and the unsurmountable 10 percent threshold that was put into practice in 1983 to prevent Kurdish parties from entering the parliament.” 

“This threshold grossly skewed every election result, so much so that in 2002 AKP came to power with 34 percent of the vote, which translated into 66 seats in the parliament,” Candas explained. “The electoral threshold designed by the military in the 1990s, that was designed to keep Kurds out, let Islamists in.”

“The second question is that of the secular republic or Sharia-based monarchy. These two fault lines cross-cut each other, in the sense that many Turkish secularists, who are for example gender and LGBTQ egalitarians turn into illiberal authoritarians on the Kurdish issue because they suspect that granting Kurds cultural rights and autonomy will lead to the partition of the country.”

“Similarly, the intensely religious portion of the Kurds supported and still support the Islamist party even when repressive policies remain in place,” she said.



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SilverSneakers exercise program fights isolation

As the holiday season prompts many Americans to think about signing up for health club memberships in the new year, it may help them to know that the gym may contain more virtues than simply helping work off that third serving of mashed potatoes. Researchers from the MIT AgeLab and Tivity Health have published an article in the Journal of Applied Gerontology that describes the social benefits of a national exercise program for older adults.

Social isolation has grown into a major public health issue, having been shown to affect mortality in equivalence to major risk factors like obesity, smoking, and cardiovascular disease. The problem is especially salient within the field of gerontology: Older adults may be particularly vulnerable to isolation due to retirement, the loss of a spouse, or declining health and mobility.

Despite having a clear impact on health, social isolation cannot be treated as an ordinary health issue. Targeted interventions to reduce isolation are questionable in their effectiveness, not least because they tend to draw middling interest from the individuals they are supposed to help.

“No one wants to raise their hand and announce to the world, ‘I’m lonely,’” says Samantha Brady of the MIT AgeLab, the lead author of the study. “There is a stigma to social isolation that makes it hard to tackle head-on.” 

SilverSneakers is a national exercise program that provides free gym memberships and specialized fitness classes to older adults with certain Medicare Advantage insurance plans. MIT researchers hypothesized that SilverSneakers, while not designed expressly to reduce social isolation, would improve participants’ levels of social engagement by bringing them into the social environment of the gym, and by promoting activity in general.

Cross-sectional data were obtained for the study through an online survey that was sent to about 1,000 SilverSneakers members and 2,000 non-members. The researchers sought to model and observe the relationships between SilverSneakers membership, physical activity, social isolation, loneliness, and self-reported health. The results showed that SilverSneakers membership had direct beneficial impacts on physical activity, social isolation, and health, as well as intermediary benefits for health through reduced social isolation, loneliness, and increased physical activity. The research was supported, in part, by Tivity Health.

“Everyone recognizes the gym as a pro-health environment, but the mechanisms by which fitness program membership benefits health for older adults are more varied than mere exercise alone,” says study co-author Lisa D’Ambrosio.

The identification of SilverSneakers as an intervention for social isolation raises further questions about what environmental mechanisms foster social engagement among older adults and whether other large-scale programs may have similar benefits.

“Old age doesn’t have to be a sentence for solitude, but we have yet to sufficiently develop places and spaces where older adults can come together and belong,” says Joseph F. Coughlin, director of the MIT AgeLab. “This study points us toward one powerful way of engaging the 65-plus population, a group that in the coming years is sure to demand more meaningful activities and experiences as they age.”

As older Americans plan their New Year’s resolutions, these results may give them yet another reason to add exercise to their list.



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Measuring cancer cell “fitness” reveals drug susceptibility

By studying both the physical and genomic features of cancer cells, MIT researchers have come up with a new way to investigate why some cancer cells survive drug treatment while others succumb.

Their new approach, which combines measurements of cell mass and growth rate with analysis of a cell’s gene expression, could be used to reveal new drug targets that would make cancer treatment more effective. Exploiting these targets could help knock out the defenses that cells use to overcome the original drug treatment, the researchers say.

In a paper appearing in the Nov. 28 issue of the journal Genome Biology, the researchers identified a growth signaling pathway that is active in glioblastoma cells that are resistant to an experimental type of drug known as an MDM2 inhibitor.

“By measuring a cell's mass and growth rate immediately prior to single-cell RNA-sequencing, we can now use a cell’s ‘fitness’ to classify it as responsive or nonresponsive to a drug, and to relate this to underlying molecular pathways,” says Alex K. Shalek, the Pfizer-Laubach Career Development Assistant Professor of Chemistry, a member of MIT’s Institute for Medical Engineering and Science (IMES), an extramural member of the Koch Institute for Integrative Cancer Research, and an associate member of the Ragon and Broad Institutes.

Shalek and Scott Manalis, the Andrew and Erna Viterbi Professor in the MIT departments of Biological Engineering and Mechanical Engineering and a member of the Koch Institute, are the senior authors of the study. The paper’s lead author is Robert Kimmerling, a recent MIT PhD recipient.

Cancer cell analysis

About a decade ago, Manalis’ lab invented a technology that allows researchers to measure the mass of single cells. In recent years, they have adapted the device, which measures cells’ masses as they flow through tiny channels, so that it can also measure cell growth rates by repeatedly weighing the cells over short periods of time.

Last year, working with researchers at Dana-Farber Cancer Institute (DFCI), Manalis and his colleagues used this approach to test drug responses of tumor cells from patients with multiple myeloma, a type of blood cancer. After treating the cells with three different drugs, the researchers measured the cells’ growth rates and found they were correlated with the cells’ susceptibility to the treatment.

“Single-cell biophysical properties such as mass and growth rate provide early indicators of drug response, thereby offering the potential to delineate sensitive cells from resistant cells while they are still viable,” Manalis says.

In their new study, the researchers wanted to add a genomic component, which they hoped could help reveal why only certain cells are susceptible to a particular drug. “We wanted to be able to take those measurements and add on some of the biological context for why a cell is growing a certain way or behaving a certain way,” Kimmerling says.

To accomplish this, Kimmerling and Manalis teamed up with Shalek, who has extensive experience in sequencing the messenger RNA (mRNA) of individual cells. This information can provide a snapshot of which genes are being expressed in a single cell at a particular moment.

The researchers modified the cell-weighing system so that cells would be spaced evenly as they flowed through, making it easier to collect them one at a time when they exit the system. The cells are weighed several times over the course of 20 minutes to determine growth rate, and as soon as they reach the end of the channel, they are immediately captured and ruptured to release their RNA for analysis. Shalek’s lab then sequenced the RNA of each of the cells. This approach enabled the mass and growth rate of each cell to be directly linked to its gene expression.

Once they had the system working, the researchers collaborated with Keith Ligon and his lab at DFCI to analyze cancer cells derived from a patient with glioblastoma, an aggressive type of brain cancer. The researchers treated the cells with an MDM2 inhibitor, a type of drug that helps to boost the function of p53, a protein that helps cells stop tumor formation. Such drugs are now in clinical trials to treat glioblastoma. In animal studies, this drug has been effective against tumors, but the tumors often grow back later. 

In this study, the researchers hoped to find out why some glioblastoma cells survive MDM2 treatment. They treated the cells, measured their growth rates about 16 hours after the treatment, and then sequenced their RNA. “Before the cells have lost viability, we can measure their mass and their growth rate to reveal drug response heterogeneity to that treatment, and then link that with their gene expression,” Kimmerling says.

Importantly, the researchers found subpopulations of cells that were not responsive to the drug. RNA sequencing revealed that in cells that were responsive, genes required for programmed cell death were turned on. Meanwhile, in cells that did not seem to be vulnerable to the drug, genes involved in mTOR, a signaling pathway involved in growth and survival, were turned up.

“What we’re excited about here is we now have this list of biological targets to look into,” Kimmerling says. “We can start to generate testable hypotheses from these gene expression signatures that are more highly expressed in the cells that continue to grow after drug treatment.”

Possible drug targets

The researchers now plan to explore the possibility of targeting some of the genes that were turned up on the nonresponding cells, in hopes of developing drugs that could be used together with the original MDM2 inhibitor. They also hope to adapt this approach for other types of cancers. Some, such as blood cancers, are easier to study than solid tumors, which are more difficult to separate into single cells.

“The hope is that we’ll be able to apply this technology to any sample that can be dissociated into a single-cell population,” Kimmerling says.

Another possible application of the cell-growth measurement technology is studying tumor cells from individual patients to try to predict how they will respond to a particular drug. Kimmerling, Manalis, and others have founded a company called Travera, which has licensed the technology and hopes to develop it for patient use. The company is currently not working on the RNA sequencing aspect of the technology, but that element could also be valuable to incorporate in the future, Kimmerling says.

The research was funded by the Cancer Systems Biology Consortium U54 Research Center and the Cancer Center Support (core) Grant from the National Cancer Institute; the Searle Scholars Program; the Beckman Young Investigator Program; the National Institutes of Health, including an NIH New Innovator Award; the Pew-Stewart Scholars; and a Sloan Fellowship in Chemistry.



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With these nanoparticles, a simple urine test could diagnose bacterial pneumonia

Pneumonia, a respiratory disease that kills about 50,000 people in the United States every year, can be caused by many different microbes, including bacteria and viruses. Rapid detection of pneumonia is critical for effective treatment, especially in hospital-acquired cases which are often more severe. However, current diagnostic approaches often take several days to return definitive results, making it harder for doctors to prescribe the right treatment.

MIT researchers have now developed a nanoparticle-based technology that could be used to improve the speed of diagnosis. This type of sensor could also be used to monitor whether antibiotic therapy has successfully treated the infection, says Sangeeta Bhatia, the John and Dorothy Wilson Professor of Health Sciences and Technology and Electrical Engineering and Computer Science and the senior author of the study.

“If the patient’s symptoms go away, then you assume the drug is working. But if the patient’s symptoms don’t go away, then you would want to see if the bacteria is still growing. We were trying to address that issue,” says Bhatia, who is also a member of MIT’s Koch Institute for Integrative Cancer Research and Institute for Medical Engineering and Science.

Graduate student Colin Buss and recent PhD recipient Jaideep Dudani are the lead authors of the paper, which appears online Nov. 29 in the journal EBioMedicine. Reid Akana, an MIT senior, and Heather Fleming, director of research for Bhatia’s lab, are also authors of the paper.

Sensors in the body

Several years ago, Bhatia and her colleagues developed a diagnostic approach that amplifies a signal from biomarkers already present in the body — specifically, enzymes called proteases, which chop up other proteins. The human genome encodes more than 500 different proteases, each of which targets different proteins.

The team developed nanoparticles coated with peptides (short proteins) that can be chopped up by certain proteases, such as those expressed by cancer cells. When these particles are injected into the body, they accumulate in tumors, if any are present, and proteases there chop the peptides from the nanoparticles. These peptides are eliminated as waste and can be detected by a simple urine test.

“We’ve been working on this idea that measuring enzyme activity could be a new way to peer inside the body,” Bhatia says.

In recent studies, she has shown that this approach can be used to detect different types of cancers, including very small ovarian tumors, which could enable earlier diagnosis of ovarian cancer.

For their new study, the researchers wanted to explore the possibility of diagnosing infection by detecting proteases that are produced by microbes. They began with a species of bacteria called Pseudomonas aeruginosa, which can cause pneumonia and is a particularly common cause of hospital-acquired cases. Pseudomonas expresses a protease called LasA, so the researchers designed nanoparticles with peptides that can be cleaved by LasA.

The researchers also developed a second nanoparticle-based sensor that can monitor the host’s immune response to infection. These nanoparticles are covered in peptides that are cleaved by a type of protease called elastase, which is produced by immune cells called neutrophils.

In some patients with pneumonia, even if an antibiotic clears out the bacteria causing the infection, a chest X-ray may still show inflammation because neutrophils are still active. Using these two sensors together could reveal whether an antibiotic has cleared the infection, in cases where a chest X-ray still shows inflammation after treatment.

“The sensors can help you distinguish between whether there’s an infection and inflammation, versus inflammation and no infection,” Bhatia says. “What we showed in the paper is that when you treat with the right antibiotic, the infection goes down but the inflammation persists.”

The researchers also showed that if they treated mice with an ineffective antibiotic, both bacteria levels and inflammation levels stayed high. This kind of test could help to reveal whether an antibiotic is working, in cases where a patient’s symptoms haven’t improved within a few days.

Diagnosing many infections

For this study, the researchers delivered the nanoparticles intravenously, but they are now working on a powdered version that could be inhaled.

Bhatia envisions that this approach could be used to determine whether a patient has bacterial or viral pneumonia, which would help doctors to decide if the patient should be given antibiotics or not. The definitive test, growing a bacterial culture from coughed up mucus, takes several days, so doctors base their decisions on the patients’ symptoms and X-ray imaging — a process that may not always be accurate.

To create a more comprehensive diagnostic, Bhatia’s lab is now working on adding peptides that could interact with proteases from other types of bacteria that cause pneumonia, as well as proteases that the host immune system produces in response to either viral or bacterial infection. The researchers are also working on sensors that could easily distinguish between active and dormant forms of tuberculosis.

Bhatia and others have started a company called Glympse Bio that has licensed the protease sensing technology and is now working on developing protease sensors for possible use in humans. Next year, they plan to begin a phase I clinical trial of a sensor that can detect liver fibrosis, an accumulation of scar tissue that can lead to cirrhosis. 

The research was funded by the Koch Institute Support (core) Grant from the National Cancer Institute, the Core Center Grant from the National Institute of Environmental Health Sciences, and the National Institute of Allergy and Infectious Diseases.



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Jacqueline Hewitt to step down as director of the MIT Kavli Institute

Jacqueline Hewitt, the Julius A. Stratton Professor in Electrical Engineering and Physics, will step down as director of the MIT Kavli Institute for Astrophysics and Space Research, effective Jan. 16, 2019. 

“In her more than 15 years in charge of Kavli, Jackie has demonstrated superlative leadership, offered sage advice, and provided tireless service to the institute, the school, MIT, and the entire astrophysics community,” Dean of the School of Science Michael Sipser says. “On behalf of us all, I thank her for her service and for her stellar career as director of Kavli.” 

With Hewitt at the helm, the MIT Kavli Institute saw its first major private foundation investment. Working with Robert Silbey, former dean of the School of Science, and Marc Kastner, former head of the Department of Physics, Hewitt developed a successful proposal to the Kavli Foundation that brought resources and an intellectual focus to the astrophysics faculty and research staff at MIT. 

As a result of the gift, the Center for Space Research (CSR) was renamed the MIT Kavli Institute for Astrophysics and Space Research (MKI) and established an endowment for the new institute. With additional funding from the Kavli Foundation and matching gifts from the Heising–Simons Foundation and others, MKI now has an endowment that can support long-range basic research projects as well as risky, high-payoff research areas that are difficult to support in other ways. 

“With her extraordinary talent for integrating the ideas of faculty into a coherent vision, Jackie enabled a high-profile, world-class research program at Kavli that spanned fundamental physics, astrophysics and extrasolar planets,” says Maria Zuber, vice president for research and the E.A. Griswold Professor of Geophysics.

During the past five years, Hewitt has led a large expansion in MIT’s program in exoplanets — planets orbiting stars other than our sun. With George Ricker acting as principal investigator and Professor Sara Seager as MIT science lead, Kavli successfully proposed a satellite mission, the Transiting Exoplanet Survey Satellite (TESS), to NASA. Significant investment in CCD detectors and optical instrumentation enabled TESS to succeed in the NASA competition, eventually bringing $100 million in research funding to MIT that supported mission development on campus and at Lincoln Laboratory. 

“TESS was launched this past April, and the exoplanet science program at MIT is thriving as the data from TESS’s four cameras pour in,” says Hewitt. 

Collaboration between Kavli and Lincoln Laboratory was critical to the success of TESS, and strengthening this partnership was one of Hewitt’s important initiatives while director. 

“Jackie was an amazing leader of MKI,” says Professor Peter Fisher, head of the MIT Department of Physics. “Her role in TESS was critical and it may not have happened without her.”

Although the Laser Interferometer Gravitational Wave Observatory (LIGO) and the advanced LIGO project was well underway before Hewitt took up her post, she worked with Professor Edmund Bertschinger and Fisher to fund and put in place laboratories and other infrastructure that helped to attract and retain critical faculty and research staff, and that helped LIGO achieve the sensitivity required for its scientific success. 

The detection of gravitational waves — a project 50 years in the making with contributions from more than 1,000 scientists within Kavli and around the world working within the LIGO Scientific Collaboration — earned Professor Emeritus Rainer Weiss a 2017 Nobel Prize.

Working to provide advice to the federal agencies that fund astrophysics research in the United States, Hewitt has made significant contributions to the process of setting priorities for the astrophysics community. She chaired the National Academy of Sciences’ panel on particle astrophysics and gravitation for the 2010 astrophysics decadal survey. In 2015 and 2016, she chaired the NAS’s midterm review of the funding agencies’ progress toward implementing the priorities of that decadal survey. 

Most recently, Hewitt has worked to develop Kavli’s program in studies of a milestone in the history of the universe: the birth of the first stars, known as the “cosmic dawn”, nearly 13 billion years ago. Major grants from the Gordon and Betty Moore Foundation and the National Science Foundation — coupled with support provided by the School of Science dean’s office and Maria Zuber, vice president for research — are enabling instruments at radio wavelengths and optical-infrared wavelengths to probe the conditions of the cosmic dawn 13 billion years ago, and chart the growth of structure and the chemical enrichment of the cosmos.

“I have truly enjoyed my time as MKI director, and have deeply appreciated the camaraderie of my fellow astrophysicists here at MIT and my research partners around the world,” says Hewitt, who begins her sabbatical in spring 2019. “I look forward to returning to my research full-time.”

Hewitt first joined MIT as a graduate student. She earned her PhD in 1986, completing the first large systematic survey of gravitational lenses for her doctoral thesis. The study of gravitational lenses, bends in light emitted from bright, distant objects created by massive objects, allowed scientists to better measure mass distribution at greater distances in space. After completing her PhD, MIT Haystack Observatory hired her as a postdoc in the Very Long Baseline Interferometry group. In 1989, after a brief stint at Princeton University, she joined the MIT faculty as an assistant professor of physics, where she continued to work on gravitational lenses, cosmology, and surveys of transient astronomical radio emission.

Former CSR Director Claude Canizares is chairing a search committee to advise Dean Sipser in selecting Hewitt’s successor as the next MKI director.



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What happens when materials take tiny hits

When tiny particles strike a metal surface at high speed — for example, as coatings being sprayed or as micrometeorites pummeling a space station — the moment of impact happens so fast that the details of process haven’t been clearly understood, until now.

A team of researchers at MIT has just accomplished the first detailed high-speed imaging and analysis of the microparticle impact process, and used that data to predict when the particles will bounce away, stick, or knock material off the surface and weaken it. The new findings are described in a paper appearing today in the journal Nature Communications.

Mostafa Hassani-Gangaraj, an MIT postdoc and the paper’s lead author, explains that high-speed microparticle impacts are used for many purposes in industry, for example, for applying coatings, cleaning surfaces, and cutting materials. They’re applied in a kind of superpowered version of sandblasting that propels the particles at supersonic speeds. Such blasting with microparticles can also be used to strengthen metallic surfaces. But until now these processes have been controlled without a solid understanding of the underlying physics of the process.

“There are many different phenomena that can take place” at the moment of impact, Hassani-Gangaraj says, but now for the first time the researchers have found that a brief period of melting upon impact plays a crucial role in eroding the surface when the particles are moving at speeds above a certain threshold.

That’s important information because the rule of thumb in industrial applications is that higher velocities will always lead to better results. The new findings show that this is not always the case, and “we should be aware that there is this region at the high end” of the range of impact velocities, where the effectiveness of the coating (or strengthening) declines instead of improving, Hassani-Gangaraj says. “To avoid that, we need to be able to predict” the speed at which the effects change.

The results may also shed light on situations where the impacts are uncontrolled, such as when wind-borne particles hit the blades of wind turbines, when microparticles strike spacecraft and satellites, or when bits of rock and grit carried along in a flow of oil or gas erode the walls of pipelines. “We want to understand the mechanisms and exact conditions when these erosion processes can happen,” Hassani-Gangaraj says.

The challenge of measuring the details of these impacts was twofold. First, the impact events take place extremely quickly, with particles travelling at upward of one kilometer per second (three or four times faster than passenger jet airplanes). And second, the particles themselves are so tiny, about a tenth of the thickness of a hair, that observing them requires very high magnification as well. The team used a microparticle impact testbed developed at MIT, which can record impact videos with frame rates of up to 100 million frames per second, to perform a series of experiments that have now clearly delineated the conditions that determine whether a particle will bounce off a surface, stick to it, or erode the surface by melting.

For their experiments, the team used tin particles of about 10 micrometers (hundred thousandths of a meter) in diameter, accelerated to speeds ranging up to 1 kilometer per second and hitting a tin surface. The particles were accelerated using a laser beam that instantly evaporates a substrate surface and ejects the particles in the process. A second laser beam was used to illuminate the flying particles as they struck the surface.

Video of the impact of a 10-micrometer particle (coming in from the left) traveling at more than 1 km/sec shows clearly the splashing away of molten material from the surface at the moment of impact. This kind of impact erosion was observed clearly for the first time in this MIT study. Courtesy of the researchers

Previous studies had relied on post-mortem analysis — studying the surface after the impact has taken place. But that did not allow for an understanding of the complex dynamics of the process. It was only the high-speed imaging that revealed that melting of both the particle and the surface took place at the moment of impact, in the high-speed cases.

The team used the data from these experiments to develop a general model to predict the response of particles of a given size travelling at a given speed, says David Veysset, a staff researcher at MIT and co-author of the paper. So far, he says, they have used pure metals, but the team plans further tests using alloys and other materials. They also intend to test impacts at a variety of angles other than the straight-down impacts tested so far. “We can extend this to every situation where erosion is important,” he says. The aim is to develop “one function that can tell us whether erosion will happen or not.”

That could help engineers “to design materials for erosion protection, whether it’s in space or on the ground, wherever they want to resist erosion,” Veysset says.

“The authors explore a new regime of high-speed impact in which the impacting particles actually melt,” says H. Jay Melosh, a professor of physics and aerospace engineering at Purdue University and a specialist on impacts, who was not involved in this study. He adds, “In this regime they can add material from the impacting particles as well as eroding the target. This may eventually find a technological application, but the work presented in the paper is mainly an analysis of the impact mechanics and gives a quantitative assessment of how much of the target (substrate) is eroded as a function of the impact velocity.”

Melosh says, “The experimental work is of very high quality. … I could imagine that it might have applications to some types of surface milling, similar to sandblasting but more aggressive than that method.”

The team included senior author Christopher Schuh, professor and head of the Department of Materials Science and Engineering, and Keith Nelson, professor of chemistry. The work was supported by the U.S. Department of Energy, the U.S. Army Research Office, and the Office of Naval research.



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miércoles, 28 de noviembre de 2018

Reproducing paintings that make an impression

The empty frames hanging inside the Isabella Stewart Gardner Museum serve as a tangible reminder of the world’s biggest unsolved art heist. While the original masterpieces may never be recovered, a team from MIT’s Computer Science and Artificial Intelligence Laboratory (CSAIL) might be able to help, with a new system aimed at designing reproductions of paintings.

RePaint uses a combination of 3-D printing and deep learning to authentically recreate favorite paintings — regardless of different lighting conditions or placement. RePaint could be used to remake artwork for a home, protect originals from wear and tear in museums, or even help companies create prints and postcards of historical pieces.

“If you just reproduce the color of a painting as it looks in the gallery, it might look different in your home,” says Changil Kim, one of the authors on a new paper about the system, which will be presented at ACM SIGGRAPH Asia in December. “Our system works under any lighting condition, which shows a far greater color reproduction capability than almost any other previous work.”

To test RePaint, the team reproduced a number of oil paintings created by an artist collaborator. The team found that RePaint was more than four times more accurate than state-of-the-art physical models at creating the exact color shades for different artworks.

At this time the reproductions are only about the size of a business card, due to the time-costly nature of printing. In the future the team expects that more advanced, commercial 3-D printers could help with making larger paintings more efficiently.

While 2-D printers are most commonly used for reproducing paintings, they have a fixed set of just four inks (cyan, magenta, yellow, and black). The researchers, however, found a better way to capture a fuller spectrum of Degas and Dali. They used a special technique they call “color-contoning,” which involves using a 3-D printer and 10 different transparent inks stacked in very thin layers, much like the wafers and chocolate in a Kit-Kat bar. They combined their method with a decades-old technique called half-toning, where an image is created by lots of little colored dots rather than continuous tones. Combining these, the team says, better captured the nuances of the colors.

With a larger color scope to work with, the question of what inks to use for which paintings still remained. Instead of using more laborious physical approaches, the team trained a deep-learning model to predict the optimal stack of different inks. Once the system had a handle on that, they fed in images of paintings and used the model to determine what colors should be used in what particular areas for specific paintings.

Despite the progress so far, the team says they have a few improvements to make before they can whip up a dazzling duplicate of “Starry Night.” For example, mechanical engineer Mike Foshey said they couldn’t completely reproduce certain colors like cobalt blue due to a limited ink library. In the future they plan to expand this library, as well as create a painting-specific algorithm for selecting inks, he says. They also can hope to achieve better detail to account for aspects like surface texture and reflection, so that they can achieve specific effects such as glossy and matte finishes.

“The value of fine art has rapidly increased in recent years, so there’s an increased tendency for it to be locked up in warehouses away from the public eye,” says Foshey. “We’re building the technology to reverse this trend, and to create inexpensive and accurate reproductions that can be enjoyed by all.”

Kim and Foshey worked on the system alongside lead author Liang Shi; MIT professor Wojciech Matusik; former MIT postdoc Vahid Babaei, now Group Leader at Max Planck Institute of Informatics; Princeton University computer science professor Szymon Rusinkiewicz; and former MIT postdoc Pitchaya Sitthi-Amorn, who is now a lecturer at Chulalongkorn University in Bangkok, Thailand.

This work is supported in part by the National Science Foundation.



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Tarana Burke, BethAnn McLaughlin, and Sherry Marts win 2018 Media Lab Disobedience Award

The MIT Media Lab’s 2018 Disobedience Award will be shared by three leaders of the #MeToo and #MeTooSTEM movement. Tarana Burke, founder of the “Me Too” movement; BethAnn McLaughlin, who brought “Me Too” conversation to STEM institutions; and Sherry Marts, who helps academic and nonprofit organizations become more fair and inclusive, have all taken a stand against sexual assault and harassment, and against the marginalization of survivors. The three winners will share the award’s $250,000 cash prize. Four finalist prizes of $10,000 will also be awarded.

The Disobedience Award, now in its second year, was created to recognize individuals and groups who engage in ethical, nonviolent acts of disobedience in service of society. The award is open to nominations for anyone still living and active in any field, including the arts, academia, law, politics, science, and social advocacy. A selection committee of 11 scientists, social justice experts, and thought leaders — including one of last year’s winners, Mona Hanna-Attisha — selected the winners and finalists from a global nomination pool. All five prizes were funded by LinkedIn co-founder Reid Hoffman.

Tarana Burke launched the “Me Too” movement in 2006. In 2017, when the #MeToo hashtag went viral, the movement gained enormous momentum, becoming a galvanizing force not only in giving survivors the courage to speak out, but also in bringing abusers to justice and bringing conversations about gender equality, toxic masculinity, and abuse of authority to the forefront. Burke, McLaughlin, and Marts represent three vital components of the movement — giving voice and strength to survivors, calling on institutions to hold abusers accountable, and helping organizations to improve their values and methods. All three have shown tremendous courage in the face of threats, derision, and professional consequences from peers and authority figures.

“This year’s winners embody the highest ideals of what the Disobedience Award is intended to honor: speaking truth to power, empowering the voiceless, accepting personal responsibility and fallout without a view to personal gain,” says Joi Ito, director of the Media Lab and co-founder of the award. “The #MeToo movement represents a sea change in American culture, in our institutions, in every professional, academic, and political arena. These three women are on the front lines of this movement, and their refusal to back down or be silenced is what will continue propelling the movement forward in the face of every kind of opposition. We have to support that kind of heroism.”

While the selection committee unanimously agreed on #MeToo and #MeTooSTEM as the clear winners for the 2018 award, their choice of finalists speaks to other important themes of responsible disobedience and voices that deserve to be heard: aiding immigrants and refugees, fighting for teachers and other public employees, and standing up for science and environmental protection. The four finalist prizes will go to Katie Endicott; Sarah Mardini and Yusra Mardini; Tara Parrish; and Deborah Swackhamer.

“Ethical, nonviolent disobedience takes many forms, and it was important to the selection committee that we acknowledge some of the many extraordinary people who were nominated this year,” says Ito. “This year’s finalists demonstrated both individual acts of courage, and organized leadership. What they have in common is a commitment to their values and a resistance to powerful authorities who have tried to stop or silence them.”

Winners

A civil rights activist who was the original founder of the "Me Too" Movement, which she started in 2006, Tarana Burke has dedicated her life to advocating for those who have experienced sexual trauma or harassment. In particular, Burke focuses on helping survivors who are women of color and from low-wealth communities — people who are frequently ignored or marginalized, even within the #MeToo movement. Burke has been honored as one of The Silence Breakers who were named TIME's 2017 Person of the Year, and named to TIME's "100 Most Influential People of 2018."

A neuroscientist at Vanderbilt University, BethAnn McLaughlin is a leader in what’s become known as #MeTooSTEM. Risking her lab’s funding and her professional reputation, McLaughlin began calling on the National Academy of Sciences and the American Association for the Advancement of Science to instate consequences for members found guilty of sexual assault or misconduct. She has organized petitions online calling for both institutions to revoke memberships of guilty parties — an act of vocal advocacy that has earned her threats and derision from academic peers. She also organized thousands of scientists and science advocates in calling for National Institutes of Health to stop funding individuals guilty of sexual assault and misconduct, which was particularly risky because her research is funded by the NIH. In addition, she founded a nonprofit to advocate for victims and a site to tell their stories. McLaughlin also launched a successful social media campaign to get the website RateMyProfessors.com to drop its red chili pepper professor “hotness” rating.

Sherry Marts experienced extensive harassment while in graduate school at Duke University. She finished her doctoral degree, but calling out her harasser may have affected her ability to succeed in academia. She is now a consultant with a particular focus on making academic and nonprofit organizations more fair and welcoming, including helping the American Geophysical Union to overhaul its code of conduct.

Finalists

A high school English teacher in Mingo County, West Virginia, and member of the West Virginia Education Association, Katie Endicott was one of the lead organizers and representatives during the West Virginia teachers’ strike in 2018, which ultimately resulted in a 5 percent pay increase for teachers and other state employees.

As competitive swimmers, sisters Sarah Mardini and Yusra Mardini were uniquely qualified to help when their boat foundered on the journey to Europe in 2015. They got in the water and helped pull the rubber dinghy toward shore, bringing their fellow refugees to safety. When they reached Greece, the sisters decided to work to help other refugees. Yusra Mardini was selected for the first-ever refugee Olympic team, competed in the 2016 games in Rio de Janeiro, and became a “goodwill ambassador” for the Office of the United Nations High Commissioner for Refugees. Sarah Mardini is currently detained in a Greek prison on charges related to efforts to rescue refugees, including espionage, violation of state secrecy laws, and criminal enterprise.

Tara Parrish is the director and lead organizer of the Pioneer Valley Project, which created the Springfield Interfaith Sanctuary Coalition. Springfield’s South Congregational Church offered sanctuary to Peruvian immigrant Gisella Collazo and her two children for over two months while she fought for a stay of deportation. The mayor publicly opposed the sanctuary, threatening to strip South Congregational of its tax-exempt status and sending inspectors and fire marshals to try to find reasons to shut it down. Parrish led the effort to mobilize the community to support Collazo and work with the city council to oppose the mayor. The council ultimately passed a resolution to ban city officials from interfering with the church, preventing the mayor or other political bodies from shutting down the sanctuary.

An environmental chemist who formerly led the U.S. Environmental Protection Agency’s Board of Scientific Counselors, Deborah Swackhamer was pressured by the EPA during a congressional hearing in 2017 to change her testimony in a way that would downplay the Trump administration’s decision not to reappoint half of the board’s executive committee members. Later that year, she was dismissed as the chair of the board.

Award ceremony

Winners and finalists will be honored in person at the Media Lab’s Disobedience event in Cambridge, Massachusetts, on Nov. 30, where they will also speak. Media Lab Director Joi Ito and Reid Hoffman will present the awards. Ethan Zuckerman, head of the Media Lab’s Center for Civic Media, will open the event, followed by a keynote from journalist Mona Eltahawy, entitled “Feminism in 3-D: Disobedience, defiance, and disruption.” Panels with the winners and finalists will be moderated by thought leaders Jamira Burley, Martha Minow, Lauren Duca, Kelsey Skaggs, and Annette Klapstein and Emily Johnston. The event is invitation-only, but will be livestreamed to the public. For a full agenda and link to the livestream, please visit disobedience.media.mit.edu.



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