miércoles, 5 de octubre de 2016

Scene at MIT: Sundown, touchdown

"One of our assistant football coaches, James Klein, took this picture out on Briggs Field during a team practice. When he showed it to another assistant coach, they immediately told him send it to me, because I run the Twitter account for MIT Football.  
 
The best thing about this photo is that it was taken at the end of practice on a Wednesday. Usually, Wednesdays are one of the most important days of the week for our game preparation. That Friday afternoon, we loaded up our buses and traveled five-plus hours to Maine for an overnight stay. The following day — the Saturday after that picture was taken — we won our first game of the season against Maine Maritime Academy.  
 
At the time that night, it was a perfect picture. But it turned into a perfect week after our victory!"

—Nicholas Perron, assistant director of member services and the Alumni-Wang Center within the Department of Athletics, Physical Education and Recreation

Have a creative photo of campus life you'd like to share? Submit to Scene at MIT.



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Scene at MIT: Sundown, touchdown

"One of our assistant football coaches, James Klein, took this picture out on Briggs Field during a team practice. When he showed it to another assistant coach, they immediately told him send it to me, because I run the Twitter account for MIT Football.  
 
The best thing about this photo is that it was taken at the end of practice on a Wednesday. Usually, Wednesdays are one of the most important days of the week for our game preparation. That Friday afternoon, we loaded up our buses and traveled five-plus hours to Maine for an overnight stay. The following day — the Saturday after that picture was taken — we won our first game of the season against Maine Maritime Academy.  
 
At the time that night, it was a perfect picture. But it turned into a perfect week after our victory!"

—Nicholas Perron, assistant director of member services and the Alumni-Wang Center within the Department of Athletics, Physical Education and Recreation

Have a creative photo of campus life you'd like to share? Submit to Scene at MIT.



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MIT shares $75 million grant to fight heart disease

MIT is one of the institutions that will share the One Brave Idea Research Award to pursue new biomarkers for atherosclerosis — the hardening of the arteries that kills about 500,000 people in the United States every year.

The American Heart Association (AHA), Verily Life Sciences (formerly Google Life Sciences), and AstraZeneca launched the One Brave Idea program earlier this year, and the winners of the five-year, $75 million award were announced today.

At the core of the proposal is a collaboration between the Brigham and Women’s Hospital and MIT. The research team will be led by Calum MacRae, chief of cardiovascular medicine at Brigham and Women’s Hospital, and the MIT effort will be led by Elazer R. Edelman, the Thomas D. and Virginia W. Cabot Professor of Health Sciences and Technology in MIT’s Institute for Medical Engineering and Science. Edelman also directs the Harvard-MIT Biomedical Engineering Center and the MIT Clinical Research Center.

Together with researchers from Stanford University, Northeastern University, and others, the scientists will seek new ways to identify patients at risk before they suffer heart attacks or strokes. These biomarkers could be based on genetic variations, molecules found in the bloodstream, or behavioral features such as gait or speech.

“The focus previously has been on people in the tail end of their life, when they have already suffered a stroke or a heart attack. But by then, the ravages of the disease are already profound,” Edelman says. “So the question is, can we use modern biology and modern technology to protect people at risk of developing disease well before their presentation is catastrophic?”

Edelman, a cardiologist and bioengineer, helped to develop generations of cardiovascular devices like endovascular stents — metal-mesh tubes that can be inserted into diseased arteries to prevent them from collapsing. Later versions of the stents were designed to release drugs that prevent cells from clogging up the stents, which are now given to millions of patients every year.

The One Brave Idea team plans to begin by studying families with exceptionally high risk for coronary heart disease, gathering data from a number of sources: lifestyle data such as sleep, activity, and stress, as monitored by wearable technologies; environmental and economic data; and crowdsourced opinions of patients and families. The project will also draw on large populations of study subjects from the Framingham Heart Study and the Million Veteran Program.

Based on the new markers they identify, the researchers also hope to develop new treatments for heart disease. One of MIT’s major roles will be to help in designing therapeutic devices based on the new discoveries and optimizing their intended use in mock clinical settings, Edelman says.

“We can leverage our ability to build prototype devices and idealized application environments to ensure much greater likelihood of clinical success,” he says.

The project also includes researchers from the University of Toronto and the Boston University School of Medicine, as well the life sciences venture capital firm Atlas Venture.



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Monitoring Parkinson’s symptoms at home

Parkinson’s disease is the second most common neurodegenerative disorder in the developed world, with around 60,000 people diagnosed in the U.S. each year.

Although there is no cure for the disease, there are treatments that can reduce the severity of a patient’s symptoms. But for these treatments to be effective, clinicians need a method to regularly monitor the patient’s symptoms in the home.

In a paper published today in the journal Scientific Reports, researchers at MIT and elsewhere describe a technique they have developed to monitor Parkinson’s disease progression as patients interact with a computer keyboard.

In this way the technique, which is based on technology originally developed to replace computer passwords, allows Parkinson’s signs to be monitored as people perform ordinary tasks such as typing emails or updating their Facebook status, according to Luca Giancardo, a former Catalyst Fellow in the Madrid-MIT M+Vision Consortium in the Research Laboratory of Electronics at MIT, and one of the paper’s lead authors.

“This approach uses something we do normally — interacting with a digital device — so it does not add any additional burden or take time away from daily activities,” he says.

Parkinson’s disease, which is caused by a loss of nerve cells in the brain leading to a reduction in levels of the chemical dopamine, is a progressive disorder with signs including tremors and motor difficulties, and ultimately severe disability and dementia.

Medication to replace dopamine levels or mimic dopamine’s activity can help to lessen the severity of its signs.

If Parkinson’s could be diagnosed earlier, researchers may even be able to develop drugs that could potentially stall the progression of the disease, according to Álvaro Sánchez-Ferro, joint lead author and a former Catalyst Fellow in the Madrid-MIT M+Vision Consortium. “The problem is that so far there has not been an easy method to provide this early detection, and one reason is that the progression of the disease is very slow,” he says.

Existing methods to evaluate the severity of Parkinson’s signs are based on trained medical personnel assessing the patient’s ability to perform a number of movement activities. However, these assessments tend to be carried out in a clinical setting, limiting how often they can be undertaken.

So the researchers set out to investigate whether keystroke dynamics, a technique used to identify a computer user by the time they take to press down and release each key — typically around 100 milliseconds — could be used to monitor the motor effects of Parkinson’s disease in the home.

In previous work the researchers had demonstrated that the technique can be used to spot signs of sleep inertia, or the decline in motor dexterity caused by grogginess on being suddenly woken.

In the new experiments, at Spanish medical clinics 12 de Octubre, Hospital Clinico, and HM CINAC, coordinated by Sánchez Ferro and co-author José Obeso at HM CINAC, the researchers asked 42 patients with early stage Parkinson’s disease and 43 healthy subjects to type out a text of their choosing for 10-15 minutes on a computer keyboard.

The computer was installed with software designed to measure the timing of each press and release.

When they analyzed the typing data, they found a significant variation in the timing of each press and release in patients with early stage Parkinson’s disease, while in the healthy control group this was much more uniform, Giancardo says.

“By looking at the variation of this press and release, we were able to find a signature that allows us to detect Parkinson’s disease in our cohort.”

To ensure the privacy of patients taking part in the test, the software does not monitor the words people type, he says.

The system can be installed as software on a standard computer, or added to the hardware of a device, or even deployed on a webpage.

“We envisage that this could be used to fill in the gaps between visits to the neurologist, for example, or between other tests that cannot be carried out continuously,” says Giancardo.

Monitoring patients’ signs as they go about their daily activities could help doctors determine the most effective dosage of medication to prescribe at that time, and could ultimately help researchers to develop treatments to halt the disease, says Sanchez-Ferro.

It could also help patients to monitor the effectiveness of activities that can reduce the effects of Parkinson’s disease, he says.

“There are activities such as sports and yoga that can significantly help with the symptoms, and so the Parkinson’s community has been looking for a way to measure Parkinson’s signs quantitatively, which has so far proven very difficult to do,” says Giancardo.

This is a very important piece of work, according to Bryan Strange, director of the Laboratory for Clinical Neuroscience within the Technical University of Madrid’s Center for Biomedical Technology, in Spain.

“At present the ability to monitor the motor signs of those with Parkinson’s or those who are starting to develop the disease is limited to a clinical setting,” he says.

This restricts the frequency with which such tests can be carried out. “This [test] is not something that requires the patient to do something out of the ordinary,” he adds.

The researchers hope the technique could ultimately be used to create algorithms that can detect signs of other neurological or motor-based disorders. They have already received interest from technology startup companies interested in helping the team translate the technology.

The work was supported, in part, by the Michael J. Fox Foundation for Parkinson’s Research, with grants awarded to Obeso and Martha Gray, the J. W. Kieckhefer Professor of Health Sciences and Technology and a professor of electrical engineering and computer science at MIT. The team also includes Teresa Arroyo Gallego, a PhD  student at the Universidad Polytecnica in Madrid; Ian Butterworth  a former Catalyst Fellow in the Madrid-MIT M+Vision Consortium; Michele Matarazzo of HM CINAC; Paloma Montero of Hospital Clinico San Carlos; and Veronica Puertas-Martin.



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martes, 4 de octubre de 2016

Beaver-inspired wetsuits in the works

Beavers and sea otters lack the thick layer of blubber that insulates walruses and whales. And yet these small, semiaquatic mammals can keep warm and even dry while diving, by trapping warm pockets of air in dense layers of fur.

Inspired by these fuzzy swimmers, MIT engineers have now fabricated fur-like, rubbery pelts and used them to identify a mechanism by which air is trapped between individual hairs when the pelts are plunged into liquid.

The results, published in the journal Physical Review Fluids, provide a detailed mechanical understanding for how mammals such as beavers insulate themselves while diving underwater. The findings may also serve as a guide for designing bioinspired materials — most notably, warm, furry wetsuits.

“We are particularly interested in wetsuits for surfing, where the athlete moves frequently between air and water environments,” says Anette (Peko) Hosoi, a professor of mechanical engineering and associate head of the department at MIT. “We can control the length, spacing, and arrangement of hairs, which allows us to design textures to match certain dive speeds and maximize the wetsuit's dry region.” 

Hosoi’s co-authors include lead author and graduate student Alice Nasto, postdoc José Alvarado, and applied mathematics instructor Pierre-Thomas Brun, all from MIT, as well as former visiting researcher Marianne Regli, and Christophe Clanet, both of École Polytechnique, in France.

Surfing science

The group’s research was motivated by a 2015 trip to Taiwan. Hosoi leads MIT’s STE@M (Sports Technology and Education at MIT), a program that encourages students and faculty to pursue projects that help advance sports technologies. In the summer of 2015, Hosoi brought a group of STE@M students to Taiwan, where they visited several sporting goods makers, including the wetsuit manufacturer, Sheico Group.

“They are interested in sustainability, and asked us, ‘Is there a bioinspired solution for wetsuits?’” Hosoi says. “Surfers, who go in and out of the water, want to be nimble and shed water as quickly as possible when out of the water, but retain the thermal management properties to stay warm when they are submerged.”

When the group returned from the trip, Hosoi assigned the problem to Nasto, encouraging her to find examples in nature that could serve as a design model for warm, dry, streamlined wetsuits. In her literature searches, Nasto zeroed in on semiaquatic mammals, including beavers and sea otters. Biologists had observed that these animals trap, or “entrain” air in their fur.

Nasto also learned that the animals are covered in two types of fur: long, thin “guard” hairs, that act as a shield for shorter, denser “underfur.” Biologists have thought that the guard hairs keep water from penetrating the underfur, thereby trapping warm air against the animals’ skin. But as Nasto notes, “there was no thorough, mechanical understanding of that process. That’s where we come in.”

Deep pockets

The team laid out a plan: Fabricate precise, fur-like surfaces of various dimensions, plunge the surfaces in liquid at varying speeds, and with video imaging measure the air that is trapped in the fur during each dive.

To make hairy surfaces, Nasto first created several molds by laser-cutting thousands of tiny holes in small acrylic blocks. With each mold, she used a software program to alter the size and spacing of individual hairs. She then filled the molds with a soft casting rubber called PDMS (polydimethylsiloxane), and pulled the hairy surfaces out of the mold after they had been cured.

In their experiments, the researchers mounted each hairy surface to a vertical, motorized stage, with the hairs facing outward. They then submerged the surfaces in silicone oil — a liquid that they chose to better observe any air pockets forming.

As each surface dove down, the researchers could see within the hairs a clear boundary between liquid and air, with air forming a thicker layer in hairs closer to the surface, and progressively thinning out with depth. Among the various surfaces, they found that those with denser fur that were plunged at higher speeds generally retained a thicker layer of air within their hairs.

Fur trap

From these experiments, it appeared that the spacing of individual hairs, and the speed at which they were plunged, played a large role in determining how much air a surface could trap. Hosoi and Nasto then developed a simple model to describe this air-trapping effect in precise, mathematical terms. To do this, they modeled the hair surfaces as a series of tubes, representing the spaces between individual hairs. They could then model the flow of liquid within each tube, and measure the pressure balance between the resulting liquid and air layers.

“Basically we found that the weight of the water is pushing air in, but the viscosity of the liquid is resisting flow (through the tubes),” Hosoi explains. “The water sticks to these hairs, which prevents water from penetrating all the way to their base.” 

Hosoi and Nasto applied their equation to the experimental data and found their predictions matched the data precisely. The researchers can now accurately predict how thick an air layer will surround a hairy surface, based on their equation.

“People have known that these animals use their fur to trap air,” Hosoi says. “But, given a piece of fur, they couldn’t have answered the question: Is this going to trap air or not? We have now quantified the design space and can say, ‘If you have this kind of hair density and length and are diving at these speeds, these designs will trap air, and these will not.’ Which is the information you need if you’re going to design a wetsuit. Of course, you could make a very hairy wetsuit that looks like Cookie Monster and it would probably trap air, but that's probably not the best way to go about it.” 

José Bico, a lecturer at ESPCI (the City of Paris Industrial Physics and Chemistry Higher Educational Institution) in Paris, points to another application for the group’s results: the process of industrial dip-coating, by which surfaces are dipped in polymer to achieve an even, protective coating.

“Air or liquid entrainment is a big deal in a lot of industrial coating applications,” says Bico, who was not involved in the research. “For instance, many treatments involve dipping of an object in a bath of some liquid. In that case, you do not want air to remain trapped. This model tells how fast one may [dip] before trapping air.”

This research was funded, in part, by the National Science Foundation.



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MIT Climate CoLab awards innovative climate proposals, presents $10,000 prize

The MIT Climate CoLab recently honored 27 climate change projects at its conference on the MIT campus. The winners presented business models, social enterprises, public engagement campaigns, digital tools, and other work that will reduce greenhouse gas emissions or help the world adapt to anticipated climate change impacts.

Climate CoLab is a global online community of over 75,000 people who collaborate and compete through a series of interrelated contests focused on different aspects of the climate change problem. From the 27 contest winners of 2016, an esteemed panel of judges selected one $10,000 grand prize winner and three honorable mentions.

The Vancouver, British Columbia, company Climate Smart took home this year’s $10,000 grand prize for its Business Energy and Emissions Profile (BEEP) Dashboard, a carbon-mapping tool that connects cities and businesses working to cut carbon emissions.

The dashboard’s data visualization features help cities understand their energy usage and carbon emissions by industry and business type, allowing officials to more effectively engage with the private sector to reduce emissions. 

“We’re deeply humbled and inspired by this recognition,” said Elizabeth Sheehan, Climate Smart president and CEO. “Cities are the front lines in the climate challenge, yet often have limited resources. Our software helps them get the most bang for their buck, so they can be more effective in their work.”

The three honorable mention proposals are:

  • Benjamin Huber and Juna Shrestha, two researchers from Switzerland and Nepal who developed a project to help rice farmers in Nepal adopt a low-methane growing method;
  • James Gula, a retired Intel engineer who proposed using a franchise model to deploy locally-owned and operated microgrids in developing countries. This model can help the 1.2 billion people who live without electricity today more quickly access energy at scale; and
  • Nishaant Sangaavi and Alex Corneglio, entrepreneurs who built My Energy Xpert, an online tool that helps home- and small-building owners conduct a cheap, 15-minute energy audit. On average, their current users accept 70 percent of their retrofit recommendations, achieving an average of 25 percent in energy savings.

The grand prize judges included Adil Najam, dean of the Frederick S. Pardee School of Global Studies at Boston University; Janos Pasztor, senior advisor to the United Nations Secretary-General on Climate Change and a senior fellow at the Carnegie Council for Ethics in International Affairs; and Elke Weber the Gerhard R. Andlinger Professor in Energy and the Environment and professor of psychology and public affairs at Princeton University.

All the 2016 winners were recognized at the fourth Crowds and Climate conference, held alongside Boston’s HUBweek with a joint session with MIT’s Solve program. Crowds and Climate brought together representatives from businesses, non-profit organizations, governments, and communities around the world to help advance a new, collective way of tackling climate change.

These contests contribute to the overall goal of Climate CoLab, which is to use crowd-based approaches to help build detailed and effective climate change action plans, like those developed by countries as part of the 2015 UN Paris Agreement.

“Our hope is to open up the elite conference rooms and meeting halls where climate strategies are developed today and allow anyone with a good idea to contribute,” says Prof Thomas Malone, director of the Center for Collective Intelligence at the MIT Sloan School of Management and founder of Climate CoLab. 

“This year’s winners represent innovative, exciting work being done around the world to address climate change, and demonstrate how we can use our global collective intelligence to tackle important societal problems like this one.”



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Raffaele Ferrari receives Cody Award in Ocean Sciences

Raffaele Ferrari, the Cecil and Ida Green Professor in Earth and Planetary Sciences and Director of the MIT Program in Atmospheres, Oceans and Climate, has been selected to receive the 2016 Robert L. and Bettie P. Cody Award in Ocean Sciences.

The Scripps Institution of Oceanography at the University of California at San Diego biannually bestows the Cody Award to a scientist in recognition of outstanding contributions to and achievement in physical oceanography, marine biology, and Earth science. While several individuals were considered for the prestigious prize, Ferrari’s “pioneering efforts toward understanding the nature and rates of oceanic mixing and their consequences for the general circulation,” were among several reasons for his selection.

MIT professor emeritus of physical cceanography Carl Wunsch’s seasoned insight and justification helped to settle the matter. The prize citation reads:

"Raffaele Ferrari is awarded the 2016 Cody Prize for his stimulating and collaborative work directed at mechanisms of oceanic mixing and their interesting and sometimes unexpected consequences. With colleagues he has worked to greatly improve the rendering of mixing processes in numerical models directed at climate change and along the way has illuminated mixing processes with special attention to the submesoscale near the ocean surface, the mixed-layer generally, and the internal tide/internal wave field in its interactions with topography. He has applied these ideas towards illuminating the oceanic energy field, the paleocirculation, and studied the consequences for climate change generally."

Ferrari’s research examines the circulation of the ocean, its impact on present and past climates, and its role on shaping biological productivity. His group combines observations, theory, and numerical models to investigate the physics and biology of the ocean from scales of centimeters to thousand of kilometers. He collaborates with several groups and centers across the institute, including the Climate Modeling Initiative, the MIT-Woods Hole Oceanographic Institution Joint Program and MIT General Circulation Model.

In addition to the accolade, Scripps Institution of Oceanography has invited Ferrari to present the Cody Award public lecture at 3 p.m. on Oct. 12 in the Robert Paine Scripps Forum for Science, Society and the Environment (Scripps Seaside Forum), in La Jolla, California, as well as another talk at UC San Diego on his work later this year. Ferrari’s lecture, “The Role of Ocean Turbulence in Climate,” will show how small-scale ocean features can translate significant effects to the larger ocean and climate systems, but because of their size, they are too small to be incorporated into global climate models. Atmospheric clouds share a similar issue.

“Clouds are the Achilles heel of our atmosphere models,” said Ferrari in a statement. “In the lecture we will explore the Achilles heels of ocean models, how they impact our understanding of present and past climates, and the progress we are making in healing the heels.”

In the moments between his research pursuits, Ferrari directs the Program in Atmospheres, Oceans and Climate (PAOC), coordinates outreach events and stories with Oceans at MIT — an organization that pulls together all oceans-related content from MIT and WHOI — and is helping to oversee and direct the upcoming Climate@MIT group.

Before arriving at MIT, Ferrari attended the Scripps Institution of Oceanography and Polytechnic University of Turin, earning PhDs in physical oceanography and fluid dynamics, respectively. So, when Ferrari learned that he’d be the 13th recipient of the Cody Award, the selection held a special significance.

“I was a graduate student at Scripps from 1995 until 2000, so I am particularly honored to receive an award from my alma mater,” Ferrari said. “I remember attending the Cody Award lectures as a student, but I never imagined I would be delivering one in the future.”

The endowment for the Cody Award was established by the late Robert Cody and his wife Bettie, along with a significant contribution from Capital Research and Management Company, in recognition of Robert Cody's service to the Los Angeles-based firm.



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