jueves, 19 de junio de 2025

When Earth iced over, early life may have sheltered in meltwater ponds

When the Earth froze over, where did life shelter? MIT scientists say one refuge may have been pools of melted ice that dotted the planet’s icy surface.

In a study appearing today in Nature Communications, the researchers report that 635 million to 720 million years ago, during periods known as “Snowball Earth,” when much of the planet was covered in ice, some of our ancient cellular ancestors could have waited things out in meltwater ponds.

The scientists found that eukaryotes — complex cellular lifeforms that eventually evolved into the diverse multicellular life we see today — could have survived the global freeze by living in shallow pools of water. These small, watery oases may have persisted atop relatively shallow ice sheets present in equatorial regions. There, the ice surface could accumulate dark-colored dust and debris from below, which enhanced its ability to melt into pools. At temperatures hovering around 0 degrees Celsius, the resulting meltwater ponds could have served as habitable environments for certain forms of early complex life.

The team drew its conclusions based on an analysis of modern-day meltwater ponds. Today in Antarctica, small pools of melted ice can be found along the margins of ice sheets. The conditions along these polar ice sheets are similar to what likely existed along ice sheets near the equator during Snowball Earth.

The researchers analyzed samples from a variety of meltwater ponds located on the McMurdo Ice Shelf in an area that was first described by members of Robert Falcon Scott's 1903 expedition as “dirty ice.” The MIT researchers discovered clear signatures of eukaryotic life in every pond. The communities of eukaryotes varied from pond to pond, revealing a surprising diversity of life across the setting. The team also found that salinity plays a key role in the kind of life a pond can host: Ponds that were more brackish or salty had more similar eukaryotic communities, which differed from those in ponds with fresher waters.

“We’ve shown that meltwater ponds are valid candidates for where early eukaryotes could have sheltered during these planet-wide glaciation events,” says lead author Fatima Husain, a graduate student in MIT’s Department of Earth, Atmospheric and Planetary Sciences (EAPS). “This shows us that diversity is present and possible in these sorts of settings. It’s really a story of life’s resilience.”

The study’s MIT co-authors include Schlumberger Professor of Geobiology Roger Summons and former postdoc Thomas Evans, along with Jasmin Millar of Cardiff University, Anne Jungblut at the Natural History Museum in London, and Ian Hawes of the University of Waikato in New Zealand.

Polar plunge

“Snowball Earth” is the colloquial term for periods of time in Earth history during which the planet iced over. It is often used as a reference to the two consecutive, multi-million-year glaciation events which took place during the Cryogenian Period, which geologists refer to as the time between 635 and 720 million years ago. Whether the Earth was more of a hardened snowball or a softer “slushball” is still up for debate. But scientists are certain of one thing: Most of the planet was plunged into a deep freeze, with average global temperatures of minus 50 degrees Celsius. The question has been: How and where did life survive?

“We’re interested in understanding the foundations of complex life on Earth. We see evidence for eukaryotes before and after the Cryogenian in the fossil record, but we largely lack direct evidence of where they may have lived during,” Husain says. “The great part of this mystery is, we know life survived. We’re just trying to understand how and where.”

There are a number of ideas for where organisms could have sheltered during Snowball Earth, including in certain patches of the open ocean (if such environments existed), in and around deep-sea hydrothermal vents, and under ice sheets. In considering meltwater ponds, Husain and her colleagues pursued the hypothesis that surface ice meltwaters may also have been capable of supporting early eukaryotic life at the time.

“There are many hypotheses for where life could have survived and sheltered during the Cryogenian, but we don’t have excellent analogs for all of them,” Husain notes. “Above-ice meltwater ponds occur on Earth today and are accessible, giving us the opportunity to really focus in on the eukaryotes which live in these environments.”

Small pond, big life

For their new study, the researchers analyzed samples taken from meltwater ponds in Antarctica. In 2018, Summons and colleagues from New Zealand traveled to a region of the McMurdo Ice Shelf in East Antarctica, known to host small ponds of melted ice, each just a few feet deep and a few meters wide. There, water freezes all the way to the seafloor, in the process trapping dark-colored sediments and marine organisms. Wind-driven loss of ice from the surface creates a sort of conveyer belt that brings this trapped debris to the surface over time, where it absorbs the sun’s warmth, causing ice to melt, while surrounding debris-free ice reflects incoming sunlight, resulting in the formation of shallow meltwater ponds.

The bottom of each pond is lined with mats of microbes that have built up over years to form layers of sticky cellular communities.

“These mats can be a few centimeters thick, colorful, and they can be very clearly layered,” Husain says.

These microbial mats are made up of cyanobacteria, prokaryotic, single-celled photosynthetic organisms that lack a cell nucleus or other organelles. While these ancient microbes are known to survive within some of the the harshest environments on Earth including meltwater ponds, the researchers wanted to know whether eukaryotes — complex organisms that evolved a cell nucleus and other membrane bound organelles — could also weather similarly challenging circumstances. Answering this question would take more than a microscope, as the defining characteristics of the microscopic eukaryotes present among the microbial mats are too subtle to distinguish by eye.

To characterize the eukaryotes, the team analyzed the mats for specific lipids they make called sterols, as well as genetic components called ribosomal ribonucleic acid (rRNA), both of which can be used to identify organisms with varying degrees of specificity. These two independent sets of analyses provided complementary fingerprints for certain eukaryotic groups. As part of the team’s lipid research, they found many sterols and rRNA genes closely associated with specific types of algae, protists, and microscopic animals among the microbial mats. The researchers were able to assess the types and relative abundance of lipids and rRNA genes from pond to pond, and found the ponds hosted a surprising diversity of eukaryotic life.

“No two ponds were alike,” Husain says. “There are repeating casts of characters, but they’re present in different abundances. And we found diverse assemblages of eukaryotes from all the major groups in all the ponds studied. These eukaryotes are the descendants of the eukaryotes that survived the Snowball Earth. This really highlights that meltwater ponds during Snowball Earth could have served as above-ice oases that nurtured the eukaryotic life that enabled the diversification and proliferation of complex life — including us — later on.”

This research was supported, in part, by the NASA Exobiology Program, the Simons Collaboration on the Origins of Life, and a MISTI grant from MIT-New Zealand.



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miércoles, 18 de junio de 2025

QS ranks MIT the world’s No. 1 university for 2025-26

MIT has again been named the world’s top university by the QS World University Rankings, which were announced today. This is the 14th year in a row MIT has received this distinction.

The full 2026 edition of the rankings — published by Quacquarelli Symonds, an organization specializing in education and study abroad — can be found at TopUniversities.com. The QS rankings are based on factors including academic reputation, employer reputation, citations per faculty, student-to-faculty ratio, proportion of international faculty, and proportion of international students.

MIT was also ranked the world’s top university in 11 of the subject areas ranked by QS, as announced in March of this year.

The Institute received a No. 1 ranking in the following QS subject areas: Chemical Engineering; Civil and Structural Engineering; Computer Science and Information Systems; Data Science and Artificial Intelligence; Electrical and Electronic Engineering; Linguistics; Materials Science; Mechanical, Aeronautical, and Manufacturing Engineering; Mathematics; Physics and Astronomy; and Statistics and Operational Research.

MIT also placed second in seven subject areas: Accounting and Finance; Architecture/Built Environment; Biological Sciences; Business and Management Studies; Chemistry; Earth and Marine Sciences; and Economics and Econometrics.



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The MIT Press acquires University Science Books from AIP Publishing

The MIT Press announces the acquisition of textbook publisher University Science Books from AIP Publishing, a subsidiary of the American Institute of Physics (AIP).

University Science Books was founded in 1978 to publish intermediate- and advanced-level science and reference books by respected authors, published with the highest design and production standards, and priced as affordably as possible. Over the years, USB’s authors have acquired international followings, and its textbooks in chemistry, physics, and astronomy have been recognized as the gold standard in their respective disciplines. USB was acquired by AIP Publishing in 2021.

Bestsellers include John Taylor’s “Classical Mechanics,” the No. 1 adopted text for undergrad mechanics courses in the United States and Canada, and his “Introduction to Error Analysis;” and Don McQuarrie’s “Physical Chemistry: A Molecular Approach” (commonly known as “Big Red”), the second-most adopted physical chemistry textbook in the U.S.

“We are so pleased to have found a new home for USB’s prestigious list of textbooks in the sciences,” says Alix Vance, CEO of AIP Publishing. “With its strong STEM focus, academic rigor, and high production standards, the MIT Press is the perfect partner to continue the publishing legacy of University Science Books.” 

“This acquisition is both a brand and content fit for the MIT Press,” says Amy Brand, director and publisher of the MIT Press. “USB’s respected science list will complement our long-established publishing history of publishing foundational texts in computer science, finance, and economics.”

The MIT Press will take over the USB list as of July 1, with inventory transferring to Penguin Random House Publishing Services, the MIT Press’ sales and distribution partner.

For details regarding University Science Books titles, inventory, and how to order, please contact the MIT Press

Established in 1962, The MIT Press is one of the largest and most distinguished university presses in the world and a leading publisher of books and journals at the intersection of science, technology, art, social science, and design.

AIP Publishing is a wholly owned not-for-profit subsidiary of the AIP and supports the charitable, scientific, and educational purposes of AIP through scholarly publishing activities on its behalf and on behalf of our publishing partners.



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Supercharged vaccine could offer strong protection with just one dose

Researchers at MIT and the Scripps Research Institute have shown that they can generate a strong immune response to HIV with just one vaccine dose, by adding two powerful adjuvants — materials that help stimulate the immune system.

In a study of mice, the researchers showed that this approach produced a much wider diversity of antibodies against an HIV antigen, compared to the vaccine given on its own or with just one of the adjuvants. The dual-adjuvant vaccine accumulated in the lymph nodes and remained there for up to a month, allowing the immune system to build up a much greater number of antibodies against the HIV protein.

This strategy could lead to the development of vaccines that only need to be given once, for infectious diseases including HIV or SARS-CoV-2, the researchers say.

“This approach is compatible with many protein-based vaccines, so it offers the opportunity to engineer new formulations for these types of vaccines across a wide range of different diseases, such as influenza, SARS-CoV-2, or other pandemic outbreaks,” says J. Christopher Love, the Raymond A. and Helen E. St. Laurent Professor of Chemical Engineering at MIT, and a member of the Koch Institute for Integrative Cancer Research and the Ragon Institute of MGH, MIT, and Harvard.

Love and Darrell Irvine, a professor of immunology and microbiology at the Scripps Research Institute, are the senior authors of the study, which appears today in Science Translational Medicine. Kristen Rodrigues PhD ’23 and Yiming Zhang PhD ’25 are the lead authors of the paper.

More powerful vaccines

Most vaccines are delivered along with adjuvants, which help to stimulate a stronger immune response to the antigen. One adjuvant commonly used with protein-based vaccines, including those for hepatitis A and B, is aluminum hydroxide, also known as alum. This adjuvant works by activating the innate immune response, helping the body to form a stronger memory of the vaccine antigen.

Several years ago, Irvine developed another adjuvant based on saponin, an FDA-approved adjuvant derived from the bark of the Chilean soapbark tree. His work showed that nanoparticles containing both saponin and a molecule called MPLA, which promotes inflammation, worked better than saponin on its own. That nanoparticle, known as SMNP, is now being used as an adjuvant for an HIV vaccine that is currently in clinical trials.

Irvine and Love then tried combining alum and SMNP and showed that vaccines containing both of those adjuvants could generate even more powerful immune responses against either HIV or SARS-CoV-2.

In the new paper, the researchers wanted to explore why these two adjuvants work so well together to boost the immune response, specifically the B cell response. B cells produce antibodies that can circulate in the bloodstream and recognize a pathogen if the body is exposed to it again.

For this study, the researchers used an HIV protein called MD39 as their vaccine antigen, and anchored dozens of these proteins to each alum particle, along with SMNP.

After vaccinating mice with these particles, the researchers found that the vaccine accumulated in the lymph nodes — structures where B cells encounter antigens and undergo rapid mutations that generate antibodies with high affinity for a particular antigen. This process takes place within clusters of cells known as germinal centers.

The researchers showed that SMNP and alum helped the HIV antigen to penetrate through the protective layer of cells surrounding the lymph nodes without being broken down into fragments. The adjuvants also helped the antigens to remain intact in the lymph nodes for up to 28 days.

“As a result, the B cells that are cycling in the lymph nodes are constantly being exposed to the antigen over that time period, and they get the chance to refine their solution to the antigen,” Love says.

This approach may mimic what occurs during a natural infection, when antigens can remain in the lymph nodes for weeks, giving the body time to build up an immune response.

Antibody diversity

Single-cell RNA sequencing of B cells from the vaccinated mice revealed that the vaccine containing both adjuvants generated a much more diverse repertoire of B cells and antibodies. Mice that received the dual-adjuvant vaccine produced two to three times more unique B cells than mice that received just one of the adjuvants.

That increase in B cell number and diversity boosts the chances that the vaccine could generate broadly neutralizing antibodies — antibodies that can recognize a variety of strains of a given virus, such as HIV.

“When you think about the immune system sampling all of the possible solutions, the more chances we give it to identify an effective solution, the better,” Love says. “Generating broadly neutralizing antibodies is something that likely requires both the kind of approach that we showed here, to get that strong and diversified response, as well as antigen design to get the right part of the immunogen shown.”

Using these two adjuvants together could also contribute to the development of more potent vaccines against other infectious diseases, with just a single dose.

“What’s potentially powerful about this approach is that you can achieve long-term exposures based on a combination of adjuvants that are already reasonably well-understood, so it doesn’t require a different technology. It’s just combining features of these adjuvants to enable low-dose or potentially even single-dose treatments,” Love says.

The research was funded by the National Institutes of Health; the Koch Institute Support (core) Grant from the National Cancer Institute; the Ragon Institute of MGH, MIT, and Harvard; and the Howard Hughes Medical Institute.



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martes, 17 de junio de 2025

New 3D chips could make electronics faster and more energy-efficient

The advanced semiconductor material gallium nitride will likely be key for the next generation of high-speed communication systems and the power electronics needed for state-of-the-art data centers.

Unfortunately, the high cost of gallium nitride (GaN) and the specialization required to incorporate this semiconductor material into conventional electronics have limited its use in commercial applications.

Now, researchers from MIT and elsewhere have developed a new fabrication process that integrates high-performance GaN transistors onto standard silicon CMOS chips in a way that is low-cost and scalable, and compatible with existing semiconductor foundries.

Their method involves building many tiny transistors on the surface of a GaN chip, cutting out each individual transistor, and then bonding just the necessary number of transistors onto a silicon chip using a low-temperature process that preserves the functionality of both materials.

The cost remains minimal since only a tiny amount of GaN material is added to the chip, but the resulting device can receive a significant performance boost from compact, high-speed transistors. In addition, by separating the GaN circuit into discrete transistors that can be spread over the silicon chip, the new technology is able to reduce the temperature of the overall system.

The researchers used this process to fabricate a power amplifier, an essential component in mobile phones, that achieves higher signal strength and efficiencies than devices with silicon transistors. In a smartphone, this could improve call quality, boost wireless bandwidth, enhance connectivity, and extend battery life.

Because their method fits into standard procedures, it could improve electronics that exist today as well as future technologies. Down the road, the new integration scheme could even enable quantum applications, as GaN performs better than silicon at the cryogenic temperatures essential for many types of quantum computing.

“If we can bring the cost down, improve the scalability, and, at the same time, enhance the performance of the electronic device, it is a no-brainer that we should adopt this technology. We’ve combined the best of what exists in silicon with the best possible gallium nitride electronics. These hybrid chips can revolutionize many commercial markets,” says Pradyot Yadav, an MIT graduate student and lead author of a paper on this method.

He is joined on the paper by fellow MIT graduate students Jinchen Wang and Patrick Darmawi-Iskandar; MIT postdoc John Niroula; senior authors Ulriche L. Rodhe, a visiting scientist at the Microsystems Technology Laboratories (MTL), and Ruonan Han, an associate professor in the Department of Electrical Engineering and Computer Science (EECS) and member of MTL; and Tomás Palacios, the Clarence J. LeBel Professor of EECS, and director of MTL; as well as collaborators at Georgia Tech and the Air Force Research Laboratory. The research was recently presented at the IEEE Radio Frequency Integrated Circuits Symposium.

Swapping transistors

Gallium nitride is the second most widely used semiconductor in the world, just after silicon, and its unique properties make it ideal for applications such as lighting, radar systems and power electronics.

The material has been around for decades and, to get access to its maximum performance, it is important for chips made of GaN to be connected to digital chips made of silicon, also called CMOS chips. To enable this, some integration methods bond GaN transistors onto a CMOS chip by soldering the connections, but this limits how small the GaN transistors can be. The tinier the transistors, the higher the frequency at which they can work.

Other methods integrate an entire gallium nitride wafer on top of a silicon wafer, but using so much material is extremely costly, especially since the GaN is only needed in a few tiny transistors. The rest of the material in the GaN wafer is wasted.

“We wanted to combine the functionality of GaN with the power of digital chips made of silicon, but without having to compromise on either cost of bandwidth. We achieved that by adding super-tiny discrete gallium nitride transistors right on top of the silicon chip,” Yadav explains.

The new chips are the result of a multistep process.

First, a tightly packed collection of miniscule transistors is fabricated across the entire surface of a GaN wafer. Using very fine laser technology, they cut each one down to just the size of the transistor, which is 240 by 410 microns, forming what they call a dielet. (A micron is one millionth of a meter.)

Each transistor is fabricated with tiny copper pillars on top, which they use to bond directly to the copper pillars on the surface of a standard silicon CMOS chip. Copper to copper bonding can be done at temperatures below 400 degrees Celsius, which is low enough to avoid damaging either material.

Current GaN integration techniques require bonds that utilize gold, an expensive material that needs much higher temperatures and stronger bonding forces than copper. Since gold can contaminate the tools used in most semiconductor foundries, it typically requires specialized facilities.

“We wanted a process that was low-cost, low-temperature, and low-force, and copper wins on all of those related to gold. At the same time, it has better conductivity,” Yadav says.

A new tool

To enable the integration process, they created a specialized new tool that can carefully integrate the extremely tiny GaN transistor with the silicon chips. The tool uses a vacuum to hold the dielet as it moves on top of a silicon chip, zeroing in on the copper bonding interface with nanometer precision.

They used advanced microscopy to monitor the interface, and then when the dielet is in the right position, they apply heat and pressure to bond the GaN transistor to the chip.

“For each step in the process, I had to find a new collaborator who knew how to do the technique that I needed, learn from them, and then integrate that into my platform. It was two years of constant learning,” Yadav says.

Once the researchers had perfected the fabrication process, they demonstrated it by developing power amplifiers, which are radio frequency circuits that boost wireless signals.

Their devices achieved higher bandwidth and better gain than devices made with traditional silicon transistors. Each compact chip has an area of less than half a square millimeter.

In addition, because the silicon chip they used in their demonstration is based on Intel 16 22nm FinFET state-of-the-art metallization and passive options, they were able to incorporate components often used in silicon circuits, such as neutralization capacitors. This significantly improved the gain of the amplifier, bringing it one step closer to enabling the next generation of wireless technologies.

“To address the slowdown of Moore’s Law in transistor scaling, heterogeneous integration has emerged as a promising solution for continued system scaling, reduced form factor, improved power efficiency, and cost optimization. Particularly in wireless technology, the tight integration of compound semiconductors with silicon-based wafers is critical to realizing unified systems of front-end integrated circuits, baseband processors, accelerators, and memory for next-generation antennas-to-AI platforms. This work makes a significant advancement by demonstrating 3D integration of multiple GaN chips with silicon CMOS and pushes the boundaries of current technological capabilities,” says Atom Watanabe, a research scientist at IBM who was not involved with this paper.

This work is supported, in part, by the U.S. Department of Defense through the National Defense Science and Engineering Graduate (NDSEG) Fellowship Program and CHIMES, one of the seven centers in JUMP 2.0, a Semiconductor Research Corporation Program by the Department of Defense and the Defense Advanced Research Projects Agency (DARPA). Fabrication was carried out using facilities at MIT.Nano, the Air Force Research Laboratory, and Georgia Tech.



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This compact, low-power receiver could give a boost to 5G smart devices

MIT researchers have designed a compact, low-power receiver for 5G-compatible smart devices that is about 30 times more resilient to a certain type of interference than some traditional wireless receivers.

The low-cost receiver would be ideal for battery-powered internet of things (IoT) devices like environmental sensors, smart thermostats, or other devices that need to run continuously for a long time, such as health wearables, smart cameras, or industrial monitoring sensors.

The researchers’ chip uses a passive filtering mechanism that consumes less than a milliwatt of static power while protecting both the input and output of the receiver’s amplifier from unwanted wireless signals that could jam the device.

Key to the new approach is a novel arrangement of precharged, stacked capacitors, which are connected by a network of tiny switches. These miniscule switches need much less power to be turned on and off than those typically used in IoT receivers.

The receiver’s capacitor network and amplifier are carefully arranged to leverage a phenomenon in amplification that allows the chip to use much smaller capacitors than would typically be necessary. 

“This receiver could help expand the capabilities of IoT gadgets. Smart devices like health monitors or industrial sensors could become smaller and have longer battery lives. They would also be more reliable in crowded radio environments, such as factory floors or smart city networks,” says Soroush Araei, an electrical engineering and computer science (EECS) graduate student at MIT and lead author of a paper on the receiver.

He is joined on the paper by Mohammad Barzgari, a postdoc in the MIT Research Laboratory of Electronics (RLE); Haibo Yang, an EECS graduate student; and senior author Negar Reiskarimian, the X-Window Consortium Career Development Assistant Professor in EECS at MIT and a member of the Microsystems Technology Laboratories and RLE. The research was recently presented at the IEEE Radio Frequency Integrated Circuits Symposium.

A new standard

A receiver acts as the intermediary between an IoT device and its environment. Its job is to detect and amplify a wireless signal, filter out any interference, and then convert it into digital data for processing.

Traditionally, IoT receivers operate on fixed frequencies and suppress interference using a single narrow-band filter, which is simple and inexpensive.

But the new technical specifications of the 5G mobile network enable reduced-capability devices that are more affordable and energy-efficient. This opens a range of IoT applications to the faster data speeds and increased network capability of 5G. These next-generation IoT devices need receivers that can tune across a wide range of frequencies while still being cost-effective and low-power.

“This is extremely challenging because now we need to not only think about the power and cost of the receiver, but also flexibility to address numerous interferers that exist in the environment,” Araei says.

To reduce the size, cost, and power consumption of an IoT device, engineers can’t rely on the bulky, off-chip filters that are typically used in devices that operate on a wide frequency range.

One solution is to use a network of on-chip capacitors that can filter out unwanted signals. But these capacitor networks are prone to special type of signal noise known as harmonic interference.

In prior work, the MIT researchers developed a novel switch-capacitor network that targets these harmonic signals as early as possible in the receiver chain, filtering out unwanted signals before they are amplified and converted into digital bits for processing.

Shrinking the circuit

Here, they extended that approach by using the novel switch-capacitor network as the feedback path in an amplifier with negative gain. This configuration leverages the Miller effect, a phenomenon that enables small capacitors to behave like much larger ones.

“This trick lets us meet the filtering requirement for narrow-band IoT without physically large components, which drastically shrinks the size of the circuit,” Araei says.

Their receiver has an active area of less than 0.05 square millimeters.

One challenge the researchers had to overcome was determining how to apply enough voltage to drive the switches while keeping the overall power supply of the chip at only 0.6 volts.

In the presence of interfering signals, such tiny switches can turn on and off in error, especially if the voltage required for switching is extremely low.

To address this, the researchers came up with a novel solution, using a special circuit technique called bootstrap clocking. This method boosts the control voltage just enough to ensure the switches operate reliably while using less power and fewer components than traditional clock boosting methods.

Taken together, these innovations enable the new receiver to consume less than a milliwatt of power while blocking about 30 times more harmonic interference than traditional IoT receivers.

“Our chip also is very quiet, in terms of not polluting the airwaves. This comes from the fact that our switches are very small, so the amount of signal that can leak out of the antenna is also very small,” Araei adds.

Because their receiver is smaller than traditional devices and relies on switches and precharged capacitors instead of more complex electronics, it could be more cost-effective to fabricate. In addition, since the receiver design can cover a wide range of signal frequencies, it could be implemented on a variety of current and future IoT devices.

Now that they have developed this prototype, the researchers want to enable the receiver to operate without a dedicated power supply, perhaps by harvesting Wi-Fi or Bluetooth signals from the environment to power the chip.

This research is supported, in part, by the National Science Foundation.



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Gaspare LoDuca named VP for information systems and technology and CIO

Gaspare LoDuca has been appointed MIT’s vice president for information systems and technology (IS&T) and chief information officer, effective Aug. 18. Currently vice president for information technology and CIO at Columbia University, LoDuca has held IT leadership roles in or related to higher education for more than two decades. He succeeds Mark Silis, who led IS&T from 2019 until 2024, when he left MIT to return to the entrepreneurial ecosystem in the San Francisco Bay area.

Executive Vice President and Treasurer Glen Shor announced the appointment today in an email to MIT faculty and staff.

“I believe that Gaspare will be an incredible asset to MIT, bringing wide-ranging experience supporting faculty, researchers, staff, and students and a highly collaborative style,” says Shor. “He is eager to start his work with our talented IS&T team to chart and implement their contributions to the future of information technology at MIT.”

LoDuca will lead the IS&T organization and oversee MIT’s information technology infrastructure and services that support its research and academic enterprise across student and administrative systems, network operations, cloud services, cybersecurity, and customer support. As co-chair of the Information Technology Governance Committee, he will guide the development of IT policy and strategy at the Institute. He will also play a key role in MIT’s effort to modernize its business processes and administrative systems, working in close collaboration with the Business and Digital Transformation Office.

“Gaspare brings to his new role extensive experience leading a complex IT organization,” says Provost Cynthia Barnhart, who served as one of Shor's advisors during the search process. “His depth of experience, coupled with his vision for the future state of information technology and digital transformation at MIT, are compelling, and I am excited to see the positive impact he will have here.”

“As I start my new role, I plan to learn more about MIT’s culture and community to ensure that any decisions or changes we make are shaped by the community’s needs and carried out in a way that fits the culture. I’m also looking forward to learning more about the research and work being done by students and faculty to advance MIT’s mission. It’s inspiring, and I’m eager to support their success,” says LoDuca.

In his role at Columbia, LoDuca has overseen the IT department, headed IT governance committees for school and department-level IT functions, and ensured the secure operation of the university’s enterprise-class systems since 2015. During his tenure, he has crafted a culture of customer service and innovation — building a new student information system, identifying emerging technologies for use in classrooms and labs, and creating a data-sharing platform for university researchers and a grants dashboard for principal investigators. He also revamped Columbia’s technology infrastructure and implemented tools to ensure the security and reliability of its technology resources.

Before joining Columbia, LoDuca was the technology managing director for the education practice at Accenture from 1998 to 2015. In that role, he helped universities to develop and implement technology strategies and adopt modern applications and systems. His projects included overseeing the implementation of finance, human resources, and student administration systems for clients such as Columbia University, University of Miami, Carnegie Mellon University, the University System of Georgia, and Yale University.

“At a research institution, there’s a wide range of activities happening every day, and our job in IT is to support them all while also managing cybersecurity risks. We need to be creative and thoughtful in our solutions, and consider the needs and expectations of our community,” he says.

LoDuca holds a bachelor’s degree in chemical engineering from Michigan State University. He and his wife are recent empty nesters, and are in the process of relocating to Boston.



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Closing in on superconducting semiconductors

In 2023, about 4.4 percent (176 terawatt-hours) of total energy consumption in the United States was by data centers that are essential for processing large quantities of information. Of that 176 TWh, approximately 100 TWh (57 percent) was used by CPU and GPU equipment. Energy requirements have escalated substantially in the past decade and will only continue to grow, making the development of energy-efficient computing crucial. 

Superconducting electronics have arisen as a promising alternative for classical and quantum computing, although their full exploitation for high-end computing requires a dramatic reduction in the amount of wiring linking ambient temperature electronics and low-temperature superconducting circuits. To make systems that are both larger and more streamlined, replacing commonplace components such as semiconductors with superconducting versions could be of immense value. It’s a challenge that has captivated MIT Plasma Science and Fusion Center senior research scientist Jagadeesh Moodera and his colleagues, who described a significant breakthrough in a recent Nature Electronics paper, “Efficient superconducting diodes and rectifiers for quantum circuitry.”

Moodera was working on a stubborn problem. One of the critical long-standing requirements is the need for the efficient conversion of AC currents into DC currents on a chip while operating at the extremely cold cryogenic temperatures required for superconductors to work efficiently. For example, in superconducting “energy-efficient rapid single flux quantum” (ERSFQ) circuits, the AC-to-DC issue is limiting ERSFQ scalability and preventing their use in larger circuits with higher complexities. To respond to this need, Moodera and his team created superconducting diode (SD)-based superconducting rectifiers — devices that can convert AC to DC on the same chip. These rectifiers would allow for the efficient delivery of the DC current necessary to operate superconducting classical and quantum processors.

Quantum computer circuits can only operate at temperatures close to 0 kelvins (absolute zero), and the way power is supplied must be carefully controlled to limit the effects of interference introduced by too much heat or electromagnetic noise. Most unwanted noise and heat come from the wires connecting cold quantum chips to room-temperature electronics. Instead, using superconducting rectifiers to convert AC currents into DC within a cryogenic environment reduces the number of wires, cutting down on heat and noise and enabling larger, more stable quantum systems.

In a 2023 experiment, Moodera and his co-authors developed SDs that are made of very thin layers of superconducting material that display nonreciprocal (or unidirectional) flow of current and could be the superconducting counterpart to standard semiconductors. Even though SDs have garnered significant attention, especially since 2020, up until this point the research has focused only on individual SDs for proof of concept. The group’s 2023 paper outlined how they created and refined a method by which SDs could be scaled for broader application. 

Now, by building a diode bridge circuit, they demonstrated the successful integration of four SDs and realized AC-to-DC rectification at cryogenic temperatures. 

The new approach described in their recent Nature Electronics paper will significantly cut down on the thermal and electromagnetic noise traveling from ambient into cryogenic circuitry, enabling cleaner operation. The SDs could also potentially serve as isolators/circulators, assisting in insulating qubit signals from external influence. The successful assimilation of multiple SDs into the first integrated SD circuit represents a key step toward making superconducting computing a commercial reality. 

“Our work opens the door to the arrival of highly energy-efficient, practical superconductivity-based supercomputers in the next few years,” says Moodera. “Moreover, we expect our research to enhance the qubit stability while boosting the quantum computing program, bringing its realization closer." Given the multiple beneficial roles these components could play, Moodera and his team are already working toward the integration of such devices into actual superconducting logic circuits, including in dark matter detection circuits that are essential to the operation of experiments at CERN and LUX-ZEPLIN in at the Berkeley National Lab.

This work was partially funded by MIT Lincoln Laboratory’s Advanced Concepts Committee, the U.S. National Science Foundation, U.S. Army Research Office, and U.S. Air Force Office of Scientific Research.



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lunes, 16 de junio de 2025

A brief history of the global economy, through the lens of a single barge

In 1989, New York City opened a new jail. But not on dry land. The city leased a barge, then called the “Bibby Resolution,” which had been topped with five stories of containers made into housing, and anchored it in the East River. For five years, the vessel lodged inmates.

A floating detention center is a curiosity. But then, the entire history of this barge is curious. Built in 1979 in Sweden, it housed British troops during the Falkland Islands war with Argentina, became worker housing for Volkswagen employees in West Germany, got sent to New York, also became a detention center off the coast of England, then finally was deployed as oil worker housing off the coast of Nigeria. The barge has had nine names, several owners, and flown the flags of five countries.

In this one vessel, then, we can see many currents: globalization, the transience of economic activity, and the hazy world of transactions many analysts and observers call “the offshore,” the lightly regulated sphere of economic activity that encourages short-term actions.

“The offshore presents a quick and potentially cheap solution to a crisis,” says MIT lecturer Ian Kumekawa. “It is not a durable solution. The story of the barge is the story of it being used as a quick fix in all sorts of crises. Then these expediences become the norm, and people get used to them and have an expectation that this is the way the world works.”

Now Kumekawa, a historian who started teaching as a lecturer at MIT earlier this year, explores the ship’s entire history in “Empty Vessel: The Global Economy in One Barge,” just published by Knopf and John Murray. In it, he traces the barge’s trajectory and the many economic and geopolitical changes that helped create the ship’s distinctive deployments around the world.

“The book is about a barge, but it’s also about the developing, emerging offshore world, where you see these layers of globalization, financialization, privatization, and the dissolution of territoriality and orders,” Kumekawa says. “The barge is a vehicle through which I can tell the story of those layers together.”

“Never meant to be permanent”

Kumekawa first found out about the vessel several years ago; New York City obtained another floating detention center in the 1990s, which prompted Kumekawa to start looking into the past of the older jail ship, the former “Bibby Resolution,” from the 1990s. The more he found out about its distinctive past, the more curious he became.

“You start pulling on a thread, and you realize you can keep pulling,” Kumekawa says.

The barge Kumekawa follows in the book was built in Sweden in 1979 as the “Balder Scapa.” Even then, commerce was plenty globalized: The vessel was commissioned by a Norwegian shell company, with negotiations run by an expatriate Swedish shipping agent whose firm was registered in Panama and used a Miami bank.

The barge was built at an inflection point following the economic slowdown and oil shocks of the 1970s. Manufacturing was on the verge of declining in both Western Europe and the U.S.; about half as many people now work in manufacturing in those regions, compared to 1960. Companies were looking to find cheaper global locations for production, reinforcing the sense that economic activity was now less durable in any given place.

The barge became part of this transience. The five-story accommodation block was added in the early 1980s; in 1983 it was re-registered in the UK and sent to the Falkland Islands as a troop accommodation named the “COASTEL 3.” Then it was re-registered in the Bahamas and sent to Emden, West Germany, as housing for Volkswagen workers. The vessel then served its stints as inmate housing — first in New York, then off the coast of England from 1997 to 2005. By 2010, it had been re-re-re-registered, in St. Vincent and Grenadines, and was housing oil workers off the coast of Nigeria.

“Globalization is more about flow than about stocks, and the barge is a great example of that,” Kumekawa says. “It’s always on the move, and never meant to be a permanent container. It’s understood people are going to be passing through.”

As Kumekawa explores in the book, this sense of social dislocation overlapped with the shrinking of state capacity, as many states increasingly encouraged companies to pursue globalized production and lightly regulated financial activities in numerous jurisdictions, in the hope it would enhance growth. And it has, albeit with unresolved questions about who the benefits accrue to, the social dislocation of workers, and more.

“In a certain sense it’s not an erosion of state power at all,” Kumekawa says. “These states are making very active choices to use offshore tools, to circumvent certain roadblocks.” He adds: “What happens in the 1970s and certainly in the 1980s is that the offshore comes into its own as an entity, and didn’t exist in the same way even in the 1950s and 1960s. There’s a money interest in that, and there’s a political interest as well.”

Abstract forces, real materials and people

Kumekawa is a scholar with a strong interest in economic history; his previous book, “The First Serious Optimist: A.C. Pigou and the Birth of Welfare Economics,” was published in 2017. This coming fall, Kumekawa will be team-teaching a class on the relationship between economics and history, along with MIT economists Abhijit Banerjee and Jacob Moscona.

Working on “Empty Vessel” also necessitated that Kumekawa use a variety of research techniques, from archival work to journalistic interviews with people who knew the vessel well.

“I had a wonderful set of conversations with the man who was the last bargemaster,” Kumekawa says. “He was the person in effect steering the vessel for many years. He was so aware of all of the forces at play — the market for oil, the prices of accommodations, the regulations, the fact no one had reinforced the frame.”

“Empty Vessel” has already received critical acclaim. Reviewing it in The New York Times, Jennifer Szalai writes that this “elegant and enlightening book is an impressive feat.”

For his part, Kumekawa also took inspiration from a variety of writings about ships, voyages, commerce, and exploration, recognizing that these vessels contain stories and vignettes that illuminate the wider world.

“Ships work very well as devices connecting the global and the local,” he says. Using the barge as the organizing principle of his book, Kumekawa adds, “makes a whole bunch of abstract processes very concrete. The offshore itself is an abstraction, but it’s also entirely dependent on physical infrastructure and physical places. My hope for the book is it reinforces the material dimension of these abstract global forces.”



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Students and staff work together for MIT’s first “No Mow May”

In recent years, some grass lawns around the country have grown a little taller in springtime thanks to No Mow May, a movement originally launched by U.K. nonprofit Plantlife in 2019 designed to raise awareness about the ecological impacts of the traditional, resource-intensive, manicured grass lawn. No Mow May encourages people to skip spring mowing to allow for grass to grow tall and provide food and shelter for beneficial creatures including bees, beetles, and other pollinators.

This year, MIT took part in the practice for the first time, with portions of the Kendall/MIT Open Space, Bexley Garden, and the Tang Courtyard forgoing mowing from May 1 through June 6 to make space for local pollinators, decrease water use, and encourage new thinking about the traditional lawn. MIT’s first No Mow May was the result of championing by the Graduate Student Council Sustainability Subcommittee (GSC Sustain) and made possible by the Office of the Vice Provost for Campus Space Management and Planning. 

A student idea sprouts

Despite being a dense urban campus, MIT has no shortage of green spaces — from pocket gardens and community-managed vegetable plots to thousands of shade trees — and interest in these spaces continues to grow. In recent years, student-led initiatives supported by Institute leadership and operational staff have transformed portions of campus by increasing the number of native pollinator plants and expanding community gardens, like the Hive Garden. With No Mow May, these efforts stepped out of the garden and into MIT’s many grassy open spaces. 

“The idea behind it was to raise awareness for more sustainable and earth-friendly lawn practices,” explains Gianmarco Terrones, GSC Sustain member. Those practices include reducing the burden of mowing, limiting use of fertilizers, and providing shelter and food for pollinators. “The insects that live in these spaces are incredibly important in terms of pollination, but they’re also part of the food chain for a lot of animals,” says Terrones. 

Research has shown that holding off on mowing in spring, even in small swaths of green space, can have an impact. The early months of spring have the lowest number of flowers in regions like New England, and providing a resource and refuge — even for a short duration — can support fragile pollinators like bees. Additionally, No Mow May aims to help people rethink their yards and practices, which are not always beneficial for local ecosystems. 

Signage at each No Mow site on campus highlighted information on local pollinators, the impact of the project, and questions for visitors to ask themselves. “Having an active sign there to tell people, ‘look around. How many butterflies do you see after six weeks of not mowing? Do you see more? Do you see more bees?’ can cause subtle shifts in people’s awareness of ecosystems,” says GSC Sustain member Mingrou Xie. A mowed barrier around each project also helped visitors know that areas of tall grass at No Mow sites are intentional.

Campus partners bring sustainable practices to life

To make MIT’s No Mow May possible, GSC Sustain members worked with the Office of the Vice Provost and the Open Space Working Group, co-chaired by Vice Provost for Campus Space Management and Planning Brent Ryan and Director of Sustainability Julie Newman. The Working Group, which also includes staff from Open Space Programming, Campus Planning, and faculty in the School of Architecture and Planning, helped to identify potential No Mow locations and develop strategies for educational signage and any needed maintenance. “Massachusetts is a biodiverse state, and No Mow May provides an exciting opportunity for MIT to support that biodiversity on its own campus,” says Ryan. 

Students were eager for space on campus with high visibility, and the chosen locations of the Kendall/MIT Open Space, Bexley Garden, and the Tang Courtyard fit the bill. “We wanted to set an example and empower the community to feel like they can make a positive change to an environment they spend so much time in,” says Xie. 

For GSC Sustain, that positive change also takes the form of the Native Plant Project, which they launched in 2022 to increase the number of Massachusetts-native pollinator plants on campus — plants like swamp milkweed, zigzag goldenrod, big leaf aster, and red columbine, with which native pollinators have co-evolved. Partnering with the Open Space Working Group, GSC Sustain is currently focused on two locations for new native plant gardens — the President’s Garden and the terrace gardens at the E37 Graduate Residence. “Our short-term goal is to increase the number of native [plants] on campus, but long term we want to foster a community of students and staff interested in supporting sustainable urban gardening,” says Xie.

Campus as a test bed continues to grow

After just a few weeks of growing, the campus No Mow May locations sprouted buttercups, mouse ear chickweed, and small tree saplings, highlighting the diversity waiting dormant in the average lawn. Terrones also notes other discoveries: “It’s been exciting to see how much the grass has sprung up these last few weeks. I thought the grass would all grow at the same rate, but as May has gone on the variations in grass height have become more apparent, leading to non-uniform lawns with a clearly unmanicured feel,” he says. “We hope that members of MIT noticed how these lawns have evolved over the span of a few weeks and are inspired to implement more earth-friendly lawn practices in their own homes/spaces.”

No Mow May and the Native Plant Project fit into MIT’s overall focus on creating resilient ecosystems that support and protect the MIT community and the beneficial critters that call it home. MIT Grounds Services has long included native plants in the mix of what is grown on campus and native pollinator gardens, like the Hive Garden, have been developed and cared for through partnerships with students and Grounds Services in recent years. Grounds, along with consultants that design and install our campus landscape projects, strive to select plants that assist us with meeting sustainability goals, like helping with stormwater runoff and cooling. No Mow May can provide one more data point for the iterative process of choosing the best plants and practices for a unique microclimate like the MIT campus.

“We are always looking for new ways to use our campus as a test bed for sustainability,” says Director of Sustainability Julie Newman. “Community-led projects like No Mow May help us to learn more about our campus and share those lessons with the larger community.”

The Office of the Vice Provost, the Open Space Working Group, and GSC Sustain will plan to reconnect in the fall for a formal debrief of the project and its success. Given the positive community feedback, future possibilities of expanding or extending No Mow May will be discussed.



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Professor Emeritus Hank Smith honored for pioneering work in nanofabrication

Nanostructures are a stunning array of intricate patterns that are imperceptible to the human eye, yet they help power modern life. They are the building blocks of microchip transistors, etched onto grating substrates of space-based X-ray telescopes, and drive innovations in medicine, sustainability, and quantum computing.

Since the 1970s, Henry “Hank” Smith, MIT professor emeritus of electrical engineering, has been a leading force in this field. He pioneered the use of proximity X-ray lithography, proving that X-rays’ short optical wavelength could produce high-resolution patterns at the nanometer scale. Smith also made significant advancements in phase-shifting masks (PSMs), a technique that disrupts light waves to enhance contrast. His design of attenuated PSMs, which he co-created with graduate students Mark Schattenburg PhD ʼ84 and Erik H. Anderson ʼ81, SM ʼ84, PhD ʼ88, is still used today in the semiconductor industry.

In recognition of these contributions, as well as highly influential achievements in liquid-immersion lithography, achromatic-interference lithography, and zone-plate array lithography, Smith recently received the 2025 SPIE Frits Zernike Award for Microlithography. Given by the Society of Photo-Optical Instrumentation Engineers (SPIE), the accolade recognizes scientists for their outstanding accomplishments in microlithographic technology.

“The Zernike Award is an impressive honor that aptly recognizes Hank’s pioneering contributions,” says Karl Berggren, MIT’s Joseph F. and Nancy P. Keithley Professor in Electrical Engineering and faculty head of electrical engineering. “Whether it was in the classroom, at a research conference, or in the lab, Hank approached his work with a high level of scientific rigor that helped make him decades ahead of industry practices.”

Now 88 years old, Smith has garnered many other honors. He was also awarded the SPIE BACUS Prize, named a member of the National Academy of Engineering, and is a fellow of the American Academy of Arts and Sciences, IEEE, the National Academy of Inventors, and the International Society for Nanomanufacturing.

Jump-starting the nano frontier

From an early age, Smith was fascinated by the world around him. He took apart clocks to see how they worked, explored the outdoors, and even observed the movement of water. After graduating from high school in New Jersey, Smith majored in physics at College of the Holy Cross. From there, he pursued his doctorate at Boston College and served three years as an officer in the U.S. Air Force.

It was his job at MIT Lincoln Laboratory that ultimately changed Smith’s career trajectory. There, he met visitors from MIT and Harvard University who shared their big ideas for electronic and surface acoustic wave devices but were stymied by the physical limitations of fabrication. Yet, few were inclined to tackle this challenge.

“The job of making things was usually brushed off the table with, ‘oh well, we’ll get some technicians to do that,’” Smith said in his oral history for the Center for Nanotechnology in Society. “And the intellectual content of fabrication technology was not appreciated by people who had been ‘traditionally educated,’ I guess.”

More interested in solving problems than maintaining academic rank, Smith set out to understand the science of fabrication. His breakthrough in X-ray lithography signaled to the world the potential and possibilities of working on the nanometer scale, says Schattenburg, who is a senior research scientist at MIT Kavli Institute for Astrophysics and Space Research.

“His early work proved to people at MIT and researchers across the country that nanofabrication had some merit,” Schattenburg says. “By showing what was possible, Hank really jump-started the nano frontier.”

Cracking open lithography’s black box

By 1980, Smith left Lincoln Lab for MIT’s main campus and continued to push forward new ideas in his NanoStructures Laboratory (NSL), formerly the Submicron Structures Laboratory. NSL served as both a research lab and a service shop that provided optical gratings, which are pieces of glass engraved with sub-micron periodic patterns, to the MIT community and outside scientists. It was a busy time for the lab; NSL attracted graduate students and international visitors. Still, Smith and his staff ensured that anyone visiting NSL would also receive a primer on nanotechnology.

“Hank never wanted anything we produced to be treated as a black box,” says Mark Mondol, MIT.nano e-beam lithography domain expert who spent 23 years working with Smith in NSL. “Hank was always very keen on people understanding our work and how it happens, and he was the perfect person to explain it because he talked in very clear and basic terms.”

The physical NSL space in MIT Building 39 shuttered in 2023, a decade after Smith became an emeritus faculty member. NSL’s knowledgeable staff and unique capabilities transferred to MIT.nano, which now serves as MIT’s central hub for supporting nanoscience and nanotechnology advancements. Unstoppable, Smith continues to contribute his wisdom to the ever-expanding nano community by giving talks at the NSL Community Meetings at MIT.nano focused on lithography, nanofabrication, and their future. 

Smith’s career is far from complete. Through his startup LumArray, Smith continues to push the boundaries of knowledge. He recently devised a maskless lithography method, known as X-ray Maskless Lithography (XML), that has the potential to lower manufacturing costs of microchips and thwart the sale of counterfeit microchips.

Dimitri Antoniadis, MIT professor emeritus of electrical engineering and computer science, is Smith’s longtime collaborator and friend. According to him, Smith’s commitment to research is practically unheard-of.

“Once professors reach emeritus status, we usually inspire and supervise research,” Antoniadis says. “It’s very rare for retired professors to do all the work themselves, but he loves it.”

Enduring influence

Smith’s legacy extends far beyond the groundbreaking tools and techniques he pioneered, say his friends, colleagues, and former students. His relentless curiosity and commitment to his graduate students helped propel his field forward.

He earned a reputation for sitting in the front row at research conferences, ready to ask the first question. Fellow researchers sometimes dreaded seeing him there.

“Hank kept us honest,” Berggren says. “Scientists and engineers knew that they couldn’t make a claim that was a little too strong, or use data that didn’t support the hypothesis, because Hank would hold them accountable.”

Smith never saw himself as playing the good cop or bad cop — he was simply a curious learner unafraid to look foolish.

“There are famous people, Nobel Prize winners, that will sit through research presentations and not have a clue as to what’s going on,” Smith says. “That is an utter waste of time. If I don’t understand something, I’m going to ask a question.”

As an advisor, Smith held his graduate students to high standards. If they came unprepared or lacked understanding of their research, he would challenge them with tough, unrelenting questions. Yet, he was also their biggest advocate, helping students such as Lisa Su SB/SM ʼ91, PhD ʼ94, who is now the chair and chief executive officer of AMD, and Dario Gil PhD ʼ03, who is now the chair of the National Science Board and senior vice president and director of research at IBM, succeed in the lab and beyond.

Research Specialist James Daley has spent nearly three decades at MIT, most of them working with Smith. In that time, he has seen hundreds of advisees graduate and return to offer their thanks. “Hank’s former students are all over the world,” Daley says. “Many are now professors mentoring their own graduate students and bringing with them some of Hank’s style. They are his greatest legacy.”



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Celebrating an academic-industry collaboration to advance vehicle technology

On May 6, MIT AgeLab’s Advanced Vehicle Technology (AVT) Consortium, part of the MIT Center for Transportation and Logistics, celebrated 10 years of its global academic-industry collaboration. AVT was founded with the aim of developing new data that contribute to automotive manufacturers, suppliers, and insurers’ real-world understanding of how drivers use and respond to increasingly sophisticated vehicle technologies, such as assistive and automated driving, while accelerating the applied insight needed to advance design and development. The celebration event brought together stakeholders from across the industry for a set of keynote addresses and panel discussions on critical topics significant to the industry and its future, including artificial intelligence, automotive technology, collision repair, consumer behavior, sustainability, vehicle safety policy, and global competitiveness.

Bryan Reimer, founder and co-director of the AVT Consortium, opened the event by remarking that over the decade AVT has collected hundreds of terabytes of data, presented and discussed research with its over 25 member organizations, supported members’ strategic and policy initiatives, published select outcomes, and built AVT into a global influencer with tremendous impact in the automotive industry. He noted that current opportunities and challenges for the industry include distracted driving, a lack of consumer trust and concerns around transparency in assistive and automated driving features, and high consumer expectations for vehicle technology, safety, and affordability. How will industry respond? Major players in attendance weighed in.

In a powerful exchange on vehicle safety regulation, John Bozzella, president and CEO of the Alliance for Automotive Innovation, and Mark Rosekind, former chief safety innovation officer of Zoox, former administrator of the National Highway Traffic Safety Administration, and former member of the National Transportation Safety Board, challenged industry and government to adopt a more strategic, data-driven, and collaborative approach to safety. They asserted that regulation must evolve alongside innovation, not lag behind it by decades. Appealing to the automakers in attendance, Bozzella cited the success of voluntary commitments on automatic emergency braking as a model for future progress. “That’s a way to do something important and impactful ahead of regulation.” They advocated for shared data platforms, anonymous reporting, and a common regulatory vision that sets safety baselines while allowing room for experimentation. The 40,000 annual road fatalities demand urgency — what’s needed is a move away from tactical fixes and toward a systemic safety strategy. “Safety delayed is safety denied,” Rosekind stated. “Tell me how you’re going to improve safety. Let’s be explicit.”

Drawing inspiration from aviation’s exemplary safety record, Kathy Abbott, chief scientific and technical advisor for the Federal Aviation Administration, pointed to a culture of rigorous regulation, continuous improvement, and cross-sectoral data sharing. Aviation’s model, built on highly trained personnel and strict predictability standards, contrasts sharply with the fragmented approach in the automotive industry. The keynote emphasized that a foundation of safety culture — one that recognizes that technological ability alone isn’t justification for deployment — must guide the auto industry forward. Just as aviation doesn’t equate absence of failure with success, vehicle safety must be measured holistically and proactively.

With assistive and automated driving top of mind in the industry, Pete Bigelow of Automotive News offered a pragmatic diagnosis. With companies like Ford and Volkswagen stepping back from full autonomy projects like Argo AI, the industry is now focused on Level 2 and 3 technologies, which refer to assisted and automated driving, respectively. Tesla, GM, and Mercedes are experimenting with subscription models for driver assistance systems, yet consumer confusion remains high. JD Power reports that many drivers do not grasp the differences between L2 and L2+, or whether these technologies offer safety or convenience features. Safety benefits have yet to manifest in reduced traffic deaths, which have risen by 20 percent since 2020. The recurring challenge: L3 systems demand that human drivers take over during technical difficulties, despite driver disengagement being their primary benefit, potentially worsening outcomes. Bigelow cited a quote from Bryan Reimer as one of the best he’s received in his career: “Level 3 systems are an engineer’s dream and a plaintiff attorney’s next yacht,” highlighting the legal and design complexity of systems that demand handoffs between machine and human.

In terms of the impact of AI on the automotive industry, Mauricio Muñoz, senior research engineer at AI Sweden, underscored that despite AI’s transformative potential, the automotive industry cannot rely on general AI megatrends to solve domain-specific challenges. While landmark achievements like AlphaFold demonstrate AI’s prowess, automotive applications require domain expertise, data sovereignty, and targeted collaboration. Energy constraints, data firewalls, and the high costs of AI infrastructure all pose limitations, making it critical that companies fund purpose-driven research that can reduce costs and improve implementation fidelity. Muñoz warned that while excitement abounds — with some predicting artificial superintelligence by 2028 — real progress demands organizational alignment and a deep understanding of the automotive context, not just computational power.

Turning the focus to consumers, a collision repair panel drawing Richard Billyeald from Thatcham Research, Hami Ebrahimi from Caliber Collision, and Mike Nelson from Nelson Law explored the unintended consequences of vehicle technology advances: spiraling repair costs, labor shortages, and a lack of repairability standards. Panelists warned that even minor repairs for advanced vehicles now require costly and complex sensor recalibrations — compounded by inconsistent manufacturer guidance and no clear consumer alerts when systems are out of calibration. The panel called for greater standardization, consumer education, and repair-friendly design. As insurance premiums climb and more people forgo insurance claims, the lack of coordination between automakers, regulators, and service providers threatens consumer safety and undermines trust. The group warned that until Level 2 systems function reliably and affordably, moving toward Level 3 autonomy is premature and risky.

While the repair panel emphasized today’s urgent challenges, other speakers looked to the future. Honda’s Ryan Harty, for example, highlighted the company’s aggressive push toward sustainability and safety. Honda aims for zero environmental impact and zero traffic fatalities, with plans to be 100 percent electric by 2040 and to lead in energy storage and clean power integration. The company has developed tools to coach young drivers and is investing in charging infrastructure, grid-aware battery usage, and green hydrogen storage. “What consumers buy in the market dictates what the manufacturers make,” Harty noted, underscoring the importance of aligning product strategy with user demand and environmental responsibility. He stressed that manufacturers can only decarbonize as fast as the industry allows, and emphasized the need to shift from cost-based to life-cycle-based product strategies.

Finally, a panel involving Laura Chace of ITS America, Jon Demerly of Qualcomm, Brad Stertz of Audi/VW Group, and Anant Thaker of Aptiv covered the near-, mid-, and long-term future of vehicle technology. Panelists emphasized that consumer expectations, infrastructure investment, and regulatory modernization must evolve together. Despite record bicycle fatality rates and persistent distracted driving, features like school bus detection and stop sign alerts remain underutilized due to skepticism and cost. Panelists stressed that we must design systems for proactive safety rather than reactive response. The slow integration of digital infrastructure — sensors, edge computing, data analytics — stems not only from technical hurdles, but procurement and policy challenges as well. 

Reimer concluded the event by urging industry leaders to re-center the consumer in all conversations — from affordability to maintenance and repair. With the rising costs of ownership, growing gaps in trust in technology, and misalignment between innovation and consumer value, the future of mobility depends on rebuilding trust and reshaping industry economics. He called for global collaboration, greater standardization, and transparent innovation that consumers can understand and afford. He highlighted that global competitiveness and public safety both hang in the balance. As Reimer noted, “success will come through partnerships” — between industry, academia, and government — that work toward shared investment, cultural change, and a collective willingness to prioritize the public good.



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Anantha Chandrakasan named MIT provost

Anantha Chandrakasan, a professor of electrical engineering and computer science who has held multiple leadership roles at MIT, has been named the Institute’s new provost, effective July 1.

Chandrakasan has served as the dean of the School of Engineering since 2017 and as MIT’s inaugural chief innovation and strategy officer since 2024. Prior to becoming dean, he headed the Department of Electrical Engineering and Computer Science (EECS), MIT’s largest academic department, for six years.

“Anantha brings to this post an exceptional record of shaping and leading important innovations for the Institute,” wrote MIT President Sally Kornbluth, in an email announcing the decision to the MIT community today. “I am particularly grateful that we will be able to draw on Anantha’s depth and breadth of experience; his nimbleness, entrepreneurial spirit and boundless energy; his remarkable record in raising funds from outside sources for important ideas; and his profound commitment to MIT’s mission.”

The provost is MIT’s senior academic and budget officer, with overall responsibility for the Institute’s educational programs, as well as for the recruitment, promotion, and tenuring of faculty. With the president and other members of the Institute’s senior leadership team, the provost establishes academic priorities, manages financial planning and research support, and oversees MIT’s international engagements.

“I feel deeply honored to take on the role of provost,” says Chandrakasan, who is also the Vannevar Bush Professor of Electrical Engineering and Computer Science. “Looking ahead, I see myself as a key facilitator, enabling faculty, students, postdocs, and staff to continue making extraordinary contributions to the nation and the world.”

Investing in excellence

Chandrakasan succeeds Cynthia Barnhart, who announced her decision to step down from the role in February. As dean of engineering, Chandrakasan worked with Barnhart closely during her tenure as provost and, before that, chancellor.

“Cindy has been a tremendous mentor,” he says. “She is always very thoughtful and makes sure she hears all the viewpoints, which is something I will strive to do as well. I so admire how deftly she approaches complex problems and supports a variety of perspectives and approaches.”

As MIT’s chief academic officer, Chandrakasan will focus on three overarching priorities: understanding institutional needs and strategic financial planning, attracting and retaining top talent, and supporting cross-cutting research, education, and entrepreneurship programming. On all of these fronts, he plans to seek frequent input from across the Institute.

“Recognizing that each school and other academic units operate within a unique context, I plan to engage deeply with their leaders to understand their challenges and aspirations. This will help me refine and set the priorities for the Office of the Provost,” Chandrakasan says.

He also plans to establish a provost faculty advisory group to hear on an ongoing basis from faculty across the five schools and the college, as well as student/postdoc advisory groups and an external provost advisory council.

“My goal is to continue to facilitate excellence at MIT at all levels,” Chandrakasan says.

He adds: “There is a tremendous opportunity for MIT to be at the center of the innovations in areas where the United States wants to lead. It’s about AI. It’s about semiconductors. It’s about quantum, the biosecurity and biomanufacturing space — but not only that. We need students who can do more than just code or design or build. We really need students who understand the human perspective and human insights. This is why collaborations between STEM fields and the humanities, arts and social sciences, such as through the new MIT Human Insights Collaborative, are so important.”

In her email to the MIT community, Kornbluth also noted that Institute Professor Paula Hammond, currently vice provost for faculty, will take on an expanded portfolio with the new title of executive vice provost, and Deputy Dean of Engineering Maria Yang will serve as interim dean until the new dean is in place.

Advancing the president’s vision

In February 2024, Chandrakasan was appointed at MIT’s first chief innovation and strategy officer, to help develop and implement plans to advance research, education, and innovation in areas that President Kornbluth identified as her top priorities.

Working closely with the president, Chandrakasan oversaw MIT’s launch of several Institute-wide initiatives, including the MIT Human Insight Collaborative (MITHIC), the MIT Health and Life Sciences Collaborative (MIT HEALS), the MIT Generative AI Impact Consortium (MGAIC, or “magic”), the MIT Initiative for New Manufacturing (INM), and multiple energy- and climate-related initiatives including the MIT-GE Vernova Energy and Climate Alliance.

These initiatives bring together MIT faculty, staff, and students from across the Institute, as well as industry partners, supporting bold, ground-breaking research and education to address pressing problems. In launching them, Chandrakasan was responsible for the “full stack” of tasks, from developing the vision to finding funding to implementing the programming — a significant undertaking on top of his other responsibilities.

“People consider me intense, which might be true,” he says, with a chuckle. “The reality is that I’m deeply passionate about the academic mission of MIT to create breakthrough technologies, educate the next generation of leaders, and serve the country and the world.”

New models for collaboration

During his time as dean of engineering, Chandrakasan played a key role in advancing a variety of historic Institute-wide initiatives, including the founding of the MIT Schwarzman College of computing and the development of the MIT Fast Forward plan for addressing climate change. He also served as the inaugural chair of the Abdul Latif Jameel Clinic for Machine Learning in Health and as the co-chair of the academic workstream for MIT’s Task Force 2021. Earlier, he led an Institute-wide working group to guide the development of policies and procedures related to MIT’s 2016 launch of The Engine, an incubator and accelerator for tough tech, and also served on its inaugural board.

He implemented a variety of interdisciplinary programs within the School of Engineering, creating new models for how academia and industry can work together to accelerate the pace of research. This work led to multiple new initiatives, such as the MIT Climate and Sustainability Consortium, the MIT-IBM Watson AI Lab, the MIT-Takeda Program, the MIT and Accenture Convergence Initiative, the MIT Mobility Initiative, the MIT Quest for Intelligence, the MIT AI Hardware Program, the MIT-Northpond Program, the MIT Faculty Founder Initiative, and the MIT-Novo Nordisk Artificial Intelligence Postdoctoral Fellows Program.

Chandrakasan also welcomed and supported 110 new faculty members to the School of Engineering, including in the Department of Electrical Engineering and Computer Science, which jointly reports between the School of Engineering and the MIT Schwarzman College of Computing. He also oversaw 274 faculty and senior researcher promotion cases in Engineering Council.

One of his priorities as dean was to bolster the School of Engineering’s sense of community, launching several programs to give students and staff a more active role in shaping the initiatives and operations of the school, including the Staff Advice and Implementation Committee (SAIC), the undergraduate Student Advisory Group, the Graduate Student Advisory Group (GradSage), and the MIT School of Engineering Postdoctoral Fellowship Program for Engineering Excellence. Working closely with GradSage, Chandrakasan also played a key role in establishing the Daniel J. Riccio Graduate Engineering Leadership Program.

A champion for EECS research and education

Chandrakasan earned his BS, MS, and PhD in electrical engineering and computer sciences from the University of California at Berkeley. After joining the MIT faculty, he was the director of the Microsystems Technology Laboratories from 2006 until 2011, when he became the EECS department head.

An active researcher throughout his time at MIT, Chandrakasan has led the MIT Energy-Efficient Circuits and Systems Group even while taking on new administrative roles. The group works on the design and implementation of integrated systems, from ultra-low-power wireless sensors and multimedia devices to biomedical systems. Chandrakasan has more than 120,000 citations and has advised or co-advised and graduated 78 PhD students. He says this experience will help him succeed as provost.

“To understand the pain points of our researcher scholars, you have to be in the trenches,” he says.

While at the helm of EECS, Chandrakasan also launched a number of initiatives on behalf of the department’s students. For example, the Advanced Undergraduate Research Opportunities Program, more commonly known as “SuperUROP,” is a year-long independent research program that launched in EECS in 2012 and expanded to the whole School of Engineering in 2015.

Chandrakasan also initiated the Rising Stars program in EECS, an annual event that convenes graduate and postdoc women for the purpose of sharing advice about the early stages of an academic career. Another program for EECS postdocs, Postdoc6, aimed to foster a sense of community for postdocs and help them develop skills that will serve their careers.

As higher education faces new challenges, Chandrakasan says he is looking forward to helping MIT position itself for the future. “I'm not afraid to try bold things,” he says.



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sábado, 14 de junio de 2025

Startup’s biosensor makes drug development and manufacturing cheaper

In the biotech and pharmaceutical industries, ELISA tests provide critical quality control during drug development and manufacturing. The tests can precisely quantify protein levels, but they also require hours of work by trained technicians and specialized equipment. That makes them prohibitively expensive, driving up the costs of drugs and putting research testing out of reach for many.

Now the Advanced Silicon Group (ASG), founded by Marcie Black ’94, MEng ’95, PhD ’03 and Bill Rever, is commercializing a new technology that could dramatically lower the time and costs associated with protein sensing. ASG’s proprietary sensor combines silicon nanowires with antibodies that can bind to different proteins to create a highly sensitive measurement of their concentration in a given solution.

The tests can measure the concentration of many different proteins and other molecules at once, with results typically available in less than 15 minutes. Users simply place a tiny amount of solution on the sensor, rinse the sensor, and then insert it into ASG’s handheld testing system.

“We’re making it 15 times faster and 15 times lower cost to test for proteins,” Black says. “That’s on the drug development side. This could also make the manufacturing of drugs significantly faster and more cost-effective. It could revolutionize how we create drugs in this country and around the world.”

Since developing its sensor, ASG’s team has received inquiries from a long list of people interested in using them to develop new therapeutics, help elite athletes train, and understand soil concentrations in agriculture, among other applications.

For now, though, the small company is focusing on lowering barriers in health care by selling its low-cost sensors to companies developing and manufacturing drugs.

“Right now, money is a limiting factor in researching and creating new drugs,” explains Marissa Gillis, a member of ASG’s team. “Making these processes faster and less costly could dramatically increase the amount of biologic testing and creation. It also makes it more viable for companies to develop drugs for rare conditions with smaller markets.”

A family away from home

Black grew up in a small town in Ohio before coming to MIT for three degrees in electrical engineering.

“Going to MIT changed my life,” Black says. “It opened my eyes to the possibilities of doing science and engineering to make the world a better place. Also, just being around so many amazing people taught me how to dream big.”

For her PhD, Black worked with the late Institute Professor Mildred Dresselhaus, a highly acclaimed physicist and nanotechnology pioneer who Black remembers for her mentorship and compassion as much as her contributions to our understanding of exotic materials. Black couldn’t always afford to go home for holidays, so she’d spend Thanksgivings with the Dresselhaus family.

“Millie was an amazing person, and her family was a family away from home for me,” Black says. “Millie continued to be my mentor — and I hear she did this with a lot of students — until the day she died.”

For her thesis, Black studied the optical properties of nanowires, which taught her about the nanostructures and optoelectronics she’d eventually use as part of the Advanced Silicon Group.

Following graduation, Black worked at the Los Alamos National Laboratory before founding the company Bandgap Engineering, which developed efficient, low-cost nanostructured solar cells. That technology was subsequently commercialized by other companies and became the subject of a patent dispute. In 2015, Black spun out the Advanced Silicon Group to apply a similar technology to protein sensing.

ASG’s sensors combine known approaches for sensitizing silicon to biological molecules, using the photoelectric properties of silicon nanowires to detect proteins electrically.

“It’s basically a solar cell that we functionalize with an antibody that’s specific to a certain protein,” Black says. “When the protein gets close, it brings an electrical charge with it that will repel light carriers inside the silicon, and doing that changes how well the electron and the holes can recombine. By looking at the photocurrent when you’re exposed to a solution, you can tell how much protein is bound to the surface and thus the concentration of that protein.”

ASG was accepted into MIT.nano’s START.nano startup accelerator and MIT’s Office of Corporate Relations Startup Exchange Program soon after its founding, which gave Black’s team access to cutting-edge equipment at MIT and connected her with potential investors and partners.

Black has also received broad support from MIT’s Venture Mentoring Service and worked with researchers from MIT’s Microsystems Technology Laboratories (MTL), where she conducted research as a student.

“Even though the company is in Lowell, [Massachusetts], I’m constantly going to MIT and getting help from professors and researchers at MIT,” Black says.

Biosensing for impact

From extensive discussions with people in the pharmaceutical industry, Black learned about the need for a more affordable protein-measurement tool. During drug development and manufacturing, protein levels must be measured to detect problems such as contamination from host cell proteins, which can be fatal to patients even at very low quantities.

“It can cost more than $1 billion to develop a drug,” Black says. “A big part of the process is bioprocessing, and 50 to 80 percent of bioprocessing is dedicated to purifying these unwanted proteins. That challenge leads to drugs being more expensive and taking longer to get to market.”

ASG has since worked with researchers to develop tests for biomarkers associated with lung cancer and dormant tuberculosis and has received multiple grants from the National Science Foundation, the National Institute of Standards and Technology, and the commonwealth of Massachusetts, including funding to develop tests for host cell proteins.

This year, ASG announced a partnership with Axogen to help the regenerative nerve repair company grow nerve tissue.

“There’s a lot of interest in using our sensor for applications in regenerative medicine,” Black says. “Another example we envision is if you’re sick in rural India and there’s no doctor nearby, you can show up at a clinic, nurses can give this to you and test for the flu, Covid-19, food poisoning, pregnancy, and 10 other things all at once. The results come in 15 minutes, then you could get what you need or teleconference a doctor.”

ASG is currently able to produce about 2,000 of its sensors on 8-inch chips per production line in its partner’s semiconductor foundry. As the company continues scaling up production, Black is hopeful the sensors will lower costs at every step between drug developers and patients.

“We really want to lower the barriers for testing so that everyone has access to good health care,” Black says. “Beyond that, there are so many applications for protein sensing. It’s really where the rubber hits the road in biology, agriculture, diagnostics. We’re excited to partner with leaders in every one of these industries.”



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viernes, 13 de junio de 2025

First-of-its-kind device profiles newborns’ immune function

Researchers from the Singapore-MIT Alliance for Research and Technology (SMART), MIT’s research enterprise in Singapore, along with colleagues from KK Women's and Children's Hospital (KKH), have developed a first-of-its-kind device to profile the immune function of newborns.  
 
Using a single drop of blood, the BiophysicaL Immune Profiling for Infants (BLIPI) system provides real-time insights into newborns’ immune responses, enabling the early detection of severe inflammatory conditions and allowing for timely interventions. This critical innovation addresses the urgent and unmet need for rapid and minimally invasive diagnostic tools to protect vulnerable newborns, especially those born prematurely.
 
Critical unmet need in newborn care
 
Premature infants are particularly vulnerable to life-threatening conditions such as sepsis and necrotizing enterocolitis (NEC). Newborn sepsis — a bloodstream infection occurring in the first weeks of life — is a major global health challenge, causing up to 1 million infant deaths worldwide annually. NEC, a serious intestinal disease that causes severe inflammation, is one of the leading causes of death in premature babies — up to 50 percent of low-birth -eight neonates who get NEC do not survive. Infants can show vague symptoms, making diagnosis of these conditions challenging. However, both conditions can worsen rapidly and require immediate medical intervention for the best chance of recovery.
 
Current diagnostic methods to detect and prevent these serious conditions in newborns rely on large blood samples — up to 1 milliliter, a significant quantity of blood for a newborn — and lengthy laboratory processes. This is not ideal for newborns whose total blood volume may be as little as 50 ml among very premature infants less than 28 weeks old, which limits repeated or high-volume sampling and can potentially lead to anemia and other complications. At the same time, conventional tests — such as blood cultures or inflammatory panels — may take hours to days to return actionable results, limiting prompt targeted clinical interventions. The novel BLIPI device addresses these challenges by requiring only 0.05 ml of blood and delivering results within 15 minutes.
 
Revolutionizing newborn care
 
In a study, “Whole blood biophysical immune profiling of newborn infants correlates with immune responses,” published in Pediatric Research, the researchers demonstrated how BLIPI leverages microfluidic technology to measure how immune cells change when fighting infection by assessing their size and flexibility. Unlike conventional tests that only look for the presence of germs, BLIPI directly shows how a baby’s immune system is responding. The cell changes that BLIPI detects align with standard tests doctors rely on, including C-reactive protein levels, white blood cell counts, and immature-to-total neutrophil ratios. This testing format can quickly reveal whether a baby’s immune system is fighting an infection.
 
In the study, BLIPI was used to screen 19 infants at multiple time points — eight full-term and 11 preterm — and showed clear differences in how immune cells looked and behaved between the babies. Notably, when one premature baby developed a serious blood infection, the device was able to detect significant immune cell changes. This shows its potential in detecting infections early.
 
The work was led by researchers from the Critical Analytics for Manufacturing Personalized-Medicine (CAMP) and Antimicrobial Resistance (AMR) interdisciplinary research groups within SMART.
 
Just one drop of blood
 
BLIPI is a portable device that can give results at the ward or the neonatal intensive care units, removing the need for transporting blood samples to the laboratory and making it easily implementable in resource-limited or rural health-care settings. Significantly, BLIPI needs just one drop of blood, and 1/20 the blood volume than what existing methods require. These swift results can help clinicians make timely, lifesaving decisions in critical situations such as sepsis or NEC, where early treatment is vital.
 
“Our goal was to create a diagnostic tool that works within the unique constraints of neonatal care — minimal blood volume, rapid turnaround, and high sensitivity. BLIPI represents a major step forward by providing clinicians with fast, actionable immune health data using a noninvasive method, where it can make a real difference for newborns in critical care,” says Kerwin Kwek, research scientist at SMART CAMP and SMART AMR, and co-lead author of the study.
 
“BLIPI exemplifies our vision to bridge the gap between scientific innovation and clinical need. By leveraging microfluidic technologies to extract real-time immune insights from whole blood, we are not only accelerating diagnostics but also redefining how we monitor immune health in fragile populations. Our work reflects a new paradigm in point-of-care diagnostics: rapid, precise, and patient-centric,” says MIT Professor Jongyoon Han, co-lead principal investigator at SMART CAMP, principal investigator at SMART AMR, and corresponding author of the paper.
 
“KKH cares for about two-thirds of all babies born weighing less than 1,500 grams in Singapore. These premature babies often struggle to fight infections with their immature immune systems. With BLIPI, a single prick to the baby’s finger or heel can give us rapid insights into the infant’s immune response within minutes. This allows us to tailor treatments more precisely and respond faster to give these fragile babies the best chance at a healthy start not just in their early days, but throughout their lives,” says Assistant Professor Yeo Kee Thai, senior consultant at the Department of Neonatology at KKH, and senior author of the study.
 
Future research will focus on larger clinical trials to validate BLIPI’s diagnostic accuracy across diverse neonatal populations with different age groups and medical conditions. The researchers also plan to refine the device’s design for widespread adoption in hospitals globally, bringing a much-needed diagnostic solution for vulnerable infants at their cot side. Beyond hospitals, pharmaceutical companies and researchers may also leverage BLIPI in clinical trials to assess immune responses to neonatal therapies in real-time — a potential game-changer for research and development in pediatric medicine.
 
The research conducted at SMART is supported by the National Research Foundation Singapore under its Campus for Research Excellence and Technological Enterprise program. This collaboration exemplifies how Singapore brings together institutions as part of interdisciplinary, multi-institution efforts to advance technology for global impact. The work from KKH was partially supported by the Nurturing Clinician Scientist Scheme under the SingHealth Duke-NUS Academic Clinical Programme.


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