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Chancellor Cynthia Barnhart announced today that Lisa Su ’90 SM ’91 PhD ’94, president and chief executive officer of Advanced Micro Devices (AMD), will be the guest speaker at MIT’s 2017 Investiture of Doctoral Hoods.
The custom of a guest speaker at the Investiture of Doctoral Hoods began in 2015. The motivation behind the selection of a guest speaker, a process that engages MIT faculty and doctoral students in the selection, is to invite an MIT alum who can elucidate a path for new PhDs and ScDs as they begin their careers. “We are delighted that Dr. Su will return to MIT this June,” said Chancellor Barnhart, host of the ceremony. “As an industry leader with a technical background, her perspective will resonate deeply with our doctoral candidates.”
Eric Grimson, chancellor for academic advancement, chairs the Commencement Committee. “It has been a terrific experience to collaborate with our faculty and students over the last three seasons to identify inspirational alumni to speak at hooding,” he said. “Dr. Su honors us with her participation, which continues what we hope will grow to be a rich MIT tradition.”
Su moved with her family to the United States from Taiwan as a young child. After her early education in New York City, she matriculated at MIT to study electrical engineering. Su manufactured test silicon wafers as part of the Undergraduate Research Opportunities Program, in addition to working during the summer at Analog Devices, on whose board she now serves and where she developed a passion for semiconductors and began to see their potential to change the world. The focus of her doctoral research was silicon-on-insulator technology.
After beginning her career as a technical staff member in the Semiconductor Process and Device Center at Texas Instruments, Su spent 13 years at IBM. There, she directed engineering and business operations in multiple roles that included vice president of the Semiconductor Research and Development Center, which was responsible for the strategic direction of IBM’s silicon technologies, joint development alliances, and semiconductor research and development operations. She then led technology roadmap and research and development efforts at Freescale Semiconductor, Inc. as chief technology officer, later serving as senior vice president and general manager for networking and multimedia. This latter role comprised responsibility for global strategy, marketing, and engineering for Freescale’s embedded communications and applications processor business.
Su joined AMD in 2012 as senior vice president and general manager for global business units, responsible for driving end-to-end business execution of AMD’s products and solutions. In 2014, she became chief operating officer, charged to integrate AMD’s business units, sales, global operations, and infrastructure enablement teams into a single market-facing organization responsible for all aspects of product strategy and execution. Today, as CEO, Su is credited for leadership that has sharpened AMD’s focus and restored market performance.
The announcement of Su as the 2017 hooding speaker was met with great enthusiasm in her home department of Electrical Engineering and Computer Science. Anantha Chandrakasan, the Vannevar Bush Professor and department head, said, “We are thrilled that Dr. Lisa Su will be the guest speaker at this year’s ceremony. She has held the highest leadership positions in major semiconductor companies and is a tremendous role model for our students. Dr. Su has had an impact in a broad range of technologies, from semiconductor devices and computing architectures to embedded systems and cloud computing. We look forward to hearing her perspectives and advice to the doctoral candidates.”
Su has published more than 40 technical articles and was named a fellow of the Institute of Electronics and Electrical Engineers in 2009. She was named a Top Semiconductor CEO on Institutional Investor magazine’s All-America Executive Team 2017 and, in 2016, received the Pinnacle Award as an Outstanding 50 Asian American in Business from the Asian American Business Development Center. Su was named “2014 Executive of the Year” at the Electrical Engineering Times and EDN 2014 Annual Creativity in Electronics Awards and was honored in Technology Review’s Top 100 Young Innovators in 2002. She serves on the board of directors for Analog Devices, the Global Semiconductor Alliance, and the U.S. Semiconductor Industry Association.
The 2017 Investiture of Doctoral Hoods will take place on June 8 at 10 a.m. in the Johnson Athletics Center Ice Rink. The ceremony is open to family and friends of doctoral candidates; no tickets are required.
A new online publication, Climate@MIT, reports on cutting-edge climate science research on campus and in the field. Co-sponsored by MIT’s Lorenz Center and the MIT Program in Atmospheres, Oceans, and Climate (PAOC) in the Department of Earth, Atmospheric and Planetary Sciences (EAPS), Climate@MIT unifies crosscutting research at MIT aimed at tackling some of the biggest questions and issues of our time into one platform. Further, it disseminates issues that MIT climate scientists confront and demystifies the complexities that they navigate while conducting their research. While focusing on climate as a fundamental science, Climate@MIT will occasionally also comment on climate action and policy.
Researchers participating in Climate@MIT are dedicated to uncovering the causes and implications of climate changes for our past, present, and future world. Using observations, theory, and models, contributors aim to unite algorithmic, computational, physical, biogeochemical, and technological innovations to illustrate how the climate has been and is being modified through time. Elements of computational fluid dynamics, statistics, meteorology, oceanography, cryospheric and land surface processes, and computer science add definition to the larger picture of Earth’s changes. Researchers also investigate interactions between organisms, human activities, and ecosystems, which provide additional levels of feedback on natural processes affecting Earth’s climate and its changes over time.
While the field of climate science is ever-evolving as new facets are discovered, a key goal of Climate@MIT is to provide current, accurate, and relevant climate research and reporting to governments, industries, and citizens — all while helping foster an informed society, aware of the intricacies involved with climate research and armed with information to understand our changing planet.
Building 7 is most known for the soaring four-story lobby that greets visitors who enter the campus from Massachusetts Avenue. Not as widely recognized is that the building is home to four galleries that feature regular exhibitions of art, architecture, and design.
After the first-ever “Building 7 Block Party and Gallery Walk” last week, however, the secret may be out: Hundreds of people from the MIT community and public filled the hallways and galleries throughout the building to celebrate the start of the spring semester and view new exhibitions of photography, drawing, and architecture.
Co-hosted by the MIT Libraries, the Department of Architecture, the MIT Museum, and the Dean for the School of Architecture and Planning — the four “neighbors” on the block — the event included food and refreshments at every gallery, a raffle of signed books by MIT authors, and a pop-up exhibit of drawings from a team of recent alumni and graduate students.
“As a place dedicated to exhibiting creative work by the community, Rotch Library was a natural partner for the event,” said Chris Bourg, the director of MIT Libraries. “This is a great example of the libraries realizing our potential as vibrant gathering places for the MIT community.”
Hashim Sarkis, dean of the School of Architecture and Planning, said the Gallery Walk produced a record turnout for the galleries. “Art is everywhere at MIT, if you know where to look,” he said. “We’re delighted that so many people responded to our invitation to take a look with us.”
The four exhibitions will remain on view throughout the semester. They are:
Rotch Library Gallery (Second floor, Room 7-238)
“Book Marks: Photographs by Thomas Gearty"
SA+P Dean’s Gallery (Second floor, Room 7-231)
Wolk Gallery (Third floor, Room 7-338)
“Reinterpreting Gropius: New Architecture for the Bauhaus Archive in Berlin"
Keller Gallery (Fourth floor, Room 7-408)
"Some Evidence of Real Alternatives: 2017 Master of Architecture Graduate Thesis Exhibition"
When Institute Professor Emerita Mildred Dresselhaus passed away on Feb. 20, MIT and the national science community lost a leader, not only in terms of her remarkable personal achievements as a nanoscience pioneer, but also her considerable effort to encourage women to seek careers in science. Dresselhaus’ achievements have inspired a great many women to follow in her footsteps — including her granddaughter, Leora Cooper, who is currently pursuing her PhD in physical chemistry with Professor Keith Nelson at MIT.
As part of a campaign to promote women’s careers in science, GE recently released a video that asks, “What if Millie Dresselhaus, female scientist, was treated like a celebrity?” In the spot, little girls play with Dresselhaus dolls and dress up in her signature braids and sweaters, parents name their daughters after her, and Dresselhaus gives celebrity interviews. As part of this campaign, GE also invited Dresselhaus to walk the red carpet at the Academy Awards in Los Angeles. Following Dresselhaus’ death, it was decided that Cooper and her cousin, Clara Dresselhaus, would attend the Academy Awards in the late Institute Professor emerita's place, representing both their grandmother and future generations of female scientists.
Q: How did growing up with one of the great female celebrities in science as a role model affect you, and what advice can you impart upon young girls who aspire to follow in your and your grandmother’s footsteps by seeking careers in STEM fields?
A: Math and science have been an important part of my life for as long as I can remember. Millie was always very modest and never wanted to impose her ideas on anyone, but science was such a large part of her life that it spilled into everything else she did. As young girls, my sister and I went on science adventures together with our mother or grandmother. We were always encouraged to be curious about our surroundings and to try to learn how things worked. The highlight of many days were my morning rides to school where my father explained how something in science or engineering worked. In family and in mentoring, Millie always led by example. I’m certain that she inspired the family spirit that science holds answers to the world around us. It wasn’t until later in my life that I started to understand that other young girls got very different childhood messages.
As I have progressed through college and now graduate school, I see inequalities that I didn’t notice as a child. I see minorities having difficulty receiving the opportunities they deserve, I see honest immigrants being turned away at the border, and I have watched women get discouraged from pursuing careers in all walks of life. I came to understand that Millie’s success story was an anomaly and not the norm. As I started struggling with many of these same issues, I started speaking with her about how changes should be made, but I always assumed that change would need to come from others. During her career, Millie gave talks in at least 30 countries, and she had advisory capacities in numerous universities, foundations, and even government agencies across the world. By example, she showed me that a career in STEM can give a voice to the issues that surround us. In my years with Millie at MIT, we began talking about ideas for changes that could help women to succeed, but in our last year together she showed me how to stand up and start seeing those ideas through to reality. She has shown me that a STEM career can give you a voice to see these changes become a reality.
My cousin, Clara, is the next generation. She is thinking of going into STEM now, and will have to be strong enough to get through these same issues that generations before her have contend with. Her grandmother gave her a wonderful role model, but not a guide as she begins to face these difficulties. Like other women in STEM, she will need to build her own support group to get the support and mentorship she needs to continue. But if scientists in our generation follow Millie’s example and push, we can make this easier in future.
For young girls, my advice is to keep asking questions, even if you need to work to find the answers. Don’t ever let yourself say “I must not be good at this”; instead, ask yourself, “what did I miss here?” But from Millie, I have learned that inspiring young girls to pursue STEM is only the first hurdle. The advice should never stop. We all benefit from having a base of people to advise us and help us continue to achieve our dreams. My advice to women, from young girls to established women, is to stand up when you see something that isn’t right, and start working to make these changes happen in the world around us.
Q: What does appearing on the Academy Awards’ red carpet in your grandmother’s stead mean to you?
A: This experience honors Millie in more ways than you would expect. As a poor girl growing up in the Bronx, Millie didn’t have the money she needed to see the movies like her friends. To join them, she took a job reviewing movies for a local newspaper, which gave her free tickets. Millie always said that this job first taught her how to write clearly and succinctly. Even at the end of her life, she wrote papers longhand on her lap, as she learned from those days.
For my part, I have seen the red carpet at the Academy Awards as a mythical place that just wasn’t for people like me. I always saw the society and science as versions of “cool” that rarely overlapped. Going into science has isolated me a lot from pop culture, but getting to bring the two together is a special opportunity. As a high school student, Clara Dresselhaus has watched more movies and followed the actors more than I have. Her connection to popular culture gives her a better understanding of how the younger generation responds to science and technology and how to get them excited by it. Clara and I can make a team that understands how to bring the important issues in science and pop culture together, just as Millie always encouraged in scientific collaborations across fields.
When GE first gave Millie the script for the Real Heroes commercial, she was extremely hesitant to let it take her away from her students, as she didn’t understand the point. She showed it to me and asked what I thought she should do. The script described scenes that painted a picture of her as a modern celebrity because of her scientific achievements, inspiring even young girls who couldn’t yet understand her contributions. With the help of her assistant, Read Schusky, I explained to her that being part of the commercial would allow her to inspire a new demographic that can be hard to reach as scientists. The commercial aired shortly before her death, and Millie never got a chance to see the impact that it will make.
GE’s invitation to attend the Academy Awards on her behalf is almost the very definition of bittersweet. Millie’s invitation gives me hope that society is learning how to value female scientists for their achievements and contributions. Millie always loved having interdisciplinary projects bring seemingly unrelated fields together. I wish she could have laughed and enjoyed seeing science and entertainment come together in this wonderful way. Millie always knew when her students needed a little push to be able to achieve something new. In walking the red carpet, I see Millie giving me that push she knew I needed to learn how to reach out to the women of the next generation. For me, the red carpet represents both the loss of my grandmother and mentor, and the opportunity to continue her legacy of encouraging society to value science.
Q: What positive impact will the Hollywood representation of female pioneers in science like your grandmother and the women whose stories are featured in the Oscar-nominated film “Hidden Figures” have on the future of women in STEM fields?
A: Science and Hollywood both spread new information to wide groups of people across the world, but they access different venues. While films reach a general demographic, science is still widely viewed as unintelligible. At MIT, most of us are familiar with trying to explain our work to a non-technical person only to have them respond, “don’t bother, I won’t understand it.” Even the most general of science talks and events have trouble reaching these non-technical people. Hollywood gives science a voice that can be heard by the non-technical. This allows people from non-technical parts of the world to see a life that they do not know or understand.
Without being accustomed to the struggles female scientists often face, non-technical people who see films like “Hidden Figures” can see injustices they weren’t aware of. This allows us to celebrate people who have overcome these injustices in much the way that Millie and the stars of “Hidden Figures” have at MIT and NASA respectively. These are often injustices that go unnoticed by people within STEM because the ubiquity of it causes us to become accustomed to it. Women’s suffrage and the civil rights movements have shown us that society better addresses issues that have a common voice. The Hollywood representation of female scientists as underrepresented heroes can help the world recognize the importance of encouraging women in STEM.
The United States shares 5,525 miles of land border with Canada and 1,989 miles with Mexico. Monitoring these borders, which is the responsibility of U.S. Customs and Border Protection (CBP), is an enormous task. Detecting, and responding to, illegal activity while facilitating lawful commerce and travel is made more difficult by the expansive, rugged, diverse, and thickly vegetated geography that spans both often-crossed borders. To help mitigate the challenges to border surveillance, a group of researchers at MIT Lincoln Laboratory is investigating whether an airborne ladar system capable of imaging objects under a canopy of foliage could aid in the maintenance of border security by remotely detecting illegal activities. Their work will be presented at the 16th Annual IEEE Symposium on Technologies for Homeland Security to be held April 25-26 in Waltham, Massachusetts.
Requisite for effective border protection is timely, actionable information on areas of interest. Leveraging the laboratory’s long experience in building imaging systems that exploit microchip lasers and Geiger-mode avalanche photodiodes, the research team developed and tested two concepts of operations (CONOPS) for using airborne ladar systems to detect human activity in wooded regions.
"For any new technology to be effectively used by CBP, an emerging sensor must bring with it a sensible deployment architecture and concept of operation," said John Aldridge, a technical staff member from the Laboratory's Homeland Protection Systems Group, who has been working with a multidisciplinary, cross-divisional team that includes Marius Albota, Brittany Baker, Daniel Dumanis, Rajan Gurjar, and Lily Lee. The CONOPS that the engineering team focused on were cued examination of a localized area and uncued surveillance of a large area. To demonstrate the approach, the engineering team conducted proof-of-concept experiments with the laboratory's Airborne Optical Systems Testbed (AOSTB), a Twin Otter aircraft outfitted with an onboard ladar sensor.
For cued surveillance, the use of an airborne ladar sensor platform (whether a piloted or unpiloted aircraft system) might be prompted by another persistent sensor that indicates the presence of activity in a localized area at or near the border. "The area of coverage for cued surveillance may be in the 1 km2 to 10 km2 range, and the laboratory has already developed and demonstrated sensor technology that can achieve this coverage in minutes," Albota said.
Uncued wide-area surveillance sorties might be flown long distances and over timelines of days or weeks to establish typical activity patterns and to discover emerging paths and structures in high-interest regions. "The area coverage required under such a CONOPS may reach as high as 300 to 800 km of border, depending on the Border Patrol Sector and vegetation density," Aldridge explained, adding, "Although the current AOSTB's area coverage rate is limited by the aircraft's airspeed, the sensor can image such a region in a matter of hours in a single sortie."
As a start to their field tests to assess their CONOPS, the team flew data collection runs over several local sites identified as representative of the northern U.S. border environment. The sites contained a variety of low-growing brush, thin ground vegetation, very tall coniferous-trees, and leafy deciduous trees. For the tests, the team positioned vehicles, tents, and other camp equipment in the woods to serve as the targets of interest. "We made 40 passes at an altitude of 7,500 feet to allow for a spatial resolution of about 25 centimeters," Dumanis said. "In between each pass, we moved the concealed items so that we could perform post-process analysis for change and motion detection," Baker added.
In this post-processing stage, the team members enhanced the data captured during the flights so that human analysts could then inspect the ladar imagery. They digitally removed ground-height data to reveal the three-dimensional ladar point cloud above ground and then digitally thresholded the height (erased 3-D points above a certain height) to eliminate the foliage cover. The resulting images gave analysts Gurjar and Lee a starting point for approximating the locations of both the planted objects as well as objects that were already on scene.
Searching through vast quantities of ladar data to spot areas for careful inspection is a labor intensive task even for experienced analysts who can recognize subtle cues that direct them to the possible presence of objects in the imagery. For the ladar data to be efficiently mined, an automated method of identifying areas of interest is needed. "One of the ways to alert analysts to potential targets is to track changes in the 3-D temporal data," Lee explained. "Changes caused by vehicle movements or alterations in a customary scene can indicate uncharacteristic activity."
To begin a change detection approach to the discovery of potential targets of interest, the research team registered the before and after ladar data and then subtracted the before data from the after dataset. This process allowed some improvement in the visual identification of vehicles that appeared where there had been none before; however, even a skilled human analyst would find it difficult to spot the small changes that signaled the presence of a vehicle.
A change detection approach, therefore, must compensate for the challenge posed by clutter in the ladar data. This clutter comes from the nature of ladar collection in densely foliated environment. As light travels through gaps between foliage, it bounces off a surface of leaves, ground, or human-made objects. The returned light is collected by the ladar sensor to form the 3-D point cloud. Because the motion induced by a flying platform causes each ladar scan to travel through different configurations of gaps between leaves, different parts of the canopy and shrubbery are sensed by the ladar. "Much of the clutter in our change detection output is from the different levels of canopy detected from different ladar scans," explained Gurjar.
To make the ladar change detection data easier for analysts to search, the team looked to automated object detection, a well-established field in computer vision that has been applied to images and radar data. Since ladar data presents in three dimensions and has unique noise characteristics, the team had to enhance the established automated detection approach with a sum of absolute difference (SAD) technique that factors in the height differences used to construct 3-D ladar imagery. Trials of the SAD technique applied to simulated vehicles in a foliated environment demonstrated that the approach yielded high detection rates and has potential as an automated method for reducing the huge amount of ladar data analysts would have to scrutinize to discover objects of interest.
"Looking forward, we hope to improve the capabilities of automated 3-D change detection to be more robust to natural temporal changes in foliage, expand the number of automatically detected object classes, and extend automated detection capability to full 3-D point clouds," said Lee, with Aldridge adding that they are also interested in exploring alternative aircraft for hosting the ladar system.
In its strategic plan "Vision and Strategy 2020," the CBP has expressed the need to apply advanced technology solutions for border management. Continued development of Lincoln Laboratory's automated approach to using a low-cost ladar system for surveillance of foliated regions may in the future offer another tool that the Department of Homeland Security's CBP can deploy to monitor the growing volume of land border activity.
The iron-containing molecule heme is necessary for life. Cells require heme to perform the chemical reactions that produce energy, among other critical tasks.
Scientists who study the malaria parasite are particularly interested in heme because many malaria drugs interact with this molecule, also known as a cofactor. However, until now researchers have lacked good ways to measure heme levels inside the parasite.
A team of MIT biological engineers has developed a method to do just that. Using a genetically encoded fluorescent protein that interacts with heme, the researchers can image heme within cells and measure how much is present. This could eventually help scientists develop better drugs to combat malaria, says Jacquin Niles, an MIT associate professor of biological engineering.
“One of our long-term goals is to use insights from these studies to understand the pathways that regulate heme and to target these for antimalarial drug discovery purposes,” says Niles, the senior author of the study, which appears in the Proceedings of the National Academy of Sciences the week of Feb. 27.
James Abshire, a recent MIT PhD recipient, is the paper’s lead author. Other authors are former postdocs Christopher Rowlands and Suresh Ganesan, and professor of biological and mechanical engineering Peter So.
Heme control
Heme is found in nearly all cells and is especially plentiful in red blood cells, which use it to carry oxygen. However, cells need to keep tight control over the cofactor because it is reactive and can damage other molecules in cells. Heme is usually embedded within other proteins that carefully control its activity. If heme levels get too high, the molecule is either broken down by enzymes or put into a storage compartment where it can’t cause cellular damage.
“There’s always a balance between how much of it you make or acquire, and how much of it you need to execute critical functions,” Niles says.
Niles was motivated to explore how the parasite Plasmodium falciparum controls heme levels because of the known interactions between this cofactor and the antimalarial drugs known as quinolones, which include chloroquine. Until recently, when the parasite became resistant to chloroquine, this drug was used widely to treat malaria.
“Many successful antimalarial compounds seem to exert their antimalarial effect through interacting with or somehow disrupting heme homeostasis within the parasite,” Niles says.
As he started to think about investigating those interactions, he realized that not much was known about how the parasite controls its heme levels. This is a particularly important task for these organisms because they spend part of their life cycle inside red blood cells, where they take up and degrade substantial quantities of hemoglobin and release heme in the process.
“The first step was to figure out how much labile heme parasites maintain in their cytosolic compartment as they develop within red blood cells, and how those levels might change with certain environmental perturbations — such as exposure to heme-interacting antimalarial drugs,” Niles says.
To achieve this, Niles and his colleagues developed a heme-sensing protein whose fluorescence dims when it binds to heme. This sensor protein can be expressed in the parasite, allowing the researchers to measure heme levels in parasites by measuring changes in fluorescence.
Daniel Goldberg, co-director of the Division of Infectious Diseases at the Washington University School of Medicine, described this as an “elegant” approach to sensing heme.
“It works beautifully and allows measurement of cytoplasmic heme in malaria parasites. This is crucial for understanding parasite metabolism and antimalarial drug mechanism,” says Goldberg, who was not involved in the research.
Drug interactions
Using this sensor, the researchers found that malaria parasites maintain higher labile heme levels than previously estimated. Most scientists studying the parasite had assumed that heme levels would be lower due to the cofactor’s potential to damage cells.
“At this time, we don’t really know the physiological role of these observed labile heme levels in the parasite,” he says. “But what this might do is set the parasite up to be particularly vulnerable to antimalarial drugs that interact with heme.”
One possibility is that drugs such as chloroquine somehow increase heme levels to the point where damage to parts of the cell (such as the cell membrane) cause parasite death. Artemisinin, another potent antimalarial drug, also seems to be dependent on heme within the parasite for its effectiveness. Thus, finding out more about the role of heme in causing parasite toxicity could help researchers develop new drugs that exploit these mechanisms.
“This could provide insights into alternate ways by which we can disrupt heme homeostasis for therapeutic purposes — ideally in a way that circumvents the mechanisms of resistance that parasites have developed to drugs like chloroquine,” Niles says.
Once widely used, chloroquine is now mostly ineffective due to widespread resistance. Artemesinin-based combinations are now standard treatment, but resistance is emerging in parts of Southeast Asia, according to the Centers for Disease Control and Prevention.
In future studies, Niles plans to adapt the heme sensors so they can be targeted to different compartments of the cell to measure how heme is distributed within the parasite. He also plans to study the sources of heme — whether parasites synthesize it on their own or scavenge most of it from red blood cells — and how those processes might be affected as the parasite moves into later stages of its life cycle.
The research was supported by the National Institute of General Medical Sciences, the National Institutes of Health, and the Wellcome Trust.